Gordon Research Conferences
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Conference Program
 
Cell Polarity Signaling
Cell Polarity
June 1-6, 2014
Bentley University
Waltham, MA
Chair:
Linda Van Aelst

Vice Chair:
Ian G. Macara

Application Deadline
Applications for this meeting must be submitted by May 4, 2014. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

The 2014 Gordon Research Conference on Cell Polarity Signaling is a forum for discussion at the frontiers of cell polarity research. Cell polarity is a universal biological process that is fundamental to all aspects of cell division, growth, development, and tissue morphogenesis. It is also perturbed in numerous developmental diseases, in aging, and in cancer. Cell polarity underlies the generation of diverse cell types by asymmetrically dividing stem cells, and provides the organizational structures for tissue architecture. The recognition that cell polarity, and defects in polarization, are of such broad biological importance has led to an explosion of interest in this area. Therefore, the conference will cover a broad range of topics from cell polarity in development and cancer, to neural stem cell biology, inheritance of DNA and centrosomes, ciliogenesis and tissue morphogenesis, and will be an excellent opportunity to discuss the latest developments in the field. Key questions to be discussed at the Conference will include the following: How do signaling networks spatially organize the cell into polarized structures? How are these signals used to polarize membrane traffic? Are similar signals and mechanisms used in different contexts, such as in neurons versus epithelial cells, germ cells, or yeast? Does differential inheritance of DNA strands occur in stem cells, and how important is it? How do stem cells orient their mitotic spindles and segregate cell fate determinants? How common is asymmetric cell division in stem/progenitor cells? How important is EMT and/or loss of polarity during cancer initiation and progression? How and why are RNAs polarized within cells? Is differential segregation of damaged proteins between daughter cells important in aging? Participants will include established investigators from disciplines both within and outside the cell polarity field, and participation by young investigators will be strongly emphasized. Poster presentations will take place on each day of the meeting, allowing for widespread participation of conference attendees at all career stages. Speakers will also be selected from the abstracts submitted for poster presentations, to provide opportunities for presentation of the newest findings. We envision that this GRC will facilitate discussion of cutting edge research in cell polarity and will foster collaborations that will help drive the field forward.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmStem Cells
7:40 pm - 8:00 pmDiscussion Leader: Margaret Fuller (Stanford University, CA, USA)
"Introduction"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmJuergen Knoblich (IMBA, Vienna, Austria)
"Asymmetric Cell Division and Brain Development - From Drosophila to Humans"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmFiona Watt (King's College, London, UK)
"Role of Cell Adhesion in Regulating Epidermal Stem Cell Fate"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell Polarity in Development
9:00 am - 9:20 amDiscussion Leader: Monica Gotta (University of Geneva, Switzerland)
"Introduction"
9:20 am - 9:30 amDiscussion
9:30 am - 9:55 amFumio Motegi (National University of Singapore, Singapore)
"Partitioning of Cell Cortex in C. elegans Zygotes"
9:55 am - 10:05 amDiscussion
10:05 am - 10:30 amBuzz Baum (LMCB, London, UK)
"Polarity and Cell Division"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:35 amDavid Bilder (University of California-Berkeley, Berkeley, CA, USA)
"Tumorous Effectors of Polarity Loss"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amTBA (Short Talk)
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmTBA (Short Talk)
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmTBA (Short Talk)
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechanisms of Polarization
7:30 pm - 7:50 pmDiscussion Leader: Crislyn D'Souza-Schorey (University of Notre Dame, IN, USA)
"Introduction"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmBarry Thompson (London Research Institute, London, UK)
"Epithelial Polarity in Drosophila"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmAlan Hall (MSKCC, New York, USA)
"Rho GTPase Signaling Pathways in Epithelial Polarity"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmOrion Weiner (UCSF, San Francisco, CA, USA)
