Gordon Research Conferences
Meeting Details

Angiotensin (GRS)
Gordon Research Seminar

New Developments in the RAS: From Bench to Bedside


March 1-2, 2014


Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy


Sean E. Thatcher

Associate Chair:
Candice M. Thomas

Meeting Description

The Gordon Research Seminar on Angiotensin is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting will be on therapies targeting the new components of the RAS; bridging the gap between basic research and clinical efficacy in pathological conditions, such as in diabetes and obesity, hypertension, aging, heart and renal failure, and auto-immune diseases.

Related Meeting

This GRS was held in conjunction with the "Angiotensin" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.


Meeting Program

1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmKeynote Session
Discussion Leader: Sean Thatcher (University of Kentucky)
3:15 pm - 3:45 pmDominik Mueller (Max-Delbruck-Centrum, Berlin, Germany)
"Unpredictable Results - The Big Chance in Science"
3:45 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pmThe RAS and Diabetes
Discussion Leaders: Rajesh Kumar and Candice Thomas (Texas A&M Health Science Center, Temple, TX)
5:30 pm - 5:50 pmCandice Thomas (Texas A&M Health Science Center)
"The Cardiac Renin Angiotensin System in Diabetes"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmKatrina Binger (Max-Delbrueck Center for Molecular Medicine, Berlin, Germany)
"(Pro)renin Receptor Conditional Knockout Causes Beta-Cell Loss and Hyperglycemia by Inducing Pathological Autophagy"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmRobin Shoemaker (Graduate Center for Nutritional Sciences, University of Kentucky)
"ACE2 Deficiency Augments the Development of Type 2 Diabetes in Obese Mice"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmJuliana Colucci (Universidade Federal de São Paulo, Sao Paulo, Brazil)
"Difference Between ACE/ACE2 Balance in Diabetic Mice Harboring One or Three Copies of Angiotensin Converting Enzyme Gene"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amNew Therapeutics for the RAS: Targeting the ACE2/Ang-(1-7)/MasR and AT2 Receptor Pathways
Discussion Leaders: Kathryn Sandberg (Georgetown University, Washington DC) and Jan Danser (Erasmus MC, Rotterdam, Netherlands)
9:00 am - 9:20 amRodrigo Fraga-Silva (Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland)
"ACE2 Activators for Cardiovascular Diseases"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amRobert Regenhardt (University of Florida, Gainesville, FL)
"Transcriptomic Modeling of the Cerebroprotective Effects of AT2R Agonist Compound 21 in Ischemic Stroke"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amEmma Jones (Monash University, Melbourne, Australia)
"Pharmacology of Novel AT2 Receptor Agonists"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amGerry Wagenaar (Leiden University Medical Center, Leiden, Netherlands)
"Intervening in AT2 Signalling Attenuates Hyperoxia-Induced Lung and Heart Injury in Newborn Rats"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmNew Developments and Signaling in the RAS
Discussion Leaders: Alan Daugherty (University of Kentucky, Lexington, KY) and Johannes Stegbauer (UKD, Dusseldorf, Germany)
1:30 pm - 1:50 pmEva Königshausen (UKD, Dusseldorf, Germany)
"Ang II Promotes Beta-Arrestin 2 Mediated Endocytosis in Podocytes"
1:50 pm - 2:00 pmDiscussion
2:00 pm - 2:20 pmQian Chen Yong (Texas A&M Health Science Center, Temple, TX)
"Hydrogen Sulfide Inhibits the Activation of the Renin-Angiotensin System in Diabetic Heart"
2:20 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13HL121852-01A1 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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