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Proteoglycans
Gordon Research Conference

Diverse Regulators of Health and Disease

Dates

July 6-11, 2014

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Nicholas Shworak

Vice Chair:
Jeremy E. Turnbull

Meeting Description

Over the past few years, the proteoglycan community has rapidly laid the foundations for translating novel fundamental processes regulated by proteoglycans into potential diagnostics, devices, commercial products and therapeutics. The 2014 Gordon Conference on Proteoglycans will present cutting-edge research on the multidisciplinary approaches of translational proteoglycan research. The early discovery process will be addressed by topics on novel analytics, such as glycomics, to identify structure/function relations for proteoglycans. Similarly the latest findings in proteoglycan homeostasis (synthesis/turnover) will be revealed. The impact of proteoglycans on cell signaling and phenotype will be a unifying theme linking numerous sessions focused on cell biology, stem cells, development, and animal genetic models. These mechanisms will be further evaluated from the prospective of pathophysiologic process including: cancer, inflammation, glycosaminoglycan storage diseases, tissue engineering, as well as normal functioning and diseases of the cardiovascular, digestive, neural, muscular and skeletal systems. The latest efforts at translating these findings to diagnostics and therapeutics will be highlighted. The conference will bring together national and international investigators at all career levels and provide a highly relaxed and exceptionally collegial environment to promote cross-disciplinary collaborations and to maximize open dissemination of ideas between all participants. The truly unique camaraderie of the proteoglycan communities provides an unparalleled opportunity for young scientists to network with senior investigators. The accompanying Gordon Research Seminal provides synergistic career-development opportunities for young investigators.

