Gordon Research Conferences
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Conference Program
 
Chromatin Structure & Function
Regulation of Chromatin Assembly and Genome Functions
June 8-13, 2014
Bentley University
Waltham, MA
Chair:
Shiv Grewal

Vice Chair:
Wendy Bickmore

The 2014 Gordon Conference on Chromatin Structure and Function will present cutting-edge research on dynamic control of the genome and its impact on various nuclear processes. The conference will highlight how variation in chromatin structure, ranging from the level of the nucleosome "building block" up to the level of defined spatial domains of chromosomes in the nucleus is achieved. The talks will cover a wide range of topics, including nucleosome structure and remodeling, covalent modification of histones, histone exchange and histone variants. Also covered will be RNA-based chromatin modifications, formation of higher order structures, long-range chromatin interactions, mitotic and meiotic mechanisms, chromatin changes during replication and repair, and DNA methylation and epigenetic genome control. Research presented by the speakers will feature a broad variety of approaches including genetics, structural biology, biochemistry, molecular biology, cell biology and bioinformatics. This conference has a long history of attracting the top researchers in the chromatin structure and function field, which is important for fostering interactions that yield new collaborations and to integrate new members into the field. The 2014 Gordon Conference will continue the trend of representing the wide variety of approaches used to study chromatin. Space will be reserved for young scientists, and all applicants will have the opportunity to present a poster on their work. Many platform presentation topics will be selected from the submitted abstracts to ensure inclusion of the latest developments during the formal sessions. Sufficient discussion time will be scheduled into every session to promote lively exchanges of ideas and interpretations. The conference schedule allows ample time in the afternoons and after the evening sessions for the informal interactions that have always played a key role at this conference.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmNucleosomes and Chromatin Dynamics
Discussion Leaders: Geeta Narlikar (University of California San Francisco) and Bob Kingston (Massachusetts General Hospital/Harvard Medical School)
7:40 pm - 8:00 pmCarl Wu (HHMI Janelia Farm Research Campus/National Cancer Institute)
"Mechanism of Histone H2A.Z Replacement by the ATP-Dependent SWR1 Chromatin Remodeling Complex"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmSteve Henikoff (HHMI / Fred Hutchinson Cancer Research Center)
"Modulating the Nucleosome Barrier to Transcription"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmDinshaw Patel (Memorial Sloan Kettering Cancer Center)
"Structural Biology of Histone Chaperones"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmKarolin Luger (HHMI / Colorado State University)
"Structure and Dynamics of Chromatin"
9:25 pm - 9:30 pmDiscussion
9:30 pmWelcome Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromatin Remodeling and Higher-Order Chromatin
Discussion Leaders: Anja Groth (University of Copenhagen) and Carl Wu (HHMI Janelia Farm Research Campus/National Cancer Institute)
9:00 am - 9:20 amGenevieve Almouzni (Institut Curie)
"Mechanisms of Chromatin Assembly"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amCraig Peterson (University of Massachusetts Medical School)
"Chromatin Dynamics: Putting Histones in Their Place"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amFrank Pugh (The Pennsylvania State University)
"Sub-Nucleosome Organization Across the Yeast Genome"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
10:50 am - 11:10 amGeeta Narlikar (University of California San Francisco)
"Mechanisms of ATP-Dependent Chromatin Remodeling"
11:10 am - 11:20 amDiscussion
11:20 am - 11:35 amBryan Harada (Harvard University)
"A Histone H4 Tail-Mediated Mechanism for the Allosteric Regulation of ACF by Linker DNA"
11:35 am - 11:40 amDiscussion
11:40 am - 11:55 amBlaine Bartholomew (MD Anderson Cancer Center)
"Regulation of ATP-Dependent Chromatin Remodelers"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:25 pmYawen Bai (National Cancer Institute)
"Structures of Chromatosomes and Their Implications for the Folding of 30nm Chromatin Fibers"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChromatin Modifications
Discussion Leaders: Barbara Meyer (HHMI/University of California Berkeley) and Steve Henikoff (HHMI/Fred Hutchinson Cancer Research Center)
7:30 pm - 7:50 pmDavid Allis (Rockefeller University)
"Histone Modifications and Epigenetic Genome Regulation"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJerry Workman (Stowers Institute for Medical Research)
"Histone Modification and Exchange During Sense and Antisense Transcription"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmAli Shilatifard (Stowers Institute for Medical Research)
"Chromatin Modifications in Development and Disease Pathogenesis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmSteve Buratowski (Harvard Medical School)
"Shaping the Eukaryotic Transcriptome with Chromatin and Non-Coding RNA"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmChromatin-Mediated Regulation of the Genome
Discussion Leaders: Genevieve Almouzni (Institut Curie) and Ali Shilatifard (Stowers Institute for Medical Research)
9:00 am - 9:20 amBob Kingston (Massachusetts General Hospital)
"Long Non-Coding RNAs and Polycomb-Group Complexes in Developmental Regulation"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amDanny Reinberg (HHMI/NYU School of Medicine)
"Polycomb, Polycomb, Polycomb"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amBing Ren (Ludwig Institute for Cancer Research/University of California, San Diego)
"Global Reconfiguration of Chromatin Organization During Differentiation of Human ES Cells"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
10:50 am - 11:10 amShelley Berger (Perelman School of Medicine at the University of Pennsylvania)
