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Conference Program
 
NOX Family NADPH Oxidases
From NOX Mechanisms to Disease
May 18-23, 2014
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy

Related Meeting Information
The NOX Family NADPH Oxidases Gordon Research Conference was held in conjunction with the NOX Family NADPH Oxidases Gordon Research Seminar. Please refer to the NOX Family NADPH Oxidases GRS web page for more information.

The GRC on NOX Family NADPH Oxidases features cutting-edge unpublished work presented by international experts across the NOX field, and will be preceded for the second time by a NOX Gordon Research Seminar for research trainees, graduate students and post-doctoral fellows. NOX family proteins are now known to be major sources of reactive oxygen species (ROS) in most mammalian cell types as well as in diverse species such as fish and plants. They are highly regulated enzymes that in recent years have been implicated in an extremely wide array of physiological and pathophysiological processes. The science in the field is moving dramatically fast with exciting advances in many areas, from basic biochemistry of the enzymes, dissection of molecular signalling events and cell biology, to the delineation of NOX isoform-specific functions in new in vivo models, human studies and therapeutic development. The 2-yearly NOX GRC is firmly established as the premier forum for the presentation and discussion of the latest advances in the field in a highly collegiate, collaborative and informal atmosphere.

The programme for the 2014 NOX GRC has been developed around the theme "From NOX Mechanisms to Disease". Session topics include NOX biochemistry and structure, a focus on NOX-dependent signalling, non-mammalian NOXs, immune functions of NOXs, and disease-oriented translational topics such as cancer, cardiovascular and central nervous disease. We expect exciting, timely and paradigm-challenging presentations in this accelerating field, with ample time for vigorous discussion after each talk. Poster sessions will be ideal opportunities for more prolonged discussion and the active involvement of earlier career investigators. The programme also allows for the inclusion of novel late-breaking science. Attracting a diverse group of male and female participants is a major priority for the meeting. The accompanying GRS programme features speakers selected from among trainee abstracts, as well as career development components and mentoring by senior scientists. Do not miss these NOX meetings!


