Gordon Research Conferences
PI_Conferences PI_Conferences_Current
Conference Program
 
Glycolipid & Sphingolipid Biology
Mechanisms Regulating Glycolipids and Sphingolipids in Physiology and Disease
January 12-17, 2014
Four Points Sheraton / Holiday Inn Express
Ventura, CA
Chair:
Walter M. Holleran

Vice Chair:
Howard Riezman

The 13th Gordon Research Conference on Glycolipid and Sphingolipid Biology is scheduled for January 12-17, 2014 at the Four Points Sheraton coastal resort in Ventura, California. This conference represents the primary international research forum on glyco/sphingolipid biology, and is focused on the biologic, metabolic, and disease-related aspects of these unique and important lipids. The organizers are assembling an excellent program, with an outstanding list of speakers and discussion leaders to address the diverse aspects of current glyco- and sphingolipid research. To further insure that recent novel perspectives are highlighted, a significant number of 'Late-Breaking Topics/Young Investigators' presentations are scheduled throughout this meeting, with the majority being selected from submitted abstracts.

Important areas of focus for this conference include: glycolipids and sphingolipids in mammalian biology, including autophagy and apoptosis, as well as emerging roles in infection, immunity, and inflammation; metabolism and function of these lipids in diseases such as cancer, neurodegeneration, metabolic syndrome, diabetes, and skin disorders; their roles in membrane dynamics; the regulation of key pathways of their metabolism, including emerging roles for microRNAs; novel imaging technologies and advanced glyco/sphingolipidomics. Importantly, the conference will have sessions dedicated to groundbreaking translational and therapeutic studies involving these lipids. In addition, the meeting will cover exciting new developments in the relationship between sphingolipids and glycolipids, lessons from model organisms and knockout models, as well as glyco/sphingolipids in nutrition.

This popular conference is generally fully- to over-subscribed, which makes it possible to accept an optimal mix of attendees from academics, industry and government, as well as a mix of young and established scientists. Submitted abstracts will be used not only to assist with consideration for conference participation, but also for the selection of presenters for the 'Late-Breaking Topics/Young Investigators' session. The organizers also are making a concerted effort to recruit speakers and encourage attendees from around the world, particularly from Asia, Eastern Europe, and Former Soviet Union countries. Ample discussion time will not only be scheduled after each talk, but also available during the poster sessions, as well as during leisurely afternoon walks on the local California beaches.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmGlyco/Sphingolipids in Biology of Infection, Inflammation & Host Defense
Discussion Leaders: Yusuf Hannun (Stony Brook Cancer Center, USA) and Yasuyuki Igarashi (Hokkaido University, Japan)
7:40 pm - 7:55 pmYusuf Hannun (Stony Brook Cancer Center, USA)
"Introduction: Key Issues & Questions"
7:55 pm - 8:20 pmJoanne Engel (University of California San Francisco, USA)
"Chlamydia Co-Opts Host Lipid Transport Systems to Establish an Onsite Sphingomyelin Synthesis Factory"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmAssaf Vardi (Weizmann Institute of Science, Israel)
"Chemical Arms Race at Sea: Rewiring Sphingolipid Metabolism by Marine Viruses Regulates the Fate of Algal Blooms in the Ocean"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmAl Merrill, Jr. (Georgia Institute of Technology, USA)
"Food for Thought: The Sphingo Snack Shack Circa 2014"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmYasuyuki Igarashi (Hokkaido University, Japan)
"Summary: Outstanding Questions"
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMembrane Dynamics and Lipid Trafficking
