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Conference Program
 
Immunochemistry & Immunobiology
Re-Evaluating the Fundamentals of Immunology, Their Clinical Potentials, Their Meaningful Measures, and the Unmet Needs
June 1-6, 2014
Sunday River Resort
Newry, ME
Chair:
Adrian Hayday

Vice Chair:
Yasmine Belkaid

Related Meeting Information
The Immunochemistry & Immunobiology Gordon Research Conference was held in conjunction with the Immunochemistry & Immunobiology Gordon-Merck Research Seminar. Please refer to the Immunochemistry & Immunobiology GMRS web page for more information.

At a time of dramatic developments in immunology, the 2014 Gordon Research Conference in Immunochemistry and Immunobiology will use the presentation and discussion of new, largely unpublished data from leading and emerging experts to fundamentally re-evaluate basic research priorities, general scholarship, and translational potentials in nine key thematic areas of immunology. Those areas are: immune cell development and renewal; immune regulatory mechanisms; immunology and metabolism; immunological memory; tissue-based immune compartments; neonatal immunology; human immune response mechanisms; cytokines and their actions; and tumour immunology. Whereas these areas have traditionally been considered in the context of protection against infection, the more contemporary and challenging backdrop for their presentation and brain-storming shall also include the emerging and unexpected roles for immune cells in basic physiologic processes; the unanticipated yet impressive efficacies of immunotherapies in areas of major clinical need; and the rapidly improving tools for the direct analysis and manipulation of human immune responses.

