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T Follicular Helper Cells
Gordon Research Conference

Basic Discoveries and Clinical Applications

Dates

July 21-26, 2013

Location

The Chinese University of Hong Kong
Hong Kong, China

Organizers

Chair:
Chen Dong

Vice Chairs:
Carola Vinuesa & Sidonia Fagarasan

Meeting Description

For us to combat the enormously diverse and numerous environmental microbial pathogens, our immune system has evolved two arms: thymus-derived T lymphocytes for cellular immunity and bone marrow-derived B lymphocytes for humoral immunity. Ever since these two important cells were discovered, there has been appreciation that T lymphocytes also provide essential instruction for B cells to produce large numbers of high affinity antibodies. B and T cell collaboration in immune responses leading to protective memory and affinity matured antibody responses occurs in the hallmark structure called germinal center, where B cells in response to T cell help proliferate extensively and undergo somatic hypermutation in their antibody genes. Dysfunction of germinal center reactions are at the core of various diseases, including immunodeficiency, lymphoma and autoimmunity. Understanding the cellular and molecular regulation of germinal center reactions is thus of high clinical relevance and will benefit the design of vaccines against infectious diseases, including HIV.

The long-term goal of this GRC series is to understand how T cells regulate humoral immunity, with a particular emphasis on the germinal center reactions. A subset of T lymphocytes has been found to express the chemokine receptor CXCR5 and to localize in germinal centers. These cells have been named as B follicular helper T (Tfh) cells and shown to play critical roles in germinal center reactions. New exciting findings by the organizers of this meeting as well as many invited speakers are starting to elucidate the unique genetic programming and biological features of these cells, in comparison with other types of T cells- including TH1, TH2, TH17 and regulatory T cells.

The goal of the conference is to facilitate exchange of the latest basic scientific findings and promote discussion on the role of Tfh in a wide range of diseases. Although the GRC title is on Tfh cells as a timely topic to draw attention from immunology community and to have distinction from other meetings on B cells and other types of T cells, we will have additional discussion on other types of T cells including effector, memory and regulatory T cells in humoral immunity and we will cover the regulation on B cells in germinal center reactions.

