Gordon Research Conferences
PI_Conferences PI_Conferences_Past
Conference Program
 
Drug Metabolism
Integrating Drug Metabolism Sciences: From Enzymology to Systems Biology
July 6-11, 2014
Holderness School
Holderness, NH

The Drug Metabolism Gordon Research Conference (GRC) provides an intimate forum for the discussion of the diverse topics of this field. This year’s meeting is focused on integrating diverse scientific principles to predict human drug disposition. Essentially all of what we do in Drug Metabolism and Pharmacokinetics (DMPK) is geared towards predicting what will happen to a drug after it is given to a human. Although much has been gained from studying the intricate details of an enzyme, transporter, or pathway, it seems there are fewer incremental gains when studying single systems. It appears to be increasingly important to consider the interactions between these enzymes, transporters, and pathways in order to accurately predict drug disposition in humans. Further, an integrated approach can provide additional insights into the cellular and whole-body organization of the drug metabolism and transporter systems. For the 2014 Drug Metabolism GRC, each session is designed to broadly cover a topic and focus on the integration of the scientific principles to predict human drug disposition. The topics in the program include: transporters, oxidative drug metabolism, liver cell biology and microphysiology, new technologies, systems biology, and biologics.

The meeting provides an ideal opportunity for young researchers to expand their scientific horizons, and graduate students and postdocs are encouraged to apply. Prior to the meeting, six of the posters submitted by graduate students and postdocs are selected for platform presentations during Wednesday evening session. In addition to the Wednesday evening session, there is also a formal discussion on career development for these scientists.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmDrug Metabolism: Integrating Concepts from Enzymology to Systems Biology
7:40 pm - 7:50 pmDiscussion Leader: Ken Korzekwa (Temple University)
"Introductory Remarks"
7:50 pm - 9:00 pmKim Brouwer (University of North Carolina - Chapel Hill)
"Integrating Knowledge to Predict Drug Disposition and Toxicity: Is a Broader Perspective Needed?"
9:00 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmDrug Transporters: Approaches Toward an Increased Understanding of Their Roles in Drug Development
Discussion Leader: Xiaoyan Chu (Merck & Co.)
9:00 am - 9:30 amSwati Nagar (Temple University)
"Modeling Intracellular Drug Concentrations in the Presence of Transporters"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amHiroshi Kusuhara (University of Tokyo)
"IVIVE and Quantitative Prediction of Transporter-Mediated Drug Disposition and DDIs"
10:15 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:30 amMaciej J. Zamek-Gliszczynski (GSK)
"In Vivo Models to Bridge the Translational Gaps in Transporter-Mediated PK and Victim DDIs"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmSteven H. Wright (University of Arizona)
"The Intersection of Biology and Methodology: Impact on Understanding Drug-Drug Interaction with Organic Cation Transporters"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell Biology and Physiology of the Liver
Discussion Leader: Gus Rosania (University of Michigan)
7:30 pm - 8:00 pmPeter Swaan (University of Maryland)
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmSusanne Keiding (Aarhus University Hospital)
"Hepatobiliary Transport of Bile Acids In Vivo: PET Studies in Pigs and Humans"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmGus Rosania (University of Michigan)
"Probing the Role of Kupffer Cells in Hepatic Drug Disposition"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIn Vivo to Biomimetic Systems for the Study of the Reduction of Cytochrome P450: Simple and Complex Systems Compliment Each Other
Discussion Leader: Jeff Jones (Washington State University)
9:00 am - 9:30 amRoland Wolf (University of Dundee)
"Dissection of In Vivo Parameters Which Define Cytochrome P-450 Activity Using Transgenic Animals"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amEmily Scott (University of Kansas)
"Cytochrome P450 Conformations and Protein/Protein Interactions"
10:15 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:30 amDmitri Davydov (University of California San Diego)
"Untangling the Interplay Between the P450 Enzymes: New Approaches to Study P450-P450 Interactions"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmJames Brozik (Washington State University)
"Physical Properties and Equilibria of P450 and P450-Reductase in Planar Supported Lipid Bilayers"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNew Technologies
Discussion Leader: Aaron Moss (Seattle Genetics)
7:30 pm - 8:00 pmRick King (PharmaCadence)
"Mass Spectrometry"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmNorm Dovichi (University of Notre Dame)
"Capillary Electrophoresis"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmAaron Moss (Seattle Genetics)
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTranslational Modelling - From Protein to Whole Body Pharmacokinetics
Discussion Leader: Aleksandra Galetin (University of Manchester)
9:00 am - 9:30 amJörg König (Universität Erlangen-Nürnberg)
"Complex Cellular Models for the Assessment of Transporter-Enzyme Interplay"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amAleksandra Galetin (University of Manchester)
"Applications of In Vitro Models and Modelling and Simulation to Predict Subcellular Drug Distribution and Impact of Transporters on Intracellular Drug/Metabolite Concentration"
10:15 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:30 amJash Unadkat (University of Washington)
"Interindividual Variability in Transporter Protein Expression - Relevance of Such Data for Translational Modeling"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmKazuya Maeda (University of Tokyo, RIKEN)
"Integration of Novel Microdosing Studies with Mechanistic Modelling to Understand Impact of Transporter-Metabolism Interplay"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmGraduate Student and Post-Doc Presentations
Discussion Leader: Henry Strobel (University of Texas - Houston Medical School)
7:30 pm - 7:45 pmJi Won Park (LSU Health New Orleans)
"Different Microdomain Localization of Cytochrome P450 System Components in the Endoplasmic Reticulum and Identification of Microdomain Targeting Sequences"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmKanika Choughule (Washington State University)
"Identification of Aldehyde Oxidase 1 Structural Determinants Responsible for Differences in Methotrexate Activity Between Human and Rabbit Liver Cytosol"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmValerie Kramlinger (Vanderbilt University)
"Enzymes Involved in Mammalian Morphine Biosynthesis"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmIan Cook (Albert Einstein College of Medicine)
"The Transition from Half- to Full-Sites Activity Regulates SULT1A1 Specificity"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmObioma Chikwendu (Temple University)
"Models for Improved Prediction of Volume of Distribution"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmXian Pan (University of Illinois at Chicago)
"Altered Hepatic Retinoic Acid Content and Small Heterodimer Partner Expression Underlie CYP2D6 Induction During Pregnancy"
9:10 pm - 9:25 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Systems Biology of Drug Metabolism
Discussion Leader: Melissa Kemp (Georgia Tech & Emory University)
9:00 am - 9:30 amMatthew Blatnik (Pfizer)
"Phenotypic Precision Medicine"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amLang Li (Indiana University)
10:15 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:30 amXiaobo Zhou (Wake Forest)
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmMelissa Kemp (Georgia Tech & Emory University)
"Modeling Redox Networks Associated with Drug Metabolism"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDo Small Molecule ADME Studies Translate to Large Molecules?
Discussion Leader: Donald Tweedie (Boehringer-Ingelheim)
7:30 pm - 8:00 pmDerry Roopenian (The Jackson Laboratory)
"Exploiting FcRn to Help Antibodies to Get Around"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmDan Rock (Amgen)
"ADME Considerations for Heterogeneous Drug Products; The Challenge for Large Molecule Discovery"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmAndrew Boswell (Genentech)
"Distribution Kinetics of Biologic Drugs in Tissues and Their Sub-Compartments"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
© 2014 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter