Gordon Research Conferences
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Conference Program
 
Vascular Cell Biology
January 27 - February 1, 2013
Four Points Sheraton / Holiday Inn Express
Ventura, CA
Chair:
Timothy Hla

Vice Chair:
Anne Eichmann

The 2013 Gordon Conference on Vascular Cell Biology will continue the tradition of excellence since its inauguration 25 years ago. Through rapid basic science discoveries, the field has entered into translational research and therapeutic arenas. Yet, significant challenges remain, such as resistance to anti-angiogenic therapeutics in cancer, effective control of vascular inflammation in atherosclerotic vascular disease and chronic inflammatory diseases, just to name a few. Cutting-edge research on developmental cues and gradients, stem/ progenitor differentiation into vascular lineages, vascular endothelial and smooth muscle cell interactions with biophysical forces, gases and extracellular matrix as well as inflammatory cytokines and lipid mediators will be presented. Importantly, progress in clinical and translational research areas will be discussed to address the critical questions, for example, "Can anti-angiogenic therapeutic strategy effectively control cancer?" and "can control of vascular inflammation inhibit progression of the atherosclerotic vascular disease?" This conference will bring together leaders of research from basic science, translational science, biotechnology and pharmaceutical areas. Both established and up-and-coming investigators from a variety of fields including biochemistry, molecular biology, cell biology, developmental biology, genomics, physiology, pathology, experimental medicine, pharmacology and therapeutics will be present. Junior investigators and trainees will have ample opportunities to interact and share views informally with senior scientists in a collegial and relaxed atmosphere. It is anticipated that the meeting will promote cross-disciplinary interactions and thereby enhance vascular biology research and applications to clinical medicine.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Vascular Biology: From Basic Science to Novel Therapeutics
Discussion Leader: Timothy Hla (Weill Cornell)
7:40 pm - 8:20 pmGarret Fitzgerald (UPenn)
"Lipid Signaling and pharmacogenomics: a paradigm for translational therapeutics"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmVishva M. Dixit (Genentech)
"Cytokine signaling mechanisms and therapeutics"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmDevelopmental Signals and Vascular Malformations
Discussion Leader: Anne Eichmann (Yale)
9:00 am - 9:25 amAnne Eichmann (Yale)
"BMP signaling"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amPaul Oh (U Florida)
"Signaling in HHT"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amHanna Mikkola (UCLA)
"Hemogenic Endothelium"
11:15 am - 11:30 amDiscussion
11:30 am - 11:45 amCecile Duplaa (INSERM)
"Regulation of Wnt/PCP signaling by the PDZRN3 ubiquitin ligase"
11:45 am - 11:55 amDiscussion
11:55 am - 12:10 pmGil Levkowitz (Weizmann Institute)
"The neurohypophysis: a rendezvous of neurons and blood vessels"
12:10 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFrontiers in Genetics and Genomics
Discussion Leader: Rama Natarajan (City of Hope)
7:30 pm - 7:55 pmStephanie Dimmeler (Goethe U)
"miRNAs in cardiovascular biology and disease"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmSohail Tavazoie (Rockefeller U)
"miRNAs in tumor angiogenesis and metastasis"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmRama Natarajan (City of Hope)
"Epigenetics and MicroRNAs in Diabetic Vascular Disease"
9:15 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel Therapeutics
Discussion Leader: Laura Benjamin (Imclone / Lilly)
9:00 am - 9:25 amLaura Benjamin (Imclone / Lilly)
"New anti-angiogenics"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amCostantino Iadecola (Weill Cornell)
"The endothelium in stroke and Alzheimers"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:05 amCarlie J.M. de Vries (Univ of Amsterdam)
"Nuclear receptor Nur77 in vascular disease"
11:05 am - 11:15 amDiscussion
11:15 am - 11:30 amSunghee Chang (Weill Cornell)
"Novel RNA regulons in angiogenesis"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amMike Sapieha (University of Montreal)
"The Role of Neuronal ER Stress in Myeloid-cell Induced Vascular Regeneration"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmYoh Takuwa (Kanezawa University)
"Endothelial PI3K-C2a, a class II PI3K in angiogenesis and vascular barrier function"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmRegenerative Biology / Stem Cells
Discussion Leader: Mark Majesky (U Washington)
7:30 pm - 7:55 pmMark Majesky (U Washington)
"Adventitial progenitors"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmShahin Rafii (Weill Cornell)
"Angiocrine directed organ regeneration"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmEli Keshet (Jerusalem)
"Neurovascular niche"
9:15 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMatrix and biomechanical signals
Discussion Leader: Linda Shapiro (University of Connecticut)
9:00 am - 9:25 amMartin Schwartz (Yale)
"Shear sensing mechanisms"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amRobert Mecham (Wash U)
"Vascular Extracellular Matrix and Vessel Wall Development"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:05 amHiromi Yanagisawa (UTexas Southwestern)
"Fibulin, ACE and aortic aneurysms"
11:05 am - 11:15 amDiscussion
11:15 am - 11:30 amSelen Catania (University of Maryland)
"Role of Smooth Muscle Cell LDL Receptor Related Protein 1 (LRP1) in Vessel Wall Integrity"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amStephanie Lehoux (McGill)
"Absence of FHL2 enhances EPC function and decreases atherosclerosis in mice"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmWang Min (Yale U)
"Endocytic protein Epsin in VEGFR2 signaling and tumor angiogenesis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmCell Biological frontiers
Discussion Leader: Mike Simons (Yale)
7:30 pm - 7:55 pmMike Simons (Yale)
"Lymphatic signaling"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmMark Kahn (UPenn)
"CCM signaling and junctions"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmPaul Fox (Cleveland Clinic)
"Programmed Translational Readthrough Generates VEGF-Ax, a Novel, Anti-Angiogenic VEGF-A Isoform in Endothelial Cells"
9:15 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSignals - Gases/Lipids
Discussion Leader: Randall Johnson (U Cambridge)
9:00 am - 9:25 amMiguel Soares (Instituto Gulbenkian de Ciencia)
"Biology of CO/Heme oxygenase"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amSteffen Massberg (Munich)
"S1P and thrombopoiesis"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amRandall Johnson (U Cambridge)
"Hypoxia signaling"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amDavid Lyden (Weill Cornell)
"Microvesicles and metastasis"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:25 pmMichael Fessler (NIEHS)
"APOE4 is associated with enhanced innate immune responses and sepsis severity in humans"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmVascular Immunology
Discussion Leader: David Harrison (Vanderbilt)
7:30 pm - 7:55 pmFrederic Geissmann (UCL)
"Vascular inflammation and atherosclerosis"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmDavid Harrison (Vanderbilt)
"T cells in hypertension"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmMarlene Rabinovitch (Stanford)
"Pulmonary hypertension"
9:15 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13HL117380-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

This activity is supported by an educational grant from Lilly USA, LLC. For further information concerning Lilly grant funding, visit www.lillygrantoffice.com.

 
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