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Conference Program
 
Molecular Mechanisms in Lymphatic Function & Disease
State-of-the-Art in Lymphatic Research and Biology
March 9-14, 2014
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy

Related Meeting Information
The Molecular Mechanisms in Lymphatic Function & Disease Gordon Research Conference was held in conjunction with the Molecular Mechanisms in Lymphatic Function & Disease Gordon-Merck Research Seminar. Please refer to the Molecular Mechanisms in Lymphatic Function & Disease GMRS web page for more information.

Lymphatic vessels are traditionally considered as transporters of fluid, solutes, lipids, and cells from peripheral tissues to lymph nodes and back to the blood circulation, and their dysfunction can lead to lymphedema. However, a renaissance of lymphatic research in the last decade has not only deepened our understanding of the molecular and biomechanical mechanisms underlying lymphatic development and function, but has also enabled us to appreciate the scope of influence that lymphatic vessels wield in many other physiological and pathophysiological processes including metabolism, inflammation, immunity, and tissue repair and remodeling, among others. For example, lymphangiogenesis has been associated with nearly all acute and chronic inflammatory processes, and the last few years have brought to light completely new roles for both lymphatic endothelial cells and their drainage functions in directly modulating adaptive immunity. The potential roles of lymphatic vessels in metabolism continues to intrigue as an increasing number of collaborations have been revealed between lymphatic vessels and adipocytes, and the cross-talk between lymphatic endothelial cells and other stromal cells (particularly in lymph stasis and fibrosis) is being revealed. The importance of biomechanical forces in lymphatic development and function are being discovered. And of course, our increasing awareness yields more questions that are currently being addresses in many research labs, such as:

  • Does lymphangiogenesis have negative or positive consequences for resolving inflammation? Should potential therapeutic targets for chronic inflammatory diseases aim to block, or promote lymphangiogenesis?
  • What are the functional consequences of lymph node lymphangiogenesis and how does it affect immunity?
  • Are there different developmental cues for the lymphatic vasculature in different organs?
  • How do lymphatic endothelial cells sense and modulate their biomechanical environment?
  • What is the relationship between lymphatic function and autoimmunity?
  • How do inflammatory cells participate in lymphangiogenesis, and how do lymphatics affect leukocyte functions?
  • How does lymphangiogenesis affect transplant rejection?
  • How do lymphatic vessels contribute to metabolism?
  • What is the relationship between adipogenesis and lymphatic function?
  • Does lymphatic function or dysfunction contribute to interstitial changes like fibrosis?
  • Do lymphatic endothelial cells actively modulate or respond to lymph composition?
  • Can strategies be designed to modulate lymphatic function?

The 2014 Gordon Conference on Molecular Mechanisms in Lymphatic Function and Disease will address these questions from a variety of perspectives, bringing together an outstanding and diverse group of basic and translational scientists at the forefront of their respective fields and including younger scientists and students as well. Its format will attempt to reflect our ever-growing appreciation of how lymphatic vessels contribute to an increasing number of homeostatic and disease processes, and continue to help bridge lymphatic biology and physiology with a number of related fields from angiogenesis and tumor metastasis to adipogenesis and immunity.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmConsequences of Lymphatic Dysfunction
