Gordon Research Conferences
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Conference Program
 
Biology of Acute Respiratory Infection
Mechanisms and Translational Science
February 23-28, 2014
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy

Related Meeting Information
The Biology of Acute Respiratory Infection Gordon Research Conference was held in conjunction with the Biology of Acute Respiratory Infection Gordon-Merck Research Seminar. Please refer to the Biology of Acute Respiratory Infection GMRS web page for more information.

Acute respiratory infections such as pneumonia and influenza are an enormous public health problem. Trends suggest that the burden of disease due to viral, bacterial and fungal respiratory infection is likely to get worse rather than better in the coming years. The 2014 Gordon Research Conference (GRC) on Biology of Acute Respiratory Infections will focus attention on new developments in mechanisms of lung infections, including insights from 'omics approaches to host and pathogen interaction, novel innate immune cells and signals, bridging innate and adaptive responses, co-infections and their pathogenesis, and advances in translating bench science to improve bedside outcomes. Perspectives to be considered include systems biology, microbiology, immunology and integrated physiology. Speakers have been chosen to give a broad, up-to -date overview of this rapidly evolving and multi-disciplinary field. The consistent aim of the GRC on Biology of Acute Respiratory Infections has been to bring together an outstanding and diverse group of experts from basic and applied science and clinical research from across the globe to foster communication among individuals and groups studying this common and important problem from distinct vantage points, to develop and encourage creative and multidisciplinary approaches to discovery. Elucidating the biology of respiratory infections will facilitate the development of innovative, effective prevention and treatment strategies.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmInnate Immunity: Novel Mechanisms
Discussion Leader: Joseph Mizgerd (Boston University)
7:40 pm - 8:20 pmAlice Prince (Columbia)
"Innate Immunity and Bacterial Pneumonia"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmTed Standiford (University of Michigan Medical Center)
"Novel IL-36 Family Members in Lung Innate Immunity"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOmics to Better Understand Infections
Discussion Leader: Jay Kolls (U. Pittsburgh)
9:00 am - 9:40 amMark Heise (U. North Carolina)
"Systems Genetics and Influenza Pathogenesis"
9:40 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:00 amPaige Lacy (U. Alberta)
"Metabolomics and Lung Infections"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amFrank van de Veerdonk (Radboud Univ.)
"Functional Genomics of Aspergillus Infection"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmJoanna Goldberg (U. Virginia)
"Pseudomonas Proteomics and Bacterial Pathogenesis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmInnate Immune Cells: Signals and Roles
Discussion Leader: Peter Openshaw (Imperial College)
6:00 pm - 6:30 pmJoseph Mizgerd (Boston University)
"Transcription Factors and Bacterial Pneumonia"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:10 pmErich Gulbins (U. Duisburg-Esse)
"The Role of Sphingolipids for Pulmonary Infections"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:50 pmMitchell Kronenberg (La Jolla Institute)
"HVEM Signalling at Mucosal Barriers Provides Host Defence Against Pathogenic Bacteria"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmInvasive and Destructive Infections
Discussion Leader: Paige Lacy (U. Alberta)
9:00 am - 9:40 amSuzan Rooijakkers (U. Utrecht)
"S. aureus Inhibitors of Neutrophil Proteases and Their Role in Bacterial Pathogenesis"
9:40 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:00 amAndreas Peschel (U. Tubingen)
"Role of the FPR2 Receptor in S. aureus Infection"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amAgostinho Carvalho (U. Perugia)
"Genetics of Tryptophan Catabolism and Host Defense Against Invasive Aspergillosis"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmChad Steele (U. Alabama)
"IL-1 Family Members and Immunity Against Invasive Aspergillosis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmBridging Innate and Adaptive Responses
Discussion Leader: Dennis Metzger (Albany Medical)
6:00 pm - 6:30 pmDawn Bowdish (McMaster U.)
"Pneumococcal Colonization, Aging and Scavenger Receptors"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:10 pmSabra Klein (Johns Hopkins U.)
"Sex Differences in Viral Pathogenesis"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:50 pmTom Braciale (U. Virginia)
"Regulating the Adaptive Immune Response to Respiratory Virus Infection"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAdvances in Influenza and Beyond
Discussion Leader: Sabra Klein (Johns Hopkins University)
9:00 am - 9:40 amKanta Subbarao (NIH)
"Determinants of Transmissibility of Influenza Viruses"
9:40 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:00 amIlona Jaspers (U. North Carolina)
"Environment and Viral Infections: A Human Model"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amDavid Dockrell (U. Sheffield)
"Alternative Strategies of Microbial Killing by Alveolar Macrophages in Health and Disease"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmArturo Zychlinsky (Max Planck Institute)
"Neutrophil NETs: Chromatin as an Immune Effector"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmPathogen Profiling for Mechanisms and Therapeutics
Discussion Leader: Suzan Rooijakkers (U. Utrecht)
6:00 pm - 6:30 pmMatthew Holden (Sanger Institute)
"What We Can Learn from Whole Genome Sequencing About S. aureus Epidemiology"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:10 pmUte Romling (Karolinska Institute)
"The Secret of Successful Clones - Biofilm Formation and Beyond"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:50 pmVaughn Cooper (U. New Hampshire)
"Evolution Events in Burkholderia Biofilm Infection"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmBacterial/Viral Co-Infection or Secondary Pneumonias
Discussion Leader: Ted Standiford (U. Michigan)
9:00 am - 9:40 amDennis Metzger (Albany Medical)
"Influenza and Secondary Pneumonia Mechanisms"
9:40 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:00 amBettina Loffler (Institute for Medicine, Munster)
"Influenza/CA-MRSA Co-Infection of the Lung"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amTom van der Poll (Univ. Amsterdam)
"Cell-Specific Signaling in Host Defense Against Pneumonia"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmTracy Hussell (U. Manchester)
"Bacterial Super Infections: A Consequence of Repair and Efferocytosis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmTranslation: Targeting the Host
Discussion Leader: Tracy Hussell (U. Manchester)
6:00 pm - 6:30 pmPeter Openshaw (Imperial College London)
"What Protects Against RSV Infection: Antibody, T Cells or Innate Defenses?"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:10 pmJay Kolls (University of Pittsburgh School of Medicine)
"Th17 Based Vaccines for Carbapenemase-Producing Klebsiella"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:50 pmAntonio DiGiandomenico (MedImmune)
"A Novel Multi-Mechanistic Antibody Platform Provides Synergistic Antibacterial Protection"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI109838-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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