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Notch Signaling in Development, Regeneration & Disease
Gordon Research Conference

Notch at the Interface of Health and Disease

Dates

July 20-25, 2014

Location

Bates College
Lewiston, ME

Organizers

Chair:
Alain Israel

Vice Chairs:
Warren Pear & Stephen Blacklow

Meeting Description

The 2014 Gordon Research Conference on "Notch Signaling in Development, Regeneration & Disease" will provide a stimulating forum for the dissemination and discussion of new research, concepts and therapeutic opportunities at the forefront of Notch related biology. The Notch signaling pathway is a central mediator of short-range inter-cellular communication in metazoans, under study since 1914 in Drosophila, and in all other model organisms since the 1980s. Alterations in Notch activity underlie or contribute to a growing list of developmental syndroms (Alagille, Spondylocostal Dysostosis, aortic valve disease), adult onset diseases (CADASIL, Alzheimer's disease, various heart and valve malformations, muscular dystrophy, multiple sclerosis) and cancers, expanding the interest in this pathway well beyond scientists interested in developmental and cell biology to those interested in stem cells, cancer biology and therapy. The meeting will include sessions on mechanistic aspects of Notch regulation, stem cells and development, immunology, cancer and therapeutics, and structure of Notch components. The meeting will bring together a diverse community of scientists from academia, biotech and the pharmaceutical industry who are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Some poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an optimum environment for productive interactions. Importantly, a Gordon Research Seminar will precede the meeting, providing students and postdocs with a forum to discuss current research results and interact with other scientists with similar experience levels and interests in a non-intimidating environment.

Related Meeting

This GRC was held in conjunction with the "Notch Signaling in Development, Regeneration & Disease" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session
Discussion Leader: Alain Israel (Institut Pasteur, France)
7:40 pm - 8:10 pmHans Clevers (Hubrecht Institute, Utrecht, Netherlands)
"Wnt, Notch and Intestinal Stem Cells"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 8:55 pmConstance Cepko (Harvard Medical School)
"Development of the Retina"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMechanistic Aspects of Notch Regulation
Discussion Leader: Alain Israel (Institut Pasteur, Paris, France)
9:00 am - 9:20 amFrançois Schweisguth (Institut Pasteur, Paris, France)
"Real-Time Single-Cell Analysis of Notch in Drosophila"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJames Posakony (UCSD)
"Notch Control of Neural Precursor-Specific Gene Expression"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:40 amTilman Borggrefe (University of Giessen, Germany)
"The Core RBP-J Repressor Complex Containing the Methyltransferase MLL/KMT2D Facilitates Notch Transcriptional Responses"
10:40 am - 10:45 amDiscussion
10:45 am - 11:05 amRaphael Kopan (Cincinatti Children's Hospital)
"Non Canonical Notch Signaling in Skin Homeostasis: Facts and Fiction"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amThomas Klein (Institut für Genetik, Düsseldorf, Germany)
"Lgd Mediated Trafficking of Notch"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmGabrielle Boulianne (Univ of Toronto, Canada)
"Deciphering the Role of Neuralized in Notch Signaling and Beyond"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmBrian McMillan (Harvard Medical School)
"A Tail of Two Sites: A Bipartite Mechanism for Recognition of Notch Ligands by Mind Bomb E3 Ligases"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStem Cells and Development: The Hematopoietic System
Discussion Leader: Lisa Minter (University of Massachusetts, Amherst)
7:30 pm - 7:50 pmAnna Bigas (IMIM, Barcelona, Spain)
"Notch Programming of the Hematopoietic Stem Cell Fate"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmIrwin Bernstein (Fred Hutchinson, Seattle)
"High Notch Signal Strength Renders the Epigenetic Landscape of Hematopoietic Precursors Permissive for T Cell Differentiation"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmRyoichiro Kageyama (Institute for Virus Research, Kyoto, Japan)
"The Significance of Oscillatory Expression of Notch Effectors in Neural Development"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmLan Zhou (Case Western Reserve University, Cleveland)
"Loss of Notch Receptor-Ligand Engagement Leads to Increased Cell Cycling and Hematopoietic Stem and Progenitor Cell Egress"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmAaron Proweller (Case Western Reserve University, Cleveland)
"Notch Ligand-Specific Regulation of Arterial Contractile Function"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNotch Signaling in Tissue Development
Discussion Leader: Irwin Bernstein (Fred Hutchinson, Seattle)
9:00 am - 9:20 amCarl Blobel (Hospital for Special Surgery, New York)
"Role of ADAMs in Notch Signaling During Vascular Development"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amLuisa Iruela-Arispe (UCLA)
"Contribution of Notch1 to Vascular Homeostasis"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amCarmen Birchmeier (Max Delbrück Center, Berlin, Germany)
"Notch Signaling in Muscle Development and Regeneration"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amStacey Rentschler (Washington University in St. Louis)
"Programming and Reprogramming the Cardiac Conduction System"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amJose Luis de la Pompa (CNIC, Madrid, Spain)
"Insights into Notch Signaling in Cardiac Development and Disease"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmMartin Baron (University of Manchester, UK)
"Nutritional Regulation of Notch Signalling in Drosophila"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmMarc Vooijs (Maastricht University, Netherlands)
"Distinct Mechanisms of Regulated Proteolysis Between Mammalian NOTCH Proteins"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmImmunology
Discussion Leader: Warren Pear (University of Pennsylvania)
7:30 pm - 7:50 pmIvan Maillard (University of Michigan, Ann Arbor)
"Notch Signaling in Alloimmunity and Autoimmunity"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJuan-Carlos Zuniga-Pflücker (University of Toronto, Canada)
"T Cell Developmental Outcomes and Insights by Temporally Regulating Notch Responsiveness In Vivo"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmCynthia Guidos (Hospital for Sick Children, Toronto, Canada)
"Notch Signaling Promotes Development of CD4+ CD8+ Precursors into Innate CD4 and CD8 T cells"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmMustafa Turkoz (Cincinnati Children's Hospital)
"RBPJ-Independent, NICD-Dependent Signals in Rbpj-/- Hair Follicle Keratinocytes Cause a Milder Phenotype in RBPjcKO Animals"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmDavid Sprinzak (Tel Aviv University, Israël)
"The Spatiotemporal Dependence of Notch Signaling on Cell-Cell Contact"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShinya Yamamoto (Baylor College of Medicine, Houston)
"Integration of Drosophila Phenotypic Screening and Human Exome Datasets to Identify New Human Disease Genes: Towards Identification of New Notch Signaling Disorders"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCancer and Therapeutics
Discussion Leader: Jon Aster (Brigham and Women's Hospital, Boston)
9:00 am - 9:20 amJon Aster (Brigham and Women's Hospital, Boston)
"Notch Regulation of Gene Expression in Cancer"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAndrew Weng (Terry Fox Lab, Vancouver, Canada)
"Role of Notch in Transformation of Human Hematopoietic Progenitors"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amPaolo Dotto (Univ of Lausanne, Switzerland)
"Notch and CSL in Cancer Fields"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amAdolfo Ferrando (Columbia Univ, New York)
"Targeting Oncogenic NOTCH1 Signaling Networks in Human Leukemia"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amChris Siebel (Genentech)
"Therapeutic Antibodies Targeting Individual Notch Ligands and Receptors"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmSean Egan (Hospital for Sick Children, Toronto, Canada)
"Genetic Analysis of Notch Signalling in Mammary Gland Development and Breast Cancer"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmLate-Breaking Topics
Discussion Leader: Raphael Kopan (Cincinatti Children's Hospital)
7:30 pm - 7:40 pmMarika Sjöqvist (Åbo Akademi University, Finland)
"Atypical PKC Regulates Notch Receptor Routing and Activity in a Notch Signaling-Dependent Manner"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmSusan Cole (Ohio State University)
"Post Translational Processing and Secretion of Lunatic Fringe Regulates Its Activity in the Segmentation Clock"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmTimothy Hoey (OncoMed Pharmaceuticals, CA)
"Development of Novel Notch Signaling Antibodies for the Treatment of Cancer"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmQuan Lu (Harvard School of Public Health)
"Non-Canonical Notch Signaling via Secreted ARMM"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmAndy Minn (University of Pennsylvania)
"Stromal Regulation of Breast Cancer Treatment Resistance by an Exosome-Mediated Anti-Viral Pathway and NOTCH3"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmXiling Shen (Cornell University, NY)
"Unique Notch Dynamics by MicroRNA to Control Cancer Stem Cell Asymmetric Division"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmIannis Aifantis (NYU School of Medicine, New York)
"Visualization of Notch Receptor Expression and Activation in the Immune System"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 9:30 amCancer and Therapeutics (continued)
Discussion Leader: Jon Aster (Brigham and Women's Hospital, Boston)
9:00 am - 9:20 amGavin Thurston (Regeneron)
"Blocking Dll4-Notch Signaling to Modulate Tumor Angiogenesis"
9:20 am - 9:30 amDiscussion
9:30 am - 12:30 pmStructure and Transcription
Discussion Leader: Stephen Blacklow (Harvard Medical School)
9:30 am - 9:50 amSarah Bray (University of Cambridge, UK)
"Decoding the Notch Response"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amSusan Lea (University of Oxford, UK)
"Structural Insights into Binding Partners of Notch Ligands"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amDoug Barrick (Johns Hopkins University, Baltimore)
"Structural and Functional Properties of the Disordered RAM Region of the Notch Receptor"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amNassif Tabaja (University of Cincinatti)
"Structural and Biophysical Characterization of the CSL-RITA Complex, a Novel Mechanism to Regulate Transcription in the Notch Signaling Pathway"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amOrly Reiner (Weizmann Institute of Science, Israël)
"Notch Activation by Shootin1 Opposing Activities on Two Ubiquitin Ligases"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmNadia Carlesso (Indiana University)
"Notch-Dependent Repression of miR-155 in the Bone Marrow Niche Regulates Hematopoiesis in a NF-kappaB Dependent Manner"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmElise Demitrack (University of Michigan)
"Notch Regulates Gastric Antral Lgr5+ Stem Cells to Control Epithelial Cell Homeostasis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 7:45 pmStructure and Transcription (continued)
Discussion Leader: Stephen Blacklow (Harvard Medical School)
7:30 pm - 7:40 pmWendy Gordon (University of Minnesotta)
"Mechanical Allostery: Proteolytic Activation of Notch Induced in the Endocytic Force Regime"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 9:30 pmNotch Regulation by Glycosylation
Discussion Leader: Stephen Blacklow (Harvard Medical School)
7:45 pm - 8:05 pmKenji Matsuno (Osaka University, Japan)
"Monomeric O-Fucose and O-Glucose Modifications Have a Redundant Role in the Folding of Notch"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmRobert Haltiwanger (Stony Brook Univ, NY)
"Regulating Notch by Glycosylation"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmPamela Stanley (Einstein, New York)
"O-Glycans that Regulate Notch Signaling"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmHamed Jafar-Nejad (Baylor College of Medicine, Houston)
"Tissue-Specific Regulation of Mammalian Notch Signaling by Rumi/POGLUT1"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by Grant 1 R13HD080297-01 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices or organizations imply endorsement by the U.S. Government.
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