Gordon Research Conferences
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Conference Program
 
Cellular & Molecular Mechanisms of Toxicity
August 11-16, 2013
Proctor Academy
Andover, NH
Chair:
Jose E. Manautou

Vice Chair:
Dana C. Dolinoy

Related Meeting Information
The Cellular & Molecular Mechanisms of Toxicity Gordon Research Conference was held in conjunction with the Cellular & Molecular Mechanisms of Toxicity Gordon-Kenan Research Seminar. Please refer to the Cellular & Molecular Mechanisms of Toxicity GKRS web page for more information.

The Gordon Research Conference on Cellular & Molecular Mechanisms of Toxicity is a premier forum for showcasing the latest, most innovative advances in mechanistic toxicological research. For the 2013 conference, the organizers have assembled a group of world-leading experts working on areas of investigation that are highly relevant to environmental, industrial and pharmaceutical toxicology.

The topics selected are varied and of great appeal to a broad audience of scientists with interest in toxicology. Mitochondrial diseases, epigenetics, transcriptional control of drug metabolizing enzymes, carcinogenesis, stem cells in toxicological research and novel functions of oxidative stress-related transcription factors are among the topics that will be highlighted at the conference. The conference will attract a mix of junior and senior investigators and trainees with a common interest in advancing their respective fields of investigation. For the first time, a Gordon Research Seminar on Cellular & Molecular Mechanisms of Toxicity will precede the conference. This provides an expanded opportunity for trainees and young scientists to be exposed to cutting-edge science and to network with their future colleagues in the field.

The poster session(s) is an essential element to the success of conference. Trainees and scientists at any level will have the opportunity to present their latest, groundbreaking work in poster format under an informal atmosphere that fosters relaxed dialog, networking and idea sharing. A special selection committee will select some abstracts/posters for short oral talks. These "late-breaking" oral sessions provide increased participation to trainees and young scientists to share their work with an audience of experts. This is a tremendous opportunity for the young talent to receive feedback from well-established leaders in the field. Another key to the success of the Gordon Conference is the social interaction of participants at meal times and during social activities in afternoon breaks. These interactions have led to long-lasting scientific collaborations and the lining up of trainees with laboratories for further education. We look forward to seeing you at The Gordon Research Conference on Cellular & Molecular Mechanisms of Toxicology in 2013!