Discussion Leaders: Kentaroh Hanada (National Institute of Infectious Disease, Japan) and Toshiro Okazaki (Kanazawa Medical School, Japan)
9:00 am - 9:10 amKentaroh Hanada (National Institute of Infectious Disease, Japan)
"Introduction: Key Issues & Questions"
9:10 am - 9:30 amLudger Johannes (Curie Institute, France)
"Glycosphingolipids in Clathrin-Independent Endocytosis"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amKenichi Suzuki (Kyoto University, Japan)
"The Very First Steps for Raft Formation and Function, Revealed by Single-Molecule Imaging"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amLate-Breaking Topic: Anne Kenworthy (Vanderbilt University, USA)
"Microtubules, Dynein, and Dynactin Bend the Plasma Membrane During Clathrin-Independent Endocytosis of Glycolipid Binding Toxins"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 amAntonella DeMatteis (Telethon Institute of Genetics and Medicine, Italy)
"Vesicular and Non Vesicular Transport Feed Distinct Glycosylation Pathways in the Golgi Complex"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amKoichi Furukawa (Nagoya University, Japan)
"Spatio-Temporal Dynamics of the Interaction Between Glycosphingolipids and Membrane Molecules"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmLate-Breaking Topic: Liana Silva (University of Lisbon, Portugal)
"Ceramide-Platforms in the Endo/Lysosomal Pathway: A Novel Mechanism by Which Ceramide Activates Intracellular Targets"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmToshiro Okazaki (Kanazawa Medical School, Japan)
"Summary: Outstanding Questions"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I (Odd-numbered posters)
6:00 pmDinner
7:30 pm - 9:30 pmGlyco/Sphingolipids in Biology of Autophagy, Apoptosis and Immune Response
Discussion Leaders: Nygel Pyne (University of Strathclyde, Scotland) and Sarah Spiegel (Virginia Commonwealth University, USA)
7:30 pm - 7:40 pmNygel Pyne (University of Strathclyde, Scotland)
"Introduction: Key Issues & Questions"
7:40 pm - 8:00 pmHong-Gang Wang (Penn State College of Medicine, USA)
"Sphingolipids: Regulators of the Interplay Between mTOR and Autophagy"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmYoshikazu Uchida (University of California San Francisco, USA)
"Sphingolipid Metabolites Regulate Innate Immunity"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmLate-Breaking Topic: Antonella Rella (Stony Brook University, USA)
"Identification of a Novel Sterylglucosidase and Its Role as Essential Regulator of Cryptococcus neoformans Pathogenicity"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmLate-Breaking Topic: Tilla Worgall (Columbia University, USA)
"Sphingolipids and Susceptibility to Airway Hyperreactivity"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmSarah Spiegel (Virginia Commonwealth University, USA)
"Summary: Outstanding Questions & Discussion"
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMolecular Mechanisms & Regulation of Lipid Metabolism
Discussion Leaders: Tony Futerman (Weizman Institute of Science, Israel) and Yoshio Hirabayashi (Brain Science Institute Riken, Japan)
9:00 am - 9:10 amTony Futerman (Weizman Institute of Science, Israel)
"Introduction: Key Issues & Questions"
9:10 am - 9:40 amKeynote Speaker: Kasey Vickers (Vanderbilt University, USA)
"MicroRNAs: Intercellular Transport and Roles in Lipid Homeostasis and Cardiometabolic Disease"
9:40 am - 9:55 amDiscussion
9:55 am - 10:20 amRobbie Loewith (University of Geneva, Switzerland)
"The Intimate Relationship Between Sphingolipids and TORC2 in Yeast"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:25 amManuel Muñiz (University of Sevilla, Spain)
"Regulation and Trafficking of GPI-Anchored Proteins"
11:25 am - 11:35 amDiscussion
11:35 am - 11:50 amLate-Breaking Topic: Per Haberkant (European Molecular Biology Laboratory)
