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Conference Program
 
Antibody Biology & Engineering
Understanding Antibody Structure, Function, Diversity, and Pathology to Improve Disease Treatment
March 23-28, 2014
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy

Related Meeting Information
The Antibody Biology & Engineering Gordon Research Conference was held in conjunction with the Antibody Biology & Engineering Gordon-Merck Research Seminar. Please refer to the Antibody Biology & Engineering GMRS web page for more information.

Antibodies are multi-faceted proteins, capable of an extraordinary array of important functions. Not only major players in protection against invading pathogens, they play critical roles in inflammatory and autoimmune diseases, their induction is central to many vaccine strategies, and they are an unrivalled platform for engineering highly effective diagnostic and therapeutic reagents. The 2014 Gordon Conference on Antibody Biology and Engineering will present in-depth coverage of recent advances in this exciting field, in an informal setting designed for maximal interaction. Bringing together academic researchers with their colleagues in the biopharma industry, it will provide an ideal opportunity for leading researchers from around the world to present and discuss cutting-edge data.

Fusing new developments in basic science with high-impact translational and clinical research, the meeting will provide a stimulating program featuring an international mix of established and upcoming researchers. A key emphasis will be on mechanisms of antibody action in health and disease and the application of this mechanistic understanding to the design of improved vaccines and monoclonal antibody therapeutics. Topics will include antibody structure and dynamics, immunoglobulin effector function, the breadth and duration of antibody repertoires, as well as the mechanisms underlying antibody involvement in major inflammatory and autoimmune diseases. The protective roles of antibodies against important viral and bacterial pathogens will also come under the spotlight, in the context of both improved vaccine strategies and development of new treatments. Novel approaches to engineer effective therapeutic antibodies will also be a key theme, including strategies to control antibody half-life and biodistribution. Building on the highly creative, congenial academia-industry interactions that characterized the previous two meetings in this series, the conference will provide the ideal setting for cross-fertilization of ideas, conceptual advances, and the promotion of synergistic collaborations.

