The Gordon Research Seminar on Plasminogen Activation & Extracellular Proteolysis is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.
The focus of this meeting is on the basic and clinical research in the field of pericellular proteolysis in general, and plasminogen activation in particular. The meeting seeks to attract young scientists to present their work on the molecular mechanism of pericellular proteolysis, its function in tissue development, homeostasis, and disease, and on the development of new, protease-related therapies for the treatment of disorders of the cardiovascular and central nervous systems, as well as cancer.
|2:00 pm - 5:00 pm||Arrival and Check-in|
|3:30 pm - 3:40 pm||Introductory Comments by GRC Site Staff|
|3:40 pm - 3:50 pm||Welcome by the GRS Conference Chairs|
|3:50 pm - 4:30 pm||Molecular Mechanisms of Extracellular Proteolysis|
|Discussion Leaders: Andre Samson (Monash University, Melbourne, Australia) and Maria Melander (The Finsen Laboratory/BRIC, University of Copenhagen, Denmark)
|3:50 pm - 4:05 pm||Joel Bucci (University of Tennessee, Knoxville TN, USA)
"Pinpointing the Molecular Basis for Metal Effects on PAI-1"
|4:05 pm - 4:10 pm||Discussion|
|4:10 pm - 4:25 pm||Yuko Tashima (National Cerebral and Cardiovascular Center Research Institute, Japan)
"Generation and Characterization of Homozygous Plasminogen-Tochigi Mutant Mice Bearing Reduced Fibrinolytic Activity"
|4:25 pm - 4:30 pm||Discussion|
|4:30 pm - 6:00 pm||Poster Session I (odd-numbered posters)|
|7:30 pm - 8:50 pm||Molecular Mechanisms of Extracellular Proteolysis
|Discussion Leaders: Andre Samson (Monash University, Melbourne, Australia) and Tine Thurison (The Finsen Laboratory/BRIC, University of Copenhagen, Denmark)
|7:30 pm - 7:45 pm||Valentina De Lorenzi (FIRC Institute of Molecular Oncology Foundation Milano, Italy)
"Urokinase Provides a Negative Feedback Between Plasminogen Activation and Cell Adhesion Through uPAR-Dependent Cleavage of Vitronectin"
|7:45 pm - 7:50 pm||Discussion|
|7:50 pm - 8:05 pm||Joni Prasad (University of Maryland, Baltimore, MD, USA)
"Genetic Deletion of LDL Receptor Family Members Supports Thrombus Resolution in a Mouse Model of DVT"
|8:05 pm - 8:10 pm||Discussion|
|8:10 pm - 8:25 pm||Maria Melander (The Finsen Laboratory/BRIC, University of Copenhagen, Denmark)
"Targeting a Novel Bone Degradation Pathway in Osteosarcoma"
|8:25 pm - 8:30 pm||Discussion|
|8:30 pm - 8:45 pm||Deborah Francois (National Institute of Health and Medical Research, INSERM U698, Paris, France)
"Role of the Serpin Protease Nexin-1 in Tissue Remodeling Occurring During Pulmonary Fibrosis"
|8:45 pm - 8:50 pm||Discussion|
|8:50 pm - 9:30 pm||Keynote Session
|8:50 pm - 9:20 pm||Sharon Stack (Professor in Chemistry & Biochemistry, Director of the Harper Cancer Research Institute, University of Notre Dame)|
|9:20 pm - 9:30 pm||Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||Proteolytic Functions in Physiology and Disease
|Discussion Leaders: Katerina Akkasoglou and Erik Martin (University of Maryland, Baltimore, MD, USA)
|9:00 am - 9:15 am||Diane Peters (NIDCR, National Institutes of Health, Bethesda, MD, USA)
"Prostasin (CAP1/PRSS8) Supports Epidermal Development and Postnatal Survival Independent of Its Catalytic Activity"
|9:15 am - 9:20 am||Discussion|
|9:20 am - 9:35 am||Marguerite Buzza (University of Maryland, Baltimore, MD, USA)
"Inflammation-Induced Loss of the Prostasin-Matriptase Barrier Promoting Pathway in Intestinal Epithelium Contributes to the Pathogenesis of Colitis"
|9:35 am - 9:40 am||Discussion|
|9:40 am - 9:55 am||Katiuchia Sales (NIDCR, National Institutes of Health, Bethesda, MD, USA)
"Non-Hematopoietic PAR-2 is Essential for Matriptase-Driven Pre-Malignant Progression and Potentiation of Ras-Mediated Squamous Cell Carcinogenesis"
|9:55 am - 10:00 am||Discussion|
|10:00 am - 10:15 am||TBA
|10:15 am - 10:20 am||Discussion|
|10:20 am - 10:35 am||Amanda Boe (Northwestern University, Chicago, IL, USA)
"The Role of PAI-1 and NO in Aging-Related Pathology in Mice"
|10:35 am - 10:40 am||Discussion|
|10:40 am - 10:55 am||Maarten Hendrickx (Faculty of Pharmaceutical Sciences, KU Leuven, Belgium)
"Development of a Sandwich-Type ELISA for the Detection of Human Active Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) and Assessment in Patients"
|10:55 am - 11:00 am||Discussion|
|11:00 am - 12:30 pm||Poster Session II (even-numbered posters)|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:50 pm||Proteolytic Functions in Physiology and Disease (continued)
|Discussion Leaders: Katerina Akkasoglou (Gladstone Institute of Neurological Disease, University of California, San Francisco) and Diana Abu-Ssaydeh (Monash University, Melbourne, Australia)
|1:30 pm - 1:45 pm||Tine Wyseure (Faculty of Pharmaceutical Sciences, KU Leuven, Belgium)
"Dual Targeting of TAFI and PAI-1 as a Novel Treatment for Acute Ischemic Stroke"
|1:45 pm - 1:50 pm||Discussion|
|1:50 pm - 2:05 pm||Patty Cunfer (University of Maryland, Baltimore, MD, USA)
"Investigation into the Mechanisms of LRP1-Mediated FVIII Clearance"
|2:05 pm - 2:10 pm||Discussion|
|2:10 pm - 2:25 pm||Dianaly Au (University of Maryland, Baltimore, MD, USA)
"Macrophage LRP1 Modulates Lipid Homeostasis and Diet-Induced Hepatic Inflammation"
|2:25 pm - 2:30 pm||Discussion|
|2:30 pm - 2:45 pm||Moamen Bydoun (Dalhousie University, Nova Scotia, Canada)
"The Plasminogen Receptor S100A10 Modulates Plasmin-Mediated Fibrinolysis in Acute Promyelocytic Leukemia"
|2:45 pm - 2:50 pm||Discussion|
|2:50 pm - 3:00 pm||Evaluation Period|
|Fill in GRS Evaluation Forms|
|3:00 pm||Seminar Concludes|
Funding for this conference was made possible (in part) by 1R13HL121916-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.