Related Meeting

This GRC was held in conjunction with the "Proteoglycans" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmLate-Breaking Topics
Discussion Leaders: Kazuyuki Sugahara (Hokkaido University, Japan) and Sarah Knox (UCSF, USA)
7:40 pm - 8:00 pmVera Gorbunova (University of Rochester, NY)
"High Molecular Weight Hyaluronan as a Mediator of Cancer Resistance and Longevity of the Naked Mole Rat"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:20 pmRenato Iozzo (Thomas Jefferson University, USA)
"A Novel Role for Proteoglycans: Regulation of Autophagy Independent of Nutrient Deprivation"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:35 pmHarry Pantazopoulos (Harvard University, USA)
"Chondroitin Sulfate Proteoglycan Abnormalities in Schizophrenic and Bipolar Disorder Subjects"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmMariana Stelling (Federal University of Rio de Janeiro, Brazil)
"Syndecan-1 and Manganese: Possible Partners in Cancer Cell Migration and Metastasis via Integrin Activation"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:05 pmMausam Kalita (University of Utah)
"Development of a Glyco-Nanoprobe for Imaging Heparanase, a Pathophysiological Biomarker"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmMatt Hoffman (NIH, USA)
"Hs3st3-Modified Heparan Sulfate Controls KIT+ Progenitor Expansion by Regulating 3-O-Sulfotransferases"
9:25 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Rise and Fall of GAGs: Biosynthesis, Catabolism and Mucopolysaccharidoses
Discussion Leaders: Lena Kjellen (Uppsala University, Sweden) and Jian Liu (University of North Carolina Chapel Hill, USA)
9:00 am - 9:20 amLars Pedersen (NIH/NIEH, USA)
"Structural Biology of Sulfotransferases"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSusan Sharfstein (State University of New York, USA)
"Metabolic Engineering of Chinese Hamster Ovary Cells for Production of a Bioengineered Heparin"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amAnders Malmstrom (Lund University, Sweden)
"Production of Recombinant Dermatan Sulfate"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amKyohei Higashi (Chiba University, Japan)
"Enhancement of the Synthesis of EXT2, EXTL3 and CHSY1 by Polyamines at the Level of Translation in Mammalian Cells"
10:25 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 amOlivier Berteau (INRA, France)
"Glycosaminoglycan Sulfatases from the Human Microbiota: Key Enzymes for Host-Microbe Interactions?"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amJoanna Philips (UCSF, USA)
"SULF2 Regulation of PDGF Signaling in Brain Cancer"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amBecky Holley (University of Manchester, UK)
"Abnormally Sulphated Heparan Sulphate Inhibits Hematopoietic Stem Cell Migration and Engraftment in MPSI"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmLena Kjellen (Uppsala University, Sweden)
"NDSTs in HS Biosynthesis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAdvances in Synthesis, Structural Analysis, Interactions and Glycomics
Discussion Leaders: Barbara Mulloy (Imperial College, UK) and Anthony Day (University of Manchester, UK)
7:30 pm - 7:50 pmDavid Jackson (Oxford University, UK)
"Roles of the Hyaluronan Receptor LYVE-1 in Lymphatic Trafficking"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmJian Liu (UNC Chapel Hill, USA)
"Chemoenzymatic Synthesis of Homogeneous Low Molecular Weight Heparins"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:30 pmPeter Tyler (Wellington University, NZ)
"Fully Synthetic HS Oligosaccharides and Dendritic Clusters"
8:30 pm - 8:35 pmDiscussion
8:35 pm - 8:45 pmLi-Kai Liu (University of Minnesota, USA)
"Molecular Basis of Hyaluronan Inhibitors Binding to Cell Receptor CD44 Based on a Tetrahydroisoquinoline Scaffold"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:00 pmElisa Migliorini (Grenoble University, France)
"Morphogens Cross-Link Heparan Sulphate"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmJoseph Zaia (Boston University)
"Discovery of a Novel Peeling Reaction that Contributes to the Underestimation of 3-O-Sulfation in HS"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmRegulation of Signaling and Development
Discussion Leaders: Pascale Zimmermann (Marseille Centre for Cancer Research, France) and Matthew Hoffman (NICDDR, NIH, USA)
9:00 am - 9:20 amJohn Couchman (University of Copenhagen, Denmark)
"Getting to Grips with Redundancy in Syndecans"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amNatasza Kurpios (Cornell University, USA)
"Right-Sided Hyaluronan Synthesis Provides a Mechanism for Asymmetric L-R Gut Rotation"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amSuneel Apte (Cleveland Clinic, USA)
"Novel Contexts for Versican Processing by ADAMTS Proteases During Morphogenesis"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amTakenori Inomata (Schepens Eye Research Institute, USA)
"Perlecan-Deficient Mutation Impairs Homeostasis and Wound Healing in Mouse Corneal Epithelium"
10:25 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:10 amSarah Knox (UCSF, USA)
"Forming a Tubular Network: A New Role for Nerves During Glandular Morphogenesis"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amLianchun Wang (CCRC, Georgia)
"Heparan Sulfate Deficiency Disrupts Developmental Angiogenesis and Causes Congenital Diaphragmatic Hernia"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amPetra Jakobs (Westphalian Willhelms University Munster, Germany)
"Emerging Roles of Heparan Sulfate Proteoglycans in the Regulated Release of Hedgehog Morphogens from Producing Cells"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amMatt Nugent (UMass)
"Control of the VEGF System by Heparan Sulfate: New Solutions for a Complex Problem"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmPascale Zimmermann (Marseille Centre for Cancer Research, France)
"Controlling the Biogenesis of Syndecan-Syntenin Exosomes, from the Interior and the Exterior of the Cell"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMultiple Roles in Cancer
Discussion Leaders: Renato Iozzo (Thomas Jefferson University, USA) and Nikos Karamanos (University of Patras, Greece)
7:30 pm - 7:50 pmJorge Filmus (University of Toronto, Canada)
"Glypican-3 Displays Tumor Suppressor Activity in Renal Cell Carcinoma"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmHide Watanabe (Aichi Medical University, Japan)
"Versican and Tumour Suppression Mechanisms"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmMartin Gotte (Muenster University Hospital, Germany)
"MicroRNAs as Regulators of Proteoglycans in Cell Motility/Invasiveness"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmThomas Neill (Thomas Jefferson University, USA)
"Decorin Evokes Mitophagy via Mitostatin in Breast Carcinoma Cells"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmNikos Karamanos (University of Patras, Greece)