For the first time in the meeting series, the conference will be preceded by a Gordon Research Seminar (GRS). The Antibody Biology and Engineering GRS is designed to further facilitate the participation of graduate students and postdoctoral researchers. Planned by and for trainees, it will provide an opportunity for our junior researchers to present seminars and posters in a supportive, interactive environment. It will act as an important springboard for the development of the future thought leaders in the field.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 7:50 pmWelcome/Introductory Comments by Conference Chairs
7:50 pm - 9:30 pmEngineering Effective Antibodies
Discussion Leaders: Jenny Woof (University of Dundee) and John Desjarlais (Xencor)
7:50 pm - 8:30 pmKeynote Talk: Dennis Burton (Scripps Research Institute)
"Neutralizing Antibodies Against HIV"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:20 pmKeynote Talk: Stephen Harrison (Harvard Medical School)
"Immunopaleontology - Affinity Enhancement During Maturation of the Antibody Response to Influenza"
9:20 pm - 9:30 pmDiscussion
9:30 pm - 11:00 pmWelcome Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAntibody Structure and Dynamics
Discussion Leader: Inger Sandlie (University of Oslo)
9:00 am - 9:25 amChristian Klein (Roche, Switzerland)
"Epitopes of CD20 mAbs and Their Relationship to Functional Properties"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amTrevor Swartz (Genentech)
"Antibody Internal Dynamics"
10:00 am - 10:10 amDiscussion
10:10 am - 10:45 amCoffee Break
10:45 am - 10:55 amLinzhong Li (Simcyp Limited)
"Modeling the Binding Kinetics of Bispecific Antibodies Under the Framework of a Minimal Human PBPK Model"
10:55 am - 11:00 amDiscussion
11:00 am - 11:10 amVaughn Smider (Scripps Research Institute)
"Holy Cow! - Biology, Diversity and Engineering of Bovine Ultralong CDR H3s"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amJaafar Haidar (ImClone/Lilly)
"Backbone Flexibility of CDR3 and the Kinetics of Antigen Recognition: A Computational and Experimental Study"
11:45 am - 11:55 amDiscussion
11:55 am - 12:05 pmMaarten Merkx (Eindhoven University of Technology)
"Reversible Control of Antibody Targeting Using Bivalent Peptide-DNA Conjugates"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pm Alexey Teplyakov (Janssen)
"Second Antibody Modeling Assessment"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmDissecting Antibody Responses
Discussion Leader: John Desjarlais (Xencor)
6:00 pm - 6:25 pmJacob Glanville (Distributed Bio)
"Synthetic Antibody Libraries"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmGreg Ippolito (University of Texas)
"Deconvolution of Polyclonal Antibody Responses and High Throughput Repertoire Sequencing"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:20 pmChristy Thomson (Amgen)
"Innate Immunological Memory to Diverse Pathogens Encoded by Immunoglobulin V Genes"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:50 pmCristina Rada (MRC Laboratory of Molecular Biology, Cambridge)
"Antibody Evolution, Mechanisms and Applications: In Honour of Dr. Michael Neuberger"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
9:30 pm - 11:00 pmPoster Session (continued)
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmImmunoglobulin Effector Function
Discussion Leader: Sally Ward (University of Texas South Western)
9:00 am - 9:25 amFalk Nimmerjahn (University of Erlangen-Nurnberg)
"Deciphering the Anti-Inflammatory Activity of IVIg - Sugars and Beyond"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amAnn White (University of Southampton)
"Role of FcγRIIB in the Agonistic Activity of Anti-TNFR mAb"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amPierre Bruhns (Institut Pasteur)
"Roles of FcγRI"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amMark Hogarth (Burnet Institute, Melbourne)
"Antibody and Fc Receptor Interactions in Humans and Other Primates: Implications for the Development of Therapeutic Antibodies and the Study of Antibody Responses"
11:40 am - 11:50 amDiscussion
11:50 am - 12:00 pmJanine Schuurman (Genmab)
"The Mechanism of Complement Activation by IgG Antibodies"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pm Gestur Vidarsson (Sanquin Research)
"Regulation of IgG Effector Functions in Humans Through Fc-Glycosylation and Clinical Implications"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmAntibody Class Distinctions
Discussion Leader: Susan Pierce (NIH)
6:00 pm - 6:25 pmSophia Karagiannis (King's College London)
"Redirected Antibody Responses in Melanoma and Insights for Designing Cancer Therapies"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmJeanette Leusen (University Medical Center, Utrecht)
"IgA as a Novel Class for Cancer Therapy: Synergy with IgG"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:35 pmMorgane Bomsel (Cochin Institute)
"Functional Significance of Antibody Class in Protection Against HIV Infection"
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmKristi Baker (Brigham and Women's Hospital and Harvard Medical School)
"FcRn in Dendritic Cells Protects Against Colorectal Cancer via the Regulation of Homeostatic Intestinal CD8+ T Cell Activation and IL-12 Production"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
9:30 pm - 11:00 pmPoster Session (continued)
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmControl of Antibody Exposure and Distribution
Discussion Leader: Derry Roopenian (Jackson Laboratory)
9:00 am - 9:25 amJavier Chaparro-Riggers (Rinat-Pfizer)
"pH Tuning for Antigen Turnover"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amNancy Stagliano (Ipierian)
"CNS Therapies"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amJeff Stavenhagen (Lundbeck)
"Blood Brain Barrier Transport"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amInger Sandlie (University of Oslo)
"Half-Life Extension by Albumin- or Fc-Fusion"
11:40 am - 11:50 amDiscussion
11:50 am - 12:00 pmJens Niewoehner (Roche)
"Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Molecular Shuttle with a Novel Binding Mode"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pm Joy Zuchero (Genentech)
"Improving Exposure and Safety of Blood-Brain Barrier Crossing Transferrin Receptor (TfR) Bispecific Antibodies"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmPathogenic Antibodies
Discussion Leader: Jenny Woof (University of Dundee)
6:00 pm - 6:25 pmDonald MacGlashan (Johns Hopkins)
"IgE-Specific Activity in Allergic Disease"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmJan Novak (University of Alabama at Birmingham)
"Pathogenesis of IgA Nephropathy: Aberrant IgA1 Glycosylation and Anti-Glycan Antibodies"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:20 pmCarl-Henrik Brogen (Bartholin Institut)
"The Regulatory NKT Cell Inhibitory Monoclonal Antibody IC2 and Its Anti-Idiotype Antibodies in Diagnosis and Therapy of Type 1 Diabetes"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:35 pmSarita Patil (Harvard Medical School)
"Induction of Ara h2-Specific Memory B Cells During Peanut Oral Immunotherapy"
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pm Anders Christiansen (Technical University of Denmark)
"Characterising the Antibody Response at the Functional Level - Epitope Mimicking Patterns in Patient Sera Unraveled by High-Throughput Sequencing Enhanced Phage Display"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
9:30 pm - 11:00 pmPoster Session (continued)
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmAntibody Therapeutics
Discussion Leader: Paul Carter (Genentech)
9:00 am - 9:25 amPhilip Tan (Emergent BioSolutions)
"Bispecific ADAPTIRTM Platform for Oncology and Autoimmunity Applications"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amFrank Ward (University of Aberdeen)
"Immune Modulation by Anti-Soluble CTLA-4 mAb"
10:00 am - 10:10 amDiscussion
10:10 am - 10:35 amCoffee Break
10:35 am - 11:00 amKerry Chester (University College London)
"Developing Dual-Specific Antibodies for Cancer Targeting"
11:00 am - 11:10 amDiscussion
11:10 am - 11:35 amAnne Messer (University of Albany and Neural Stem Cell Institute)
"Engineering Intracellular Antibodies to Retarget or Refold Misfolded Proteins"
11:35 am - 11:45 amDiscussion
11:45 am - 12:10 pmAlan Wahl (Ambrx)
"Optimising ADCs with an Expanded Genetic Code"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pm Matthias Peipp (Christian Albrechts University)
"The Dual-Dual-Targeting (DDT) Concept - Activating NK Cell Receptors as Trigger Molecules for Bifunctional Antibody-Derivatives to Enhance Anti-Tumor NK Cell Responses"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmAnti-Pathogen Antibodies
Discussion Leader: Mark Hogarth (Burnet Institute)
6:00 pm - 6:25 pmGalit Alter (Harvard Medical School)
"Links Between Innate and Adaptive Immunity in HIV"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 6:45 pmEva Archer (Wellcome Trust Sanger Centre)
"Evolution of Antigen-Specific B Cell Receptor Repertoires in Early SIV Infection"
6:45 pm - 6:50 pmDiscussion
6:50 pm - 7:00 pmOhad Mazor (Israel Institute for Biological Research)
"A Novel Mechanism for Antibody-Based Anthrax Neutralization: Inhibition of Prepore-to-Pore Conversion"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:35 pmJoann Suzich (MedImmune)
"Protective Antibodies Against Bacterial Infection"
7:35 pm - 7:45 pmDiscussion
7:45 pm - 8:00 pm Concluding Remarks
8:00 pmDinner
9:30 pm - 11:00 pmFarewell reception
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI109793-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Last Updated: March 31, 2014
 
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