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Conference Program
 
Mechanisms of Epilepsy & Neuronal Synchronization
Dissecting Epilepsy from Genes to Circuits
August 17-22, 2014
Mount Snow Resort
West Dover, VT

The 2014 Gordon Research Conference on Mechanisms of Epilepsy and Neuronal Synchronization will present state-of-the-art, unpublished findings related to basic mechanisms of epilepsy, current translational studies and synchronization of neuronal activity in cerebral networks. The meeting will bring together prominent investigators, graduate students, and postdoctoral fellows for 5 days in an intensive, interactive environment. The conference itself, the 4th in this highly successful series, is designed to stimulate extensive discussion, and is geared towards fostering interactions between students and established researchers, and to facilitate in-depth discussions and collaborations between investigators in the interest of furthering the field. Addressing how basic science findings can someday be translated into new therapies for the nearly 3 million Americans suffering with epilepsy is an important goal. A unique, intellectually challenging aspect of epilepsy research arises from the fact that it encompasses virtually all major levels of biological organization, from circuits and behavior to stem cells and neurodevelopment. Thus a major purpose of this Gordon Research Conference is to bring together geneticists, molecular biologists, developmental neuroscientists, neuroanatomists, electrophysiologists, clinician-scientists and computational neuroscientists working on basic mechanisms related either directly or indirectly to seizure generation to synthesize current advances and to set the stage for future discoveries.

This Gordon Research Conference will offer a collegial atmosphere with substantial time for interactions among scientists and trainees during the multiple Poster Sessions and informal gatherings in the afternoons and evenings. Trainees will also have an informational session on funding with an NINDS representative. Together, this setting aims to promote interactions among investigators in diverse areas of basic epilepsy research, highlight outstanding work related to the field, and stimulate new investigator interest in epilepsy research.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
5:00 pm - 6:00 pmWelcome Reception (Meet and Relax Before Dinner)
6:00 pmDinner
7:30 pm - 7:40 pmIntroductory Comments by GRC Site Staff
Welcome by: Jack Parent (Co-Chair), Scott Baraban (Co-Chair), Heinz Beck (Vice-Chair) and Steven Danzer (Vice Chair)
7:40 pm - 9:30 pmKeynote Session
Discussion Leaders: Jack Parent (Co-Chair) and Scott Baraban (Co-Chair)
7:50 pm - 8:50 pmDavid Prince (Stanford)
"Fifty Years of Epilepsy Research: How Does the Past Inform the Future"
8:50 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIon Channel Defects in Intractable Epilepsies
9:00 am - 9:10 amDiscussion Leader: Miriam Meisler (University of Michigan)
"Introduction"
9:10 am - 9:35 amJennifer Kearney (Northwestern University)
"Ion Channel Defects and Genetic Modifiers"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amWilliam Catterall (University of Washington)
"Selectively Impaired Excitability of Interneurons in a Mouse Model of Dravet Syndrome"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 10:50 amBrian Grone (University of California, San Francisco)
"Creating and Decoding Zebrafish Models of Genetic Epilepsies"
10:50 am - 10:55 amDiscussion
10:55 am - 11:20 amEdward Cooper (Baylor School of Medicine)
"The KCNQ2-Associated Epilepsy Spectrum: Bedside, Bench, and Back"
11:20 am - 11:30 amDiscussion
11:30 am - 11:55 amAlfonso Represa (Inmed, Inserm, Marseille)
"Neuropathological Basis of Epilepsy in Cortical Development Disorders: Insights from a Rat Model of Doublecortex"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmJacy Wagnon (University of Michigan)
"Mouse Model of a Human SCN8A Epilepsy Mutation"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBring in the Genes: Identification and Characterization of Epilepsy Mutations
7:30 pm - 7:40 pmDiscussion Leader: Annapurna Poduri (Boston Children's Hospital, Harvard)
"Introduction"
7:40 pm - 8:05 pmHeather Mefford (University of Washington)
"Targeted Approaches to Gene Discovery in Epilepsy and Related Disorders"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmDiane O'Dowd (University of California, Irvine)
"Modeling SCN1A-Related Seizure Disorders with Drosophila Knock-in Mutants"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmDavid Goldstein (Duke University)
"Genetic Causes of the Epilepsies: Rare Mutations and Common Pathways?"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmRebecca Boumil (The Jackson Laboratory)
"Pleiotropy in a Dynamin 1 Mouse Model of Epileptic Encephalopathy"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmDevelopment and Maldevelopment of the Central Nervous System
9:00 am - 9:10 amDiscussion Leader: Peter Crino (Temple University)
"Introduction"
9:10 am - 9:35 amJoseph LoTurco (University of Connecticut)
"Modeling Neuronal Developmental Disruptions by CRISPR-Mediated Genome Editing"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amXinyu Zhao (University of Wisconsin)
"Neural Stem Cells as Model for Studying Autism-Spectrum Disorders"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 10:50 amGary Brennan (University of California, Irvine)
"The Transcription Factor NRSF Contributes to Epileptogenesis by Selective Repression of a Subset of Target Genes"
10:50 am - 10:55 amDiscussion
10:55 am - 11:20 amAngelique Bordey (Yale University)
"Epilepsy in Focal Cortical Dysplasia"
11:20 am - 11:30 amDiscussion
11:30 am - 11:55 amArnold Kriegstein (UCSF)
"New Insights in Development of the Human Cerebral Cortex"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmMegan Wyeth (NIH)
"Neto1 Interactions with Kainate Receptors in Somatostatin Interneurons"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNeuronal Microcircuits in Normal and Epileptic Brain
7:30 pm - 7:40 pmDiscussion Leader: Mark Beenhaker (University of Virginia)
"Introduction"
7:40 pm - 8:05 pmJ. Troy Littleton (MIT)
"Glial Regulation of Neuronal Excitability"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmRoger Traub (IBM, Columbia University)
"Gap Junctions, High Frequency Oscillations, and Epilepsy?"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmRosa Cossart (Inserm, Marseille)
"How Inhibition Shapes Interictal Dynamics in Awake Epileptic Mice"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmOmar Ahmed (Harvard University)
"Inhibitory Neuronal Control of Human Epilepsy and the Role of Potassium Channels"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStem Cells to the Rescue
9:00 am - 9:10 amDiscussion Leader: Jennifer Hsieh (UT Southwestern)
"Introduction"
9:10 am - 9:35 amHongjun Song (Johns Hopkins University)
"Studying 15q11.2 Risk Factor by Patient-Derived iPSC and Mouse Models"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amLinda Overstreet-Wadiche (University of Alabama at Birmingham)
"Assessing the Function of Adult-Born Hippocampal Neurons"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 10:50 amCandi LaSarge (Cincinnati Children's Hospital)
"Evidence of Recurrent Network Activation in a PTEN Knockout Model of TLE"
10:50 am - 10:55 amDiscussion
10:55 am - 11:20 amLori Isom (University of Michigan)
"Role of Sodium Channel SCN1A in Dravet Syndrome and SUDEP"
11:20 am - 11:30 amDiscussion
11:30 am - 11:55 amVania Broccoli (San Raffaele Scientific Institute, Milan)
"Generation of Functional Forebrain iGABA Interneurons by Direct Genetic Conversion of Skin Fibroblasts"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmSudhir Sivakumaran (Tufts University)
"Erosion of Inhibition and the Development of Pharmacoresistant Status Epilepticus"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmCo-Morbidities of Network Dysfunction in Epilepsies and Related Disorders
7:30 pm - 7:40 pmDiscussion Leader: Amy Brooks-Kayal (University of Colorado, Denver)
"Introduction"
7:40 pm - 8:00 pmTimothy Miller (Washington University School of Medicine)
"Antisense Reduction of Tau as a Therapy for Seizures"
8:00 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmFrances Jensen (University of Pennsylvania)
"Altered Synaptic Plasticity Following Seizures Contributes to Cognitive Impairment and Epileptogenesis"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmChristophe Bernard (Inserm, Marseille)
"Double Hit Scenario Leading to Reversible Depression and Cognitive Deficits in Epilepsy"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:15 pmAnne Anderson (Baylor School of Medicine)
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel Therapeutic Strategies: From Gene Therapy to Drug Interventions
9:00 am - 9:10 amDiscussion Leader: Avtar Roopra (University of Wisconsin, Madison)
"Introduction"
9:10 am - 9:35 amAnne Schaefer (Mount Sinai School of Medicine)
"MicroRNA-128, a Novel Regulator of Neuronal Excitability and Motor Behavior in Mice"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amNicholas Poolos (University of Washington)
"c-Jun N-Terminal Kinase (JNK) as an Anti-Epileptic Target"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 10:50 amCaren Armstrong (University of California, Irvine)
"Optogenetics, Epilepsy, and the 'Dentate Gate'"
10:50 am - 10:55 amDiscussion
10:55 am - 11:20 amManisha Patel (University of Colorado, Denver)
"Targeting Seizure-Induced Oxidative Stress and Mitochondrial Dysfunction"
11:20 am - 11:30 amDiscussion
11:30 am - 11:55 amDavid Henshall (Royal College of Surgeons, Ireland)
"MicroRNA Regulation of Neuroinflammation and Epileptogenesis by Targeting Ion Channels"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmLaura Ewell (UCSD)
"Pathological High Frequency Oscillations Disrupt Hippocampal Spatial Coding"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBalancing Inhibition and Excitation: Implications for Epileptogenesis
7:30 pm - 7:40 pmDiscussion Leader: Jaideep Kapur (University of Virginia)
"Introduction"
7:40 pm - 8:05 pmCarolyn Houser (University of California, Los Angeles)
"Reorganized GABA Circuits in Epilepsy"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmVijayalakshmi Santhakumar (Rutgers University)
"Seizure-Induced Plasticity of Interneuronal Inhibition: Implications for Epileptogenesis"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmJohn White (University of Utah)
"GCaMPs in New Places -- Shining a Light on Reactive Glia"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS089138. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 
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