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Biointerface Science
Gordon Research Conference

Engineered Biomolecular Interfaces

Dates

June 15-20, 2014

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chair:
Stefan Zauscher

Vice Chair:
Atul N. Parikh

Meeting Description

The 2014 GRC on Biointerface Science brings together scientists and engineers that work and learn in diverse fields of physics, chemistry, biology, biotechnology, materials science, diagnostics, medicine and environmental technologies. The broad focus of the 2014 Biointerface Science GRC is directed onto engineered biomolecular interfaces. These interfaces are not only designed to recapitulate the functions of their natural counterparts, but also to provide platforms for interfacing and signal transduction. By consolidating physical science and engineering of surfaces and interfaces with biology, new opportunities open toward building model synthetic cells "bottom-up", toward rewiring intercellular interactions, and devising novel material interfaces that control and manipulate cellular behavior.

By presenting, discussing, and examining the latest fundamental research and the most advanced aspects involving interfacial interactions between biomolecules and surfaces of various materials, this GRC seeks to bridge the gap and enhance the intellectual interactions between molecular/cellular biology and the medical disciplines on one side, and the physical and chemical sciences on the other. This cross-disciplinary interchange is expected to enhance the quantitative understanding of the molecular mechanisms that govern the behavior of biomolecules (e.g., proteins, lipids, and carbohydrates) and their complex conformational and aggregative states (e.g., conformational folds, vesicles, cellular and tissue organization) at native (e.g., cells, ECM, cytoskeleton) and synthetic interfaces (e.g., culture surfaces, material surfaces, transducers). By integrating engineers and materials experts into the discussion this GRC contributes to the translation of the developed biomolecular concepts into the world of applications (e.g., biomedical devices, sensors, etc.) that are urgently needed for diagnostic strategies and new medical treatments of human diseases, for process monitoring, or in environmental technologies.

The associated Gordon Research Seminar (GRS) program will provide a venue with sufficient intimacy for junior investigators and young scientists to readily establish informal networks with senior investigators for long-term collaborations and a life-time of scientific citizenship.

Related Meeting

This GRC was held in conjunction with the "Biointerface Science" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmBiointerface Design Challenges for Synthetic Cellular Interfaces
Discussion Leader: Christine Keating (Penn State University, US)
7:40 pm - 8:20 pmLuigi Luisi (ETH, Switzerland)
"The Synthetic Biology of Minimal Cells"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmHagan Bayley (University of Oxford, UK)
"Functional 3-D Droplet Networks"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSynthetic Cells and Interfaces
Discussion Leader: Sebastien Lecommandoux (University of Bordeaux, FR)
9:00 am - 9:40 amDan Hammer (University of Pennsylvania, US)
"Engineered Adhesion of Synthetic Vesicles and Cells"
9:40 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:10 amCornelia Palivan (University of Basel, CH)
"Protein-Polymer Supramolecular Assemblies: A Key Combination for Medical Applications"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmJan van Hest (Radboud University, NL) "Multistep Biocatalytic Processes via Conjugation and Compartmentalization Strategies"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmCell-Material Interface
Discussion Leader: Jeff Karp (Harvard University, US)
6:00 pm - 6:40 pmMolly Stevens (Imperial College, UK)
"Investigating and Engineering the Cell-Material Interface"
6:40 pm - 7:00 pmDiscussion
7:00 pm - 7:40 pmChris Chen (Boston University, US)
"Mechanotransduction at the Cell-Material Interface: Implications for Materials Design"
7:40 pm - 8:00 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEngineering "Smart" Biointerfaces
Discussion Leader: Chris Bettinger (Carnegie Mellon University, US)
9:00 am - 9:40 amAtul Parikh (Nanyang Technological University, Singapore and University of California, Davis, US)
"Animating the Membrane Surface Through the Osmotic Activity of Bulk Water"
9:40 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:10 amJeff Brinker (Sandia National Laboratory, US)
"Silica @ Cells - A Special Interface"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmNoo Li Jeon (Seoul National University, KR)
"Engineering Multiscale Biointerface with Nanofabrication to Microfluidics"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmDissecting Cellular Signaling
Discussion Leader: Ann-Sophie Cans (Chalmers University, SE)
6:00 pm - 6:40 pmJay Groves (Mechanobiology Institute, Singapore and University of California, Berkeley - Berkeley, US)
"Signal Transduction Reactions on Membrane Surfaces"
6:40 pm - 7:00 pmDiscussion
7:00 pm - 7:40 pmMadan Rao (NCBS, IN)
"Cell Surface as an Active Reconfigurable Computing Platform"
7:40 pm - 8:00 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProgress in Biosurface Imaging
Discussion Leader: Peter Jönsson (Cambridge, UK)
9:00 am - 9:40 amJürgen Plitzko (University of Uetrecht, NL)
"Novel Approaches and Recent Advances in 3-D Cryo-Electron Microscopy"
9:40 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:10 amStefan Hell (MPI Biophysical Chemistry, Goettingen, DE)
"Far-Field Optical Nanoscopy: Principles and Recent Advancements"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmMary Kraft (University of Illinois, Urbana-Champaign, US)
"Imaging Distinct Lipid and Protein Species in the Plasma Membrane with High-Resolution Secondary Ion Mass Spectrometry"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmProgress in Nanopores: Diagnostics and Information Exchange
Discussion Leader: Päivi Laaksonen (Aalto Univeristy, FI)
6:00 pm - 6:40 pmCees Dekker (Technical University Delft, NL)
"Nanopores and Nanostructures for Biophysics Experiments from Single Molecules to Bacteria"
6:40 pm - 7:00 pmDiscussion
7:00 pm - 7:40 pmAleksei Aksimentiev (University of Illinois, US)
"Modeling Nanopores for Sequencing DNA"
7:40 pm - 8:00 pmDiscussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmNew Biointerfacial Diagnostics and Design
Discussion Leader: Ryan Hill (Duke University)
9:00 am - 9:40 amAshutosh Chilkoti (Duke University, US)
"Harnessing Polymerization at the Solid-Liquid Interface for the Design of Protein and Nucleic Acid Diagnostics"
9:40 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:10 amScott Phillips (Penn State University, US)
"Detection on Depolymerizable Surfaces"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmCarsten Werner (Leibniz-Institut für Polymerforschung Dresden, DE)
"Bio-Interactive Polymer Hydrogels"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmAlexander M. Cruickshank Award Lecture / Selected Poster Presentations
Discussion Leader: Monique Beaudoin (ONRG, London, UK)
6:00 pm - 6:40 pmAlexander M. Cruickshank Award Lecture: Joanna Aizenberg (Harvard University, US)
"Hairy and Slippery Surfaces in Biological Applications"
6:40 pm - 7:00 pmDiscussion
7:00 pm - 7:40 pmTBA (Best Poster Winners)
7:40 pm - 8:00 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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