Nothing in biology can be understood without an understanding of both its structure and its history. In 2014, the "Origins of Life" Gordon Conference has expanded its purview to consider not only possible origins of the very life on Earth, but also the origins of the eukaryote cell, the origins of multicellularity, the origins of advanced vertebrate behavior, and the origins of human physiology and human disease. These topics require the Conference to draw upon perhaps the most multidisciplinary science of any Gordon Conference, since chemistry (physical, inorganic, and organic), biology (molecular, organismic, synthetic and evolutionary), astronomy, physics and planetary science, informatics, and engineering and medicine, are all relevant to the origins theme, and all can benefit from "origins" perspectives. Lectures will be structured accordingly, to allow students and specialists in each of these disciplines to understand the frontiers in the others, in the hope of understanding the paradoxes associated with the creation of new behavior in molecular systems having access to Darwinian mechanisms. Also of special importance will be discussions of how "big questions" might be addressed in light of the focus in current life science (and its funding) on molecular details, few of which reflect general principles of biology. In addition to how "big question" science should be structured, we will also ask how it might be funded, by emphasizing its relation to disease, to philanthropy, and to Hollywood. As is customary for GRC conferences, lectures will be scheduled in the mornings and evenings, allowing afternoon time for formal and informal discussions, posters, and presentations.