"Bifunctional Sphingosine for Cell-Based Mapping of Protein-Sphingolipid Interactions"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmLate-Breaking Topic: Wayne Lencer (Harvard Medical School, USA)
"Unsaturated Glycoceramides as Molecular Carriers for Mucosal Drug Delivery of GLP-1"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmYoshio Hirabayashi (Brain Science Institute Riken, Japan)
"Summary: Outstanding Questions"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II (Odd-numbered posters)
6:00 pmDinner
7:30 pm - 9:30 pmTranslational Studies and Therapeutics: Sphingosine-1-Phosphate
Discussion Leaders: Richard Kolesnick (Sloan-Kettering Cancer Center, USA) and Richard Proia (NIDDK, NIH, USA)
7:30 pm - 7:40 pmRichard Kolesnick (Sloan-Kettering Cancer Center, USA)
"Introduction: Key Issues & Questions"
7:40 pm - 8:00 pmAndreas Billich (Novartis, Switzerland)
"Second Generation S1P Modulators"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmRoger Sabbadini (Lpath Inc., USA)
"Therapeutic Potential of Antibodies to S1P and LPA"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmLate-Breaking Topic: Alison McCracken (University of California Irvine, USA)
"Characterization of an FTY720 Analog Lacking S1P1 and S1P3 Activity that Exhibits Enhanced Anti-Leukemic Activity Against BCR-ABL+ Leukemias"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmLate-Breaking Topic: Mari Kono (NIDDK/National Institutes of Health, USA)
"Mapping Sphingosine-1-Phosphate Receptor 1 Signaling In Vivo"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmRichard Proia (NIDDK, NIH, USA)
"Summary: Outstanding Questions & Discussion"
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSphingolipid Metabolism in Infection, Diabetes, Obesity and Cardiovascular Disease
Discussion Leaders: Johannes Aerts (Academic Medical Center Amsterdam, Netherlands) and Mark Kester (University of Virginia, USA)
9:00 am - 9:10 amJohannes Aerts (Academic Medical Center Amsterdam, Netherlands)
"Introduction: Key Issues & Questions"
9:10 am - 9:35 amScott Summers (Duke-NUS Medical School, Singapore)
"Ceramides and Metabolic Disease: A Survey of Therapeutic Targets"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amThorsten Hornemann (University of Zurich, Switzerland)
"Atypical Sphingolipids as Biomarkers and Therapeutic Targets in Cardio-Metabolic Diseases"
10:15 am - 10:30 amDiscussion
10:30 amCoffee Break
10:50 am - 11:15 amErich Gulbins (University Duisburg-Essen, FRG)
"Ceramide and Sphingosine in Bacterial Infections and Cystic Fibrosis"
11:15 am - 11:30 amDiscussion
11:30 am - 11:45 amLate-Breaking Topic: William Holland (University of Texas Southwestern, USA)
"Regulation of Hepatic Glucose and Lipid Metabolism via Ceramidase Action in the Adipocyte"
11:45 am - 11:55 amDiscussion
11:55 am - 12:10 pmLate-Breaking Topic: Ashley Cowart (Medical University of South Carolina, USA)
"The Distinct Features and Functions of Cardiac Lipid Metabolism in Diabetic Cardiomyopathy"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmMark Kester (University of Virginia, USA)
"Summary: Outstanding Questions"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III (Even-numbered posters)
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmAdvanced Sphingolipidomics, Imaging and Structural Characterization (In Honor of Prof. Charles C. Sweeley)
Discussion Leaders: Al Merrill (Georgia Institute of Technology, USA) and Alessandro Prinetti (University of Milan, Italy)
7:30 pm - 7:40 pmAl Merrill (Georgia Institute of Technology, USA)
"Introduction & Retrospective on Scientific Contributions of Charles C. Sweeley"
7:40 pm - 8:00 pmCameron Sullards (Georgia Institute of Technology, USA)
"Complex Glyco/Sphingolipidomics"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmMasaru Ishii (Osaka University, Japan)
"S1P-Mediated Control of Bone Cell Dynamics Visualized by Intra-Vital Microscopy"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmLate-Breaking Topic: Richard Drake (Medical University of South Carolina, USA)
