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Proteolytic Enzymes and Their Inhibitors (GRS)
Gordon Research Seminar

Proteases: Making the Cut in Biological Processes and Diseases

Dates

June 21-22, 2014

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chair:
Antoine H. Dufour

Associate Chair:
Laura Edgington

Meeting Description

The Gordon Research Seminar on Proteolytic Enzymes & Their Inhibitors is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to highlight recent developments in the field of protease biology including the five classes of proteases (aspartic, cysteine, metallo, serine and threonine) and their inhibitors. The discussions will center on the role of these enzymes in regulating the complex biological processes involved in development, tissue homeostasis, immune regulation and diseases such as immune disorders, cardiovascular and pathogenic diseases, and cancer.

Proteases act in the context of complex cascades, networks and pathways, thereby creating a multifaceted universe of protein-protein interactions. This web of protein interactions is not static but dynamic and is further modulated in disease states. The emergence of genomics and proteomics has revolutionized how we view proteases, their substrates and their inhibitors at the levels of whole organisms.

The GRS attendees are also suggested to attend the related GRC on Proteolytic Enzymes and their Inhibitors (Chair, James C. Whisstock and Vice Chair, Johanna Joyce). This meeting will indeed have a strong representation from the next generation of scientists (and bring down the median age of attendees!).

The second GRS on Proteolytic Enzymes and their Inhibitors will feature oral presentations, two poster sessions and a career panel to advise on and discuss the range of career paths available to graduate students and postdoctoral fellows.

Looking forward to seeing everyone is beautiful Tuscany.

Antoine Dufour (Chair) and Laura Edgington (Associate Chair), 2014 Proteolytic Enzymes and their Inhibitors GRS

Related Meeting

This GRS was held in conjunction with the "Proteolytic Enzymes and Their Inhibitors" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

SATURDAY
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmGlobal Approaches to Protease Inhibition
Discussion Leader: Dion Kaiserman (Monash University)
3:15 pm - 3:30 pmVeronica Anania (Genentech)
"DEADomics: Caspases and Cell Death During ER Stress"
3:30 pm - 3:35 pmDiscussion
3:35 pm - 3:55 pmAnne Wiemhoefer (AMC University of Amsterdam)
"Proteomic Application of B6, a New Reversible Inhibitor, to Study the Pleitropic Role of Tripeptidyl Peptidase 2"
3:55 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pmRock, Paper and Molecular Scissors: Regulating the Game of Immunity
Discussion Leader: Nehul Saxena (ICGEB, India)
5:30 pm - 5:45 pmAllison Goldberg (Yale University)
"Dissection of Anthrax Lethal Factor Interactions with MAP Kinase Kinase Substrates"
5:45 pm - 5:50 pmDiscussion
5:50 pm - 6:05 pmStavroula Hatzios (Brigham & Women's Hospital/Harvard University)
"Chemoproteomic Discovery of Serine Proteases Active During Vibrio cholera Infection"
6:05 pm - 6:10 pmDiscussion
6:10 pm - 6:25 pmSabrina Muhlen (University of Melbourne)
"Inhibition of Host Immune Responses by an Effector Protease of Enteropathogenic E. coli"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:45 pmAnthony O'Donoghue (University of California San Francisco)
"Global Substrate Profiling of Proteases in Human Neutrophil Extracellular Traps Reveals Consensus Motif Predominantly Contributed by Elastase"
6:45 pm - 6:50 pmDiscussion
6:50 pm - 6:55 pmHendrika Duivenvoorden (La Trobe Institute for Molecular Science)
"The Role of Cell Specific Cathepsin Inhibitors in Blocking Early Breast Cancer Invasion"
6:50 pm - 6:55 pmDiscussion
6:55 pm - 7:00 pmSuelem Ramlaho (Federal University of São Carlos)
"Light Activation of Cathepsin B Dipeptidyl Nitrile Inhibitor and Evaluation in 3D Models Using Human Triple-Negative Breast Cancer Cells"
7:00 pm - 7:05 pmDiscussion
7:05 pm - 7:10 pmHao Li (Stanford University)
"MSP-MS Substrate Profiling Coupled with Small Molecule Inhibition Reveals Unique Characteristics of the Plasmodium 20S Proteasome β2 Active Site"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:20 pmJennifer Cleary (University College Dublin)
"NMR, Providing a Direct Insight into How Aldehyde Inhibitors Interact with the Serine Proteases"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:30 pmGeneral Discussion
8:00 pmDinner
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amCutting the Scene Made by Cancer and Inflammation: New Perspectives
Discussion Leader: Jessica Lisle (Queensland University of Technology)
9:00 am - 9:15 amJanna Hachmann (Sanford-Burnham Medical Research Institute)
"Mechanism and Specificity of the Human Paracaspase MALT1"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amDaniela Loessner (Queenland University of Technology)
"Peptidase-Associated Functions Shape the Tumour Microenvironment"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amLeila Akkari (Memorial Sloan Kettering Cancer Center)
"Cathepsin Z in Glioma"
9:55 am - 10:00 amDiscussion
10:00 am - 10:50 amKeynote Speaker: Matt Bogyo (Stanford University)
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmCareer Panel
Panelists:
  • Christopher Overall (University of British Columbia)
  • Margarete Heck (University of Edinburgh)
  • Bruno Martoglio (Novartis Institute for BioMedical Research)
  • Bonnie Sloane (Wayne State University)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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