Gordon Research Conferences
PI_Conferences PI_Conferences_Current
Conference Program
 
Chemotactic Cytokines
Positioning Cells in Immunity and Disease
July 27 - August 1, 2014
Mount Snow Resort
West Dover, VT
Chair:
Andrew D. Luster

Vice Chair:
Tracy M. Handel

Related Meeting Information
The Chemotactic Cytokines Gordon Research Conference was held in conjunction with the Chemotactic Cytokines Gordon Research Seminar. Please refer to the Chemotactic Cytokines GRS web page for more information.

The 2014 Gordon Conference on Chemotactic Cytokines will present cutting-edge research on the basic biology of chemokines and their roles in normal physiology and disease. This Conference is the only major international conference focused solely on chemokines. The last 25 years witnessed the birth and growth of the chemokine field and its involvement in many areas of biology and medicine. While much has been learned about this fascinating family of proteins, many important questions remain, and a deeper understanding of the complexity of the chemokine system will allow translation of this knowledge into new therapies for disease. The 2014 GRC titled "Positioning Cells in Immunity and Disease" will feature a wide range of topics, such as how chemokine gradients are established and maintained in vivo, how chemokines regulate innate and adaptive immune responses, how chemokine function is regulated in vivo, how chemokines participate in the host response to infectious, inflammatory and malignant diseases, how chemokines regulate tumor cell growth and metastasis and how chemokines regulate central nervous system function and disease. Invited speakers represent a variety of scientific disciplines, including immunology, cell biology, imaging, tumor biology, neurobiology and structural biology. The Conference will bring together investigators at the forefront of their field, and will provide many opportunities for junior scientists and students to present their work in poster format and exchange ideas with scientific leaders. Short talks and flash talks will be selected from poster abstracts so participants are encouraged to submit their most exciting work. The GRC will be preceded by a 1.5 day Gordon Research Seminar, a satellite meeting for post-docs and students, titled "Frontiers in Chemokine Research". This meeting will allow young chemokine researchers to interact, exchange ideas, gain confidence as speakers and achieve higher personal visibility in an informal setting and with concerted mentoring by outstanding senior scientists.

For the first time in 10 years, our GRC will be returning to the United Sates. The Conference will be held at the Mount Snow Resort in scenic West Dover, Vermont from July 27 - August 1, 2014. Scientific sessions and accommodations will be at the Grand Summit Resort Hotel, a modern, air-conditioned hotel with access to hiking trails, golfing, mountain biking and kayaking. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented. The Chemotactic Cytokines GRCs have traditionally been oversubscribed, so, to ensure your participation, register early! We look forward to seeing you in the pristine Green Mountains of Vermont July 2014.

