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Conference Program
 
Host-Parasite Interactions, Biology of
Molecular Mechanisms of Pathogenesis and Treatment of Parasitic Diseases
June 8-13, 2014
Salve Regina University
Newport, RI

The 2014 GRC on the Biology of Host-Parasite Interactions is focused on new concepts and approaches in the study of pathogenesis associated with parasite infection. The conference will place special emphasis on human and animal diseases such as malaria, toxoplasmosis, trypanosomiasis, leishmaniasis, trichomoniasis, giardiasis, schistosomiasis and gastrointestinal nematode infection. The program will feature a wide range of topics, such as host and parasite co-evolution, parasite cell and developmental biology, pathogenesis and virulence, host invasion, metabolic interaction, immune response and immune evasion, and drug action and resistance. Bringing the research community together allows an acceleration of our understanding of infectious diseases at the cellular and organism level.

The aim of the meeting is to bring together scientists from a variety of disciplines in order to define the current state of this dynamic field and to discuss and set future research agendas. This GRC conference offers the unique opportunity for junior investigators and graduate students to get together and exchange ideas with leaders in the field in a friendly and relaxed atmosphere at the Salve Regina University Campus, Newport. Submitted abstracts reporting ground-breaking findings will be selected for short talks. Students and post-docs are strongly encouraged to apply. We are making a special effort to obtain funds to provide individuals from endemic countries with travel awards.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmEpigenetics, Chromatin Remodeling and Gene Regulation
Discussion Leader: Luisa Miranda Figueiredo (University of Lisbon, Portugal)
7:40 pm - 8:00 pm Luisa Miranda Figueiredo (University of Lisbon, Portugal)
"Chromatin Dynamics and Gene Expression in Trypanosoma brucei"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:30 pm Jonathan Weitzman (University of Paris, France)
"Rewiring of Host Gene Regulation Networks by Theileria"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:00 pm Till Voss (Swiss Tropical Institute, Basel Switzerland)
"Heterochromatic Protein 1 Regulates Antigenic Variation and Mitotic Proliferation in Malaria Blood Stage Parasites"
9:00 pm - 9:10 pm Discussion
9:10 pm - 9:30 pm General Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMetabolism and Sensing of Host Environment
Discussion Leader: Malcolm McConville (University of Melbourne, Australia)
9:00 am - 9:20 am Malcolm McConville (University of Melbourne, Australia)
"The Metabolic Adaptations of Intracellular Parasites"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Maria Mota (University of Lisbon, Portugal)
"Plasmodium Ability to Sense Changes in the Host"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Upi Singh (Stanford University, USA)
"Unusual Aspects of RNAi-Mediated Gene Silencing in the Protist Entamoeba histolytica"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Richard Grencis (University of Manchester, UK)
"Genes, Molecules and Cells in the Whipworm/Host Relationship"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Chris West (University of Oklahoma Health)
"The Role of Toxoplasma Skp1 Prolyl Hydroxylation and Glycosylation in Oxygen Sensing"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Anthony Szempruch (University of Georgia)
"Bloodstream for T. brucei Excellular Vesicles Mediate Intercellular and Host Interactions"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Mark Robinson (Queen's University, Belfast)
"Helminth Extracellular Vesicles: The Key to Parasite Control?"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Katherine Harker (University of California, Irvine)
"Shear Forces Enhance Toxoplasma gondii Tachyzoite Motility on Vascular Endothelium"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmOrganelles Biogenesis and Trafficking
Discussion Leader: Kasturi Haldar (University of Notre Dame, USA)
7:30 pm - 7:50 pm Kasturi Haldar (University of Notre Dame, USA)
"Host Remodeling by Malaria, in Virulence and Disease"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Boris Striepen (University of Georgia, USA)
"Apicoplast Biogenesis"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Andre Schneider (University of Bern, Switzerland)
"How Do Trypanosomes Build Their Mitochondrion?"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Gang Dong (Max F. Perutz Laboratories, Austria)
"Structure and Assembly Mechanism of TbBILBO1 an Essential Protein for Formation of the Flagellar Collar of Trypanosoma brucei"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Alexandar Paredez (University of Washington)
"Rac Regulation of Membrane Trafficking in Giardia"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmParasite Persistence and Differentiation
Discussion Leader: Kent Hill (University of California Los Angeles, USA)
9:00 am - 9:20 am Kent Hill (University of California Los Angeles, USA)
"Flagellum Biology in the African Trypanosome, Trypanosoma brucei"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Rita Tewari (University of Nottingham, UK)
"A Functional Screen of the Plasmodium Phosphatome Reveals Key Regulators of Parasite Development and Differentiation"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Matthias Marti (Harvard School of Public Health, USA)
"Mechanisms of Gametocyte Formation and Sequestration in the Human Malaria Parasite, Plasmodium falciparum"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Maria Yazdanbakhsh (Leids Universitair Medisch Centrum, Netherlands)
"Immune Modulation by Parasitic Helminths: The TH2 and the Regulatory Network"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Dan Zilberstein (Technion-Israel Institute of Technology, Israel)
"Signaling Pathways Identified by Systems Analysis of Lesihmania Differentiation"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Tania De Koning-Ward (Deakin University, Australia)
"Functional Proof for the Role of PTEX in the Export of Diverse Protein Cargo"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Kristian Stodkilde-Jprgensen (Aarhus University - Denmark)
"Heme Piracy by Trypnosome Parasites"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Jun Liu (Indiana University Bloomington)
"The Regulation of the Organization and Function of Toxoplasma gondii Cortical Microtubule"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTherapeutic Interventions/Drugs and Drug Resistances
