Gordon Research Conferences
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Conference Program
 
Protein Folding Dynamics
From the Computer to the Cell: Protein Folding, Function and Evolution
January 5-10, 2014
Hotel Galvez
Galveston, TX
Chair:
Sheena E. Radford

Vice Chair:
Peter G. Wolynes

The 2014 Gordon Research Conference on Protein Folding Dynamics will bring together experimentalists and theoreticians to discuss basic issues in protein folding dynamics and their role in function, in the evolution of protein sequences and in disorders associated with protein misfolding. It has become increasingly clear that understanding the details of Protein Folding Dynamics is crucial in describing virtually all processes of life, including protein synthesis, co-translational folding, protein allostery, protein function and diseases related to protein misfolding. Not only do we need to understand these processes in vitro, but additional challenges arise in our quest to understand Protein Folding Dynamics within living cells. In order to solve the fundamental problems of protein folding and dynamics a multifaceted approach is required that requires development of sophisticated new biophysical methods, advances in theory and simulation and the use of powerful methods such as NMR and other spectroscopic measurements. To explore recent exciting developments in this field this conference will bring together researchers with diverse backgrounds assembling a forum that will encourage open discussions from researchers working on different systems, apply different methods and bring together different ideas. The Gordon Research Conference in Protein Folding Dynamics was established specifically to bring experiment and theory together to explore advances in the field. The program will cover a range of topics, not restricted to, in vitro and in vivo folding, protein aggregation, protein evolution and design, and the role of protein dynamics in function. The conference will strive to encourage interactions between junior scientists and graduate students through abstract-selected presentations and posters.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmCurrent Discoveries in Experimental and Theoretical Analysis of Protein Folding Dynamics
Discussion Leader: Jane Clarke (University of Cambridge, UK)
7:40 pm - 8:20 pmLewis Kay (University of Toronto)
"Seeing the Invisible by Solution NMR Spectroscopy"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmAngel Garcia (Rensselaer Polytechnic Institute)
"Simulations of Protein Folding and Dynamics - What is Missing?"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 am Group Photo
9:00 am - 12:30 pmMechanisms of Protein Folding and Assembly
9:00 am - 9:10 amDiscussion Leader: Ben Schuler (University of Zurich)
"Introduction"
9:10 am - 9:35 amStefano Piana (D. E. Shaw Research)
"Equilibrium Simulations of Slow and Fast Folding Proteins"
9:35 am - 9:45 amDiscussion
9:45 am - 9:55 amCaitlin Davis (Emory University)
"Dynamics of an Ultrafast Folding Subdomain in the Context of a Larger Protein Fold"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:55 amVijay Pande (Stanford University)
"Simulating Protein Folding on the Millisecond Timescale"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amMikael Oliveberg (University of Stockholm)
"In-Cell Thermodynamics"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmNeil Ferguson (University College, Dublin)
"Connections Between the Energy Landscapes for Folding, Allostery and Virus Capsid Formation"
12:05 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmErrors of Protein Folding
7:30 pm - 7:40 pmDiscussion Leader: Joan Emma Shea (University of California, Santa Barbara)
"Introduction"
7:40 pm - 8:05 pmMargaret Sunde (University of Sydney)
"Interface-Triggered Formation of Functional Amyloid by Hydrophobin Proteins"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmRohit Pappu (Washington University in St Louis)
"Cis Modulation of Polyglutamine Aggregation in Huntingtin"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmJean Baum (Rutgers)
"The Accessible Conformations of N-Terminal Acetylated α-Synuclein: Implications for Aggregation"
9:15 pm - 9:25 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFolding in the Cell
9:00 am - 9:10 amDiscussion Leader: Lila Gierasch (University of Massachusetts Amherst)
"Introduction"
9:10 am - 9:35 amGunnar von Heijne (University of Stockholm)
"Co-Translational Folding of Membrane Proteins"
9:35 am - 9:45 amDiscussion
9:45 am - 9:55 amChris Waudby (University College London)