Andrew Luster and Tracy Handel


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session
7:40 pm - 8:00 pm Discussion Leader: Andrew D. Luster (Massachusetts General Hospital)
"Introduction"
8:00 pm - 9:00 pm Ron Germain (NIH)
"Dissecting Immune Cell Navigation Control Using Systems Methods in In Vivo Imaging"
9:00 pm - 9:20 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChemokine Gradient Sensing
9:00 am - 9:10 am Discussion Leader: Ronen Alon (Weizmann Institute of Science)
"Introduction"
9:10 am - 9:30 am Michael Sixt (Institute of Science and Technology Austria)
"Leukocyte Navigation in Physiological Chemokine Gradients"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 am Carol Parent (NCI, National Institutes of Health)
"Live Imaging of Signal Relay During Chemotaxis and Its Relevance to Inflammation and Cancer"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:30 am - 10:50 am Holger Knaut (New York University School of Medicine)
"Generation and Dynamics of Self-Generated SDF1 Signaling Gradient Across a Migrating Tissue"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Susan Schwab (New York University Langone Medical Center)
"Mapping Sphingosine 1-Phosphate Distribution in the Spleen"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Cornelia Halin Winter (ETH Zurich)
"CCL21 Guides Intralymphatic Dendritic Cell Migration in Downstream Direction of the Draining Lymph Node"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Jingsong Xu (University of Illinois)
"Neutrophil Chasing Bacteria Requires a Symmetry-Keeping Mechanism"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Hai Qi (Tsinghua University)
"Total Chemical Synthesis of a Two-Photon-Activable Chemokine and Photon-Guided T Cell Migration In Vivo"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:30 pm Poster Previews
Short Presentations Selected from Posters, Including Brief Discussion
  • Gertrud Hjortoe (University of Copenhagen)
    "Autocrine CCL19 Blocks Dendritic Cell Migration Against Weak Gradients of CCL21 and May Affect Lymph Node Homing"
  • Wei-Jen Tang (The University of Chicago)
    "Structures of Human CCL3, CCL4, and CCL18 Reveal the Molecular Basis of Oligomerization and Oligomerization-Mediated Functions"
  • Alison Gaylo (University of Rochester Medical Center)
    "The Inflamed Dermal Microenvironment Influences Requirements for CD4+ T Cell Interstitial Motility"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChemokines in Innate Immune Responses
7:30 pm - 7:45 pm Discussion Leader: Phil Murphy (NIAID, National Institutes of Health)
"Introduction"
7:45 pm - 8:05 pm G. Scott Worthen (University of Pennsylvania)
"Chemokines and Granulocyte Mobilization"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Wolfgang Weninger (Centenary Institute for Cancer Medicine and Cell Biology)
"Perivascular Macrophages as Regulators of Immune Cell Trafficking and Activation"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:05 pm Stefan Kaufmann (Max Planck Institute for Infection Biology)
"Control of Neutrophile Influx into the Lung During Tuberculosis"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Lai Guan Ng (Singapore Immunology Network)
"Dynamic Imaging of Neutrophil Responses During Immune Complex-Mediated Inflammation"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmChemokines in Adaptive Immunity
9:00 am - 9:10 am Discussion Leader: Michael Dee Gunn (Duke University)
"Introduction"
9:10 am - 9:30 am Frances Lund (University of Alabama at Birmingham)
"CXCL13 Tunes the Th2 Priming Capacity of DCs and Regulates Th2 Development in LNs"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 am Dan Littman (New York University Langone Medical Center)
"Signals Guiding Effector and Regulatory T Cells to the Intestinal Lamina Propia"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:30 am - 10:50 am Reinhold Forster (Hannover Medical School)
"A Differential Role for CXCL12, CXCL13, and IL17 in Development and Function of Tertiary Lymphoid Tissue"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Adrian Erlebacher (New York University Cancer Institute)
"Epigenetic Regulation of the Decidual Immune Response"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am John Harris (University of Massachusetts Medical School)
"Spatial, Temporal, and Cell-Specific Differences in the Expression of CXCL10 in the Skin Conduct T Cell Activity During the Progression of Vitiligo"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Albert Zlotnik (University of California Irvine)
"The CXCL17/CXCR8 Axis Is a Major Macrophage Recruitment Signal in Mucosal Tissues"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:15 pm General Discussion
12:15 pm - 12:30 pm Poster Previews
Short Presentations Selected from Posters, Including Brief Discussion
  • Graeme O'Boyle (University of Sunderland)
    "Graft-Versus-Host Disease: Anti-Inflmmatory Efficacy of a CXCR3 Agonist"
  • Ji Ming Wang (National Cancer Institute)
    "A Chemoattractant Receptor FPR2 Is Critical for Colon Epithelial Homeostasis, Inflammation and Tumorigenesis"
  • Amanda Nevins (Medical College of Wisconsin)
    "Effect of Structural Alterations on the Antimicrobial Activity of Chemokines"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmRegulation of Chemokine Function
7:30 pm - 7:40 pm Discussion Leader: Marcus Thelen (Institute for Research in Biomedicine)
"Introduction"
7:40 pm - 8:00 pm Gerry Graham (University of Glasgow)
"Modelling of the Lymphatic Vasculature by the Atypical Chemokine Receptor ACKR2"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:30 pm Antal Rot (University of Birmingham)
"Expression and Function of CCRL1 (ACKR4)"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:00 pm Tracy Handel (University of California, San Diego)
"Structure of a CXCR4: Chemokine Complex and Role of Receptor Dimers"
9:00 pm - 9:10 pm Discussion
9:10 pm - 9:20 pm Mette Rosenkilde (University of Copenhagen)
"Biased and G Protein-Independent Signaling in CCR5 and CCR7"
9:20 pm - 9:25 pm Discussion
9:25 pm - 9:30 pm Poster Preview
Short Presentation Selected from Posters, Including Brief Discussion
  • James Pease (Imperial College London)
    "Biased Agonism at Chemokine Receptors - Challenge or Opportunity for Drug Discovery?"
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChemokines in Memory Cell Function
