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Centromere Biology
Gordon Research Conference

The Genomics and Epigenomics of Centromere Function and Dysfunction

Dates

July 27 - August 1, 2014

Location

Bentley University
Waltham, MA

Organizers

Chair:
Rachel J. O'Neill

Vice Chair:
Beth A. Sullivan

Meeting Description

The centromere is the chromosomal locus at which the kinetochore is assembled and that drives chromosome movement during cell division. Abnormal centromere function is a hallmark of genome instability as observed in many birth defects, reproductive disorders, and diseases such as cancer. Defining how centromeres are organized and assembled is important for understanding principles of cell division, Mendelian inheritance and segregation distortion, species and chromosome evolution, human disease and for developing therapies and cures.

This inaugural, biennial GRC in Centromere Biology welcomes participants from across the globe, working in classical genetic model organisms and non-traditional/emerging model systems. The Centromere Biology GRC will include experts in cell visualization, structural biology, genetics and biochemistry, and chromatin biology, who all share a common interest in understanding centromere organization, assembly, and dynamics. The Centromere Biology GRC was conceived to include scientists whose research programs span many exciting and highly relevant areas in the field that are typically under-represented at other chromosome and centromere meetings. Such topics include, but are not limited to, genomics, comparative analyses, synthetic and mutant centromeres, and centromere behavior in disease states. The meeting is intended to create a welcoming, inclusive atmosphere for junior scientists and students to present their work and exchange ideas through poster sessions and informal discussions. Short talks in each session will include those chosen from the abstracts.