"Mapping the Co-Translational Folding Energy Landscape of the ddFln5 Immunoglobulin Domain"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:55 amKingshuk Ghosh (University of Denver)
"Physical Limits and Heterogeneity in Cells and Proteomes: Model Prediction Using Protein Knowledge Bases"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amPatricia Clark (University of Notre Dame, Indiana)
"Folding Proteins from One End to the Other"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmMartin Gruebele (University of Illinois)
"Folding: In Silico - In Vitro - In Vivo"
12:05 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMembrane Protein Folding
7:30 pm - 7:40 pmDiscussion Leader: Susan Marqusee (University of California, Berkeley)
"Introduction"
7:40 pm - 8:05 pmDaniel Otzen (Aarhus University)
"Towards a Complete Description of the Folding Mechanism of the Integral Membrane Protein, GlpG"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmMark Sansom (University of Oxford)
"Membrane Protein/Protein and Protein/Lipid Interactions Probed via Multiscale MD Simulations"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmPhil Thomas (UT Southwestern University)
"Molecular Pathologies of CF-Causing Mutations and Mechanisms of Membrane Protein Folding"
9:15 pm - 9:25 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProtein Dynamics and Function
9:00 am - 9:10 amDiscussion Leader: Peter Tompa (Free University of Brussels)
"Introduction"
9:10 am - 9:35 amDorothee Kern (Brandeis University)
"Separated at Birth, the Evolution of Protein Dynamics over a Billion Years"
9:35 am - 9:45 amDiscussion
9:45 am - 9:55 amLauren Metskas (Yale University)
"Conformation and Dynamics of the Troponin I C-Terminal Domain"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:55 amJane Dyson (The Scripps Research Institute)
"Dynamics of Unfolded and Partly Folded Proteins"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amShoji Takada (Kyoto University)
"Functional Dynamics of Disordered Regions in Multi-Domain Proteins"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmDave Thirumalai (University of Maryland)
"Towards a Theoretical Description of Function of a Molecular Motor"
12:05 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmForced Unfolding Dynamics
7:30 pm - 7:40 pmDiscussion Leader: David Brockwell (University of Leeds)
"Introduction"
7:40 pm - 8:05 pmMatthias Rief (Technical University, Munich)
"Single Molecule Mechanics and Dynamics of Protein Folding"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmDominika Gruszka (University of Cambridge)
"Forced Unfolding of SasG"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmDaniel Müller (ETHl, Zurich)
"Forced Unfolding, Refolding and Misfolding of Single Beta-Barrel Proteins into Lipid Membranes"
9:15 pm - 9:25 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProtein Design and Evolution
9:00 am - 9:10 amDiscussion Leaders: TJ Lane (Stanford University) and Adrian Nickson (University of Cambridge)
"Introduction"
9:10 am - 9:35 amEugene Shaknovitch (Harvard University)
"Linking Protein Folding to Biology, One Mutation at a Time"
9:35 am - 9:45 amDiscussion
9:45 am - 9:55 amShion An (University of California, Berkeley)
"Exploring the Energy Landscape Through Ancestral Proteins: A Ribonuclease H Study"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:55 amYousif Shamoo (Rice University)
"Driving Protein Folding and Dynamics Through the Lens of Natural Selection"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amPat Jennings (University of California, San Diego)
"Probing the Interplay of the Folding and Functional Energy Landscapes of Designer Cytokines"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmTanja Kortemme (University of California, San Francisco)
"Molecular Design and Functional Specificity - From Proteins to Cells"
12:05 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmProtein Folding: Outlook and Challenges Ahead
7:30 pm - 7:40 pmDiscussion Leader: Jose Onuchic (Rice University)
"Introduction"
7:40 pm - 8:05 pmZan Luthey-Schulten (University of Illinois)
"Structural Intermediates in the Early Assembly of the Ribosomal Small Subunit"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmJeff Kelly (The Scripps Research Institute)
"From Studying Protein Folding and Misfolding In Vitro to Studying Folding and Misfolding in Living Organisms"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmCharlie Brooks (University of Michigan)
"Merging Experiment, Theory and Simulation in Studies of Complex Folding Processes"
9:15 pm - 9:25 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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