Gordon Research Conferences
PI_Conferences PI_Conferences_Past
Conference Program
 
Stem Cells & Cancer
Stem Cell Features in Cancer and Metastasis
April 21-26, 2013
Les Diablerets Conference Center
Les Diablerets, Switzerland
Chair:
Andreas Trumpp

Vice Chair:
Leonard I. Zon

The 2013 Gordon Conference on Stem Cells and Cancer will present cutting-edge research on the molecular, cellular and genetic mechanisms controlling self-renewal and differentiation of both normal and cancer stem cells. Normal stem cells are essential to maintain regenerative tissues, and are a critical component of repair in response to tissue injury. Genetic alterations of stem cells or their progeny can lead to the generation of cancer stem cells (CSCs) that drive tumorigenesis in hierarchically organized cancer entities. Related to their remarkable resistance to chemotherapy and radiation, CSCs are thought to be responsible not only for tumor re-occurrence but also for initiation and maintenance of metastases. The goal of this meeting is to discuss the genetic, epigenetic, molecular and cellular mechanisms that control stem cell activity in normal and cancerous tissues. Topics that will be explored in this meeting include: regulation of self-renewal, cellular reprogramming mechanisms, stem cell niches, cancer stem cell generation, dynamic evolution of cancer stem cells during tumor progression and metastasis formation, novel methods to isolate normal and cancer stem cells, mathematical modeling of stem cell driven populations and innovative strategies to target cancer and metastasis stem cells. The conference will bring together world-wide leaders at the forefront of stem cell and cancer research and will provide opportunities for postdoctoral fellows and graduate students to present their work in poster sessions and in a selected set of short talks. The conference will provide ample opportunities for discussions in an informal setting thus helping to foster interactions between researchers studying different areas of stem cell and cancer biology.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmThe Evolving "Cancer Stem Cell" Concept
Discussion Leader: Elaine Fuchs (New York)
7:40 pm - 7:50 pmAndreas Trumpp (Heidelberg)
"Welcome and Introduction"
7:50 pm - 8:30 pmKeynote Lecture: Irving Weissman (Stanford)
"Normal and Neoplastic stem cells"
8:30 pm - 8:45 pmDiscussion
8:45 pm - 9:20 pmAna Martin-Villalba (Heidelberg)
"Death receptors and cancer stem cells"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenetic Analysis of Stem Cell Biology
Discussion Leader: Shahragim Tajbakhsh (Paris)
9:00 am - 9:35 amJürgen Knoblich (Vienna)
"Using Drosophila as a model system for tumorigenesis and cancer stem cells"
9:35 am - 9:45 amDiscussion
9:45 am - 10:20 amBruce Edgar (Heidelberg)
"Stem cell tumors in the Drosophila intestine"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:35 amLenhard Rudolph (Jena)
"Telomeres and telomerase in aneuploidy"
11:35 am - 11:45 amDiscussion
11:45 am - 12:20 pmMaarten van Lohuizen (Amsterdam)
"In vivo screening for Polycomb targets in Glioblastoma"
12:20 pm - 12:30 pmDiscussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pmHSCs and Leukemia
Discussion Leader: Catriona Jamieson (San Diego)
5:30 pm - 6:05 pmTimm Schroeder (Munich)
"Long-term single stem cell tracking: New tools for old questions"
6:05 pm - 6:20 pmDiscussion
6:20 pm - 6:55 pmMargaret A. Goodell (Houston)
"DNA methylation in normal and malignant hematopoiesis"
6:55 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmShort Talk: Annika Fendler (Berlin)
"Identification of a Cancer Stem Cell Population with High Activity of Wnt/ß-Catenin and Notch Signaling in Clear Cell Renal Cell Cancer"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEpithelial Stem Cells
