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Proteoglycans (GRS)
Gordon Research Seminar

The Rise of Proteoglycans in Mechanotransduction and Microenvironmental Signaling

Dates

July 5-6, 2014

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Thomas E. Neill

Meeting Description

The Gordon Research Seminar on Proteoglycans is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to investigate the pivotal roles proteoglycans play in regulating mechano-sensitive pathways and coordinating instructive microenvironmental cues essential for differentiation, morphogenesis, and disease progression. The Seminar will also discuss these implications for proteoglycan based therapeutics, clinical applicability, and translational efficacy.

Related Meeting

This GRS was held in conjunction with the "Proteoglycans" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

SATURDAY
1:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Rise of the Proteoglycans
Discussion Leader: Megan S. Lord (University of New South Wales, Sydney)
3:45 pm - 4:15 pm Pyong Woo Park (Children's Hospital, Harvard Medical School, Boston)
4:15 pm - 4:30 pm Discussion
4:30 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmMechanosignaling in Development and Disease
Discussion Leaders: Brooke Farrugia (Graduate School of Biomedical Engineering, Australia) and Varun Krishnamurthy (Rice University, Houston, Texas)
7:30 pm - 7:50 pm Megan S. Lord (University of New South Wales, Sydney)
"Sulfation of the Chondroitin Sulfate Chain of Inter-α-Trypsin Inhibitor Controls the Formation of Hyaluronan-Heavy Chain Complexes: Implications for Functional Changes During Arthritis"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Beata Filipek-Gorniok (Uppsala University, Sweden)
"The Ndst Gene Family in Zebrafish: Role of Ndst1b in Pharyngeal Arch Formation"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Varun Krishnamurthy (Rice University, Houston, Texas)
"Inhibition of Complementary TGF-β Pathways Differentially Regulate Glycosaminoglycan Homeostasis in Mechanosensitive Aortic Valve Interstitial Cells"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Marissa Maciej (University of Manchester, United Kingdom)
"Inhibition of HS and Not CS by a Novel Competitive Inhibitor Displays Phenotype Similarities to Hereditary Multiple Exotoses in Xenopus"
9:20 pm - 9:30 pm Discussion
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:20 amSignaling Through the Sugar
Discussion Leaders: Marissa Maciej (University of Manchester, UK) and Paul Keire (Benaroya Research Institute, Seattle, Washington)
9:00 am - 9:15 am Zehra Firat (Amkara University, Turkey)
"Global ADAMTS and TIMP Profiling in Diabetic Nephropathy Formation Reveals Deregulated Matrix Proteinaises in Diabetic Mice"
9:15 am - 9:20 am Discussion
9:20 am - 9:35 am Tabea Dierker (Uppsala University, Sweden)
"Unexpected Sulfation of Chondroitin in C. elegans"
9:35 am - 9:40 am Discussion
9:40 am - 9:55 am Brooke Farrugia (Graduate School of Biomedical Engineering, Australia)
"Glycosaminoglycans Modulate the Response of Inflammatory Cells to Implanted Materials"
9:55 am - 10:10 am Discussion
10:10 am - 10:15 am Aurijit Sarkar (Virginia Commonwealth University, Richmond, Virginia)
"Glycosaminoglycan-Protein Binding Specificity Constitutes More Than Arg/Lys-Sulfate Interactions"
10:15 am - 10:20 am Discussion
10:20 am - 11:00 amMentorship Component: Grantsmanship and Writing Seminar
William C. Parks (Cedars-Sinai Medical Center, Seattle, Washington)
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:45 pmThe Instructive Matrix: Microenvironmental Cues
Discussion Leaders: Tabea Dierker (Uppsala University, Sweden) and Aurijit Sarkar (Virginia Commonwealth University, Richmond, Virginia)
1:30 pm - 1:50 pm Annabel Torres (Thomas Jefferson University, Philadelphia, Pennsylvania)
"Decorin Induces Autophagy in Endothelial Cells by Activating the Peg3/Beclin 1 Axis"
1:50 pm - 1:55 pm Discussion
1:55 pm - 2:15 pm Elisa Migliorini (University of Grenoble Alpes, France)
"Morphogens Crosslink Heparan Sulfate"
2:15 pm - 2:20 pm Discussion
2:20 pm - 2:40 pm Paul Keire (Benaroya Research Institute, Seattle, Washington)
"Versican and Cancer: Role in the Development of Leiomyosarcoma"
2:40 pm - 2:45 pm Discussion
2:45 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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