The consideration of these issues will be aided by a broad constituency of delegates, while retaining a major goal of training and motivating the next generation of research leaders in basic, clinical, and applied science. In this regard, the opportunities for more junior attendees to make oral and poster presentations have been increased over previous years, and the Conference will benefit from a directly preceding Gordon Research Seminar in Immunology.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmImmune Cell Development and Renewal
Discussion Leader: Cynthia Guidos (Hospital for Sick Children, U of Toronto)
7:40 pm - 8:00 pmCynthia Guidos (Hospital for Sick Children, U of Toronto)
"Functions of Notch Signaling in Programming 'Innate-Like' Lymphocyte Effector Functions"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmPaul Frenette (Albert Einstein College of Medicine, Yeshiva University, New York)
"A Novel Pro-Inflammatory Neutrophil Subset"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmLivija Deban (London Research Institute, Cancer Research UK)
"An Epithelial Determinant Required for the Development of Signatory Murine Intestinal Intraepithelial T Cells"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmMiriam Merad (Mt Sinai University Hospital, New York)
"Macrophage are Critical for the Maintenance of Tissue Homeostasis"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegulation of Immune Cells and Systems
Discussion Leader: Gillian Griffiths (University of Cambridge)
9:00 am - 9:25 amGillian Griffiths (University of Cambridge)
"Ordering Events Leading to CTL Killing"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amMadeleine Hipp (University of Oxford)
"Novel Insights into the Biology of Human Toll-Like Receptor 7"
9:45 am - 9:50 amDiscussion
9:50 am - 10:00 amDaniel Popkin (Case Western Reserve University)
"Combating Persistent Viral Infections with Dendritic Cell-Specific Protease Inhibition"
10:00 am - 10:05 amDiscussion
10:05 amCoffee Break
10:30 am - 11:00 amRuslan Medzhitov (Yale University)
"New Perspectives on the Regulation of Immune Responses"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amArt Weiss (U California, San Francisco)
"Controlling Kinases that Interact with the T Cell Receptor"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmReinhold Förster (University of Hannover, Germany)
"Homing of Immune Cells via Afferent Lymphatics: A Novel Role for CCRL1 in Creating Gradients for CCR7 Ligands"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmImmunology and Metabolism
Discussion Leader: Erika Pearce (Washington University, St Louis)
7:30 pm - 8:00 pmErika Pearce (Washington University, St Louis)
"Metabolic Regulation of T Cell Function and Fate"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmClaudia Kemper (King's College, London)
"Complement as a Key Controller of Basic Metabolic Processes in CD4+ T Cells"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmPeter Ghazal (University of Edinburgh)
"Coupling of Interferon Response to Sterol Metabolism"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmLudvig Sollid (Oslo University Medical Centre, Norway)
"Celiac Disease: When Food Is the Problem"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMemory in Innate and Adaptive Cells
Discussion Leader: Federica Sallusto (Institute for Biomedical Research, Bellinzona)
9:00 am - 9:25 amFederica Sallusto (Institute for Biomedical Research, Bellinzona)
"Human Memory T Cell Subsets in Immunity and Autoimmunity"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amDaniel Utzschneider (Swiss Vaccine Research Institute)
"Linking Functional Diversity and TCR Signal Strength in Chronic Infections"
9:45 am - 9:50 amDiscussion
9:50 am - 10:00 amRobert Kimmerling (MIT)
"A Toolset for Multigenerational Lineage Characterization of Single CD8+ T Cells"
10:00 am - 10:05 amDiscussion
10:05 amCoffee Break
10:30 am - 11:00 amSusan Kaech (Yale University)
"The Top 10 Ways to Help Memory CD8 T Cells Develop"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amErin Adams (University of Chicago)
"Antigenic Signals that Regulate Gamma Delta T Cells in Human Health and Disease"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmHans-Gustaf Ljunggren (Karolinska Institute)
"Not So Innate Immune Reactions by NK Cells in Human Viral Infections"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmImmunity Within Tissues
Discussion Leader: Yasmine Belkaid (National Institutes of Health, Bethesda)
7:30 pm - 8:00 pmYasmine Belkaid (National Institutes of Health, Bethesda)
"Compartmentalized Control of Tissue Immunity by Commensals"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmDan Littman (Skirball Institute, New York University)
"Mechanisms of Microbiota-Directed Effector T Cell Differentiation"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmScott Mueller (University of Melbourne, Australia)
"Surveillance and Protective Responses by Skin Tissue-Resident Memory T Cells"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmWendy Garrett (Harvard University)
"Microbial Metabolites and Gut Immune Homeostasis"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmHuman Immunobiology
Discussion Leader: Rafi Ahmed (Emory University)
9:00 am - 9:25 amRafi Ahmed (Emory University)
"Immune Memory to Vaccines"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amAlex Sigal (Max Planck Institute of Infection Biology & University of KwaZulu-Natal, S.Africa)
"Determinants of Mycobacterium tuberculosis Control in Macrophages"
9:45 am - 9:50 amDiscussion
9:50 am - 10:00 amZaza Ndhlovu (Harvard University & Nelson Mandela School of Medicine, KwaZulu-Natal)
"T Cell Immunity in Acute HIV Subtype C Infection, Implications for the Development of an Effective AIDS Vaccine"
10:00 am - 10:05 amDiscussion
10:05 amCoffee Break
10:30 am - 11:00 amDanny Douek (National Institutes of Health, Bethesda)
"Type I Interferon Signaling in SIV Infection"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amAntonio Lanzavecchia (Institute for Biomedical Research, Bellinzona)
"Affinity Maturation of Broadly Neutralizing Antibodies"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmMark Davis (Stanford U., California)
"Immunology for the People: Studying the Immune System as a 'System'"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmImmunity in the Very Young
Discussion Leader: Juan Carlos Zuniga-Pflucker (University of Toronto)
7:30 pm - 8:00 pmTrevor Burt (University of California, San Francisco)
"Human Fetal T Cell Development and Its Impact on Neonatal Immune Function"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmJuan Carlos Zuniga-Pflucker (University of Toronto)
"In Vitro Model of Human T Cell Development for Primary Immune Deficiencies"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmDeena Gibbons (King's College London)
"Interleukin-8 (CXCL8) Production is a Signatory T Cell Effector Function of Human Newborn Infants"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmArnaud Marchant (Institute of Medical Immunology, Free University of Brussels)
"Anti-Viral Immunity During Fetal Life"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmThe Mechanisms of Cytokine Action
Discussion Leader: Fiona Powrie (Oxford University)
9:00 am - 9:25 amFiona Powrie (Oxford University)
"Gut Reactions: Immune Pathways in the Intestine in Health and Disease"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amHeather Pua (UCSF)
"Coordinate Regulation of Th2 Cell IL-4 Production by miR-23 Cluster miRNAs"
9:45 am - 9:50 amDiscussion
9:50 am - 10:00 amMarie Wehenkel (St Jude's Children's Research Hospital)
"Erk2 is a Critical Regulator of Spontaneous Osteochondromas"
10:00 am - 10:05 amDiscussion
10:05 amCoffee Break
10:30 am - 11:00 amHergen Spits (University of Amsterdam)
"Regulation of Cytokine Production by Human Innate Lymphoid Cell Subsets"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amJose-Carlos Gutierrez-Ramos (Pfizer)
"Novel Human Pharmacology and Clinical Immunology Revealed Through Differential Inhibition of JAK Pathway Kinases"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmAjay Chawla (University of California, San Francisco)
"Type 2 Immunity and Metabolism"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmTumor Immunology
Discussion Leader: Padmanee Sharma (MD Anderson Cancer Centre, Texas)
5:30 pm - 6:00 pmJim Allison (MD Anderson Cancer Centre, Texas)
"Immune Checkpoint Blockade in Cancer Therapy: New Insights and Opportunities"
6:00 pm - 6:10 pmDiscussion
6:10 pm - 6:35 pmPadmanee Sharma (MD Anderson Centre, Texas)
"Anti-CTLA-4 and Anti-PD-1/PD-L1 Therapies: Clinical Data and Immune Monitoring Results"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 6:55 pmRobert Johnston (Genentech)
"TIGIT Inhibits CD8+ T Cell Effector Function During Chronic Viral Infection and Cancer"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmKai Wucherpfennig (Dana Farber Cancer Center, Harvard)
"In Vivo Discovery of Novel Targets for Immunotherapy"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI112169-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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