Applications for this meeting must be submitted by June 8, 2014. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.
The Drug Metabolism Gordon Research Conference (GRC) provides an intimate forum for the discussion of the diverse topics of this field. This year’s meeting is focused on integrating diverse scientific principles to predict human drug disposition. Essentially all of what we do in Drug Metabolism and Pharmacokinetics (DMPK) is geared towards predicting what will happen to a drug after it is given to a human. Although much has been gained from studying the intricate details of an enzyme, transporter, or pathway, it seems there are fewer incremental gains when studying single systems. It appears to be increasingly important to consider the interactions between these enzymes, transporters, and pathways in order to accurately predict drug disposition in humans. Further, an integrated approach can provide additional insights into the cellular and whole-body organization of the drug metabolism and transporter systems. For the 2014 Drug Metabolism GRC, each session is designed to broadly cover a topic and focus on the integration of the scientific principles to predict human drug disposition. The topics in the program include: transporters, oxidative drug metabolism, liver cell biology and microphysiology, new technologies, systems biology, and biologics.
The meeting provides an ideal opportunity for young researchers to expand their scientific horizons, and graduate students and postdocs are encouraged to apply. Prior to the meeting, six of the posters submitted by graduate students and postdocs are selected for platform presentations during Wednesday evening session. In addition to the Wednesday evening session, there is also a formal discussion on career development for these scientists.
A list of preliminary session topics and speakers is displayed below (discussion leaders, where known, are noted in italics). The detailed program is currently being developed by the Conference Chair and will be available by March 6, 2014. Please check back for updates.
- Keynote Session: Integrating Knowledge to Predict Drug Disposition and Toxicity: Is a Broader Perspective Needed?
(Ken Korzekwa / Kim Brouwer)
- Drug Transporters: Approaches Toward an Increased Understanding of Their Roles in Drug Development
(Xiaoyan Chu / Swati Nagar / Hiroshi Kusuhara / Steven H Wright / Maciej Zamek-Gliszczynski)
- Cell Biology and Physiology of the Liver
(Gus Rosania / Susanne Keiding / Gus Rosania)
- In Vivo to Biomimetic Systems for the Study of Cytochrome P450: Simple and Complex Systems Compliment Each Other
(Jeff Jones / Jeff Jones / Roland Wolf / Emily Scott)
- New Technologies
(Aaron Moss / Richard Caprioli/ Norm Dovichi / Aaron Moss)
- Translational Modelling - From Protein to the Whole Body Pharmacokinetics
(Aleksandra Galetin / Aleksandra Galetin / Kazuya Maeda/ Jörg König / Jash Unadkat)
- Young Investigator Presentations
- Expanding Our View: Systems Biology of Drug Metabolism
(Melissa Kemp / Melissa Kemp / Lang Li / Ian Blair)
- Do Small Molecule ADME Studies Translate to Large Molecules?
(Donald Tweedie / Dan Rock / Andy Boswell)