Gordon Research Conferences
Meeting Details

Cyclic Nucleotide Phosphodiesterases (GRS)
Gordon Research Seminar

Novel Paradigms in Cyclic Nucleotide Signaling


May 31 - June 1, 2014


Mount Holyoke College
South Hadley, MA


Lindsay Wilson

Associate Chair:
Nadiia Rozmaritsa

Meeting Description

The Gordon Research Seminar on Cyclic Nucleotide Phosphodiesterases is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to highlight new and innovative techniques and models that are advancing our understanding of PDEs and cyclic nucleotide signaling. These include, but are not limited to: novel biosensors, molecular modeling tools and unique in vivo and in vitro models that aid in investigating PDEs and their signaling partners. The meeting will also feature a mentorship session which will explore the challenges and changing landscape of research today, and the opportunities that exist to bridge academic and industry research.

Related Meeting

This GRS was held in conjunction with the "Cyclic Nucleotide Phosphodiesterases" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.


Meeting Program

1:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session
Discussion Leader: Nadiia Rozmaritsa (Oxford University)
3:45 pm - 4:15 pm Joe Beavo (University of Washington)
"How Do Phosphodiesterases Regulate Cyclic Nucleotide Function?"
4:15 pm - 4:30 pm Discussion
4:30 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmInnovative Techniques for the Study of PDEs
Discussion Leader: Wito Richter (UCSF)
7:30 pm - 7:50 pm Martin Schwarzel (Freie Universitat Berlin)
"Photoactivatable Adenylyl Cyclases"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Alessandra Ghigo (University of Torino)
"PDE4 Regulation by the A-Kinase Anchoring Function of PI3Kgamma in Heart Failure and Allergic Asthma"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Ambhi Ghanesan (Johns Hopkins University)
"Spatiotemporal Dynamics of PKA-ERK Signaling Crosstalk in Pheochromocytoma Cells"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Peter Wright (Imperial College London)
"Anatomical Variations in the Compartmentation of B2AR-cAMP Signaling Within the Myocardium"
9:20 pm - 9:30 pm Discussion
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amNovel Models for Furthering PDE Research
Discussion Leader: Stefania Monterisi (University of Oxford)
9:00 am - 9:20 am Jan Schuelke (Pfizer Inc)
"Utilizing Chemoproteomics to Interrogate Phosphodiesterase Biology"
9:20 am - 9:30 am Discussion
9:30 am - 9:40 am Chaitali Basole (University of Connecticut Health Center)
"Role of PDE8 in EAE"
9:40 am - 9:45 am Discussion
9:45 am - 10:05 am Anchal Chandra (Max Plank Institute for Molecular Physiology)
"PDEdelta: Role as GSF in Tuning Oncogenic KRAS Signaling and Its Therapeutic Targeting"
10:05 am - 10:15 am Discussion
10:15 am - 10:25 am Lise Roman Moltzau (University of Oslo)
"Enhancement of β1-Adrenoceptor Signaling by C-Type Natriuretic Peptide Through Natriuretic Peptide Receptor B in Normal and Failing Hearts and Regulation by Phosphodiesterase 2"
10:25 am - 10:30 am Discussion
10:30 am - 10:50 am Sarah Rampersad (Queen's University)
"cAMP-Signaling Regulates the Expression of Atheroprotective Genes in Vascular Endothelial Cells Exposed to Differential Fluid Shear Stresses"
10:50 am - 11:00 am Discussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component
Discussion Leaders: Peder Cedervall (Pfizer Inc) and Fabien Hubert (Queen's University)
1:30 pm - 2:20 pm George Baillie (University of Glasgow), John Dunlop (AstraZeneca), Anthony West (Rosalind Franklin University) and Manuela Zaccolo (Oxford University)
"Integrating Industry and Academia"
2:20 pm - 2:30 pm Discussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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