7:40 pm - 7:50 pmDiscussion Leader: TBA
"Introduction"
7:50 pm - 8:10 pmPeter Mortimer (University of London, UK)
"Mechanisms of Lymphatic Dysfunction in Genotyped Human Lymphoedema"
8:10 pm - 8:18 pmDiscussion
8:18 pm - 8:38 pmMichael Davis (University Missouri, Columbus, USA)
"Unexpected Consequences of Lymphatic Valve Dysfunction for Lymphatic Pumping"
8:38 pm - 8:46 pmDiscussion
8:46 pm - 9:06 pmDavid Zawieja (Texas A&M University, Temple, USA)
"Lymphatic Dysfunction and Inflammation"
9:06 pm - 9:14 pmDiscussion
9:14 pm - 9:22 pmMichael Jeltsch (Wilhuri Research Institute, Helsinki, FI)
"The Molecular Basis of Hennekam Syndrome"
9:22 pm - 9:26 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLymphatic Function and Homeostasis
Discussion Leader: Melody Swartz (Ecole Polytechnique Fédérale de Lausanne, Switzerland)
"Introduction"
9:00 am - 9:20 amKari Alitalo (University of Helsinki, Finland)
"Lymphangiogenesis: Novel Insights to Basic Mechanisms"
9:20 am - 9:28 amDiscussion
9:28 am - 9:48 amJens Titze (Vanderbilt University, Nashville, USA)
"Lymph Vessels and Immune Cells Control Skin Electrolyte Composition and Blood Pressure"
9:48 am - 9:56 amDiscussion
9:56 am - 10:04 amBrian Wong (Vesalius Research Center, Leuven, Belgium)
"Fatty Acid Beta-Oxidation is Required for Lymphatic Endothelial Cell Differentiation and Function"
10:04 am - 10:08 amDiscussion
10:08 am - 10:16 amLeonid Nikitenko (University of Oxford, UK)
"Adrenomedullin Haploinsufficiency Predisposes to Secondary Lymphedema"
10:16 am - 10:20 amDiscussion
10:20 amCoffee Break
10:50 am - 11:10 amDaniela Negrini (University of Insubria, Italy)
"Lymphatic Microvasculature in Thoracic Tissues: Structure, Function and Modulation"
11:10 am - 11:18 amDiscussion
11:18 am - 11:38 amMichael Detmar (ETH, Zürich, Switzerland)
"Strategies to Modulate and Quantify Lymphatic Function"
11:38 am - 11:46 amDiscussion
11:46 am - 12:06 pmHelge Wiig (University of Bergen, Norway)
"Role of the Skin Interstitium and Lymphatics in Fluid Volume Regulation"
12:06 pm - 12:14 pmDiscussion
12:14 pm - 12:24 pmBrandon Dixon (Georgia Institute of Technology, Atlanta, USA)
"In Vivo Quantification of Perturbations to Lymphatic Pump Function and Their Consequence to Lymph Transport"
12:24 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session I
6:00 pm - 8:00 pmLymphatics in Metabolism and Lipid Regulation
Discussion Leader: Guillermo Oliver (St. Jude's Children's Hospital, Memphis, TN)
"Introduction"
6:00 pm - 6:20 pmGwendalyn Randolph (Washington University, St. Louis, USA)
"Chronic Inflammatory Disease, Lipid Transport, and Lymphatic Transport"
6:20 pm - 6:28 pmDiscussion
6:28 pm - 6:48 pmPatrick Tso (University of Cincinnati, OH, USA)
"Studying Intestinal Incretin Secretion and Function Using the Intestinal Lymph Fistula Model"
6:48 pm - 6:56 pmDiscussion
6:56 pm - 7:16 pmMariappan Muthuchamy (Texas A&M University, College Station, USA)
"Roles of Mesenteric Lymphatics in Metabolic Syndrome and Inflammation"
7:16 pm - 7:24 pmDiscussion
7:24 pm - 7:44 pmVéronique Angeli (National University of Singapore)
"Is Cholesterol a Friend or Foe of Lymphatic Vessels?"
7:44 pm - 7:52 pmDiscussion
7:52 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmLymphatics in Inflammation
Discussion Leader: Nancy Ruddle (Yale University, New Haven, USA)
"Introduction"
9:00 am - 9:20 amDontscho Kerjaschki (Medical University Vienna, Austria)
"Podoplanin, PDGF and Pericytes"
9:20 am - 9:28 amDiscussion
9:28 am - 9:48 amGerald Graham (University of Glasgow, UK)
"Roles for Chemokine Scavenger Receptor D6 in Lymphatic Vessel Function"
9:48 am - 9:56 amDiscussion
9:56 am - 10:04 amJoshua Scallan (University of Missouri, Columbia, USA)
"Lymphatic Vascular Integrity is Disrupted in Diabetes: Dual Roles for Nitric Oxide"
10:04 am - 10:08 amDiscussion
10:08 am - 10:16 amBabak Mehrara (Memorial Sloan-Kettering Cancer Center, New York, USA)
"CD4+ Cells are Key Regulators of Pathologic Changes in Lymphedema"
10:16 am - 10:20 amDiscussion
10:20 amCoffee Break
10:50 am - 11:10 amAnatoliy Gashev (Texas A&M University, College Station, USA)
"Aging of Lymphatic Vessels: Novel Role of Endothelium-Derived Histamine and Mast Cells Located by Lymphatic Vessels"
11:10 am - 11:18 amDiscussion
11:18 am - 11:38 amClaus Cursiefen (University of Cologne, Germany)
"Regression of Lymphatic Vessels Prior to Transplantation to Promote Corneal Graft Survival"
11:38 am - 11:46 amDiscussion
11:46 am - 12:06 pmLaura Santambrogio (Albert Einstein College of Medicine, New York, USA)
"Carrying Yourself: Self-Antigen Composition of the Lymphatic Fluid"
12:06 pm - 12:14 pmDiscussion
12:14 pm - 12:24 pmJeremy Goldman (Michigan Technological University, Houghton, MI USA)
"Wound Site Fibrosis Worsens Lymphedema in Both Acute and Chronic Animal Models"
12:24 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session I
6:00 pm - 8:00 pmLymphatics in Immunity
Discussion Leader: Mike Carroll (Harvard Medical School, Boston, MA)
"Introduction"
6:00 pm - 6:20 pmRonald Germain (National Institute of Allergy and Infectious Diseases, Bethesda, USA)
"Relating Tissue Organization and Cell Dynamics to Immune Function Using Advanced Optical Imaging Methods"
6:20 pm - 6:28 pmDiscussion
6:28 pm - 6:48 pmStéphanie Hugues (University of Geneva, Switzerland)
"Lymph Node Stromal Cells and CD4+ T Cell Tolerence"
6:48 pm - 6:56 pmDiscussion
6:56 pm - 7:16 pmVictor Engelhard (University of Virginia, Charlottesville, USA)
"Modulation of Immune Responses by Subsets of Lymphatic Endothelial Cells"
7:16 pm - 7:24 pmDiscussion
7:24 pm - 7:32 pmEfthymia Vokali (Ecole Polytechnique Fédérale de Lausanne, Switzerland)
"Antigen Presentation by Lymphatic Endothelial Cells in Inflammation"
7:32 pm - 7:36 pmDiscussion
7:36 pm - 7:44 pmEchoe Bouta (University of Rochester, NY USA)
"Amelioration of Inflammatory Arthritis by Anti-TNF Therapy is Associated with Restoration of Lymphatic Contraction"
7:44 pm - 7:48 pmDiscussion
7:48 pm - 7:56 pmJonathan Sleeman (University of Heidelberg, Germany)
"Small Hyaluronan Oligosaccharides: Novel Regulators of Lymphangiogenesis and Metastasis"
7:56 pm - 8:00 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMechanisms of Leukocyte and Pathogen Entry in to Lymphatics
Discussion Leader: Donald McDonald (University of California, San Francisco, USA)
"Introduction"
9:00 am - 9:20 amReinhold Förster (Hannover Medical School, Germany)
"Lymph Node Homing of Immune Cells via Afferent Lymphatics"
9:20 am - 9:28 amDiscussion
9:28 am - 9:48 amGou-Young Koh (Korean Advanced Institute of Science and Technology, Seoul, Korea)
"Interactions Between Macrophages and Lymphatric Vessels in Extra- and Intra-Nodal Tissues"
9:48 am - 9:56 amDiscussion
9:56 am - 10:04 amAlanna Ruddell (University of Washington, Seattle USA)
"Rapid Activation of Lymph Node Lymphangiogenesis"
10:04 am - 10:08 amDiscussion
10:08 am - 10:16 amFumiko Itoh (Tokyo University of Pharmacy and Life Sciences, Japan)
"TGF-β Signaling Regulates Lymphangiogenesis In Vivo"
10:16 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:10 amDavid Jackson (University of Oxford, UK)
"Roles of LYVE-1 and Hyaluronan in Lymphatic Trafficking"
11:10 am - 11:18 amDiscussion
11:18 am - 11:38 amCoralie Martin (INSERM, Paris, France)
"Mechanisms of Filarial Larvae Entry into Lymphatics"
11:38 am - 11:46 amDiscussion
11:46 am - 12:06 pmCornelia Halin-Winter (ETH Zürich, Switzerland)
"Leukocyte Interactions with Lymphatic Endothelium"
12:06 pm - 12:14 pmDiscussion
12:14 pm - 12:26 pmCaname Iwata (University of Tokyo, Japan)
"Surface Expression of Podoplanin/Aggrus on Haptokinetic Scaffolds Positively Regulates Adhesive Migration of T Lymphocytes"
12:26 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session II
6:00 pm - 8:00 pmLymphatics in Cancer
Discussion Leader: Bronek Pytowski (imClone/Lilly, New York, USA)
"Introduction"
6:00 pm - 6:20 pmTimothy Padera (Harvard Medical School, Boston, USA)
"Imaging the Growth of Lymphatic Metastases"
6:20 pm - 6:28 pmDiscussion
6:28 pm - 6:48 pmMarc Achen (Peter MacCallum Cancer Centre, Melbourne, Australia)
"Molecular Control of Lymphangiogenesis in Cancer"
6:48 pm - 6:56 pmDiscussion
6:56 pm - 7:16 pmMihaela Skobe (Mt. Sinai School of Medicine, New York, USA)
"Lymphatic Vessel Microenvironment and Metastasis"
7:16 pm - 7:24 pmDiscussion
7:24 pm - 7:32 pmSophia Ran (Southern Illinois University School of Medicine, Springfield, USA)
"Self-Autonomous Role of Tumor Macrophages in Breast Cancer Lymphangiogenesis"
7:32 pm - 7:36 pmDiscussion
7:36 pm - 7:44 pmTraci Lyons (University of Colorado Anschutz Medical Campus, Aurora USA)
"Increased Lymphangiogenesis Associated with Postpartum Mammary Tumors is Driven by COX-2"
7:44 pm - 7:48 pmDiscussion
7:48 pm - 7:56 pmTetsuro Watabe (Tokyo University of Pharmacy and Life Sciences, Japan)
"BMP-9/ALK-1 Signals Negatively Regulate Lymphatic Vessel Formation During Development and Cancer Progression Through Down-Regulation of Prox1 Expression"
7:56 pm - 8:00 pmDiscussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmMolecular Regulators of Lymphangiogenesis
Discussion Leader: Mark Kahn (University of Pennsylvania, Philadelphia, USA)
"Introduction"
9:00 am - 9:20 amMinhong Yan (Genentech, San Francisco, USA)
"BMP, Notch and Eph Signaling in Lymphatic Development"
9:20 am - 9:28 amDiscussion
9:28 am - 9:48 amNatasha Harvey (Center for Cancer Biology, Adelaide, Australia)
"Development Mechanisms of Lymphangiogenesis"
9:48 am - 9:56 amDiscussion
9:56 am - 10:04 amJames Moore (Imperial College, London, UK)
"Biomechanical Investigations for Lymphatic Physiology"
10:04 am - 10:08 amDiscussion
10:08 am - 10:16 amPhilip King (University of Michigan Medical School, Ann Arbor, USA)
"Understanding the Pathophysiology of Lymphatic and Blood Vessel Abnormalities in CM-AVM"
10:16 am - 10:20 amDiscussion
10:20 amCoffee Break
10:50 am - 11:10 amGuillermo Oliver (St. Jude's Children's Hospital, Memphis, USA)
"Characterization of the Early Steps in Mammalian LEC Specification"
11:10 am - 11:18 amDiscussion
11:18 am - 11:38 amKathleen Caron (University of North Carolina, Chapel Hill, USA)
"Decoy Receptors in Lymphangiogenesis"
11:38 am - 11:46 amDiscussion
11:46 am - 12:06 pmMasataka Majima (Kitasato University, Kitasato, Japan)
"Prostanoids as Regulators of Pathological Lymphangiogenesis"
12:06 pm - 12:14 pmDiscussion
12:14 pm - 12:26 pmRene Haegerling (Max Planck Institute for Molecular Biomedicine, Muenster, Germany)
"The Role of the Rho Guanine Exchange Factor Beta-Pix in Lymphatic Development"
12:26 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session II
6:00 pm - 8:00 pmLymphatic Vessel Morphogenesis
Discussion Leader: Alanna Ruddell (University of Washington, Seattle, USA)
6:00 pm - 6:20 pmTatiana Petrova (University of Lausanne, Switzerland)
"Transcriptional Mechanisms of Lymphatic Vascular Remodeling and Maintenance"
6:20 pm - 6:28 pmDiscussion
6:28 pm - 6:48 pmMark Kahn (University of Pennsylvania, Philadelphia, USA)
"Signaling Mechanisms in Lymphatic Development"
6:48 pm - 6:56 pmDiscussion
6:56 pm - 7:16 pmTaija Mäkinen (University of Uppsala, Sweden)
"Organ-Specific Mechanisms of Lymphatic Vascular Morphogenesis"
7:16 pm - 7:24 pmDiscussion
7:24 pm - 7:32 pmDörte Schulte (Hubrecht Institute, Utrecht, Netherlands)
"CCBE1 - A Critical Regulator of Mature VEGFC Bioavailability"
7:32 pm - 7:36 pmDiscussion
7:36 pm - 7:44 pmTsutomu Kume (Northwestern University, Chicago, IL USA)
"Foxc1 and Foxc2 are Required for Lymphangiogenesis During Embryonic Development"
7:44 pm - 7:48 pmDiscussion
7:48 pm - 7:56 pmDaniel Vittet (INSERM, Grenoble, France)
"BMP9 Signaling is Crucial for Normal Lymphatic Vessel Maturation and Valve Formation"
7:56 pm - 8:00 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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