"Using Optogenetics to Dissect the Spatial and Temporal Logic of Cell Signaling"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRNA Localization, Differential Inheritance of DNA and Centrosomes, Aging
9:00 am - 9:20 amDiscussion Leader: Matthew Gibson (Stowers Institute, Kansas City, MO, USA)
"Introduction"
9:20 am - 9:30 amDiscussion
9:30 am - 9:55 amFabrice Caudron (ETH, Zurich, Switzerland)
"Mechanisms of Asymmetric Inheritance of a Memory in Budding Yeast"
9:55 am - 10:05 amDiscussion
10:05 am - 10:30 amSonghai Shi (MSKCC, New York, USA)
"Par Proteins in Specifying the Polarity of Mammalian Neural Progenitors and Neurons"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:35 amAnne Ephrussi (EMBL, Heidelberg, Germany)
"Localization Mechanisms of Oskar mRNA"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amTBA (Short Talk)
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmTBA (Short Talk)
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmTBA (Short Talk)
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNeuronal Polarity
7:30 pm - 7:50 pmDiscussion Leader: Mary E. Hatten (Rockefeller University, New York, USA)
"Introduction"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmSilvia Cappello (HZM, Munich, Germany)
"Emerging Roles of Neural Stem Cells in Neuronal Migration Disorders"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:00 pmFrank Polleux (Columbia University, New York, USA)
"Molecular Mechanisms Underlying the Polarization of Mammalian Neurons In Vivo"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmTBA (Short Talk)
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPolarity, EMT and Cancer
9:00 am - 9:20 amDiscussion Leader: Zena Werb (UCSF, San Francisco, CA, USA)
"Introduction"
9:20 am - 9:30 amDiscussion
9:30 am - 9:55 amSenthil Muthuswamy (University of Toronto, Toronto, Canada)
"Cell Polarity and Cancer Progression"
9:55 am - 10:05 amDiscussion
10:05 am - 10:30 amTsukasa Shibue (Whitehead Institute, Cambridge, MA, USA)
"The Polarity Regulating Protein Machinery and Entrance into Metastatic Dormancy"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:35 amKeynote Speaker: Valerie Weaver (UCSF, San Francisco, CA, USA)
"Microenvironment and Mechanical Force in Tissue Development and Tumor Progression"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amTBA (Short Talk)
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmTBA (Short Talk)
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmTBA (Short Talk)
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmVesicle Traffic and Cell Polarization
7:30 pm - 7:50 pmDiscussion Leader: Ulrich Tepass (University of Toronto, Toronto, Canada)
"Introduction"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmKeith Mostov (UCSF, San Francisco, CA, USA)
"Cracking the Molecular Code for Epithelial Tissue Organization and Polarity"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:00 pmEnrique Rodriguez-Boulan (Weill Cornell Medical College, New York, USA)
"Polarity and Differentiation of Retinal Pigment Epithelium"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmTBA (Short Talk)
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPlanar Cell Polarity and Tissue Morphogenesis
9:00 am - 9:20 amDiscussion Leader: Yohanns Bellaiche (Institute Curie, Paris, France)
"Introduction"
9:20 am - 9:30 amDiscussion
9:30 am - 9:55 amJennifer Zallen (MSKCC, New York, USA)
"Shaping the Embryo: Cellular Dynamics in Development"
9:55 am - 10:05 amDiscussion
10:05 am - 10:30 amAron Jaffe (Novartis, Cambridge, MA, USA)
"Regulation of Cell Fate Decisions in the Airway"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:35 amLila Solnica-Krezel (Washington University, St. Louis, MO, USA)
"Genetic Regulation of Cell Polarity During Zebrafish Gastrulation Movements"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amTBA (Short Talk)
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmTBA (Short Talk)
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmTBA (Short Talk)
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPolarity and the Primary Cilium
7:30 pm - 7:50 pmDiscussion Leader: Tim Stearns (Stanford, CA, USA)
"Introduction"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmBenjamin Margolis (University of Michigan Medical School, Ann Arbor, MI, USA)
"Crumbs Polarity Proteins and Tissue Morphogenesis"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:00 pmPeter Jackson (Genentech, South San Francisco, CA, USA)
"Organizing Trafficking and Signaling in Primary Cilia"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Last Updated: January 29, 2014
 
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