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session
Discussion Leader: Charlene McQueen (USEPA)
7:40 pm - 8:25 pmMartin Philbert (University of Michigan)
"The Nanoness of Nanotechnology: What Makes Nano Toxic"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:20 pmKenneth Ramos (University of Louisville)
"Reorganization of the Genome by Toxic Injury: A Story of LINES"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenetic Susceptibility in Toxicology: Am I the 1 in 1,000?
Discussion Leader: Ruth Roberts (AstraZeneca)
9:00 am - 9:35 amHans Ketelslegers (ExxonMobil Biomedical Sciences, Belgium)
"Genetic Susceptibility and Environmental Carcinogenesis"
9:35 am - 9:45 amDiscussion
9:45 am - 10:20 amAnn Daly (Newcastle University)
"Identification of Genes Predicting Drug Toxicity and Response in the Parent Genome"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:35 amJudit Marsillach (University of Washington)
"Genetic Susceptibility to Organophosphates and Disease States"
11:35 am - 11:45 amDiscussion
11:45 am - 12:30 pmShort Presentation Talks
Discussion Leader: Jason Richardson (Robert Wood Johnson Medical School; EOHSI)
11:45 am - 12:00 pmBrandon Pierce (University of Chicago)
"Genetic Variation Influences Arsenic Metabolism and Toxicity in Humans"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:20 pmAswin Mangerich (University of Konstanz)
"Analysis of Drug- and Toxicant-Dependent Cellular Poly(ADP-ribosyl)ation Dynamics"
12:20 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNew Horizons in Toxicology
Discussion Leader: John Richburg (University of Texas at Austin)
7:30 pm - 8:00 pmTom Van de Wiele (Ghent University, Belgium)
"Interplay of the Human Gut Microbiome with Xenobiotic Bioavailability and Toxicity"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmShawn Bratton (MD Anderson Cancer Center)
"Regulation of Ubiquitination and Protein Degradation by Caspases"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:30 pmShort Presentation Talks
Discussion Leader: Jason Richardson (Robert Wood Johnson Medical School; EOHSI)
8:50 pm - 9:05 pmDavid Leong (National University of Singapore)
"Endothelial Cell Toxicity from Nanomaterials: Mechanism and Implications"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmLaura Kubik (University of Michigan)
"1,3-Dinitrobenzene Induces Age-Specific and Region-Specific Oxidation to Mitochondria-Related Proteins in Rat Brain"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmAdvances in Stem Cell: Their Utility in Investigative Environmental Toxicology and Xenobiotic Metabolism
Discussion Leader: Theodore Rasmussen (University of Connecticut)
9:00 am - 9:35 amHu Guang (National Institute of Environmental Health Sciences)
"Understanding embryonic Stem Cell Self-Renewal and Differentiation: From Developmental Biology to Environmental Health Sciences"
9:35 am - 9:45 amDiscussion
9:45 am - 10:20 amMark Mercola (Sanford-Burnham Medical Research Institute)
"Kinetic Imagining Cytometry of Human Stem Cell Derived Cardiomyocytes for Safety Pharmacology and Drug Discovery"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 12:30 pmSelected Late Breaking Abstracts
Discussion Leaders: Patrick Allard (UCLA) and Lauren Aleksunes (Rutgers University; EOHSI)
11:00 am - 11:25 amQin Wang (University of Cincinnati)
"Activation of the Aryl Hydrocarbon Receptor by Dioxin during Embryonic Stem Cell Differentiation Disrupts the Expression of Homeobox Transcription Factors that Control Cardiomyogenesis"
11:25 am - 11:30 amDiscussion
11:30 am - 11:55 amErik Danen (Leiden University)
"Systems Biology Approach to Delineate Genotoxic Stress Response Signaling Networks"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:25 pmQiang Wu (Shanghai Jiao Tong University)
"Zebrafish Phase II Drug-metabolizing UGT Enzymes for Toxicity Studies"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEpigenetic Mechanisms of Transcriptional and Translational Regulation of Gene Expression by Xenobiotic Receptors
Discussion Leader: Yanan Tian (Texas A&M University)
7:30 pm - 8:00 pmRonald Hines (USEPA)
"Molecular Mechanisms Regulating Drug and Toxicant Metabolizing Enzyme Ontogeny"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmAnn-Bin Shyu (The University of Texas Medical School - Houston)
"Roles of Intrinsically Disordered Proteins in Controlling Mammalian mRNA Turnover"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmXiaobo Zhong (University of Connecticut)
"Chromatin interactions, epigenomics, and transcriptional response to drug induction"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmmiRNA as Circulating and Mechanism-Based Biomarkers of Disease
Discussion Leader: Jim Stevens (Elli Lilly and Company)
9:00 am - 9:35 amChris Goldring (University of Liverpool, UK)
"Circulating miRNA and Biomarkers of Drug-Induced Liver Injury"
9:35 am - 9:45 amDiscussion
9:45 am - 10:20 amScot Matkovich (Washington University School of Medicine)
"microRNA Regulation and Signaling in Cardiac Disease"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 12:30 pmSelected Late Breaking Abstracts
Discussion Leaders: Patrick Allard (UCLA) and Lauren Aleksunes (Rutgers University; EOHSI)
11:00 am - 11:25 amNatasa Zamurovic (Novartis Institutes for Biomedical Research)
"Identification of Off-Target Binding Proteins by Chemical Proteomics to Elucidate Mechanisms of Toxicity"
11:25 am - 11:30 amDiscussion
11:30 am - 11:55 amVishal Vaidya (Harvard Medical School)
"Non-Invasive Micro-Markers in Kidney Disease"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:25 pmAshley Green (Rutgers University)
"Epigenetic Regulation of the Dopamine Transporter Following in Vitro Histone Deacetylase Inhibitor Treatment"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmEpigenomics at the Intersection of Toxicity and Disease
Discussion Leader: Dana Dolinoy (University of Michigan)
7:30 pm - 8:00 pmJay Goodman (Michigan State University)
"An integrated View of Epigenetics: Implications for Safety Assessment"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmTrevor Archer (National Institute of Environmental Health Sciences)
"Chromatin Remodeling Proteins in Transcription and Development"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmFolami Y. Ideraabdullah (University of North Carolina at Chapel Hill)
"Epigenetic response to endocrine disrupting chemicals, a genetic approach"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNuclear Factor (Erythroid-derived 2) - Like 2 (Nrf2): Is it all Good?
Discussion Leader: Bhagavatula Moorthy (Baylor College of Medicine)
9:00 am - 9:35 amDonna Zhang (University of Arizona)
"The regulation of Nrf2 and its dual role in cancer"
9:35 am - 9:45 amDiscussion
9:45 am - 10:20 amDavid Tuveson (Cold Spring Harbor)
"Nrf2 Promotes Pancreatic Cancer"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:35 amThomas Kensler (University of Pittsburgh)
"Targeting Nrf2 for Disease Prevention"
11:35 am - 11:45 amDiscussion
11:45 am - 12:30 pmSelected Late Breaking Abstracts
Discussion Leaders: Patrick Allard (UCLA) and Lauren Aleksunes (Rutgers University; EOHSI)
11:45 am - 12:00 pmJoel Meyer (Duke University)
"Fate and Consequences of Persistent Mitochondrial DNA Damage"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:20 pmElzbieta Janda (University Magna Graecia)
"Prolonged Oxidative Stress Inhibits Basal Autophagy while Inducing Pro-Autophagic Signals in Astroglial Cells: Role of Quinone Oxidoreductase 2"
12:20 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 8:50 pmMitochondrial Diseases
Discussion Leader: Alvaro Puga (University of Cincinnati)
7:30 pm - 8:00 pmGary Fiskum (University of Maryland)
"Mitochondrial Mechanism of Toxicity and Cytoprotection"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmRuben Dagda (University of Nevada School of Medicine)
"Regulation of Mitophagy by Serine/Theronine Kinases and Cardiolipin at the Outer Mitochondrial Membrane: Implications for Mitochondrial Diseases"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:30 pmKeynote Lecture
Discussion Leader: Ivan Rusyn (University of North Carolina at Chapel Hill)
8:50 pm - 9:20 pmLeona Samson (Massachusetts Institute of Technology)
"Inter-individual Variations in DNA Repair"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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