Discussion Leader: Joshua Farber (NIAID, National Institutes of Health)
9:00 am - 9:20 am Joshua Farber (NIAID, National Institutes of Health)
"Regulation of the Differentiation of Human Memory T Cell Subsets"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Akiko Iwasaki (Yale University School of Medicine)
"Chemokine Control of Tissue Resident Memory T Cells"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Thomas Gebhardt (University of Melbourne)
"Skin Immune Surveillance by Tissue-Resident Memory T Cells"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
10:50 am - 11:10 am Ulrich von Andrian (Harvard Medical School)
"CX3CR1 Expression Distinguishes Three Distinct Subsets of Antigen-Experienced CD8 T Cells"
11:10 am - 11:20 am Discussion
11:20 am - 11:30 am Michelle McCully (Cardiff University School of Medicine)
"Vitamin D3 Synergizes with cAMP/PKA-Mediated Signaling to Drive Expression of the Skin Homing Receptor CCR8 in Human T Cells"
11:30 am - 11:35 am Discussion
11:35 am - 11:45 am Gerold Bongers (Icahn School of Medicine at Mount Sinai)
"The HCMV Encoded Chemokine Receptor US28 Modulates Autophagy and Promotes Pancreatitis in Mice"
11:45 am - 11:50 am Discussion
11:50 am - 12:00 pm Krishna Rajarathnam (University of Texas Medical Branch)
"Molecular Bases of How CXCL1-Glycosaminoglycan Interactions Orchestrate In Vivo Neutrophil Trafficking"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:30 pm Poster Previews
Short Presentations Selected from Posters, Including Brief Discussion
  • Gudrun Debes (University of Pennsylvania)
    "T Cell Egress from the Skin via the Afferent Lymph Determines the Course of Local Tissue Inflammation"
  • Aleksandra Ozga (Theodor Kocher Institute, University of Bern)
    "Dynamic Control of T Cell Activation by Peptide Affinity"
  • Richard Gomer (Texas A&M University)
    "The Human Protein DPPIV Is a Neutrophil Chemorepellent"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmChemokines in Inflammatory Diseases in the Clinic
7:30 pm - 7:40 pm Discussion Leader: Amanda Proudfoot (Novimmune)
"Introduction"
7:40 pm - 8:00 pm Ziad Mallat (Addenbrooke's Hospital)
"B Cell Control of Monocyte Mobilization to the Ischemic Myocardium"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:30 pm Jose-Carlos Gutierrez-Ramos (Pfizer)
"Therapeutic Control of Diabetic Nephropathy Through CCR2 Inhibition"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:00 pm Tom Schall (ChemoCentryx)
"Lessons from the Clinic: CCR9 and Other Chemokine Receptor Antagonists"
9:00 pm - 9:10 pm Discussion
9:10 pm - 9:20 pm Yun Sok Lee (University of California San Diego)
"A Novel Pathway for Regulation of Insulin Secretion by Fractalkine and CX3CR1 System"
9:20 pm - 9:25 pm Discussion
9:25 pm - 9:30 pm Poster Preview
Short Presentation Selected from Posters, Including Brief Discussion
  • Wanming Zhao (Mount Sinai School of Medicine)
    "CX3CR1 Deficiency Delayed Acute Skeletal Muscle Injury Repair by Impairing Macrophage Functions"
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChemokines in Cancer
9:00 am - 9:10 am Discussion Leader: Ann Richmond (Vanderbilt University School of Medicine)
"Introduction"
9:10 am - 9:30 am Sharon Evans (Roswell Park Cancer Institute)
"Chemokine Landscape Dictating Tumor Immunity: A Tale of Two Niches"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 am Mihaela Skobe (Mount Sinai Hospital)
"Role of Chemokines in Lymphatic Metastasis"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:30 am - 10:50 am Naofumi Mukaida (Kanazawa University)
"Crucial Roles of CCL3 in Leukemogenesis and Hematopoiesis"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Bodduluri Haribabu (University of Louisville)
"Chemoattractant Regulated Leukocyte Networks in Tumors"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Matthew Albert (Institut Pasteur)
"Dipeptidylpeptidase 4 Diminishes Chemokine-Mediated Leucocyte Trafficking and Limits Naturally Occurring Tumor Immunity"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Raffaella Bonecchi (Humanitas Clinical and Research Center)
"ERK-Dependent Downregulation of the Atypical Chemokine Receptor D6 Drives Tumor Aggressiveness in Kaposi's Sarcoma"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Robert Loewe (Medical University of Vienna)
"Identification of a Chemokine Profile Associated to Melanoma Progression"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:30 pm Poster Previews
Short Presentations Selected from Posters, Including Brief Discussion
  • Amnon Peled (Hadassah Hebrew University Hospital)
    "The CXCR4 Antagonist BL-8040 Synergizes with the FLT3 Inhibitor AC220 to Induce Apoptosis and Reduce Minimal Residual Disease of AML Cells In Vivo"
  • Martine Smit (VU University Amsterdam)
    "Targeting the Chemokine Receptor System Using Llama-Derived Antibodies (Nanobodies)"
  • Laetitia Comps-Agrar (Genentech)
    "CXCL17 Promotes Angiogionesis In Vitro Through Release of PDGF-BB by Monocytes"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChemokines in CNS Function and Disease
7:30 pm - 7:40 pm Discussion Leader: Sergio Lira (Mount Sinai Hospital)
"Introduction"
7:40 pm - 8:00 pm Richard Ransohoff (Cleveland Clinic)
"CXCR2: Surprises from a Conditional Knock-Out"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:30 pm Robyn Klein (Washington University)
"Control of T Cell Entry at CNS Endothelial Barriers During Neuroinflammation"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:00 pm Marie-Eve Tremblay (Laval University)
"Microglial Chemokine Receptors and Synaptic Refinement"
9:00 pm - 9:10 pm Discussion
9:10 pm - 9:20 pm Nathan Karin (Technioin, Rappaport Faculty of Medicine)
"The Role of Chemokines in Directing the Polarization and Biological Function of Regulatory T Cells"
9:20 pm - 9:25 pm Discussion
9:25 pm - 9:30 pm Poster Preview
Short Presentation Selected from Posters, Including Brief Discussion
  • Yongting Wang (Shanghai Jiao Tong University)
    "Post-Acute CXCL12 Gene Therapy Protects Against Cerebral White Matter Injury in Ischemic Mice by Promoting Oligodendrocyte Progenitor Cell Proliferation, Migration and Remyelination"
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI112004-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Last Updated: August 12, 2014
 
© 2014 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter