Gordon Research Conferences
Meeting Details

Notch Signaling in Development, Regeneration and Disease (GRS)
Gordon Research Seminar

From Molecular Mechanisms to Translational Research


July 19-20, 2014


Bates College
Lewiston, ME


Shinya Yamamoto

Associate Chair:
Mustafa Turkoz

Meeting Description

The Gordon Research Seminar on Notch Signaling in Development, Regeneration & Disease is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to explore the developmental and physiological roles of Notch signaling in model organisms such as worms, flies, fish and mice, and to understand the molecular pathophysiology of Notch related human diseases by integrating biochemical, cell biological, structural and bioinformatic approaches. As the Notch signaling field has become highly multidisciplinary over the last several decades, we welcome applicants from diverse scientific and medical fields to facilitate the translation of basic knowledge into clinical settings such as cancer therapeutics and regenerative medicine.

Related Meeting

This GRS was held in conjunction with the "Notch Signaling in Development, Regeneration and Disease" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.


Meeting Program

1:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session
Discussion Leader: Shinya Yamamoto (Chair, Baylor College of Medicine)
3:45 pm - 4:15 pmRaphael Kopan (Cincinnati Children's Hospital Medical Center)
"New Technology Developed to Probe Target Selection by Specific Notch Complexes In Vivo"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 8:30 pmNotch Signaling in Model Organisms
Discussion Leaders: Laurie Holt (University of Oxford, UK) and Sarah Bray (University of Cambridge, UK)
7:30 pm - 7:45 pmErika Sorensen (University of Wisconsin-Madison)
"Visualization of GLP-1/Notch Signaling in Stem Cells Within an Organism"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmKazuya Hori (Harvard Medical School)
"Regulation of Notch Signal by a Lysosomal Associated Transmembrane Protein"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmJohn Jacob (Oxford University Hospitals NHS Trust)
"Cryptic Notch Signaling Mediates Teratogenic Effects of Valproate in a Zebrafish Chemical-Genetics Model of Fetal Valproate Syndrome"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 9:30 pmMolecular Mechanisms of Notch Signaling
Discussion Leaders: Beth Harvey (Stony Brook University) and Stephen Blacklow (Harvard Medical School)
8:30 pm - 8:45 pmRolake Alabi (Weill Medical College of Cornell University)
"Understanding the Contributions of ADAM10 and ADAM17 to Notch1 Signaling"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmCatherine Deatherage (Vanderbilt University)
"Comparison of the Structures of Gamma-Secretase Substrates Notch and C99-APP"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmRoger Habets (Maastricht University, Netherlands)
"Distinct Mechanisms of Regulated Proteolysis Between Mammalian NOTCH Proteins"
9:25 pm - 9:30 pmDiscussion
7:30 am - 8:30 amBreakfast
9:00 am - 10:12 amNotch Signaling in Development and Stem Cells
Discussion Leaders: Bahman Rostama (Maine Medical Center Research Institute) and Christian Siebel (Genentech)
9:00 am - 9:15 amTobias Hohenauer (RIKEN Brain Science Institute)
"Evi1 (Prdm3) Maintains Neural Stem Cell Self-Renewal Through Chromatin Control Over Notch Target Activation"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amElise Demitrack (University of Michigan)
"Notch Regulates Gastric Antral Lgr5+ Stem Cells to Control Epithelial Cell Homeostasis"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amKai-Yuan Chen (Cornell University)
"A Gradient Modulated NOTCH Intercellular Feedback Controlling Stem Cell/Niche Pattern Inside Intestinal Crypts"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amKostandin Pajcini (University of Pennsylvania)
"The Notch1 Transcriptional Activation Domain is Required for Development and Reveals a Novel Role for Notch1 Signaling in Fetal Hematopoietic Stem Cells"
10:15 am - 10:20 amDiscussion
10:20 am - 11:00 amPanel Discussion: How Notch Signaling Shapes One's Career
Discussion Leader: Mustafa Turkoz (Cincinnati Children's Hospital Medical Center)
  • Stephen Blacklow (Harvard Medical School, USA)
  • Sarah Bray (University of Cambridge)
  • Alain Israël (Institut Pasteur)
  • Raphael Kopan (Cincinnati Children's Hospital Medical Center)
  • Warren Pear (University of Pennsylvania)
  • Christian Siebel (Genentech)
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmNotch Signaling in Disease
Discussion Leaders: Gillian Horne (Paul O'Gorman Leukaemia Research Centre, UK) and Warren Pear (University of Pennsylvania, USA)
1:30 pm - 1:45 pmSarah Peterson (Maine Medical Center Research Institute)
"Notch Signaling in Vascular Remodeling Following Injury"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmSurajit Sinha (Memorial Sloan Kettering Cancer Center)
"An In Vivo Gain of Function Genetic Screen for Lung Metastasis Identifies NUMB as an Enforcer of Tumor Dormancy"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:25 pmJooho Chung (University of Michigan)
"Delta-Like Ligands Expressed by Stromal Cells in Secondary Lymphoid Organs Deliver an Early Pulse of Notch Signaling and Drive T Cell Pathogenicity During Graft-Versus-Host-Disease"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by Grant 1 R13HD080297-01 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices or organizations imply endorsement by the U.S. Government.
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