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Conference Program
 
Salivary Glands & Exocrine Biology
From Development to Disease and Beyond
February 3-8, 2013
Hotel Galvez
Galveston, TX

The ninth Salivary Gland and Exocrine Biology Gordon Research Conference will continue the tradition of pioneering multi-disciplinary conferences. It will serve as a forum for presentations of novel, cutting-edge unpublished discoveries in the area of exocrine tissue biology. The forthcoming conference will bring together outstanding basic, translational and clinical investigators working in salivary, lacrimal, pancreas and lung research. In addition, the conference will serve as a venue to display and promote work of promising young scientists through oral presentations and poster exhibits. By serving as a platform for highlighting advances in diverse areas of exocrine biology and exocrine disease research, the conference will align and focus scientific advances to reveal new directions in the areas of development, homeostasis and disease. The conference will also showcase the latest advances in the identification of biomarkers and therapeutics for salivary and other exocrine dysfunctions.

The scientific program will focus on the latest findings in salivary, pancreas and lung biology and disease, including development (e.g. lineage tracing, expression landscapes), mechanotransduction, cell adhesion, polarity and signaling networks, exocytosis and secretion, and physiological control of ion and water transport. The meeting will also devote a large number of sessions to salivary gland dysfunction, including salivary exocrinopathies, such as Sjogren’s syndrome, inflammation, fibrosis and cancer. Lastly, topics related to salivary gland repair and regeneration with a focus on stem cell niches, nanobiotechnology and engineering, including network modeling, will be included. By showcasing innovative science, the conference will facilitate exchanges of ideas and future collaborations among researchers from diverse disciplines.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmOpening Keynote Presentation
Discussion Leaders: Indu Ambudkar (NIDCR) and Maria Kukuruzinska (Boston University)
7:30 pm - 7:45 pmIntroduction
7:45 pm - 8:30 pmElisabetta Dejana (University of Milan, Italy)
"Transcriptional regulation of endothelial cell differentiation"
8:30 pm - 9:30 pmDiscussion
9:30 pmReception
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmDevelopment
Discussion Leaders: Deborah Andrew (John Hopkins University) and Catherine Ovitt (University of Rochester)
9:00 am - 9:20 amWellington Cardoso (Boston University)
"Regulation of Cell Fate and Diversity in Secretory Progenitors in Developing Airways"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJennifer Zallen (Sloan Kettering Institute)
"Cellular dynamics in development"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amPoster Talk: Takayoshi Sakai (Osaka University Graduate School of Dentistry)
"Melatonin regulates the branching morphogenesis of embryonic salivary glands by adjusting the adhesion and morphology of epithelial cells"
10:10 am - 10:15 amDiscussion
10:15 amCoffee Break
10:45 am - 11:05 amMatthew Hoffman (NIDCR)
"Progenitor cell communication during submandibular gland development"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amRay MacDonald (University of Texas Southwestern)
"Transcriptional Control of the Acinar Phenotype"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amPoster Talk: Farid El-Sayed (University of Missouri - Columbia)
"The Role of the P2Y2 Nucleotide Receptor in Salivary Gland Regeneration"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmCeleste Nelson (Princeton University)
"Mechanical control of branching morphogenesis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSpatial and Molecular Determinants of Protein Trafficking and Secretion
Discussion Leaders: Mary Reyland (University of Colorado) and Gary Weisman (University of Missouri)
7:30 pm - 7:50 pmRoberto Weigert (NIDCR)
"Regulated exocytosis in exocrine glands in live animals"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmIan Mather (University of Maryland)
"Intra-vital imaging of milk secretion"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmSarah Hamm-Alvarez (University Southern California)
"Determinants of the fidelity of secretory protein sorting: insights from knockout mouse models"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmGuy Groblewski (University of Wisconsin)
"Endolysosomal membrane trafficking controls zymogen granule secretory polarity and pancreatitis responses in pancreatic acinar cells"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCalcium Signals and Spatial Compartmentalization
Discussion Leaders: Jim Melvin (NIDCR) and Masataka Murakami (National Institute of Physiological Sciences, Japan)
9:00 am - 9:20 amDavid Yule (University of Rochester)
"Polarization of Signals and Effectors in Salivary Acinar cells"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amBrij Singh (University of North Dakota)
"Calcium and saliva secretion: old saga, but new players"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amPoster Talk: Kietaro Satoh (Dokkyo Medical University, Japan)
"Effects of a naturally occurring point mutation of AQP5 on carbachol-induced volume decrease and on the activation energy for water transport by rat parotid acinar cells"
10:10 am - 10:15 amDiscussion
10:15 amCoffee Break
10:45 am - 11:05 amAldebaran Hofer (Veterans Affairs, Boston)