Discussion Leader: Meg Phillips (UT Southwestern Medical Center, USA)
7:30 pm - 7:50 pm Meg Phillips (UT Southwestern Medical Center, USA)
"Dihydroorotate Dehydrogenase Inhibitors for the Treatment of Malaria"
7:50 pm - 8:00 pm Discusion
8:00 pm - 8:20 pm Kip Guy (St. Jude Children's Research Hospital, USA)
"The Dihydroisoquinolones: Orally Available Antimalarials"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Marc Ouellette (Canadian Institutes of Health Research, Montreal, Canada)
"Functional Genomics and Drug Resistance Genes Discovery in Leishmania"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Shilpi Khare (Novartis (Genomics Institute))
"Trypanosoma cruzi Cytochrome B as a Chagas Disease Drug Target: Discovery of a Selective Inhibitor Blocking Parasite Growth"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Celia Miguel (GlaxoSmithKline - Spain)
"Plasmodium falciparum Female Gamete Formation as a Novel Target for High Throughput Screening in Malaria Drug Discovery"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHost Immune Defenses and Parasite Evasion
Discussion Leader: Edward Pearce (Washington University, USA)
9:00 am - 9:20 am Edward Pearce (Washington University, USA)
"The Role of Lipolysis in Alternative Macrophage Activation During Helminth Infection"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Annette MacLeod (University of Glasgow, UK)
"The Co-Evolutionary Arms Race Between Humans and African Trypanosomes"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Felix Yarovinsky (University of Texas Southwestern Medical Center, USA)
"Cell-Specific Regulation of Innate Immune Defense to Toxoplasma gondii"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Karine Le Roch (University of California Riverside)
"Three-Dimensional Modeling of the P. falciparum Genome During the Erythrocytic Cycle: A Major Organizational Role of Virulence Genes in the Genome Architecture"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Galadriel Hovel-Miner (Rockefeller University)
"Specific DNA Repeats Control the Frequency and Diversity of Surface Antigen Gene Selection in Trypanosoma brucei"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Rudo Kieft (University of Georgia)
"Trypanosoma brucei Rhodesiense Has Evolved Mechanisms to Avoid Human Adaptive and Innate Immunity"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Jason Pinger (The Rockefeller University)
"The Dynamics of VSG Coat Turnover During Antigenic Variation in African Trypanosomes"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Teresa Cristina Calegari Silva (Federal University of Rio de Janeiro, Brazil)
"NF-KappaB-Mediated Transcription Repression in Leishmania amazonensis Infection: Role of the Chromatin Remodeling Enzyme HDAC1"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmProtein Structure and Vaccine Development
Discussion Leader: Simon Draper (University of Oxford, UK)
7:30 pm - 7:50 pm Simon Draper (University of Oxford, UK)
"Towards the Development of a Broadly-Neutralising Vaccine Against Blood-Stage Plasmodium falciparum"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Gavin Wright (Sanger Institute, UK)
"Identifying Extracellular Host-Pathogen Interactions Using Systematic Protein Interaction Screens"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Martin Boulanger (University of Victoria, Canada)
"Molecular Crosstalk Between Apicomplexan Parasite and Host Cell: Building a Model of Invasion"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Ajay Saxena (Jawaharlal Nehru University, India)
"Crystal Structure and Biochemical Analysis of P. falciparum Falstatin in Complex with Plasmodium Cysteine Proteases FP2 and FP3"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Hong You (QIMR Berghofer Medical Research, Australia)
"The Insulin Receptor: An Achilles' Heel for Schistosome Vaccine Development"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInvasion and Subversion of Host Functions
Discussion Leader: Isabelle Coppens (John Hopkins University, USA)
9:00 am - 9:20 am Isabelle Coppens (John Hopkins University, USA)
"Toxoplasma Auxotrophies: Discovery and Therapeutic Exploration"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Ali Hakimi (CNRS, Grenoble, France)
"Toxoplasma Exports a Novel Sub-Family of Dense Granule Proteins into the Host Cell Nucleus to Rewire the Host Genome Expression"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Volker Heussler (University of Bern, Switzerland)
"Two Sides of the Same Coin: Beneficial and Deleterious Effects of Host Cell Autophagy in Plasmodium-Infected Hepatocytes"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Christina Hull (University of Wisconsin, USA)
"When Sex is Hazardous to Your Health: Pathogenesis of Cryptococcus Spores"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Chun-Ti Chen (Boston College)
"Functional Dissection of the Toxoplasma gondii Mitotic Apparatus"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Aditya Paul (Harvard School of Public Health)
"Plasmodium calcineurin Regulates Attachment to Erythrocytes for Invasion by Parasites"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Jennifer Lumb (Stanford University)
"Systematic Identification of Genes Involved in IFN Gamma Signaling FP3"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm James Collins (University of Illinois/HHMI)
"Adult Somatic Stem Cells Rapidly Renew the Schistosome Host-Parasite Interface FP3"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmHost/Parasite Co-Evolution
Discussion Leader: L. Aravind (NIH, USA)
7:30 pm - 7:50 pm L. Aravind (NIH, USA)
"Evolution of Strategies for Encoding Epigenetic Information in Eukaryotic Parasites"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Sven Gould (Heinrich-Heine-Universität,Düsseldorf, Germany)
"The Unique Biology of Trichomonas vaginalis Infection"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm TBA
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Philip McQueen (National Institutes of Health)
"Thalassemia Trait Erythrocytes Inhibit the Asexual Multiplication of Plasmodium falciparum In Vitro FP3"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Bridget Penman (University of Oxford, United Kingdom)
"Malaria Selects for Globin Gene Variation in the Long-Tailed Macaque FP3"
9:25 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI112168-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Last Updated: June 4, 2014
 
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