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff and Meeting Chair
7:40 pm - 9:30 pmNOX-Dependent Signalling and Molecular Targets
7:40 pm - 7:50 pmDiscussion Leader: Chihiro Yabe-Nishimura (Kyoto Prefectural University of Medicine, Japan)
"Overview"
7:50 pm - 8:15 pmRichard Cohen (Boston University School of Medicine, USA)
"NOX Signalling and SERCA Function"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:45 pmLars Maier (University of Göttingen, Germany)
"NOX2-Dependent Cardiomyocyte Calcium Signalling"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmAlbert Van der Vliet (University of Vermont, USA)
"DUOX1 Signalling in Airway Epithelial Biology and Pathology"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmImmune and Defense Functions of NOXs
9:00 am - 9:10 amDiscussion Leader: Nathalie Grandvaux (Université de Montréal, Canada)
"Overview"
9:10 am - 9:35 amLuigina Romani (University of Perugia, Italy)
"Dendritic Cell Cross-Presentation of Antigens in CGD"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amBrahm Segal (University at Buffalo School of Medicine, USA)
"NOX-Dependent Regulation of Inflammation and Innate Immunity"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amAsma Nusrat (Emory University, USA)
"The Role of FPRs and Nox1 in Regulating Intestinal Mucosal Wound Repair"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amJanice Blum (Indiana University School of Medicine, USA)
"NOX and MHC Class II Ag Presentation by B Cells"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJulie Brault (Universite Joseph Fourier, Grenoble, France)
"Generation of Functional Neutrophils and Macrophages from Patient Specific iPS Cells - Ex Vivo Models of CGD"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmAmelia Hofstetter (Emory University, USA)
"NOX1 as a Therapeutic Target to Improve Survival in Influenza A Infection"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session I
6:00 pm - 8:00 pmStructure and Biochemistry of NOXs
6:00 pm - 6:10 pmDiscussion Leader: Mary Dinauer (Washington University St Louis, USA)
"Overview"
6:10 pm - 6:35 pmBecky Diebold (Emory University, USA)
"Regulation of NOX4-Generated Hydrogen Peroxide Signaling by Oxygen Tension"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmFranck Fieschi (Université Joseph Fourier, France)
"Structure-Function Relationships of NOX Proteins"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:45 pmJamel El-Benna (INSERM, France)
"Molecular Events Underlying NOX2 Priming"
7:45 pm - 8:00 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNOX Isoforms and Cardiovascular Pathology
9:00 am - 9:10 amDiscussion Leader: Kathy Griendling (Emory University, USA)
"Overview"
9:10 am - 9:35 amAllen Cowley (Medical College of Wisconsin, USA)
"Role of NOXs in Hypertension Dissected in Rat Knockouts"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amCelio Santos (King's College London, UK)
"NOX4 and the Integrated Stress Response in the Heart"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amRhian Touyz (University of Glasgow, UK)
"Role of NOX5 in Vascular Pathobiology"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amPamela Kleikers (Maastricht University, Netherlands)
"Hypertension and Worsened Stroke Outcome in Endothelial NOX5 Knock-In Mice'"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmImad Al Ghouleh (University of Pittsburgh, USA)
"A Pivotal Role for ERM-Binding Phosphoprotein 50 in p47-Nox1 Binding and Vascular Flow"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmCraig Harrison (King's College London, UK)
"Vascular Remodelling and Hypertension in Response to Chronic Angiotensin II Involves Fibroblast NOX2"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session I
6:00 pm - 8:00 pmNon-Mammalian and Plant NOXs
6:00 pm - 6:10 pmDiscussion Leader: David Lambeth (Emory University, USA)
"Overview"
6:10 pm - 6:35 pmJorg Kudla (University of Muenster, Germany)
"Calcium and ROS Signalling in Arabidopsis"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmAnna Huttenlocher (University of Wisconsin - Madison, USA)
"ROS and Wound Healing in Zebrafish"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:45 pmEnrique Amaya (University of Manchester, UK)
"Xenopus Tadpole Tail Regeneration"
7:45 pm - 8:00 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRedox Proteomics and ROS Imaging
9:00 am - 9:10 amDiscussion Leader: Phil Eaton (King's College London, UK)
"Overview"
9:10 am - 9:35 amKate Carroll (The Scripps Research Institute, USA)
"Quantifying the Thiol Redox Proteome"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amVsevolod Belousov (Shemyakin-Ovchinnikov Inst. of Bioorganic Chemistry, Russia)
"Multicolor Redox Imaging with New HyPer Probes"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amLeslie Poole (Wake Forest School of Medicine, USA)
"Probes to Detect Protein Thiol Oxidation and Use in Cell Signalling Studies"
11:15 am - 11:25 amDiscussion
11:25 am - 11:40 amEdgar Pick (Tel Aviv University, Israel)
"NOX2 Functions as and Resembles Protein Disulfide Isomerase A3"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amJesus Aguirre (Instituto de Fisiología Celular, Mexico)
"The NADPH Oxidase and Tetraspanin Functions in Cell Fusion, Growth and Differentiation in the Fungus Neurospora crassa"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmStephanie Carnesecchi Acker (University of Geneva, Switzerland)
"NOX2 in Macrophages Contributes to the Development of Lung Emphysema Through SIRT1/MMP-9 Pathways"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmMichael Schramm (University of Cologne, Germany)
"DUOX1 Deficiency Augments Immunity of Mice to Intestinal Bacterial Infection"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session II
6:00 pm - 8:00 pmNOXs in the Central Nervous System
6:00 pm - 6:10 pmDiscussion Leader: Karl-Heinz Krause (University of Geneva, Switzerland)
"Overview"
6:10 pm - 6:35 pmMargarita (Marga) Behrens (Salk Institute, San Diego, USA)
"NOX Enzymes in Psychotic Disorders"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmAchim Schmidtko (Witten/Herdecke University, Germany)
"Roles of NOXs in Pain Perception and Signalling"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:45 pmRaymond Swanson (University of California San Francisco, USA)
"NOX and PARP-1 Mediated Excitotoxic Cell Death in Brain Disease"
7:45 pm - 8:00 pmDiscussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmNOX Biology in Humans
9:00 am - 9:10 amDiscussion Leader: Ralf Brandes (J.W. Goethe University, Germany)
"Overview"
9:10 am - 9:35 amFrancesco Violi (University of Rome, Italy)
"Studying Non-Phagocytic NOX2 Function in CGD Patients"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amTheodosia Kalfa (Cincinnati Children's Hospital Medical Center, USA)
"RBC NADPH Oxidase in Sickle Cell Disease"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amKarl Lackner (University Medical Center Mainz, Germany)
"Endosomal NOX Signalling in Human Immune Cells"
11:15 am - 11:25 amDiscussion
11:25 am - 11:35 amPatti Hayes (University College Dublin, Ireland)
"NADPH Oxidases - New Players in Inflammatory Bowel Disease"
11:35 am - 11:40 amDiscussion
11:40 am - 11:50 amSilvia Trevelin (University of Sao Paulo, Brazil)
"Endothelial NOX2 Controls Systemic Inflammatory Response and Reduces Lipopolysaccharide-Induced Organ Dysfunction"
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pmValeska Helfinger (J.W. Goethe University, Germany)
"Endogenous NOX4 Limits Fibrosarcoma Development in the Murine 3-Methylcholanthrene Model"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmThalita Abrahao (InCor-FMUSP, Brazil)
"NOX4 Mediates ER-Stress Induced Protein Degradation by Regulating the Ubiquitin-Proteasome System"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session II
6:00 pm - 8:00 pmNOX Enzymes and Cancer
6:00 pm - 6:10 pmDiscussion Leader: Francisco Laurindo (University of Sao Paolo, Brazil)
"Overview"
6:10 pm - 6:35 pmTohru Kamata (Shinshu University Graduate School of Medicine, Japan)
"NOX1 and NOX4 in Cancer"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmCorinne Dupuy (Institut Gustave Roussy, France)
"NOX4, DNA Damage Response and Oncogenic Senescence"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:45 pmJames Doroshow (National Cancer Institute, USA)
"Epithelial NADPH Oxidases and Cancer"
7:45 pm - 8:00 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute of Allergy And Infectious Diseases of the National Institutes of Health under Award Number R13AI112021. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 
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