"Epigenetic Regulation of Senescence and Aging"
11:10 am - 11:20 amDiscussion
11:20 am - 11:40 amJurg Muller (Max-Planck Institute of Biochemistry)
"The Function of Histone H2A Monoubiquitination"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmAnwesha Dey (Genentech)
"BAP1: An Emerging Player in Epigenetics and Cancer"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmTakeshi Mizuguchi (National Institutes of Health)
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSpecialized Chromatin Domains
Discussion Leaders: Susan Gasser (Friedrich Miescher Institute) and Craig Peterson (University of Massachusetts Medical School)
7:30 pm - 7:50 pmBarbara Meyer (HHMI/University of California Berkeley)
"Roles of Chromosome Structure and Chromatin Modification in C. elegans Dosage Compensation"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJulie Cooper (National Cancer Institute)
"Telomeric Chromatin Regulates Assembly of Meiotic Centromeric Chromatin"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmRobin Allshire (Wellcome Trust Centre for Cell Biology/University of Edinburgh)
"Establishment and Maintenance of Specialized Chromatin States"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmPeter Becker (Ludwig-Maximilians-Universität)
"Targeting the X for Chromosome-Wide Regulation in Drosophila"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHeterochromatin and RNA-Mediated Shaping of Chromatin
Discussion Leaders: Julie Cooper (National Cancer Institute) and Steve Jacobsen (HHMI/University of California Los Angeles)
9:00 am - 9:20 amRamin Shiekhattar (University of Miami)
"Long Non-Coding RNAs with Enhancer-Like Functions"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJeanie Lee (HHMI/Massachusetts General Hospital/Harvard Medical School)
"Epigenetic Regulation by Long Noncoding RNA"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amJulius Brennecke (IMBA - Institute of Molecular Biotechnology)
"The Roles of Chromatin in the Drosophila piRNA Pathway"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
10:45 am - 11:05 amYasushi Hiraoka (Osaka University)
"Nuclear Membranes and Heterochromatin in S. pombe"
11:05 am - 11:10 amDiscussion
11:10 am - 11:25 amRichard Festenstein (Imperial College)
"Breaking the Silencing in Friedreich's Ataxia: A Prototypic 'Position-Effect' Disease?"
11:25 am - 11:30 amDiscussion
11:30 am - 11:45 amDelphine Quenet (National Institutes of Health)
"Centromeric Long Non-Coding RNAs Are Required for CENP-A Recruitment to the Human Centromere"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmDavid Tremethick (Australian National University)
"Tissue Specific Histone Variant Exchange During Transcriptional Activation and Its Link With Pre-mRNA Splicing"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmNelson Lau (Brandeis University)
"Transposable Element Dynamics and PIWI Regulation Impacts LncRNA and Gene Expression Diversity in Drosophila Ovarian Cell Cultures"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmDNA Methylation, Chromatin and Development
Discussion Leaders: Jeanie Lee (HHMI/Massachusetts General Hospital) and Ramin Shiekhattar (University of Miami)
7:30 pm - 7:50 pmSteve Jacobsen (HHMI/University of California Los Angeles)
"Mechanisms of Epigenetic Inheritance"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmEric Selker (University of Oregon)
"Structure, Function and Control of Heterochromatin in Neurospora"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmKristian Helin (University of Copenhagen)
"Role of Polycomb Group Proteins in Transcriptional Regulation, Stem Cells and Cancer"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmKen Zaret (Perelman School of Medicine, University of Pennsylvania)
"Initiation of Cellular Programming and Reprogramming"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromatin Changes During DNA Replication and Repair
Discussion Leaders: Karolin Luger (HHMI / Colorado State University) and TBA
9:00 am - 9:20 amAnja Groth (University of Copenhagen)
"Chromatin Replication and Epigenome Maintenance"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amIestyn Whitehouse (Memorial Sloan Kettering Cancer Center)
"Replicating Chromatin: A View from the Lagging Strand"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amScott Keeney (HHMI/Memorial Sloan Kettering)
"Chromatin Structure Shapes the Landscape of Meiotic Recombination Initiation"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
10:50 am - 11:10 amZhiguo Zhang (Mayo Clinic)
"Checkpoint-Dependent PCNA Unloading from Lagging Strands of Stalled DNA Replication Forks Maintains Genome Stability"
11:10 am - 11:20 amDiscussion
11:20 am - 11:40 amToshi Tsukiyama (Fred Hutchinson Cancer Research Center)
"The Impact of RNAi on Non-Coding RNA Transcriptome"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmKyle Miller (University of Texas at Austin)
"Bromodomain Proteins: Linking Chromatin to the DNA Damage Response"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmHugh Cam (Boston College)
"Transcriptome Control and Genome Organization by a Highly Conserved Histone Methyltransferase"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChromosome Architecture
Discussion Leaders: Wendy Bickmore (MRC Human Genetics Unit/University of Edinburgh) and Toshi Tsukiyama (Fred Hutchinson Cancer Research Center)
7:30 pm - 7:50 pmNick Gilbert (Institute of Genetics and Molecular Medicine)
"Organization and Function of Supercoiling Domains in the Human Genome"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmBas van Steensel (Netherlands Cancer Institute)
"Architecture and Dynamics of Genome - Nuclear Lamina Interactions"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmVictor Corces (Emory University)
"Stress-Induced Re-Organization of 3D Chromatin Architecture"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmSusan Gasser (Friedrich Miescher Institute)
"The Sequestration of Heterochromatin: How and Why"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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