Gordon Research Conferences
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Conference Program
 
Quantitative Genetics & Genomics
Genetics of Complex Disease and Other Phenotypes
February 17-22, 2013
Hotel Galvez
Galveston, TX
Chair:
Jack Dekkers

Vice Chair:
Michel A. Georges

Related Meeting Information
The Quantitative Genetics & Genomics Gordon Research Conference was held in conjunction with the Quantitative Genetics & Genomics Gordon Research Seminar. Please refer to the Quantitative Genetics & Genomics GRS web page for more information.

Many diseases that affect humans, animals, and plants are so-called complex traits, in that variation in susceptibility between individuals is affected by multiple genetic and environmental factors. Thus, strategies to understand and utilize the genetic basis and genetic architecture of these traits relies on the application of quantitative genetics. Traditionally built upon statistical abstractions of genetic effects, the field of quantitative genetics is now rapidly advancing by making use of the extensive and rapid developments in genetic and genomic technologies to reveal explicit links between genes and complex phenotypes. The field of quantitative genetics, therefore, serves as a focal point for bringing together many existing and emerging areas of genetics, genomics, physiology, epidemiology, statistics, and computational biology. The strength and aim of the Gordon Research Conference on "Quantitative Genetics & Genomics" is that it brings leaders in the fields of human genetics, plant and animal breeding and genetics, and evolutionary genetics together in a unique format that promotes an open exchange of ideas and presentation of unpublished results on cutting edge developments in the field. In 2013, the Gordon Research Conference will be preceded by a Gordon Research Seminar, which will allow an unparalleled opportunity for up and coming students and postdoctoral researchers to exchange ideas on the most cutting edge science, gain experience presenting their work in a high-profile setting, and interact with leaders in their field. The 2013 Conference and Seminar will focus on many cutting-edge developments in the field of quantitative genetics but with specific emphasis on the genetics of complex disease, including whole genome and next generation sequencing approaches to understanding and exploiting genetic variation, to identify causal genes and pathways, genome architecture and regulation, systems genetics, host-pathogen interaction and co-evolution, non-traditional forms of inheritance, and statistical genetics and genomics.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmChallenges and Prospects for Complex Disease Genetics and Genomics
Discussion Leader: Jack Dekkers (Iowa State University)
7:45 pm - 8:25 pmAravindra Chakravarti (Johns Hopkins University)
"Is complete genetic dissection of complex traits possible?"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmBruce Walsh (University of Arizona)
"Is disease susceptibility a standard quantitative trait or an atypical one?"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmIntegrated Strategies for Genome-Wide Association Studies
9:00 am - 9:20 amDiscussion Leader: Natalia DeLeon (University of Wisconsin - Madison)
"Introduction and Concepts"
9:20 am - 9:55 amSusan McCouch (Cornell University)
"Are we learning anything new from genome wide association studies (GWAS) in rice?"
9:55 am - 10:10 amDiscussion
10:10 amCoffee Break
10:50 am - 11:25 amStephan Beck (University College London)
"EWAS: the new kid on the block for epigenome-wide association studies"
11:25 am - 11:40 amDiscussion
11:40 am - 12:15 pmPatrick Schnable (Iowa State University)
"GBS-enabled GWAS: Identification and Validation of Kernel Row Number-associated SNPs in Maize"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEvolutionary Genetics
7:30 pm - 7:50 pmDiscussion Leader: Patrick Phillips (University of Oregon)
"Introduction and Concepts"
7:50 pm - 8:25 pmHunter Fraser (Stanford University)
"Adaptive evolution of gene expression in yeast and human"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmEhab Abouheif (McGill University)
"Ancestral developmental potential is essential for understanding the genetic and evolutionary basis of complex disease"
9:15 pm - 9:30 pmDiscussion
9:30 pmPosters and refreshments
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenetic Architecture of Complex Traits
9:00 am - 9:20 amDiscussion Leader: Sue DeNise (Pfizer Animal Health)
"Introduction and Concepts"
9:20 am - 9:55 amJohn Stamatoyannopoulos (University of Washington)
"Gene regulation and common disease"
9:55 am - 10:10 amDiscussion
10:10 amCoffee Break
10:50 am - 11:25 amKaren Mohlke (University of North Carolina)
"What do uncommon variants reveal about complex metabolic traits?"
11:25 am - 11:40 amDiscussion
11:40 am - 12:15 pmDorian Garrick (Iowa State University)
"In search of the missing heritability: architecture of complex traits in livestock"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenetics of Host-Microbe Interactions
7:30 pm - 7:50 pmDiscussion Leader: Susan Lamont (Iowa State University)
"Introduction and Concepts"
7:50 pm - 8:25 pmAndrew Benson (University of Nebraska)
"Host genetic control of gut microbiome configuration by modulation of microbes with keystone-like characteristics"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmAndrea Wilson-Doeschl (Roslin Institute)
"Vive la rèsistance? Exploiting host genetic defenses to conquer infections"
9:15 pm - 9:30 pmDiscussion
9:30 pmPosters and refreshments
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenomic prediction and selection
9:00 am - 9:20 amDiscussion Leader: Roel Veerkamp (Wageningen Agricultural University)
"Introduction and Concepts"
9:20 am - 9:55 amNaomi Wray (University of Queensland)
"Estimation and prediction analyses of disease in human populations"
9:55 am - 10:10 amDiscussion
10:10 amCoffee Break
10:50 am - 11:25 amGustavo de los Campos (University of Alabama)
Genomic Prediction: the Forces that Drive Prediction Accuracy of Genomic BLUP
11:25 am - 11:40 amDiscussion
11:40 am - 12:15 pmJean-Luc Jannink (USDA-ARS)
"Long-term comes quickly: maintaining genetic gain under genomic selection"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStatistical Genetics and bioinformatics
7:30 pm - 7:50 pmDiscussion Leader: Bruce Weir (University of Washington)
"Introduction and Concepts"
7:50 pm - 8:25 pmSharon Browning (University of Washington)
"Applications of identity by descent segment detection in population samples"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmStephen Goff (iPlant Collaborative)
"Using iPlant to explore the links between inbreeding, heterosis, aging, and protein metabolism; Are older hybrid individuals more like inbreds than young hybrids?"
9:15 pm - 9:30 pmDiscussion
9:30 pmPosters and refreshments
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmFunctional Dissection of Complex Phenotypes
9:00 am - 9:20 amDiscussion Leader: Michel Georges (University of Liege)
"Introduction and Concepts"
9:20 am - 9:55 amElinor Karlsson (Broad Institute / University of Uppsala)
"Dissecting complex phenotypes in dogs as a model for human disease"
9:55 am - 10:10 amDiscussion
10:10 amCoffee Break
10:50 am - 11:25 amSoumy Raychauduri (Broad Institute)
"Identifying critical cell-types to fine-map complex trait variants with chromatin marks"
11:25 am - 11:40 amDiscussion
11:40 am - 12:15 pmStudent Presentations
Moderators: Suzanne McGaugh (Duke University) and James Koltes (Iowa State Univ.)
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSystems Genetics
7:30 pm - 7:50 pmDiscussion Leader: Rebecca Doerge (Purdue University)
"Introduction and Concepts"
7:50 pm - 8:25 pmElias Chaibub Neto (Sage Bionetworks)
"Causal inference in systems genetics"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmAntonio Reverter (CSIRO, Australia)
"Information theory and digital organisms: A cane and a guide dog aiding the dissection of complex phenotypes"
9:15 pm - 9:30 pmDiscussion
9:30 pmPosters and refreshments
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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