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Conference Program
 
Protons & Membrane Reactions
Connecting Membrane Protein Function with Structure
February 23-28, 2014
Four Points Sheraton / Holiday Inn Express
Ventura, CA

The 2014 Gordon Conference on Protons and Membrane Reactions will present cutting-edge research on the molecular structure and function of membrane proteins involved in the transport of protons and other ions. The Conference will feature a wide range of topics, such as the structure and function of proton channels, electron transport chain complexes, P-type ATPases, intramembrane proteases, and symporters. Invited speakers represent a variety of scientific disciplines, including biophysics, biochemistry, structural biology, and molecular dynamics simulations. The Conference will bring together a collection of investigators who are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Some poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmProtons in Channels
Discussion Leader: Francesco Tombola (UC Irvine)
7:40 pm - 8:20 pmScott Ramsey (Virginia Commonwealth University)
"pH- and Voltage-Dependent Gating in Hv1 Channels"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmGerhard Fischer (University of Cambridge)
"Proton Exclusion and Water Interactions in Aquaporins"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmSymporters, Antiporters, and Their Kin
9:00 am - 9:15 amDiscussion Leader: Robert Stroud (UC San Francisco)
9:15 am - 9:40 amLan Guan (Texas Tech University)
"Insights into the Symport Mechanism of the Na+-Coupled Melibiose Permease MelB"
9:40 am - 9:50 amDiscussion
9:50 am - 10:15 amBjørn Pedersen (UC San Francisco)
"Eukaryotic Examples of Symport and Antiport from a Structural Perspective"
10:15 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amChristine Ziegler (University of Regensburg)
"Proton Versus Sodium: Insights into the Coupling Mechanism in Secondary Transport"
11:20 am - 11:30 amDiscussion
11:30 am - 11:55 amJoseph Mindell (NIH)
"The Other Ion: Counterion Movements Necessary for Organellar Acidification"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmIntramembrane Proteases
Discussion Leader: Nicoleta Bondar (Free University of Berlin)
7:30 pm - 8:10 pmSin Urban (Johns Hopkins)
"Rhomboid Proteolysis: What Drives an Improbable Intramembrane Reaction?"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmMichael Wiener (University of Virginia)
"The CaaX Protease Ste24p: Novel Structure Begets Novel Mechanism?"
9:10 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNMR Approaches to Membrane Protein Structure and Function
9:00 am - 9:15 amDiscussion Leader: Mei Hong (Iowa State University)
9:15 am - 9:40 amGerhard Wagner (Harvard Medical School)
"Integral Membrane Protein Structures and Interactions in Micelles and Nanodiscs"
9:40 am - 9:50 amDiscussion
9:50 am - 10:15 amMarkus Weingarth (Utrecht University)
"An NMR-Based Study of Water-Protein Contacts During the Gating Cycle of a Membrane-Embedded Potassium Channel"
10:15 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amRoger Koeppe (University of Arkansas)
"Approaching the Measurement of Single-Residue Protonation and Ionization Properties in Lipid Bilayer Membranes"
11:20 am - 11:30 amDiscussion
11:30 am - 11:55 amAnn McDermott (Columbia University)
"Conformational Exchange Processes in Membrane Proteins: Allosteric Coupling in a Potassium Channel"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmElectron Transport Chain Complexes
Discussion Leader: Shelagh Ferguson-Miller (Michigan State University)
7:30 pm - 7:55 pmMarilyn Gunner (City College of New York)
"Cycle of Proton Affinity Shifts Needed for Proton Pumping in Cytochrome C Oxidase"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmUlrich Brandt (Nijmegen Center for Mitochondrial Disorders)
"How Structure Controls Complex I Activity"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmRosemary Stuart (Marquette University)
"Understanding of the Functional Relevance of Diverse Populations of Respiratory Chain Supercomplexes in Mitochondria"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:30 pmGeneral Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOpsins
9:00 am - 9:15 amDiscussion Leader: Janos Lanyi (UC Irvine)
9:15 am - 9:40 amJohn Spudich (U Texas, Houston)
"Divergence of Photoactive Site Proton Transfers and Conformational Changes in Microbial Rhodopsins"
9:40 am - 9:50 amDiscussion
9:50 am - 10:15 amJoachim Heberle (Free University of Berlin)
"Proton Transfers that Drive Gating of Channelrhodopsin"
10:15 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amSergei Balashov (UC Irvine)
"Proton Transfers in a Novel Rhodopsin from Exiguobacterium sibiricum"
11:20 am - 11:30 amDiscussion
11:30 am - 11:55 amHideki Kandori (Nagoya Institute of Technology)
"Role of Proton Transfer in a Light-Driven Sodium Ion Pump"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTheory and Simulations of Proton Reaction
Discussion Leader: Douglas Tobias (UC Irvine)
7:30 pm - 7:55 pmGerhard Hummer (Max Planck Institute of Biophysics)
"Motions in the Molecular Machinery Powering Life"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmGregory Voth (University of Chicago)
"Multiscale Computer Simulation of Proton Transport in Proteins"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmAli Hassanali (International Centre for Theoretical Physics, Trieste)
"A Network View of Liquid Water: Implications on Proton Transfer, Quantum Effects and Ion Solvation"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:30 pmGeneral Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmATPases
9:00 am - 9:15 amDiscussion Leader: David Stokes (Skirball Institute)
9:15 am - 9:40 amBrandy Akin (Indiana University)
"X-Ray Crystal Structure of SERCA Bound with Its Regulatory Partner Phospholamban"
9:40 am - 9:50 amDiscussion
9:50 am - 10:15 amTodd Graham (Vanderbilt University)
"Probing the Inner Workings of Phospholipid Pumps"
10:15 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amTakeshi Murata (Chiba University)
"Rotation Mechanism of V-ATPase Based on Crystal Structures"
11:20 am - 11:30 amDiscussion
11:30 am - 11:55 amTerry Krulwich (Mount Sinai Hospital)
"Structural Adaptations Required for Alkaliphile ATP Synthase Function at High pH"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 8:30 pmKeynote Lecture
Discussion Leader: Joseph Mindell (NIH)
7:30 pm - 8:10 pmH. Ronald Kaback (UCLA)
"The Life and Times of Lac Permease"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:30 pmJunior Investigator Presentations
TBA (Chosen from Posters)
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Last Updated: February 24, 2014
 
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