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Conference Program
 
Cell Polarity Signaling
Cell Polarity
June 1-6, 2014
Bentley University
Waltham, MA
Chair:
Linda Van Aelst

Vice Chair:
Ian G. Macara

The 2014 Gordon Research Conference on Cell Polarity Signaling is a forum for discussion at the frontiers of cell polarity research. Cell polarity is a universal biological process that is fundamental to all aspects of cell division, growth, development, and tissue morphogenesis. It is also perturbed in numerous developmental diseases, in aging, and in cancer. Cell polarity underlies the generation of diverse cell types by asymmetrically dividing stem cells, and provides the organizational structures for tissue architecture. The recognition that cell polarity, and defects in polarization, are of such broad biological importance has led to an explosion of interest in this area. Therefore, the conference will cover a broad range of topics from cell polarity in development and cancer, to neural stem cell biology, inheritance of DNA and centrosomes, ciliogenesis and tissue morphogenesis, and will be an excellent opportunity to discuss the latest developments in the field. Key questions to be discussed at the Conference will include the following: How do signaling networks spatially organize the cell into polarized structures? How are these signals used to polarize membrane traffic? Are similar signals and mechanisms used in different contexts, such as in neurons versus epithelial cells, germ cells, or yeast? Does differential inheritance of DNA strands occur in stem cells, and how important is it? How do stem cells orient their mitotic spindles and segregate cell fate determinants? How common is asymmetric cell division in stem/progenitor cells? How important is EMT and/or loss of polarity during cancer initiation and progression? How and why are RNAs polarized within cells? Is differential segregation of damaged proteins between daughter cells important in aging? Participants will include established investigators from disciplines both within and outside the cell polarity field, and participation by young investigators will be strongly emphasized. Poster presentations will take place on each day of the meeting, allowing for widespread participation of conference attendees at all career stages. Speakers will also be selected from the abstracts submitted for poster presentations, to provide opportunities for presentation of the newest findings. We envision that this GRC will facilitate discussion of cutting edge research in cell polarity and will foster collaborations that will help drive the field forward.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff and Conference Chairs
Chair: Linda Van Aelst (Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA); Vice Chair: Ian Macara (Vanderbilt University, Nashville, TN, USA)
7:40 pm - 9:30 pmStem Cells
Discussion Leader: Margaret Fuller (Stanford University, CA, USA)
7:40 pm - 8:00 pmMargaret Fuller (Stanford University, CA, USA)
"Oriented Divisions and Asymmetric Outcomes: Self-Renewal vs. Differentiation in an Adult Stem Cell Lineage"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:50 pmFiona Watt (King's College, London, UK)
"Role of Cell Adhesion in Regulating Epidermal Stem Cell Fate"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmTsukasa Shibue (Whitehead Institute, Cambridge, MA, USA)
"The Polarity Regulating Protein Machinery and Entrance into Metastatic Dormancy"
9:25 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell Polarity in Development
Discussion Leader: Monica Gotta (University of Geneva, Switzerland)
9:00 am - 9:20 amMonica Gotta (University of Geneva, Switzerland)
"Cell Polarity and Cell Division Timing"
9:20 am - 9:30 amDiscussion
9:30 am - 9:55 amFumio Motegi (National University of Singapore, Singapore)
"Partitioning of Cell Cortex in C. elegans Zygotes"
9:55 am - 10:05 amDiscussion
10:05 am - 10:30 amBuzz Baum (LMCB, London, UK)
"Polarity and Cell Division"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:35 amDavid Bilder (University of California-Berkeley, Berkeley, CA, USA)
"Tumorous Effectors of Polarity Loss"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amShort Talk: Vladimir Gelfand (Northwestern University)
"Generation of Cell Polarity by Microtubule Sliding"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk: Shaul Yalovsky (Tel Aviv University)
"Integration of ROP and Ca2+ Signaling in Regulation of Cell Polarity and Pattern Formation in Plants"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk: Andrej Susor (IAPG , Czech Republic)
"Translational Asymmetry in the Mammalian Oocyte"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechanisms of Polarization
Discussion Leader: Ulrich Tepass (University of Toronto, Toronto, Canada)
7:30 pm - 7:50 pmUlrich Tepass (University of Toronto, Toronto, Canada)
"Linking Polarity Proteins and Vesicle Trafficking in Epithelial Cells"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmBarry Thompson (London Research Institute, London, UK)
"Epithelial Polarity in Drosophila"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmStephane Angers (University of Toronto, Toronto, Ontario)
"SAPCD2 Negatively Regulates the LGN-Galphai Complex During Spindle Positioning and Asymmetric Cell Division"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmOrion Weiner (UCSF, San Francisco, CA, USA)
"Using Optogenetics to Dissect the Spatial and Temporal Logic of Cell Signaling"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmRNA Localization, Differential Inheritance of DNA and Centrosomes, Aging
Discussion Leader: David Solecki (St. Jude Children's Research Hospital, Memphis, TN, USA)
9:00 am - 9:25 amDavid Solecki (St. Jude Children's Research Hospital, Memphis, TN, USA)
"An Interesting Parallel Between Epithelial and Neuronal Polarity: Zeb-1 Regulates Cerebellar Granule Neuron Differentiation and Migration"
9:25 am - 9:35 amDiscussion
9:35 am - 10:05 amFabrice Caudron (ETH, Zurich, Switzerland)