Discussion Leader: Bruce Edgar (Heidelberg)
9:00 am - 9:40 amKeynote Lecture: Elaine Fuchs (New York)
"Skin stem cells in homeostasis, wound-repair and cancer"
9:40 am - 9:55 amDiscussion
9:55 am - 10:30 amFred de Sauvage (South San Francisco)
"Targeting Developmental Pathways in Stem Cells and Cancer Stem Cells"
10:30 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:30 amShort Talk: Somdutta Roy (San Francisco)
"Rare Somatic Cells from Human Breast Tissue Exhibit Extensive Lineage Plasticity"
11:30 am - 11:40 amDiscussion
11:40 am - 12:15 pmRuggero de Maria (Rome)
"Cancer stem cell targeting in advanced solid tumors"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session II
5:30 pm - 7:30 pmCarcinoma Stem Cells
Discussion Leader: Andreas Trumpp (Heidelberg)
5:30 pm - 6:05 pmJane Visvader (Melbourne)
"Mammary stem cells and the evolving hierarchy"
6:05 pm - 6:20 pmDiscussion
6:20 pm - 6:35 pmShort Talk: Christian Eisen (Heidelberg)
"Subtype-specific models of pancreatic ductal adenocarcinoma reveal signaling pathways that can be exploited therapeutically"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:20 pmEduard Batlle (Barcelona)
"From Colon Stem Cells to Colorectal Cancer"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStem Cells and Metastasis
Discussion Leader: Jane Visvader (Melbourne)
9:00 am - 9:35 amThomas Brabletz (Freiburg)
"MicroRNAs, EMT and cancer stem cells"
9:35 am - 9:50 amDiscussion
9:50 am - 10:25 amAndreas Trumpp (Heidelberg)
"Circulating metastasis-initiating cells in breast cancer"
10:25 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:45 amDaniel Haber (Boston)
"Dissecting cancer metastasis through circulating tumor cells"
11:45 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmShort Talk: Robert Clarke (Manchester)
"Targeting CXCR1/2 Significantly Reduces Breast Cancer Stem Cell Activity and Increases the Efficacy of Inhibiting HER2 via HER2-dependent and -independent Mechanisms"
12:15 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session III
5:30 pm - 7:30 pmInnovative Strategies to Target Cancer Stem Cells
Discussion Leader: Fred de Sauvage (South San Francisco)
5:30 pm - 6:05 pmCatriona Jamieson (San Diego)
"Leukemia Stem Cell Evolution: Biologic and Therapeutic Implications"
6:05 pm - 6:20 pmDiscussion
6:20 pm - 6:55 pmDavid Langenau (Boston)
"Mechanisms of Clonal Evolution and Relapse in T-cell Acute Lymphoblastic Leukemia"
6:55 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmShort Talk: Eleni Lagadinou (Rochester)
"Metabolic dormancy and leukemia stem cells"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmEMT, Dormant Stem Cells and Stem Cell Niches
Discussion Leader: Leonard Zon (Boston)
9:05 am - 9:40 amGerhard Christofori (Basel)
"VEGF-Mediated Angiogenesis Links EMT-Induced Cancer Stemness to Tumor Initiation"
9:40 am - 9:55 amDiscussion
9:55 am - 10:25 amCoffee Break
10:25 am - 11:00 amShahragim Tajbakhsh (Paris)
"Skeletal muscle stem cells in distinct states"
11:00 am - 11:15 amDiscussion
11:15 am - 11:50 amHiromitsu Nakauchi (Tokyo)
"Novel non-stepwise early differentiation pathways of HSCs revealed by 5-lineage in vivo tracing"
11:50 am - 12:10 pmDiscussion
12:10 pm - 12:20 pmShort Presentation: Les Reinlib (NIH/NIEHS)
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session IV
5:30 pm - 7:30 pmMolecular Basis of self-renewal
Discussion Leader: Maarten van Lohuizen (Amsterdam)
5:30 pm - 6:05 pmMichael Clarke (Stanford)
"The yen and yang of self renewal in normal stem cells and disease"
6:05 pm - 6:20 pmDiscussion
6:20 pm - 7:00 pmKeynote Lecture: Leonard Zon (Boston)
"Transcription Elongation in Melanoma"
7:00 pm - 7:15 pmDiscussion
7:15 pm - 7:30 pmConcluding Remarks
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
© 2014 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter