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Conference Program
 
Lipoprotein Metabolism
Molecular Mechanisms in Physiology and Disease
June 15-20, 2014
Waterville Valley Resort
Waterville Valley, NH

Related Meeting Information
The Lipoprotein Metabolism Gordon Research Conference was held in conjunction with the Lipoprotein Metabolism Gordon Research Seminar. Please refer to the Lipoprotein Metabolism GRS web page for more information.

The Gordon Research Conference on Lipoprotein Metabolism is one of the longest standing conferences in the 80-year history of the GRC. The scientific content of our conference has continually evolved since the first meeting and, traditionally, is considered the preeminent forum in our discipline for the presentation of high impact leading edge science. The program for the 2014 Conference on Lipoprotein Metabolism will communicate new and exciting advances in the field and will bring together a range of established investigators, new investigators, and trainees from around the world to present and discuss a spectrum of topics related to new developments in lipid and lipoprotein metabolism, particularly in those areas that impact upon human disease. Basic molecular and cell biological studies, animal models of metabolism, and genetic studies in humans will be presented. Topics include lipases, hepatic and intestinal lipid metabolism, HDL and reverse cholesterol transport, lipoprotein receptors and the vascular wall, CNS lipid metabolism, intracellular lipid metabolism and lipid droplets, genetics of lipid and lipoprotein metabolism, and therapeutics of lipid and cardiovascular disease. In addition to outstanding leading-edge lectures and discussion, poster presentations represent an integral part of the scientific program. There will be a keynote speaker, and additional Oral Session presentations will be selected from among submitted abstracts.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:20 pm - 7:25 pmWelcome / Introductory Comments by GRC Site Staff
7:25 pm - 7:35 pmWelcome Address by Chairs Robert V. Farese, Jr. (Gladstone/UCSF) and Joachim J. Herz (UTSW)
7:35 pm - 9:30 pmLipases
Discussion Leader: Rudolf Zechner (University of Graz, Austria)
7:35 pm - 8:05 pmRudolf Zechner (University of Graz, Austria)
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmPerry Bickel (UTSW)
"A Lipid Droplet Protein Doubles as a Transcriptional Coregulator of Mitochondrial Function"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:15 pmJorge Plutzky (Harvard)
"Programmatic Control of Gene Expression in Metabolism and Inflammation"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHepatic and Intestinal Lipid Metabolism
Discussion Leader: Jay Horton (UTSW)
9:00 am - 9:30 amJay Horton (UTSW)
"Post-Transcriptional Regulation of Fatty Acid Synthesis"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amSteven Kliewer (UTSW)
"Physiology and Pharmacology of Metabolic Hormone FGF21"
10:15 am - 10:30 amDiscussion
10:30 amGroup Photo / Coffee Break
10:50 am - 11:20 amCarlos Fernandez-Hernando (Yale)
"Identification of Novel Regulators of LDL Receptor Pathway Using Genome-Wide RNAi Cellular Screens"
11:20 am - 11:35 amDiscussion
11:35 am - 12:05 pmChih-Hao Lee (Harvard)
"Hepatic Control of Peripheral Lipid Metabolism"
12:05 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmHDL and Reverse Cholesterol Transport
Discussion Leader: Peter Edwards (UCLA)
7:30 pm - 8:00 pmThomas Vallim (UCLA)
"Transcriptional Control of Cholesterol Catabolism"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMark Brown (Cleveland Clinic)
"Novel Mechanisms Regulating Non-Biliary Reverse Cholesterol Transport"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmMarina Cuchel (University Pennsylvania)
"Assessing In Vivo Reverse Cholesterol Transport: From Mice to Humans"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLipoprotein Receptors, Inflammation, and the Vascular Wall
Discussion Leader: Joachim Herz (UTSW)
9:00 am - 9:30 amIra Tabas (Columbia)
"Receptor-Mediated Pathways of Inflammation Resolution in Atherosclerosis"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amPhilippe Boucher (University of Strasbourg)
"An LRP1/Wnt Signaling Pathway for Intracellular Cholesterol Homeostasis"
10:15 am - 10:30 amDiscussion
10:30 amCoffee Break
10:50 am - 11:20 amPhilip Shaul (UTSW)
"Endothelial Cell Biology of LRP8/ApoER2"
11:20 am - 11:35 amDiscussion
11:35 am - 12:05 pmAndreas Niemeier (University of Hamburg)
"Emerging Functions of Lipoprotein Receptors and Apolipoprotein E in the Skeleton"
12:05 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCNS and Lipids
Discussion Leader: Cheryl Wellington (University of British Columbia)
7:30 pm - 8:00 pmCheryl Wellington (University of British Columbia)
"HDL in the Central Nervous System: More than apoE"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmDavid Holtzman (Washington U.)
"Potential Role of apoE in Both Amyloid-Beta and Tau Metabolism In Vivo"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmEmily Osterweil (University Edinburgh)
"Lovastatin for the Treatment of Neurodevelopmental Disorders"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIntracellular Lipid Metabolism
Discussion Leader: Tobias Walther (Yale)
9:00 am - 9:30 amTobias Walther (Yale)
"Mechanisms of Intracellular Lipid Storage in Droplets"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amPeng Li (Tsinghua U.)
"Control of Lipid Droplet Fusion by CIDE Proteins"
10:15 am - 10:30 amDiscussion
10:30 amCoffee Break
10:50 am - 11:20 amAnders Naar (Harvard)
"MicroRNA Regulation of Cholesterol/Lipid and Energy Homeostasis"
11:20 am - 11:35 amDiscussion
11:35 am - 12:05 pmJin Ye (UTSW)
"Lipid Metabolism in Cancer Development and Treatment"
12:05 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmShort Talks / Keynote Talk on Lipid and Lipoprotein Metabolism
Discussion Leader: Robert V. Farese, Jr. (Gladstone/UCSF)
7:30 pm - 7:40 pmShort Talk: Amnon Schlegel (University Utah)
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmRyan Temel (University of Kentucky)
"Species-Specific Regulation of Plasma LDL Levels by the LXR-Idol Pathway"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmAbigail Haka (Weill Cornell Medical College)
"TLR4 Signaling Regulates a Novel Form of Aggregated LDL Endocytosis"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 9:15 pmKeynote: Dan Rader (University Penn)
9:15 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenetics of Lipid and Lipoprotein Metabolism
Discussion Leader: Daniel Rader (University Pennsylvania)
9:00 am - 9:30 amJake Lusis (UCLA)
"Systems Genetics of Lipoproteins"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amAlan Shuldiner (University Maryland)
"Genomics of Lipoprotein Metabolism: Lessons from a Founder Population"
10:15 am - 10:30 amDiscussion
10:30 amCoffee Break
10:50 am - 11:20 amKaren Reue (UCLA)
"Molecular Basis of Lipin-Related Diseases"
11:20 am - 11:35 amDiscussion
11:35 am - 12:05 pmSekar Kathiresan (Harvard)
"Impact of Human Gene Knockouts on Lipoproteins and Risk for Myocardial Infarction"
12:05 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTherapeutics of Lipid and Cardiovascular Disease
Discussion Leader: Stephen Previs (Merck)
7:30 pm - 7:50 pmAlan Remaley (NIH)
"Recombinant Lecithin:Cholesterol Acyltransferase for the Treatment of Familial LCAT Deficiency and Cardiovascular Disease"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmRosanne Crooke (Isis)
"Targeting Cardiovascular Risk Factors with Second Generation Antisense Oligonucleotides"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmAmy Simon (Alnylam)
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmDebora Keefe (Novartis)
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13HL123268-01A1 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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