"Mechanisms of Asymmetric Inheritance of a Memory in Budding Yeast"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amSonghai Shi (MSKCC, New York, NY, USA)
"Par Proteins in Specifying the Polarity of Mammalian Neural Progenitors and Neurons"
10:45 am - 10:55 amDiscussion
10:55 am - 11:20 amCoffee Break
11:20 am - 11:50 amAnne Ephrussi (EMBL, Heidelberg, Germany)
"Localization Mechanisms of Oskar mRNA"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk: Judith Paridaen (Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG))
"Asymmetric Inheritance of Primary Ciliary Membrane in Dividing Embryonic Neural Progenitors"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmVesicle Traffic and Cell Polarization
Discussion Leader: Crislyn D'Souza-Schorey (University of Notre Dame, Notre Dame, IN, USA)
7:30 pm - 7:50 pmCrislyn D'Souza-Schorey (University of Notre Dame, Notre Dame, IN, USA)
"Signaling Endosomes and Epithelial Morphogenesis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmKeith Mostov (UCSF, San Francisco, CA, USA)
"Cracking the Molecular Code for Epithelial Tissue Organization and Polarity"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:00 pmEnrique Rodriguez-Boulan (Weill Cornell Medical College, New York, NY, USA)
"Polarity and Differentiation of Retinal Pigment Epithelium"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmShort Talk: Chris Janetopoulos (Vanderbilt University)
"Pulling a Reversal: How PI(4,5)P2 Levels Contribute to Cell Polarity in Migrating and Dividing Cells"
9:20 pm - 9:25 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPolarity, EMT and Cancer
Discussion Leader: Senthil Muthuswamy (University of Toronto, Toronto, Canada)
9:00 am - 9:25 amSenthil Muthuswamy (University of Toronto, Toronto, Canada)
"Cell Polarity and Cancer Progression"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amNasreen Akhtar (University of Sheffield, Sheffield, UK)
"An Integrin-ILK-Microtubule Network Orients Cell Polarity and Lumen Formation in Glandular Epithelium"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amShort Talk: Eliah Shamir (Johns Hopkins School of Medicine)
"Molecular and Cellular Regulators of Twist1-Induced Epithelial Dissemination"
10:20 am - 10:25 amDiscussion
10:25 am - 10:35 amShort Talk: Yongliang Huo (Vanderbilt University)
"The Par3-Like Polarity Protein, Par3L, is Essential for Mammary Stem Cell Maintenance"
10:35 am - 10:40 amDiscussion
10:40 am - 11:00 amCoffee Break
11:00 am - 12:00 pmKeynote Speaker: Valerie Weaver (UCSF, San Francisco, CA, USA)
"Microenvironment and Mechanical Force in Tissue Development and Tumor Progression"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmShort Talk: Francesco Baschieri (University of Kostanz)
"Cdc42 Spatial Activity is Regulated by GM130-RasGRF Interaction and Regulates Cellular Polarity and Tumorigenesis"
12:20 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmNeuronal Polarity
Discussion Leader: Mary E. Hatten (Rockefeller University, New York, NY, USA)
7:30 pm - 7:50 pmMary E. Hatten (Rockefeller University, New York, NY, USA)
"Polarity Pathways in CNS Neuronal Migration"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmSilvia Cappello (HZM, Munich, Germany)
"Emerging Roles of Neural Stem Cells in Neuronal Migration Disorders"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:00 pmFrank Polleux (Columbia University, New York, USA)
"Molecular Mechanisms Underlying the Polarization of Mammalian Neurons In Vivo"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmShort Talk: Jernej Murn (Boston Children's Hospital)
"Translational Control of a Neuronal Morphology Program by an RNA-Binding Zinc Finger Protein Unkempt"
9:20 pm - 9:25 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPlanar Cell Polarity and Tissue Morphogenesis
Discussion Leader: Yohanns Bellaiche (Institute Curie, Paris, France)
9:00 am - 9:20 amYohanns Bellaiche (Institute Curie, Paris, France)
"Planar Cell Polarity and Mechanical Forces in Epithelial Tissues"
9:20 am - 9:30 amDiscussion
9:30 am - 9:55 amJennifer Zallen (MSKCC, New York, NY, USA)
"Shaping the Embryo: Cellular Dynamics in Development"
9:55 am - 10:05 amDiscussion
10:05 am - 10:30 amAron Jaffe (Novartis, Cambridge, MA, USA)
"Regulation of Cell Fate Decisions in the Airway"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:35 amLila Solnica-Krezel (Washington University, St. Louis, MO, USA)
"Genetic Regulation of Cell Polarity During Zebrafish Gastrulation Movements"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amShort Talk: Basile Tarchini (Institute de Recherches Cliniques de Montreal)
"Regulation of Planar Asymmetry in Cochlear Hair Cells by the LGN/Gai/Insc Complex"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk: Huajing Wan (Sichuan University)
"Control of CDC42-Dependent Epithelial Cell Polarity by KLF5"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk: Bryan Phillips (University of Iowa)
"C. elegans Asymmetric Stem Cell Divisions Are Polarized by Wnt/Beta-Catenin Signaling"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPolarity and the Primary Cilium
Discussion Leader: Tim Stearns (Stanford University, Stanford, CA, USA)
7:30 pm - 7:55 pmTim Stearns (Stanford University, Stanford, CA, USA)
"A New Member of the Tubulin Superfamily Orients Cilia in Multiciliated Epithelial Cells"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmBenjamin Margolis (University of Michigan Medical School, Ann Arbor, MI, USA)
"Crumbs Polarity Proteins and Tissue Morphogenesis"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmShort Talk: Clemens Cabernard (University of Basel)
"Centrosome Asymmetry in Drosophila Neural Stem Cells"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:05 pmShort Talk: Louise Stephen (Roslin Institute, University of Edinburgh)
"TALPID3 Is a Centrosomal Protein Working in the Wnt/PCP Pathway"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmClosing Remarks / Overall Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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