The 2014 conference will focus on the following topics: de novo centromere assembly, centromere structure and maintenance, and unusual centromeric states. Major emphasis will be given to emerging genomic maps, comparative and functional studies, centromeric RNAs, and epigenetic mechanisms of centromere function.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff and by Chair Rachel O'Neill (University of Connecticut) and Vice Chair Beth Sullivan (Duke University)
7:40 pm - 9:30 pmCentromere Genomics
Discussion Leader: Michael Freitag (Oregon State University)
7:40 pm - 8:00 pmJiming Jiang (University of Wisconsin)
"Rapid Turnovers of Megabase-Sized DNA Sequences in Plant Centromeres"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmKaren Hayden-Miga (University of California Santa Cruz)
"The Dark Side of the Genome: Sequence and Epigenomic Maps of Human Centromeric Regions"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmKaustuv Sanyal (Jawaharial Nehru Center for Advance Scientific Research, India)
"Genetic and Epigenetic Determinants of Centromere Identity in Candida"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCentromere Organization and Dynamics
Discussion Leader: Arshad Desai (University of California, San Diego)
9:00 am - 9:45 amKeynote Speaker: Steve Henikoff (Fred Hutchinson Cancer Research Center)
"Centromeric Chromatin: What's the Point?"
9:45 am - 9:55 amDiscussion
9:55 amCoffee Break
10:30 am - 10:50 amTatsuo Fukagawa (National Institute of Genetics, Japan)
"Centromere Specification and Assembly in Vertebrates"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amDan Foltz (University of Virginia)
"Regulating Centromeric Chromatin Assembly Through the Mis18 Heterotetramer"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amAna Stankovic (Instituto Gulbenkian de Ciência)
"Cell Cycle Control Mechanisms of Mammalian Centromere Assembly
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk: Mohan Marimuthu (UC Davis/HHMI-GBMF)
"Differential Specification of Parental Centromeres Leads to Genome Elimination in Early Arabidopsis Embryos"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCENP-A Nucleosomes and Centromere Structure
Discussion Leader: Gary Karpen (UC Berkley)
7:30 pm - 7:50 pmBen Black (University of Pennsylvania)
"Locking in the Chromatin Foundation of the Centromere"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmHiroshi Masumoto (Kazusa DNA Research Institute)
"The Centromeric Acetyl/methyl Histone Modification Balance Regulates CENP-A Assembly on Alphoid DNA"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmDon Cleveland (UCSD)
"Two Step Mechanism of Centromere Assembly"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk: Hisashi Tamaru (Gregor Mendel Institute, Austria)
"Active Mechanism of Centromere Disassembly"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmCoordination of Essential Centromeric Domains
Discussion Leader: Patrick Heun (Max Planck Institute, Germany)
9:00 am - 9:20 amKristin Scott (Duke University)
"Centromeric Barrier Disruption Leads to Mitotic Defects in Fission Yeast"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amGary Karpen (UC Berkley)
"Relating Centromere Protein Stability to Cancer"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amRobin Allshire (Wellcome Trust Center for Biology, University of Edinburgh)
"Establishing and Maintaining Specialized Chromatin States"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amBarbara Mellone (University of Connecticut)
"Mechanisms of CENP-A Deposition in Drosophila"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amArshad Desai (University of California San Diego)
"Control of Kinetochore-Microtubule Attachment Formation"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk: Jonathan Gent (University of Georgia)
"Precise and Stable Positioning of cenH3 Through Maize Lineages"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBuilding the Centromere/Kinetochore
Discussion Leader: Don Cleveland (University of California San Diego)
7:30 pm - 7:50 pmKerry Bloom (University of North Carolina)
"The Centromere Force Landscape"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMunira Basrai (NCI/National Institutes of Health)
"Post Translational Modifications of Centromeric Histone H3 Variant Cse4 Regulates Its Proteolysis for Genome Stability"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmIain Cheeseman (Massachusetts Institute of Technology)
"Regulating Centromere Inheritance"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk: Daniele Fachinetti (LICR - UCSD)
"A Non-Epigenetic Pathway for Centromere Function Dependent on Centromeric Protein CENP-B"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSynthetic, De Novo, and Ectopic Centromeres
Discussion Leader: Bill Earnshaw (Wellcome Trust Center for Cell Biology, University of Edinburgh)
9:00 am - 9:20 amKelly Dawe (University of Georgia)
"Molecular Basis of Neocentromere Activity and Meiotic Drive by Maize Abnormal Chromosome 10"
9:20 am - 9:30 amDiscussion
9:30 am - 9:40 amShort Talk: Laura Burrack (Grinnell University)
"Neocentromere Formation and Chromosome Segregation Efficiency in Candida albicans"
9:40 am - 9:50 amDiscussion
9:50 amCoffee Break
10:30 am - 10:50 amPaul Kalitsis (Murdoch Children's Research Institute)
"Investigation of Centromere Structural Abnormalities in Cancer Cell Lines"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amJim Birchler (University of Missouri)
"Centromere Epigenetics in Maize: On, Off, On Again and De Novo Activity"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amAaron Straight (Stanford University)
"Chromatin Requirements for Sustaining Complex Centromeres"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk: Bernard Lee (University of Hong Kong)
"Determining the Mechanisms of De Novo Centromere Formation in C. elegans Embryos"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmCentromeres, Transcription, and RNAs
Discussion Leader: Barbara Mellone (University of Connecticut)
7:30 pm - 7:50 pmMike Blower (Harvard University)
"Microtubule-Localized RNAs Activate Aurora-B Kinase Activity During Mitosis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmDelphine Quenet (NCI/NIH)
"Non-Coding RNAs Are Required for Centromere Integrity in Human Cells"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmSylvia Erhardt (ZMBH)
"Repetitive Centromeric Satellite III RNA Is Essential for Kinetochore Formation and Cell Division"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk: Rafael Contreras-Galindo (University of Michigan)
"Expansion of Endogenous Retroviruses Throughout the Centromeres of Modern Humans"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCentromeres: Comparative Studies and Evolution
Discussion Leader: Karen Hayden-Miga (University of California Santa Cruz)
9:00 am - 9:20 amMariano Rocchi (University of Bari, Italy)
"Evolutionary Neocentromeres"
9:20 am - 9:30 amDiscussion
9:30 am - 9:45 amShort Talk: Gernot Presting (University of Hawaii)
"The Role of Centromeric Retrotransposons in Centromere Function"
9:45 am - 9:55 amDiscussion
9:55 amCoffee Break
10:30 am - 10:50 amLucia Carbone (Oregon Health and Science University)
"How Did the 'LAVA' Flow Shape the Gibbon Genome?"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amMichael Freitag (Oregon State University)
"Centromeres of Filamentous Fungi"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amHarmit Malik (Fred Hutchinson Cancer Research Center)
"Genetic Innovations in Insect Centromeric Proteins"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk: Lukas Chmatal (University of Pennsylvania)
"Variation in Centromere Strength Biases Meiotic Chromosome Segregation to Drive Karyotype Evolution"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmVariant Centromeres
Discussion Leader: Ben Black (University of Pennsylvania)
7:30 pm - 7:50 pmPatrick Heun (Max Planck Institute, Germany)
"Dissecting the Functional Domains of dCENP-A"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmSusan Forsburg (University of Southern California)
"Structural Instability in the S. pombe Centromere: A Model for Robertsonian Translocation"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmClosing Speaker: Bill Earnshaw (Wellcome Trust Center for Cell Biology, University of Edinburgh)
"From Cold White Hands to Synthetic Chromosomes With and Without Heterochromatin"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:30 pmGeneral Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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