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Conference Program
 
Musculoskeletal Biology & Bioengineering
Identifying and Overcoming Barriers to Translation
August 3-8, 2014
Proctor Academy
Andover, NH

Related Meeting Information
The Musculoskeletal Biology & Bioengineering Gordon Research Conference was held in conjunction with the Musculoskeletal Biology & Bioengineering Gordon-Merck Research Seminar. Please refer to the Musculoskeletal Biology & Bioengineering GMRS web page for more information.

In recent years there has been a major drive to translate research findings into clinically useful products and procedures. The establishment of the journal Science Translational Medicine (launched 2009) and NIH’s National Center for Advancing Translational Sciences (NCATS; established December, 2011) bear witness to this. Despite such encouragement, translating musculoskeletal research findings into the clinic has been slow and difficult. More generally, it is now widely acknowledged that translation is much more difficult than was originally thought.

Bearing this in kind, the theme of the 2014 GRC in Musculoskeletal Biology and Bioengineering is "Identifying and Overcoming Barriers to Translation". The aim is to bring together individuals from academia, industry, government, non-profits and the clinical arena to address the issue of research translation as it applies to the musculoskeletal system. This exchange of information should facilitate and accelerate the translational activities of the orthopaedic community and beyond.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmIntroductory Comments by GRC Site Staff
7:40 pm - 7:55 pmWelcome Remarks by Chris Evans (Mayo Clinic)
7:55 pm - 9:30 pmThe Research Translation Landscape
Discussion Leader: Peter Johnson (Avery Dennison)
7:55 pm - 8:30 pmCheryl Blanchard (Blanchard Consulting)
"Translating from the Lab to the Patient"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmMichael Dunn (Rutgers University)
"An Academic Perspective of Translation Research"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGetting Stem Cells into the Clinic
Discussion Leader: George Muschler (Cleveland Clinic)
9:00 am - 9:25 amMalcolm Moos (FDA)
"Cell Identity - Nomenclature and Metrics"
9:25 am - 9:40 amDiscussion
9:40 am - 9:50 amSeán Gaynard (University of Galway)
"Effect of Hypoxia on Growth Kinetics and Differentiation of MSCs Cultured in a Novel Serum/Xeno-Free Culture System"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amGeorge Muschler (Cleveland Clinic)
"Clinical Barriers"
10:55 am - 11:10 amDiscussion
11:10 am - 11:20 amSharon Ansboro (University of Galway)
"Tracking the Fate of Mesenchyme Progenitor Cells (MPC) Following Intra-Articular Injection in a Post-Traumatic OA Mouse Model"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amAlan Davis (Baylor College of Medicine)
"Heterotopic Bone Is Derived in Large Part from Progenitors in Local Peripheral Nerves: Major Difficulties in Animal Models for BMP2 Testing"
11:40 am - 11:50 amDiscussion
11:50 am - 12:15 pmRobert Deans (Athersys)
"Industry Perspective"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmOsteoarthritis
Discussion Leader: Virginia Kraus (Duke Medical School)
7:30 pm - 7:55 pmVirginia Kraus (Duke Medical School)
"Biomarkers"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmSharmila Majundar (University California, San Francisco)
"Quantitative Imaging in OA: Going Beyond Single Site Studies"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmFrank Barry (NUI Galway, IE)
"Mesenchymal Stem Cells"
9:15 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmLigament/Tendon/Muscle
Discussion Leader: Lisa Larkin (University of Michigan)
9:00 am - 9:25 amLisa Larkin (University of Michigan)
"Engineering Ligaments"
9:25 am - 9:40 amDiscussion
9:40 am - 9:50 amBrian Syverud (University of Michigan)
"Engineered Skeletal Muscle Units for Repair of Volumetric Muscle Loss in the Tibialis Anterior Muscle of a Rat"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amAnthony Ratcliffe (Synthasome)
"Tendon and Ligament Repair and Replacement: Transition from Translation to Commercialization"
10:55 am - 11:10 amDiscussion
11:10 am - 11:35 amJohnny Huard (University of Pittsburgh)
"Muscle Derived Stem Cells"
11:35 am - 11:50 amDiscussion
11:50 am - 12:15 pmMaurizio Pacifici (University of Pennsylvania)
"Drug Repurposing for the Treatment of Fibrodysplasia Ossificans Progressiva"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGene Therapy
Discussion Leader: Paul Robbins (Scripps Research Institute)
7:30 pm - 7:55 pmJay Lieberman (University of Southern California)
"Regional Gene Therapy for Bone Repair"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmSteven Ghivizzani (University of Florida)
"AAV Mediated IL-1Ra Gene Delivery to the Equine OA Joint: Pharmocokinetics and Efficacy"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmHenning Madry (University of Saarland, DE)
"Gene Therapy for Cartilage Defects"
9:15 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBone
Discussion Leader: Edward Schwarz (University of Rochester)
9:00 am - 9:25 amJoost de Bruijn (University of Twente, NL)
"Bone Repair Using Instructive Materials"
9:25 am - 9:40 amDiscussion
9:40 am - 9:50 amAnne Gingery (Mayo Clinic)
"TIEG Suppresses SOST Expression and Mediates the Skeletal Response to Sclerostin Antibody Therapy"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amSheldon Lin (Rutgers Medical School)
"rhPDGF: Animal Studies to Clinical FDA Trials"
10:55 am - 11:10 amDiscussion
11:10 am - 11:35 amIvan Martin (University of Basle, CH)
"Engineering Developmental Processes for Bone Repair"
11:35 am - 11:50 amDiscussion
11:50 am - 12:15 pmRobert Guldberg (Georgia Institute of Technology)
"Vascularization Strategies for Bone Regeneration"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMeniscus and Cartilage
Discussion Leader: Robert Mauck (University of Pennsylvania)
7:30 pm - 7:55 pmSuzanne Maher (Hospital for Special Surgery)
"Predicting the Clinical Performance of Meniscal Substitutes"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmMartin Englund (Lund, SE)
"The Meniscal Pathway to Knee Osteoarthritis"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmJeremy Mao (Columbia University)
"Meniscus Injury and Repair: Cell Differentiation in 3D Printed Scaffolds"
9:15 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmCreating a Translational Research Environment
Discussion Leader: Cyril Frank (University of Calgary)
9:00 am - 9:25 amMartin Stoddart (AO Research Institue, Davos, CH)
"AO Research Institute Davos Within the AO Foundation: A Model for Translation of Science to the Clinics"
9:25 am - 9:40 amDiscussion
9:40 am - 9:50 amElizabeth Balmayor (Technical University of Munich)
"Chemically Modified Messenger RNA as an Alternative for Non-Viral Gene Therapy"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amAndrew Carr (Oxford University)
"Translational Research in Musculoskeletal Disease - The Oxford Model"
10:55 am - 11:10 amDiscussion
11:10 am - 11:35 amKelly LaMarco (Science Translational Medicine)
"Biomedical Translation: Minding the Gaps"
11:35 am - 11:50 amDiscussion
11:50 am - 12:15 pmPeter Amadio (Mayo Clinic)
"The Mayo Model"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session
Discussion Leader: Chris Evans (Mayo Clinic)
7:30 pm - 8:30 pmPeter Johnson (Avery Dennison)
"Strategies and Requirements for Successful Research Translation"
8:30 pm - 9:00 pmDiscussion
9:00 pm - 9:30 pmGeneral Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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