The Gordon Research Seminar on the Molecular Mechanisms in Lymphatic Function & Disease is a unique forum for graduate students and postdoctoral scholars interested in the lymphatic system to present their work, learn about the cutting-edge research of their peers, and exchange ideas about the future research directions in understanding the biology and physiology of lymphatic circulation. Each oral session will feature discussions led by senior researchers with the openness and equity that defines the Gordon mission and all participants will have to opportunity to present posters. 2014 will be the inaugural Gordon Research Seminar to be associated with the Molecular Mechanisms in Lymphatic Function & Disease GRC and the program seeks to bring together interested junior researchers from across the spectrum of lymphatic research frontiers.
The lymphatic system has become increasingly appreciated as a major player in a host of pathologies and our understanding of its genetic, biochemical, and biophysical regulators continues to expand. Lymphatic circulation plays roles in tissue fluid balance and interstitial flow regulation, immune regulation and leukocyte trafficking, lipid uptake and transport, and cancer growth and metastasis. Emerging research has discovered that lymphatic biology is a critical component in inflammation and chronic diseases beyond cancer and lymphedema; new tools and therapies are being developed to explore and clinically address the spectrum of lymphatic-associated pathologies. The 2014 meeting will focus on these new frontiers while incorporating the continued extensive efforts to understand lymphatic development and function. Graduate students and postdoctoral scholars with any interest in any aspect of lymphatic research are encouraged to submit an abstract and participate with novel, unpublished works being chosen for oral presentations.
Seed funding for this new Gordon Research Seminar has been provided by Merck Research Laboratories.
|1:30 pm - 4:30 pm||Arrival and Check-in|
|3:00 pm - 3:15 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair|
|3:15 pm - 4:00 pm||Expanding Frontiers of Lymphatic Research|
|Discussion Leader: Amelie Sabine (University of Lausanne; Switzerland)|
|3:15 pm - 3:45 pm ||Donald McDonald (University of California, San Francisco; USA)|
"Mechanisms of Lymphangiectasia"
|3:45 pm - 4:00 pm ||Discussion|
|4:00 pm - 5:30 pm||Poster Session I|
|5:30 pm - 7:30 pm||Lymphatic Growth and Development: Novel Regulating Pathways and Models|
|Discussion Leader: Dontscho Kerjaschki (Medical University of Vienna; Austria)|
|5:30 pm - 5:50 pm ||Cathrin Pollmann (Max Planck Institute for Molecular Biomedicine; Germany)|
"The CXCR4/SDF1 Signaling Axis Is Important for Initial Lymphangiogenesis and Patterning of Lymphatic Vessels"
|5:50 pm - 6:00 pm ||Discussion|
|6:00 pm - 6:20 pm ||Lukas Stanczuk (Uppsala University; Sweden)|
"Different Requirement of PI3 Kinase Signalling for Embryonic and Postnatal Lymphatic Development"
|6:20 pm - 6:30 pm ||Discussion|
|6:30 pm - 6:50 pm ||Deniz Hos (University of Cologne; Germany)|
"Prolymphangiogenic Phenotype of M2-Polarized Macrophages"
|6:50 pm - 7:00 pm ||Discussion|
|7:00 pm - 7:20 pm ||Leonid Nikitenko (University College London; United Kingdom)|
"Endogenous Adrenomedullin Plays a Role in the Pathogenesis of Secondary Lymphedema: Lessons from Acute and Chronic Experimental Models"
|7:20 pm - 7:30 pm ||Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||Inflammation and Immunity: A Role in Chronic Disease|
|Discussion Leader: Gwendalyn G. Randolph (Washington University in St. Louis; USA)|
|9:00 am - 9:20 am ||Echoe Bouta (University of Rochester; USA)|
"Amelioration of Inflammatory Arthritis by Anti-TNF Therapy is Associated with Restoration of Lymphatic Contraction"
|9:20 am - 9:30 am ||Discussion|
|9:30 am - 9:50 am ||Walter Cromer (Texas A&M Health Science Center; USA)|
"Regulation of Lymphatic Transport During Intestinal Inflammation is Regulated by Immune Cell Interaction with the Vessel"
|9:50 am - 10:00 am ||Discussion|
|10:00 am - 10:20 am ||Stoyan Ivanov (Washington University in St. Louis; USA)|
"Thermogenic UCP-1+ Brown Fat and Suppressed Lymphatic Transport to Skin-Draining Lymph Nodes"
|10:20 am - 10:30 am ||Discussion|
|10:30 am - 10:50 am ||Manuel Fankhauser (École Polytechnique Fédérale de Lausanne, Switzerland)
"Lymphangiogenic Melanomas Establish an Immunosuppressive Microenviroment to Dampen CD8 T Cell Infiltration and Functionality In Situ"
|10:50 am - 11:00 am ||Discussion|
|11:00 am - 12:30 pm||Poster Session II|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:45 pm||Lymphatic Therapies: New Advances, Research Tools and Challenges|
|Discussion Leader: David C. Zawieja (Texas A&M Health Science Center; USA)|
|1:30 pm - 1:47 pm ||Timothy Kassis (Georgia Institute of Technology; USA)|
"Role of Mesenteric Lymphatic Vessels in Lipid Transport and Their Response to Increased Mechanical Load"
|1:47 pm - 1:55 pm ||Discussion|
|1:55 pm - 2:12 pm ||Alexandra Ochsenbein (ETH Zurich; Switzerland)|
"A Novel Model for Physiological Lymphangiogenesis"
|2:12 pm - 2:20 pm ||Discussion|
|2:20 pm - 2:37 pm ||Marco Borri (CR-UK and EPSRC Cancer Imaging; United Kingdom)|
"Quantitative Contrast-Enhanced Magnetic Resonance Lymphangiography of the Upper Limbs in Breast Cancer Related Lymphoedema"
|2:37 pm - 2:45 pm ||Discussion|
|2:45 pm - 3:00 pm||Evaluation Period|
|Fill in GRS Evaluation Forms|
|3:00 pm||Seminar Concludes|