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Genomic Instability
Gordon Research Conference

Mechanisms That Cause DNA Damage and Related Diseases

Dates

July 6-11, 2014

Location

The Hong Kong University of Science and Technology
Hong Kong, China

Organizers

Chairs:
Bik K. Tye & Marco Foiani

Vice Chair:
Robert S. Weiss

Meeting Description

Cells are under constant threat of DNA damage from both internal and external sources, including reactive oxygen species (ROS) produced during normal cellular metabolism and environmental stresses like ultraviolet (UV) radiation from the sun. Failure to correct genome damage can have a variety of negative consequences, ranging from cell death to uncontrolled oncogenic proliferation. Consequently, eukaryotic cells employ a variety of evolutionarily-conserved mechanisms to protect genomic integrity. Inherited defects in these genome protection mechanisms are responsible for a variety of human diseases, such as Ataxia Telangiectasia, Fanconi Anemia, Bloom’s syndrome, Cockayne syndrome, Xeroderma pigmentosum, Nijmegen breakage syndrome, and Werner syndrome, which are associated with premature aging and dramatically increased risk for age-related diseases, such as cancer.

The 2014 Conference on Genomic Instability seeks to bring together a diverse group of participants to comprehensively address the primary topics in the field, including mechanisms of DNA damage signaling, replication fidelity, DNA recombination and chromosome segregation, as well as the physiological significance of these processes in aging and age-related diseases. The proposed meeting is distinct in providing broader coverage to the entire field of Genomic Instability and integrating basic and applied elements. Broader topics include programmed genome rearrangements during development of the immune system and of ciliates, as well as conflicts between the replication and transcription machineries. To date, most meetings on this topic focus either on the mechanisms that cause genetic instability or the diseases that stem from it. This conference covers both ends of this topic and aims to promote dialog that bridges the gulf between the causes and consequences of genomic instability.