Contributors

Meeting Program

SUNDAY
2:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Evolution and interaction of lymphocyte subsets
Discussion Leader: Chen Dong (Tsinghua University/MD Anderson Cancer Center)
7:40 pm - 8:20 pmMax Cooper (Emory University)
"Evolution of T-B collaboration"
8:20 pm - 8:35 pmDiscussion
Short Talks
8:35 pm - 8:45 pmNicholas Fazilleau (INSERM)
"Monocyte-derived dendritic cells promote T Follicular Helper cell differentiation in response to TLR agonists"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:00 pmMadelene Dahlgren (Lund University)
"T follicular helper cell development and GC formation in the absence of conventional dendritic cells"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:15 pmMichelle Linterman (University of Cambridge)
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenetic program of Tfh cells
Discussion Leader: Liwei Lu (Hong Kong University)
9:00 am - 9:30 amChen Dong (Tsinghua University/MD Anderson Cancer Center)
"Transcription factors in Tfh cells"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amGroup Photo / Coffee Break
10:10 am - 10:40 amDi Yu (Monash University)
"Circulating Tfh memory cells"
10:40 am - 10:50 amDiscussion
10:50 am - 11:20 amMasato Kubo (REIKEN)
"Cytokine gene regulation in Tfh cells"
11:20 am - 11:30 amDiscussion
Short Talks
11:30 am - 11:40 amChangchun Xiao (The Scripps Research Institute)
"MicroRNA Control of Tfh Differentiation"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amLukas Jeker (University of California San Francisco)
"The microRNA cluster miR-17-92 is a critical regulator of Treg and TFH biology"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmVigo Heissmeyer (Ludwig-Maximilians-University Munich)
"Control of Tfh differentiation by Roquin family proteins"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (Last names: A-G)
6:00 pmDinner
7:30 pm - 9:30 pmImaging of germinal centers
Discussion Leader: Vigo Heissmeyer (Ludwig-Maximilians-University)
7:30 pm - 8:00 pmHai Qi (Tsinghua University)
"ICOS in Tfh development"
8:00 pm - 8:05 pmDiscussion
8:05 pm - 8:35 pmTakaharu Okada (REIKEN)
"Bcl6 imaging"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:20 pmKeynote: Jason Cyster (UCSF)
"Lymphocyte localization, migration and interaction in germinal center reactions"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMucosal and ectopic germinal centers
Discussion Leader: Wenjun Ouyang (Genentech)
9:10 am - 9:40 amSidonia Fagarasan (REIKEN)
"Treg/Tfh in mucosal immunity"
9:40 am - 9:50 amDiscussion
9:50 am - 10:10 amCoffee Break
10:10 am - 10:40 amVijay Kuchroo (Harvard)
"Tfh in EAE"
10:40 am - 10:50 amDiscussion
10:50 am - 11:20 amMi-Na Kweon (International Vaccine Center)
"Mucosal vaccine and Tfh cells"
11:20 am - 11:30 amDiscussion
Short Talks
11:30 am - 11:40 amIrah King (Mcgill University)
"Integrin-mediated retention of T follicular helper cells in the germinal center during infection"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amDerek Rookhuizen (University Of California San Francisco)
"TLR9 signaling acts on multiple elements of the germinal center to enhance antibody responses"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmLilin Ye (Third Military Medical University)
"mTOR mediates humoral immunity by differentially regulating follicular helper T cell and B cell responses"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (Last names: H-L)
6:00 pmDinner
7:30 pm - 9:30 pmTfh signaling and homeostasis
Discussion Leader: Maria A. Curotto de Lafaille (Astar)
7:30 pm - 8:00 pmJoe Craft (Yale University)
"Tfh regulation and function in autoimmune lupus"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmRoza Nurieva (MD Anderson Cancer Center)
"Factors that regulate Tfh cells"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmPam Schwartzberg (NIH)
"SAP and Tfh cells"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTfh in infection
Discussion Leader: Kai Michael Toellner (University of Birmingham)
9:10 am - 9:40 amMichael McHeyzer-Williams (Scripps)
"Tfh generation"
9:40 am - 9:50 amDiscussion
9:50 am - 10:10 amCoffee Break
10:10 am - 10:40 amShane Crotty (LIAI)
"Informing vaccine design with Tfh biology"
10:40 am - 10:50 amDiscussion
10:50 am - 11:20 amElina Züñiga (UCSD)
"Tfh cells in chronic infection"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmZhigang Tian (Chinese University of Science and Technology)
"Tfh and HBV"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (Last names: M-Z)
6:00 pmDinner
7:30 pm - 9:30 pmRegulatory mechanisms in GC reaction
Discussion Leader: Michelle Linterman (University of Cambridge)
7:30 pm - 7:55 pmCarola Vinuesa (Australian National University)
"Regulation of Tfh cells"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmLuis Graça
"Treg cells in GC"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmHarvey Cantor (Dana Farber)
"Follicular CD8+ regulatory T cells"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmArlene Sharpe (Harvard)
"PD-1 and Tfr cells"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmTfh cells in Autoimmunity
Discussion Leader: Biao Zheng (GSK China)
9:00 am - 9:30 amArlene Sharpe (Harvard)
"PD-1 and Tfr cells"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amCoffee Break
10:10 am - 10:40 amChris Goodnow (Australian National University)
"Redeeming self-reactivity in the germinal center"
10:40 am - 10:50 amDiscussion
10:50 am - 11:20 amRobert Brink (Garvan Institute)
"B cells in autoimmunity"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmCecile King (Garvan Institute)
"IL-21 and autoimmunity"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmHuman Tfh cells
Discussion Leader: Ho-Youn Kim (St. Mary's Hospital)
4:00 pm - 4:30 pmStuart Tangye (Garvan Institute)
"Role of STAT3 in human Tfh and B cell biology"
4:30 pm - 4:40 pmDiscussion
4:40 pm - 5:10 pmHideki Ueno (Baylor Institute)
"Human Blood Tfh cells"
5:10 pm - 5:20 pmDiscussion
5:20 pm - 5:50 pmTak Mak (Toronto)
"Tfh-like lymphoma"
5:50 pm - 6:00 pmDiscussion
6:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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