Gordon Research Conferences
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Conference Program
 
Cell Death
Cell Death Mechanisms at the Interface of Health and Disease
June 8-13, 2014
Mount Snow Resort
West Dover, VT
Chair:
Eric H. Baehrecke

Vice Chair:
Henning Walczak

Cell death is a fundamental biological process, universally required for normal development and firmly established in the etiology, pathogenesis and treatment of many diseases. This Gordon Conference will explore the frontiers of Cell Death research, with themes that focus on newly discovered molecules, pathways and mechanisms that specify active forms of cell death in health and disease. The Conference will feature talks and poster presentations on a wide range of topics that span apoptotic signaling networks and non-canonical cell death pathways, including necrosis and autophagy. Invited speakers are recruited from a variety of scientific disciplines, including biochemistry, genetics, structural biology, cell biology, developmental biology, cancer biology, neurobiology and immunology. The Conference will gather established experts who are leaders of the field together with junior scientists, postdocs and graduate students to share discoveries and exchange ideas. Some poster presenters will be selected for short talks. The intimate format and collegial atmosphere of this Conference is designed to enable brainstorming and promote collaborations.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmPast Chair's Lecture and Keynote Address
Discussion Leader: Doug Green (St. Jude Children's Research Hospital)
7:40 pm - 8:20 pmJohn Abrams (University of Texas Southwestern Medical Center)
"Repurposing the Death Machine"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmVishva Dixit (Genentech)
"Interplay Between Regulators of Apoptosis and Necroptosis"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell Signaling, Survival and Death
Discussion Leader: Joan Brugge (Harvard Medical School)
9:00 am - 9:20 amKevin Ryan (The Beatson Institute for Cancer Research)
"p53 Modulates Cytokine Responses to Promote Cell Death"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAndreas Bergmann (University of Massachusetts Medical School)
"Autophagy Regulates Tissue Overgrowth in a Context-Dependent Manner"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amSharad Kumar (University of South Australia)
"How Caspase-2 Might Suppress Tumorigensis?"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amDomagoj Vucic (Genentech)
"Targeting XIAP in NOD2 Mediated Inflammatory Diseases"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amNader Yatim (Institut Pasteur)
"Necroptotic Cells Induce Efficient Cross-Priming to Ag-Specific CD8+ T Cells"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmSeamus Martin (Trinity College)
"Inflammatory Outcomes of Apoptosis and Necroptosis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMitochondria and Cell Death
Discussion Leader: Anthony Letai (Harvard Medical School)
7:30 pm - 7:50 pmMarie Hardwick (Johns Hopkins University School of Medicine)
"Bcl-xL and Bax Cooperate to Bend Membranes"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmRichard Youle (National Institutes of Health)
"Parkin and Regulation of Mitophagy"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmStephen Tait (Beatson Institute)
"Apoptosis as a Tumor Promoter: Failure to Execute Cell Death Leads to DNA Damage and Genomic Instability"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmAndreas Strasser (The Walter and Eliza Hall Institute of Medical Research)
"Control of Cell Deletion During Embryogenesis - Apoptosis, Necroptosis or Something Else?"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmApoptotic Linchpins
Discussion Leader: Domagoj Vucic (Genentech)
9:00 am - 9:20 amPascal Meier (Institute of Cancer Research)
"The Ripoptosome as Molecular Timer and Mitotic Checkpoint"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMarion MacFarlane (MRC Toxicology Unit)
"The FLIP Side of the DISC: New Insights into c-FLIP Regulation of Caspase-8"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amJerry Chipuk (Mount Sinai)
"Outer Mitochondrial Membrane Shape Engages BAX a9 to Initiate Terminal Unfolded Protein Responses"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amSandra Zinkel (Vanderbilt University)
"BID as a Central Regulator of Cell Death Fates in Hematopoiesis to Preserve Hematopoietic Homeostasis and Stem Cell Function"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amXin Huang (Amgen Inc.)
"Structural Basis for the Cooperative Anti-Tumor Activity of Apo2L/TRAIL and the Death Receptor 5(DR5) Agonist Antibody Conatumumab"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmGuy Salvesen (Sanford-Burnham Medical Research Institute)
"Netosis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmClearance of Dying Cells
Discussion Leader: John Abrams (University of Texas Southwestern Medical Center)
7:30 pm - 7:50 pmShige Nagata (Kyoto University)
"Exposure of Phosphatidylserine and Engulfment of Apoptotic Cells"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmLin Lin (University of Massachusetts Medical School)
"Complement Factor Mcr Regulates Autophagy in a Non-Cell-Autonomous Manner"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmFrancesca Peri (European Molecular Biology Laboratory)
"Neuronal Cell Death Goes Live: How Do Microglia Collect the Dying Neurons?"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmWill Wood (University of Bath)
"Inflammatory Decisions in Damage and Death"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell Survival and Death in Cancer
Discussion Leader: Huseyin Mehmet (Merck Research Laboratories)
9:00 am - 9:20 amMarcus Peter (Northwestern University)
"Death Induced by CD95/CD95L Elimination (DICE) Preferentially Targets Cancer Stem Cells"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJoan Brugge (Harvard Medical School)
"Microenvironment Influences on Cell Survival in Cancer"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amRicky Johnstone (Peter MacCallum Cancer Centre)
"Advancing Cancer Treatment by Identifying and Targeting Critical Tumor Cell Survival Pathways"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amSilvia von Karstedt (University College London)
"KRAS-Driven Cancer Progression, Invasion and Metastasis Require Constitutive Endogenous TRAIL/TRAIL-R2 Signaling"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amGerry Melino (University of Rome)
"p53 Family Members in Stem Cell Maintenance and Cancer"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmAnthony Letai (Harvard Medical School)
"Precision Cancer Therapy with BH3 Profiling"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmCell Survival and Death in the Nervous System
Discussion Leader: Marie Hardwick (Johns Hopkins University School of Medicine)
7:30 pm - 7:50 pmPhil Barker (McGill University)
"Caspase Regulation in Axonal Degeneration and Synaptic Plasticity"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmCheng-Yu Lee (University of Michigan)
"Regulation of Neural Stem Cell Survival by Suppressing Necrosis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmBeth Stevens (Harvard Medical School)
"Glia, Immune Signaling and Synapse Clearance"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmMarc Freeman (HHMI/ University of Massachusetts Medical School)
"Molecular Pathways Promoting Axon Degeneration"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNon-Apoptotic Death Pathways
Discussion Leader: Guy Salvesen (Sanford-Burnham Medical Research Institute)
9:00 am - 9:20 amJunying Yuan (Harvard Medical School)
"Necroptosis in Human Diseases"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAndreas Linkermann (Christian Albrechts University)
"Regulated Necrosis in Acute Kidney Injury"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amWilliam Kasier (Emory University)
"Balancing RIP1, RIP3 and Caspase 8 Activities in Mammalian Development, Inflammation and Host Defense"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amZhirong Shen (National Institute of Biological Sciences)
"Novel Regulators of Programmed Necrosis"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amChristine Watson (University of Cambridge)
"Stat3 Coordinately Regulates and Exploits the Lysosomal System to Control Cell Death In Vivo"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmMichael Overholtzer (Memorial Sloan-Kettering Cancer Center)
"Death by Engulfment"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmProgrammed Necrosis and Inflammation
Discussion Leader: Junying Yuan (Harvard Medical School)
7:30 pm - 7:50 pmFrancis Chan (University of Massachusetts Medical School)
"Rising from the Grave: How RIP3 Promotes Inflammation"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJohn Silke (The Walter and Eliza Hall Institute of Medical Research)
"IAPs, Necroptosis, Auto-Inflammatory Diseases and Cancer: Exciting Therapeutic Opportunities"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmPete Gough (Glaxo Smith Kline)
"Therapeutic Targeting of RIP1 Kinase and Necroptosis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmDoug Green (St. Jude Children's Research Hospital)
"Lapping Up Death: How Non Canonical Autophagy Controls the Consequences of Cell Death?"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13CA186195-01 from the National Cancer Institute and the National Institute of Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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