Gordon Research Conferences
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Conference Program
 
Basal Ganglia
Basal Ganglia Cells and Circuits in Health and Disease
February 2-7, 2014
Four Points Sheraton / Holiday Inn Express
Ventura, CA
Chair:
D. James Surmeier

Vice Chair:
Nicole Calakos

The basal ganglia are a richly interconnected set of forebrain, diencephalic and mesencephalic nuclei that control movement and thought. Parkinson disease, Huntington disease, Tourette's Syndrome and schizophrenia are widely viewed as disorders of the basal ganglia. This clinical linkage and the recent and rapid expansion of molecular tools to probe circuit function have led to an explosion in basal ganglia research in the last decade.

The goal of this GRC is to create a forum for discussing key advances in the understanding of the major basal ganglia nuclei as well as new insights into the operation of the network as a whole. An emphasis will be placed on developments arising from recent methodological advances and developments that have translational significance. The program will include a diverse collection of investigators from around the world. We hope to continue the tradition of the highly interactive and cutting-edge nature of GRC conferences to provide an opportunity for scientists of diverse backgrounds, career stages, and approaches to gather and achieve new and synthetic views of this field of neuroscience, define the major challenges, and build cross-cutting collaborations that could lead to breakthroughs.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmIn Vivo Approaches to Understanding How Basal Ganglia Activity Shapes Behavior
7:40 pm - 7:45 pm Discussion Leader: Mahlon Delong (Emory)
"Introduction"
7:45 pm - 8:10 pm Allison Doupe (UCSF)
"Basal Ganglia Pathways and Vocal Motor Plasticity: Cellular and Circuit Mechanisms"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Rui Costa (Champalimaud Center, Portugal)
"Generating and Shaping Novel Action Repertoires"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Ann Graybiel (MIT)
"Dynamics of Neuronal Activity in Corticostriatal Loops During Habit Learning"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmStriatal Interneurons: The Glue That Holds It Together
9:00 am - 9:10 am Discussion Leader: Michael Levine (UCLA)
"Introduction"
9:10 am - 9:35 am James Tepper (Rutgers)
"Novel Striatal Interneuron Networks"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Stephanie Cragg (Oxford)
"Are Cholinergic Interneurons the Gatekeepers of Dopamine Signals?"
10:10 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:15 am Charles Wilson (UT-San Antonio)
"Resonant Subcircuits in the Striatum"
11:15 am - 11:25 am Discussion
11:25 am - 11:40 am Adam Aron (UCSD)
"Suppression of a Specific Motor Response is Implemented by Striatum and Pallidum in Humans"
11:40 am - 11:45 am Discussion
11:45 am - 12:00 pm Juan Meno-Segovia (Oxford)
"Cholinergic Neurons in the Brainstem Topographically Innervate and Differentially Modulate Neurons of the Striatum and Nucleus Accumbens"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:20 pm John Reynolds (Univ. of Otago)
"A Temporally Critical Convergence of Dopaminergic and Cholinergic Activity Drives Behaviourally-Relevant Synaptic Plasticity in the Striatum"
12:20 pm - 12:25 pm Discussion
12:25 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSynaptic Plasticity: Consensus and Controversy
7:30 pm - 7:40 pm Discussion Leader: David Lovinger (NIH)
"Introduction"
7:40 pm - 8:05 pm Jeffrey Wickens (Okinawa Institute of Science and Technology)
"A Synaptic Eligibility Trace in the Striatum"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Marc Fuccillo (Stanford)
"Enhanced Procedural Learning Due to Neuroligin-3 Deletion in Nucleus Accumbens Direct Pathway Neurons"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Barbara Picconi (University of Perugia)
"Dopamine-Dependent Striatal Synaptic Plasticity: The Black, the White, and the Gray"
9:15 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSub-Striatal Networks in the Basal Ganglia
9:00 am - 9:10 am Discussion Leader: Rob Turner (University of Pittsburgh)
"Introduction"
9:10 am - 9:35 am Peter Magill (Oxford)
"External Globus Pallidus: A Tale of Two Cell Types"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Mark Bevan (Northwestern)
"Plasticity of the Subthalamic Nucleus in Health and Disease"
10:10 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:15 am Constance Hammond (Inserm, Marseilles)
"Presymptomatic Electrophysiological Signatures of Parkinson's Disease"
11:15 am - 11:25 am Discussion
11:25 am - 11:40 am Alexandra Nelson (Gladstone Institute)
"Aberrant Striatal Indirect Pathway Activity in a Mouse Model of Dyskinesia"
11:40 am - 11:45 am Discussion