Contributors

Meeting Program

SUNDAY
2:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 7:45 pmWelcoming Remarks by Chair Bik Tye (Hong Kong University of Science & Technology/Cornell University)
7:45 pm - 9:30 pmGenome Maintenance During Development
Discussion Leader: Laura Landweber (Princeton University)
7:45 pm - 8:05 pmLaura Landweber (Princeton University)
"Programmed Genomic Instability: The Ciliate Oxytricha as a Model"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmFred Alt (Harvard Medical School)
"Mechanisms of Long-Range and Orientation Specific Joining of DSBs in Developing and Activated Lymphocytes"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmKarl Herrup (Hong Kong University of Science & Technology)
"ATM and ATR in Neurons: DNA Damage and Beyond"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShan Zha (Columbia University)
"Distinct Modes of DNA-PKcs Phosphorylation Regulate End-Ligation and Hairpin Opening Respectively"
9:25 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDNA Damage Checkpoints
Discussion Leader: Karlene Cimprich (Stanford University School of Medicine)
9:00 am - 9:25 amKarlene Cimprich (Stanford University School of Medicine)
"Mechanisms for the Maintenance of Genome Stability"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amJunjie Chen (UT MD Anderson)
"Balance BRCA1 and 53BP1 at DSB Sites"
9:55 am - 10:05 amDiscussion
10:05 amGroup Photo / Coffee Break
10:30 am - 10:50 amMichael Huen (Hong Kong University)
"Ubiquitin Machineries in DNA Damage-Signaling and Repair"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amMarcus Smolka (Cornell University)
"Non-Canonical Modes of Mec1/ATR Signaling During DNA Replication"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amRobert Weiss (Cornell University)
"Novel DNA Repair Functions for the 9-1-1 Complex"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmChengmin Qian (Hong Kong University)
"Timeless Interacts with Parp1 to Facilitate Homologous Recombination Repair"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSamuel Sidi (Mount Sinai School of Medicine)
"A Caspase Activation Platform that Integrates DNA-Damage and Mitotic Checkpoint Signaling"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChromosome Segregation and Aneuploidy
Discussion Leader: Tatsuya Hirano (RIKEN, Japan)
7:30 pm - 7:55 pmTatsuya Hirano (RIKEN, Japan)
"Condensins and Chromosome Condensation"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:20 pmAaron Severson (Cleveland State University)
"Establishing and Releasing Cohesion During Meiosis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pm Andrew Wood (Edinburgh University)
"Tissue-Specific Vulnerability to Chromosome Segregation Stress Revealed by Condensin II-Deficient Mice"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmUttam Surana (Institute of Molecular and Cell Biology, Singapore)
"Dynamics of the Recovery from Spindle Assembly Checkpoint"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmRaymond Chan (University of Michigan)
"Homolog-Independent DNA Repair in Meiosis Affects Genomic Structural Variation"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmReplication Fork Conflict and Epigenetic Inheritance
Discussion Leader: Rob Martienssen (Cold Spring Harbor Laboratory)
9:00 am - 9:25 amRob Martienssen (Cold Spring Harbor Laboratory)
"Replication, Recombination and RNA Interference in Fission Yeast"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amJade Wang (University of Wisconsin, Madison)
"Transcription-Replication Conflict Impacts Bacterial Genome Organization"
9:55 am - 10:05 amDiscussion
10:05 am - 10:15 amWenyi Feng (SUNY Upstate Medical School)
"Dangerous Rendezvous: Chromosome Fragility Induced by Replication-Transcription Conflict"
10:15 am - 10:20 amDiscussion
10:20 amCoffee Break
10:45 am - 11:05 amAnindya Dutta (University of Virginia)
"What Happens to Transcription in the Vicinity of Stalled Replication Forks?"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amZhiguo Zhang (Mayo Clinic, Rochester, Minnesota)
"Dynamics of Replication Proteins at Leading and Lagging Strands of DNA Replication Forks"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amYuanliang Zhai (HKUST)
"The Role of Mcm10 in Resolving Replication Forks Stalled at Unfired Replication Origins"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmPiero Bianco (SUNY Buffalo)
"RecG Acts First to Regress Stalled Forks, Producing Substrates for RuvAB"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmJennifer Cobb (University of Calgary)
"The NuA4 Complex Cunctions on the Translesion Synthesis (TLS) Pathway During DNA Post Replication Repair"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmReplication Stress, Fidelity and Mutagenesis
Discussion Leader: Wei Yang (National Institutes of Health, USA)
7:30 pm - 7:50 pmWei Yang (National Institutes of Health)
"All Roads Lead to Translesion DNA Synthesis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmThomas Kunkel (NIEHS, NIH)
"Generating and Repairing Leading and Lagging Strand Replication Errors"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pm Roger Woodgate (NIH)
"Posttranslational Regulation of Human DNA Polymerase Iota"
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:05 pmDana Branzei (FIRC Institute of Molecular Oncology Foundation, Milan)
"Mechanisms and DNA Structures Mediating Replication of Damaged Chromosomes"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmGrant Brown (University of Toronto)
"Checkpoint Signaling at Stressed DNA Replication Forks"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDNA Recombination and Repair
Discussion Leader: Stephen West (London Research Institute)
9:00 am - 9:25 amStephen West (London Research Institute)
"Regulatory Control of Recombination and Repair"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amYijun Qi (Tsinghua University, China)
"Ago2 Facilitates Rad51 Recruitment and DSB Repair"
9:55 am - 10:05 amDiscussion
10:05 am - 10:15 amZhongsheng You (Washington University School of Medicine)
"Coordinated Regulation of Exo1 Controls the Extent of DNA End Resection"
10:15 am - 10:20 amDiscussion
10:20 amCoffee Break
10:45 am - 11:05 amJun Huang (Zhejiang University, China)
"Chromatin Remodeling and Homologous Recombination Repair"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amTasuku Honjo (Kyoto University)
"Acetylated Histone Reader Brd4 Functions as Repair Adaptor in Immunoglobulin Class Switch Recombination"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmAkira Shinohara (Osaka University)
"Control of Chromosome Dynamics and Recombination During Meiosis"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmMaria Moriel Carretero (Institute of Human Genetics, Montpellier, France)
"A Constitutive Role for Fanconi Anemia Proteins in Splicing"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmChromatin Dynamics and Genome Maintenance
Discussion Leader: Anja Groth (BRIC, University of Copenhagen)
7:30 pm - 7:50 pmAnja Groth (BRIC, University of Copenhagen)
"Chromatin Replication and Epigenome Maintenance"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJessica Downs (University of Sussex, UK)
"Chromatin Dynamics and Transcriptional Responses at Double-Strand Breaks"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pm Susan Gasser (Friedrich Miescher Institute for Biomed Research/University of Basel)
"Remodelers and Actin in DSB Position and Dynamics"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pmQing Li (Peking University)
"A Direct Role of Histone Chaperone FACT in Replication-Coupled Nucleosome Assembly"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmBenoit Le Tallec (Institut Curie, Paris, France)
"Mechanisms of Common Fragile Sites Instability"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenomic Instability-Induced Cancer and Aging
Discussion Leader: Takehiko Kobayashi (National Institute of Genetics, Japan)
9:00 am - 9:25 amTakehiko Kobayashi (National Institute of Genetics, Japan)
"rDNA Instability and Cellular Senescence"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amJan Hoeijmakers (Erasmus University, Rotterdam, Netherlands)
"The Impact of DNA Damage and Diet on Aging, Cancer and Longevity"
9:55 am - 10:05 amDiscussion
10:05 am - 10:15 amBrian Kirby (Cornell University)
"Single-Cell Copy Number Analysis of Prostate Cancer Cells Captured with GEDI Microdevices"
10:15 am - 10:20 amDiscussion
10:20 amCoffee Break
10:45 am - 11:05 amAlex Strunnikov (Guangzhou Institute of Biomedicine and Health, China)
"Chromosome Deregulation in Cancer Cells"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amHannah Xue (HKUST)
"Alu Transposable Elements Associated Instability in Caner Genome"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amWenfeng An (Washington State University)
"Mouse Model of LINE-1 Retrotransposition"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmJiri Bartek (Danish Cancer Society)
"Response to DNA Double Strand Breaks: Mechanisms and Relevance for Tumorigenesis and Cancer Treatment"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmDNA Repair Pathways as Therapeutic Targets
Discussion Leader: Thomas Helleday (Karolinska Institute, Sweden)
4:00 pm - 4:20 pmThomas Helleday (Karolinska Institute, Sweden)
"Targeting DNA Repair: From PARP to MTH1 Inhibitors"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 4:50 pmChris Williamson (ICR/UK)
"Directing the Clinical Use of ATR Inhibitors"
4:50 pm - 5:00 pmDiscussion
5:00 pm - 5:20 pmJos Jonkers (Netherlands Cancer Institute)
"Mechanisms of PARP Inhibitor Resistance in Mouse Models of BRCA-Deficient Breast Cancer"
5:20 pm - 5:30 pmDiscussion
5:30 pm - 5:50 pm Mark O'Connor (AstraZeneca, UK)
"Activity of the PARP Inhibitor Olaparib in ATM-Deficient Gastric Cancer: From Preclinical Models to the Clinic"
5:50 pm - 6:00 pmDiscussion
6:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Any opinions, findings, conclusions or recommendations expressed in this material/event (or by members of the project team) do not reflect the views of the Government of the Hong Kong Special Administrative Region, the Innovation and Technology Commission or the Vetting Committee of the General Support Programme of the Innovation and Technology Fund.
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