"An On-Tissue Profiling Workflow for Ceramides Using High Resolution MALDI-Imaging Mass Spectrometry"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:15 pmLate-Breaking Topic: Xueli Guan (Swiss Tropical & Public Health Institute, SWI)
"Sphingolipidomics and Genomics of Medically Relevant Pathogens - A Novel Pathway and Biomarker Discovery Tool For Infectious Diseases"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmAlessandro Prinetti (University of Milan, Italy)
"Summary: Outstanding Questions & Discussion"
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLate-Breaking Topics and Young Investigators: Cancer, Cell Regulation, & Metabolism: (In Honor of Prof. Norman S. Radin)
Discussion Leaders: Lina Obeid (Stony Brook University, USA) and Besim Ogretmen (Medical University of South Carolina, USA)
9:00 am - 9:10 amJames Shayman (University of Michigan, USA)
"Retrospective on Scientific Contributions from Norman S. Radin"
9:10 am - 9:20 amLina Obeid (Stony Brook University, USA)
"Introduction: Key Issues & Questions"
9:20 am - 9:35 amLate-Breaking Topic: Stefka Spassieva (Medical University of South Carolina, USA)
"A Role of Deoxysphingolipids in Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients"
9:35 am - 9:45 amDiscussion
9:45 am - 10:00 amLate-Breaking Topic: Simone Filosto (University of California Davis, USA)
"Paradigm Shift for nSMase2-Derived Ceramide in the Lung: From Injury to Cancer and Fibrosis"
10:00 am - 10:10 amDiscussion
10:10 am - 10:25 amLate-Breaking Topic: Toshiyuki Yamaji (National Institute of Infectious Disease, Japan)
"TALEN-Mediated Disruption of Several Sphingolipid-Related Genes in a HeLa Cell Line"
10:25 am - 10:35 amDiscussion
10:35 amCoffee Break
11:00 am - 11:15 amLate-Breaking Topic: Jonathan Markham (University of Nebraska-Lincoln, USA)
"Role of Unsaturated VLCFA in Sphingolipids and Plant's Response to Low Temperature Stress"
11:15 am - 11:25 amDiscussion
11:25 am - 11:40 amLate-Breaking Topic: Akio Kihara (Hokkaido University, Japan)
"The Fatty Acid Elongase ELOVL1 and the P450 Family Member CYP4F22 are Involved in the Production of Epidermal Acylceramide"
11:40 am - 11:50 amDiscussion
11:50 am - 12:10 pmLate-Breaking Topic: Jin-Ichi Inokuchi (Tohoku Pharmaceutical University, Japan)
"GM3 and Diabetes"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmBesim Ogretmen (Medical University of South Carolina, USA)
"Summary: Outstanding Questions & Discussion"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session IV (Even-numbered posters)
6:00 pmDinner
7:30 pm - 9:30 pmGlycolipids and Sphingolipids in Neurologic Disorders
Discussion Leaders: Thierry Levade (INSERM & Center of Research on Cancer of Toulouse, France) and Ed Schuchman (Mt. Sinai School of Medicine, USA)
7:30 pm - 7:40 pmThierry Levade (INSERM & Center of Research on Cancer of Toulouse, France)
"Introduction: Key Issues"
7:40 pm - 8:00 pmJohannes Kornhuber (University of Erlangen-Nuremberg, FRG)
"Acid Sphingomeylinase-Ceramide Mediates Effects of Antidepressant Drugs"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmSilke Walter (Saarland University, FRG)
"The Role of Acid Sphingomyelinase in Multiple Sclerosis"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmLate-Breaking Topic: Einat Vitner (Weizmann Institute of Science, Israel)
"RIPK3 as a Novel Potential Therapeutic Target for Gaucher Disease"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:15 pmMarco Presta (University of Brescia, Italy)
"Inhibition of Angiogenesis by Beta-GalactoslCeramide Deficiency in Globoid Cell Leukodystrophy (Krabbe's Disease)"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmEd Schuchman (Mt. Sinai School of Medicine, USA)
"Summary: Outstanding Questions & Discussion"
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Last Updated: April 4, 2014
 
© 2014 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter