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Conference Program
 
Tropical Infectious Diseases
From Bench to Field
February 10-15, 2013
Hotel Galvez
Galveston, TX
Chair:
David L. Sacks

Vice Chair:
Serap Aksoy

The 2013 Gordon Conference on Tropical Infectious Diseases: from bench to field, will present cutting edge research on the most prevalent and medically important tropical infectious diseases (TIDs), with special emphasis on research areas that have made significant recent progress. This will be the third time that this particular GRC has been held, and it will retain the general thematic organization of the very successful conference last held in 2011. The intent is to gather a multidisciplinary community of scientists discussing basic and field based or translational research in TIDs.

The 2013 Conference will include disease focused sessions on arboviral diseases (including dengue), filariasis, malaria, leishmaniasis, and tuberculosis. In addition, there will be two thematic sessions, one on enteric infections, vaccines, and nutrition, and the other on vector physiology and disease control. For each session, invited speakers who are at the forefront of their respective fields will strive to discuss how progress made at the bench is being translated to actions in the field, emphasizing interventions based on treatment, vaccination, or interrupting the transmission cycle in the vector or reservoir hosts. An important goal of the Conference is to attract junior scientists and graduate students, including those from disease endemic countries, to present their work in poster format and exchange ideas with leaders in the field. Some poster presenters will be selected for short oral presentations. The Conference will be held in a historic seaside hotel in Galveston, Texas, which offers relaxing beaches and one of the best-preserved concentrations of Victorian architecture in the country. The presentations of cutting edge research, along with the programmed discussion sessions and opportunities for informal gatherings in the afternoons and evenings, will serve to greatly enrich the community of multidisciplinary scientists working on TIDs.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Addresses
Discussion Leader: David Sacks (NIAID, NIH)
7:40 pm - 8:20 pmChris Wilson (Director, Discovery and Translational Sciences, Gates Foundation)
"Eroding Silos and Bridging Barriers that Separate Discovery Science from Global Infectious Diseases Solutions"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmDavid Kaslow (Director, PATH Malaria Vaccine Initiative)
"Translational Research and Development Priorities Supported by PATH Malaria Vaccine Initiative"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEnteric Infections, Vaccines and Nutrition
Discussion Leader: Bill Petri (University of Virginia)
9:00 am - 9:25 amEdward Ryan (Harvard)
"Human innate and adaptive immune responses to Vibrio cholerae"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amCherry Kang (Christian Medical College, Vellore, India)
"Natural history of rotavirus infection"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amCoffee Break
10:30 am - 10:55 amDick Guerrant (University of Virginia)
"Interaction of diarrhea with malnutrition"
10:55 am - 11:05 amDiscussion
11:05 am - 11:25 amBill Petri (University of Virginia)
"The Immunodeficiency of malnutrition"
11:25 am - 11:35 amDiscussion
11:35 am - 12:05 pmTBA (short talks selected from posters)
12:05 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmVisceral Leishmaniasis
Discussion Leader: Jennie Blackwell (University of Western Australia)
7:30 pm - 7:55 pmPeter Melby (University of Texas Medical Branch, Galveston)
"Parasite induced signaling pathways driving susceptibility in visceral leishmaniasis"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmRicardo Gazzinelli (Fundação Oswaldo Cruz, Belo Horizonte, Brazil)
"Towards an effective vaccine against visceral leishmaniasis"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmJennie Blackwell (University of Western Australia, Perth)
"Results of genome wide association studies of visceral leishmaniasis"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmTBA (Short talk selected from posters)
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMalaria
Discussion Leader: Marcelo Jacobs-Lorena (Johns Hopkins)
9:00 am - 9:25 amPhotini Sinnis (Johns Hopkins)
"The Plasmodium sporozoites journey: from skin to liver"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amSangeeta Bhatia (MIT)
"3D microtissue suspensions to model liver - Plasmodium interactions"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amCoffee Break
10:30 am - 10:55 amPeter Crompton (NIAID, NIH)
"Immunologic memory in human malaria"
10:55 am - 11:05 amDiscussion
11:05 am - 11:25 amRick Fairhurst (NIAID, NIH)
"Hemoglobinopathies confer malaria protection by a novel mechanism"
11:25 am - 11:35 amDiscussion
11:35 am - 12:05 pmMarcelo Jacobs-Lorena (Johns Hopkins)
"Genetic modification of mosquitoes / paratransgenesis"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmTBA (Short talk selected from posters)
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmVector Physiology and Disease Control
Discussion Leader: Serap Aksoy (Yale)
7:30 pm - 7:55 pmJesus Valenzuela (NIAID, NIH)
"Targeting saliva antigens to protect against sand fly transmission of Leishmania"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmLaura Harrington (Cornell)
"Vector behavior essential for genetic control"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmSerap Aksoy (Yale)
"Symbiotic influences on vector immunity (tsetse)"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmTBA (Short talk selected from posters)
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmArboviruses
Discussion Leader: Stephen Whitehead (NIAID, NIH)
9:00 am - 9:25 amTed Pierson (NIAID, NIH)
"Dynamic structure of dengue virions"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amAry Hoffmann (University of Melbourne)
"Wolbachia mediated suppression of dengue transmission"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amCoffee Break
10:30 am - 10:55 amMark Heise (University of North Carolina)
"Chikungunya virus pathogensis"
10:55 am - 11:05 amDiscussion
11:05 am - 11:25 amAravinda de Silva (University of North Carolina)
"Dengue virus variation and its effect on neutralizing antibody epitopes"
11:25 am - 11:35 amDiscussion
11:35 am - 12:05 pmAnna Durbin (Johns Hopkins)
"Clinical evaluation of the NIH live attenuated dengue vaccine"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmTBA (Short talk selected from posters)
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmFilariasis
Discussion Leader: Elodie Ghedin (University of Pittsburgh)
7:30 pm - 7:55 pmJudy Allen (University of Edinburgh)
"Immune regulation in helminth infections"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmShelly Michalski (University of Wisconsin)
"Deep sequencing of the transcriptomes of life cycle stages of filarial worms"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmElodie Ghedin (University of Pittsburgh)
"Brugia malayi genomic analyses"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmTBA (Short talk selected from posters)
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTuberculosis
Discussion Leader: Willem Hanekom (University of Capetown, South Africa)
9:00 am - 9:25 amDavid Tobin (Duke)
"Lessons from the zebrafish about tailored treatment for TB"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amSarah Fortune (Harvard)
"Superbugs: Strain based determinants of treatment response and drug resistance in Mycobacterium tuberculosis"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amCoffee Break
10:30 am - 10:55 amJoanne Flynn (University of Pittsburgh)
"Understanding latent tuberculosis"
10:55 am - 11:05 amDiscussion
11:05 am - 11:25 amTom Hawn (University of Washington)
"Innate immunogenetics and risk of TB"
11:25 am - 11:35 amDiscussion
11:35 am - 12:05 pmWillem Hanekom (University of Capetown, South Africa)
"Correlates of risk of TB"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmTBA (Short talk selected from posters)
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Addresses
Discussion Leader: David Sacks (NIAID, NIH)
7:30 pm - 8:10 pmAlan Sher (Chief, Laboratory of Parasitic Diseases, NIAID, NIH)
"Pathogenic Functions of CD4 T Cells in TB and TB/HIV Co-Infections"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmStephen Hoffman (Chief Executive and Scientific Officer, Sanaria)
"Progress in the development of a live, attenuated sporozoite vaccine against Plasmodium falciparum"
9:10 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI103999-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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