"New twists on Ca2+-dependent cAMP signaling"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amRajini Rao (Johns Hopkins University)
"Secretory Pathway Calcium ATPases in Golgi and Post-Golgi Compartments: Role in Mammary glands and Breast Tumors"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amPoster Talk: Yoshinori Sahara (Iwate Medical University School of Dentistry, Japan)
"The function of V-ATPases in salivary glands of mouse"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmSandip Patel (University College London)
"NAADP, two-pore channels and complex calcium signalling"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmRegulation of Electrolyte and Water Transport
Discussion Leaders: David Yule (University of Rochester) and Brij Singh (University of North Dakota)
7:30 pm - 7:50 pmMin Goo Lee (Younsei College of Medicine, Korea)
"Dynamic regulation of anion permeability of CFTR and ANO1 anion channels"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmThomas Jentsch (Leibniz-Institut, Germany)
"Role of Cl transport in epithelial function"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmIvana Novak (University of Copehhagen, Denmark)
"Role of Purinergic signalling in pancreatic function"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmShmuel Muallem (NIDCR)
"Synergism in epithelial fluid and bicarbonate secretion"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSalivary Gland Dysfunction I: Inflammation, Autoimmunity, and Fibrosis
Discussion Leaders: David Ann (City of Hope/Beckman Research Institute) and Denise Faustman (Harvard University)
9:00 am - 9:20 amAntony Rosen (John Hopkins University)
"Interactions of interferons and cytotoxic lymphocyte granule pathways in Sjogren's syndrome in humans: Implications for pathogenesis"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amRoland Jonson (University of Bergen, Norway)
"Exploring the complex pathogenesis of Sjögren's syndrome"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amPoster Talk: Andrew McCall (University at Buffalo)
"Vascular and lymphatic remodeling in salivary glands with Sjögren's Syndrome"
10:10 am - 10:15 amDiscussion
10:15 amCoffee Break
10:45 am - 11:05 amIlias Alveizos (NIDCR)
"MicroRNA alterations in Sjogren's syndrome"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amMaria Trojanowska (Boston University)
"Endothelial dysfunction in tissue repair and fibrosis"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amPoster Talk: Scott Lieberman (The Children's Hospital of Philadelphia)
"Sex-specific regulatory T cell dysfunction in a mouse model of Sjögren syndrome"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmAustin Mircheff (University of Southern California)
"Each Lacrimal Gland is a System in Which Immune Cells Performing Diverse Functions Interact with Each Other and with Acinar- and Ductal Epithelial Cells"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmSalivary Gland Dysfunction II: Cancer
Discussion Leaders: Silvio Gutkind (NIDCR ) and Maria Trojanowska (Boston University)
7:30 pm - 7:50 pmJacques Nor (University of Michigan)
"Salivary gland cancer stem cells"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmPeter Friedl (Radboud University, Netherlands)
"Collective invasion of epithelial and mesenchymal cancer cells"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmPatrick Ha (John Hopkins University)
"Promoter Methylation Alterations in Adenoid Cystic Carcinoma"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmJeff Meyers (The University of Texas)
"Head and Neck Cancer Genomics as a Gateway to Personalizing Treatment Decisions"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSalivary Gland Repair and Regeneration
Discussion Leaders: Austin Mircheff (University of Southern California) and Sarah Hamm-Alvarez (University of Southern California)
9:00 am - 9:20 amCara Gottardi (Northwestern University)
"Adhesion and signaling through the cadherin/catenin system"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSue Menko (Thomas Jefferson University)
"Novel paradigms of epithelial wound repair - implications for the submandibular gland"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amPoster Talk: Nan Xiao (Stanford University)
"Characterizing a new population of adult mouse submandibular gland stem cells"
10:10 am - 10:15 amDiscussion
10:15 amCoffee Break
10:45 am - 11:05 amMelinda Larsen (SUNY, Albany)
"Advances Towards Salivary Gland Tissue Engineering"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amCatherine Ovitt (University of Rochester)
"Gene targeting in the salivary glands using siRNA/nanoparticle complexes"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amPoster Talk: Kirsten Limesand (University of Arizona)
"Prevention of Radiation-Induced Salivary Gland Dysfunction Utilizing a CDK Inhibitor"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmJay Chiorini (NIDCR)
"Spit, Genes, and Viruses: A New Approach to the Treatment of Xerostomia"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmClosing Keynote Presentation
Discussion Leaders: Indu Ambudkar (NIDCR) and Maria Kukuruzinska (Boston University)
7:30 pm - 7:45 pmIntroduction
7:45 pm - 8:30 pmKenneth Yamada (NIDCR)
"Cell-Matrix Dynamics"
8:30 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13DE023467-01 from the National Institutes of Dental and Craniofacial Research. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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