11:45 am - 12:00 pm Huaibin Cai (National Institute on Aging, NIH)
"LRRK2 Regulates Striatal Neuron Synaptogenesis and Dopamine Activation Through Modulation of PKA Activities"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:20 pm Izhar Bar-Gad (Bar-Ilan University)
"Tic Related Neuronal Activity in Freely Moving Rats"
12:20 pm - 12:25 pm Discussion
12:25 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNetwork Dysfunction in Movement Disorders (Dystonia, Dyskinesia and PD)
7:30 pm - 7:40 pmDiscussion Leader: Jose Obeso (University of Navarra)
"Introduction"
7:40 pm - 8:05 pm Kamran Khodakhah (Albert Einstein College of Medicine)
"Cerebello-Basal Ganglia Interactions and Dystonia"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Angela Cenci Nilsson (Lund University)
"Striatal Plasticity in L-DOPA-Induced Dyskinesia"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Hagai Bergman (Hebrew University)
"Multi-Objective Optimization in the Neural Networks of the Basal Ganglia"
9:15 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBeyond Synapses: Neuromodulators in the Striatum
9:00 am - 9:10 am Discussion Leader: Sten Grillner (Karolinska Institute)
"Introduction"
9:10 am - 9:35 am Michael Higley (Yale University)
"Multiplexing Modulation by RGS4 Control of PKA Signaling in Dendritic Spines"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Enrico Bracci (University of Sheffield)
"How do Striatal Neurons Really Talk to Each Other? Role of Presynaptic Interactions"
10:10 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:15 am Margaret Rice (New York University)
"Volume Transmission: Rule Rather than Exception"
11:15 am - 11:25 am Discussion
11:25 am - 11:40 am Benjamin Pasquereau (Univ. of Pittsburgh)
"Dopamine Neurons Encode Errors in Estimating Event Probability Independent of Incentive Value"
11:40 am - 11:45 am Discussion
11:45 am - 12:00 pm Emmanuel Valjent (INSERM)
"New Insights in the Anatomy of D1R- and D2R-Expressing MSNs in the Mouse Striatum"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:20 pm Yevgenia Kozorovitzkiy (Harvard)
"Dopamine Signaling Mediates Rapid, Pathway-Specific Development in the Basal Ganglia"
12:20 pm - 12:25 pm Discussion
12:25 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair(s); Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pmWhat Makes the SNc Go?
7:30 pm - 7:40 pm Discussion Leader: Jochen Roeper (Goethe University)
7:40 pm - 8:05 pm Peter Redgrave (University of Sheffield)
"Phasic Dopamine Responses Signal Reward Prediction Errors (Sometimes): Right for the Wrong Reasons"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Naoshige Uchida (Harvard University)
"Dissecting Computations in the Dopamine Reward Circuit: Experimental Approaches"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Bruce Bean (Harvard University)
"Ionic Basis of Pacemaking and Burst Firing in Midbrain Dopaminergic Neurons"
9:15 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDevil in the Detail: Dendrites and Synapses in the Striatum
9:00 am - 9:10 am Discussion Leader: Yoland Smith (Emory University)
9:10 am - 9:35 am Bernardo Sabatini (Harvard University)
"Unexpected Interactions in the Basal Ganglia"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Jose Bargas (UNAM, Mexico)
"Cortical Activation of the Striatal Microcircuit"
10:10 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:15 am Paul Bolam (Oxford)
"Dopamine Neurons: Synapses and Susceptibility"
11:15 am - 11:25 am Discussion
11:25 am - 11:40 am Jill Crittenden (MIT)
"Cholinergic Interneurons Modulate Striatal Neuron Activation and Behavior Through M1 Acetylcholine Receptor and CalDAG-GEFI Signaling"
11:40 am - 11:45 am Discussion
11:45 am - 12:00 pm Joshua Plotkin (Northwestern)
"Impaired TrkB Receptor Signaling Underlies Corticostriatal Dysfunction in Huntington's Disease"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:20 pm Gilad Silberberg (Karolinska Institute)
"Multisensory Integration in the Mouse Striatum - A Whole-Cell In Vivo Study"
12:20 pm - 12:25 pm Discussion
12:25 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechanisms Driving Huntington's Disease
7:30 pm - 7:40 pm Discussion Leader: David Standaert (University of Alabama, Birmingham)
"Introduction"
7:40 pm - 8:05 pm Isabel Perez-Otano (University of Navarra)
"A New NMDA Receptor Mechanism in Huntington's Disease Neurodegeneration"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Baljit S. Khakh (UCLA)
"Astrocyte Dysfunction in Mouse Models of Huntington's Disease"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Marie Francoise-Chesselet (UCLA)
"Clues About HD Progression from Knockin Mouse Models"
9:15 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS087696. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 
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