Gordon Research Conferences
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Conference Program
 
Viruses & Cells
May 5-10, 2013
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy
Chair:
Paula Traktman

Vice Chair:
Sean P. Whelan

The 2013 Viruses and Cells Gordon Research Conference, the premier conference in the field, will address key questions in virology: viral infectious cycles, virus/cell interactions, the host immune response and viral immune evasion, pathogenesis, and the development of antiviral therapeutics and vaccines. The meeting will be held at Il Ciocco, the beautiful GRC conference site in Barga, Italy, from May 5-10, 2013.

Invited speakers will present new findings on the determinants of viral host range and tropism, the cell biology of viral entry and assembly, the diverse mechanisms of viral replication, the impact of viral infections on key cellular processes and organelles, the innate and adaptive immune responses to viral infection and the counteracting viral mechanisms of immune evasion, the innate and adaptive host responses to infection, viral pathogenesis, and the development of antiviral therapeutics and vaccines. Session conveners, who are experts in the topics covered in each session, will lead lively discussions following each presentation. In addition to the invited speakers, shorter talks will be chosen at the time of registration from the abstracts submitted for the poster sessions. Selections will be made to highlight exciting new developments in virology research with an emphasis on younger scientists. The evening poster sessions are a prominent part of this conference and will provide an important opportunity for participants to present and discuss their research findings in an informal and congenial atmosphere. The conference will bring together investigators at the forefront of the field, young investigators launching independent research careers, postdoctoral fellows and graduate students, and investigators from industry to discuss new ideas and foster collaborations.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pmVirus Entry and Assembly
Discussion Leader: Rebecca Dutch (University of Kentucky)
7:35 pm - 7:55 pmKeynote Presentation: Stephen Harrison (Harvard Medical School)
"Entry mechanisms for non-enveloped viruses"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmPriscilla Yang (Harvard Medical School)
"Chemical Approaches to the Study of Dengue Virus Entry"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmMatthew Evans (Icahn School of Medicine at Mount Sinai)
"The complexities of hepatitis C virus host cell entry"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmBrett Lindenbach (Yale University)
"In a network of lines that enlace: the interplay between hepatitis C virus replication and assembly"
9:25 pm - 9:30 pmDiscussion
9:30 pm - 10:30 pmWelcome Reception (LaVeranda Terrace)
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Intricacies of Viral Replication
Discussion Leaders: Yves Gaudin (CNRS, Gif sur Yvette., France) and Wendy Barclay (Imperial College., London, UK)
9:00 am - 9:20 amCraig Cameron (Penn State University)
"Contributions of HCV NS5a phosphorylation to viral replication and viral persistence"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amErica Ollman Saphire (Scripps Research Institute)
"The filovirus matrix: protein plasticity permits multiple functions"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amGroup Photo / Coffee Break
10:30 am - 10:50 amSandra K. Weller (University of Connecticut)
"Manipulation of Host Stress Response pathways by Herpes Simplex Virus"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amPeter Cresswell (Yale University)
"Viperin: a central regulator of metabolic changes induced by HCMV infection"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amEverett Smith (Vanderbilt University)
"Coronaviruses lacking exoribonuclease activity are susceptible to multiple RNA mutagens: implications for viral evolution and therapeutics"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amNoam Stern-Ginossar (University of California, San Francisco)
"Decoding human cytomegalovirus by ribosome profiling"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmYael Mutsafi (Weizmann Institute of Science)
"Membrane assembly during the infection cycle of the giant mimivirus"
12:10 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pmViral Manipulation of Cellular Membranes and Lipids
Discussion Leader: Richard Kuhn (Purdue University)
5:30 pm - 5:50 pmNihal Altan-Bonnet (Rutgers University)
"Panviral Lipid Remodeling for Replication"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmGlenn Randall (University of Chicago)
"Manipulation of cellular lipid synthesis and signaling in viral replication compartment formation"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmJeanmarie Verchot (Oklahoma State University)
"Linking the endoplasmic reticulum and unfolded protein response to plant virus movement proteins"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmSriram Subramaniam (NCI/NIH)
"3D Imaging of HIV entry"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
9:30 pmPoster Session I (continued - presenters will be at their posters)
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmViral Manipulation of Nuclear/Cellular Functions
Discussion Leaders: David Knipe (Harvard Medical School) and Cristina Risco (CNB, Madrid ESP)
9:00 am - 9:20 amMichael Way (London Research Institute, UK)
"Subversion of signalling and cytoskeletal function by vaccinia virus"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amRobert Garcea (University of Colorado, Boulder)
"Nuclear Factories for Polyomavirus Assembly"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amAlison McBride (NIAID/NIH)
"Replication and Maintenance of Papillomaviruses by Manipulation of Host Chromatin Processes"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amLori Frappier (University of Toronto, Canada)
"EBNA1-Host Interactions Contribute to Cell Immortalization and Reactivation of Epstein-Barr Virus"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amDaniel DiMaio (Yale University)
"Role of the retromer in HPV entry"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amCovadonga Alonso (INIA, Madrid Spain)
"Building the viral replication organelle by a double stranded DNA virus"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJason Botten (University of Vermont)
"The Intracellular Cargo Receptor ERGIC-53 Is Required for the Formation of Infectious Arenavirus Particles"
12:10 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session I (continued)
5:30 pm - 7:30 pmVirus-Mediated Changes in Transcriptional & Translational Control
Discussion Leader: Roz Sandri-Goldin (UC Irvine)
5:30 pm - 5:50 pmBritt Glaunsinger (University of California at Berkeley)
"RNA-based manipulation of host and viral gene expression by gammaherpesviruses"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmChris Sullivan (University of Texas at Austin)
"RNAi: A Tool for the Enemy During Viral Infection of Mammalian Cells"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmIan Mohr (New York University)
"Control of herpes simplex virus latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmK. Andrew White (York University, Canada)
"Global structure of a plus-strand RNA virus genome regulates viral gene expression and replication"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIntrinsic and Innate Immune Response to Viral Infection
Discussion Leaders: Joanna Shisler (University of Illinois Champaign/Urbana) and Otto Haller (University of Freiburg, DEU)
9:00 am - 9:20 amGanes Sen (Cleveland Clinic)
"Innate Immune Response to Virus Infection"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJon Kagan (Harvard Medical School)
"Cell Biological Analysis of Antiviral Innate Immunity"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amBlossom Damania (University of North Carolina)
"Interactions of Herpesviruses with the Innate Immune System"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amGeoffrey Smith (University of Cambridge, United Kingdom)
"Learning about innate immunity from vaccinia virus evasion strategies"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amStacy Horner (University of Washington)
"The dynamics of innate antiviral immune regulation on the mitochondrial-associated ER membrane (MAM) during RNA virus infection"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amJuliet Morrison (Icahn School of Medicine at Mount Sinai)
"Dengue Virus Co-opts UBR4 to Degrade STAT2 and Antagonize Type I Interferon Signaling"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJennifer Lumb (Stanford University)
"Systemic identification of interferon antiviral effectors"
12:10 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session II
5:30 pm - 7:30 pmVirus Evolution: Finding a Niche
Discussion Leader: Colin Parrish (Cornell University)
5:30 pm - 5:50 pmHarmit Malik (University of Washington)
"Rules of Engagement: Molecular Insights From Host-Virus Arms Races"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmMarco Vignuzzi (Pasteur Institute, France)
"Predicting emergence: Intrahost evolutionary studies identify arbovirus variants with epidemic potential"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmTatyana Golovkina (University of Chicago)
"Role of microbiota in viral infections"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmMark Young (Montana State University)
"Host-virus interactions across all three domains of life"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
9:30 pmPoster Session II (continued - presenters will be at their posters)
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmViral Pathogenesis
Discussion Leaders: Mark Heise (University of North Carolina) and Edward Mocarski (Emory University)
9:00 am - 9:20 amAnn Arvin (Stanford University)
"Molecular Mechanisms of Varicella-Zoster Virus Pathogenesis"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amTerence Dermody (Vanderbilt University)
"Reovirus invasion of the brain"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amMario Santiago (University of Colorado School of Medicine)
"Innate restriction factor hierarchy in a mouse model of pathogenic retrovirus infection"
10:50 am - 11:00 amDiscussion
11:00 am - 11:10 amBenadetta Assetta (Brown University)
"Serotonin 2 receptors facilitate JC polyomavirus entry"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amMegan Orzalli (Harvard Medical School)
"Mechanisms of IFI16 Sensing of HSV DNA and Restriction of HSV Replication"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amHyelim Cho (Washington University)
"Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive stranded RNA viruses"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amRyan Langlois (Icahn School of Medicine at Mount Sinai)
"Molecular risk mitigation of gain-of-function studies with influenza viruses"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJulie Pfeiffer (UT Southwestern)
"How gut microbes enhance enteric virus infectivity"
12:10 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session II (continued)
5:30 pm - 7:30 pmVaccines and Therapeutics: Development and Deployment
Discussion Leader: Kanta Subbarao (NIH)
5:30 pm - 5:50 pmAlexandra Trkola (University of Zurich, CHE)
"Shedding light on HIV neutralization"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmTed Pierson (NIH-NIAID)
"Impact of the dynamic structure of flaviviruses on antibody-mediated neutralization: Hitting a moving target"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmPei-Yong Shi (Novartis Institute for Tropical Diseases)
"Targeting viral RNA methylation for therapeutics and vaccine development"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmKeynote Presentation: Grant McFadden (University of Florida at Gainesville)
"Oncolytic Virotherapy with Myxoma Virus: The path from the lab bench to the clinic"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 8:00 pmClosing Reception (LaVeranda Terrace)
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI106191-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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