"ERs as New Players in EMT, Matrix Expression and Functional Properties in Breast Cancer"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmRalph Sanderson (University of Alabama, USA)
"Heparanase Regulation of Exosome-Mediated Crosstalk Within the Tumor Microenvironment"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInsights into Neural, Muscular and Skeletal Diseases
Discussion Leaders: Hideto Watanabe (Aichi Medical University, Japan) and Amanda Fosang (Murdoch Childrens Research Institute, Melbourne, Australia)
9:00 am - 9:20 amLiliana Schaefer (University of Frankfurt, Germany)
"Biglycan Signaling in Podocytes"
9:20 am - 9:30 amDiscussion
9:30 am - 9:40 amDaisy Shum (Hong Kong University, China)
"Emerging Role of Perineural Chondroitin Sulfates and Semaphorin 3A in Maturation of the Central Vestibular Circuitry"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amChenqi Tao (Columbia University, USA)
"Cell Surface Proteoglycans Control Astrocyte Migration and Retinal Angiogenesis by Regulating Basement Membrane Assembly"
9:55 am - 10:00 amDiscussion
10:00 am - 10:10 amYu Yamaguchi (Sanford-Burnham Medical Institute, USA)
"Hyaluronan, the Regulator of Brain Extracellular Space and Neuronal Excitability"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amMarian Young (NIH, USA)
"Biglycan and Fibromodulin Deficiency Leads to Increased Bone Remodeling that Can Be Rescued by Exogenous Treatment with Osteoclast Inhibitor Osteoprotegerin (OPG)"
10:25 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:10 amAnders Aspberg (Copenhagen University, Denmark)
"The Unique G2 Domain of Aggrecan Binds Fibril-Forming Collagens"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amWarren Knudson (East Carolina University, USA)
"Viral Transduction of HAS2 Enhances Cartilage Hyaluronan and Modulates Chondrocyte Homeostasis"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amMegan Lord (University of New South Wales, Australia)
"Sulfation of the Chondroitin Sulfate Chain of Inter-A-Trypsin Inhibitor Controls the Formation of Hyaluronan-Heavy Chain Complexes: Implications for Functional Changes During Arthritis"
11:40 am - 11:45 amDiscussion
11:45 am - 12:05 pmAmanda Fosang (Murdoch Childrens Research Institute, Melbourne, Australia)
"Bioactivity in an Aggrecan 32mer Fragment Is Mediated via Toll-Like Receptors"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmRachel Miller (Rush University Medical Center, USA)
"An Aggrecan 32mer Fragment Provides a Link Between Joint Tissue Damage and Pain Through Direct Activation of Sensory Neurons"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmModulation of Stem Cell Fate for Regenerative Medicine
Discussion Leaders: Catherine Merry (University of Manchester, UK) and Alison Nairn (University of Georgia/CCRC, USA)
7:30 pm - 7:50 pmEri Arikawa-Hirasawa (Juntendo University, Japan)
"Role of Perlecan in Neurogenesis and Ageing"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmCheryl Knudson (East Carolina University, USA)
"Hyaluronan-CD44 Interactions in Chondrogenic and Osteogenic Differentiation Using Murine Mesenchymal Progenitor Cells"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmAkira Asari (Hyaluranon Research Institute, Japan)
"Hyaluronan Tetrasaccharides Promotes Stemness and Sirtuin Expression"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmVivien Coulson-Thomas (Cambridge University, UK)
"Umbilical Cord Mesenchymal Stem Cells Regulate Inflammatory Response: The Vital Role of the Glycocalyx"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmCathy Merry (Manchester University, UK)
"GAG-Dependent Signalling Unpicked in Mesenchymal Stem Cells"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmMichael Kluppel (Northwestern University, USA)
"Biphasic Role of Chondroitin Sulfate in Cardiac Differentiation of ES Cells Through Control of Wnt/Beta-Catenin Signaling"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmControlling the Cross Roads of Inflammation and Cardiovascular Disease
Discussion Leaders: Vincent Hascall (Cleveland Clinic, USA) and Liliana Schaefer (University of Frankfurt, Germany)
9:00 am - 9:20 amAlberto Passi (University of Insubria, Italy)
"Epigenetic Regulation in Hyaluronan Synthesis"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amInkyung Kang (Benaroya Research Institute, Seattle)
"Expression of Versican Isoforms and the Control of Inflammation in the Cardiovascular System"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amCaroline Bandlien (University of Oslo, Norway)
"Lack of Lumican in Cardiac Pressure Overload Attenuates Development of Cardiac Fibrosis Leading to Premature Left Ventricle Dilatation"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amBrooke Farrugia (University of New South Wales, Australia)
"Glycosaminoglycans Modulate the Response of Inflammatory Cells to Implanted Materials"
10:25 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 amBryan Thacker (UC San Diego, USA)
"Macrophage Heparan Sulfate Protects Against Atherosclerosis and Obesity"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amSamantha Borland (Manchester University, UK)
"Regulation of Vascular Calcification by GAGs"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amMari Strand (University of Oslo, Norway)
"Syndecan-4 Shedding Mediates Immune Cell Infiltration to the Heart in Response to Lipopolysaccharide Challenge"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmJin-ping Li (Uppsala University, Sweden)
"Pro-and Anti-Inflammatory Mechanisms of Heparanase"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTranslational Glycanology: Diagnostics and Therapeutics
Discussion Leaders: Shukti Chakravarti (Johns Hopkins University, USA) and Mauro Pavão (Universidade Federal do Rio de Janeiro, Brasil)
7:30 pm - 7:50 pmJake Reder (Celdera Medical, USA)
"Translating Research: The Celdara Medical Model as a Case Study"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmPaulo Mourão (Federal University of Rio De Janeiro, Brasil)
"A Particular 'Heparin Crisis' in Brazil: The Case of Bovine Heparin"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmNicholas P. Farrell (Virginia Commonwealth University, USA)
"Toward Antimetastatic Platinum"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmLap Kei Kenneth Wu (University of Hong Kong, China)
"The Use of a Heparin Mimetic for the Treatment of Smoking-Related Neutrophilic Inflammation"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmScott Guimond (Liverpool University, UK)
"Synthetic and Semi-Synthetic Heparins for Alzheimers Disease and Metastasis: Ex-Vivo, In-Vivo and Oral Availability Studies in Mice"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmMitchell Ho (NIH/NCI, USA)
"Inactivation of Wnt and Yap Signaling by Human Antibodies Therapeutically Targeting Glypican-3 in Liver Cancer"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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