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Conference Program
 
Protein Transport Across Cell Membranes
Mechanisms, Structure, and Physiology
March 9-14, 2014
Hotel Galvez
Galveston, TX

Related Meeting Information
The Protein Transport Across Cell Membranes Gordon Research Conference was held in conjunction with the Protein Transport Across Cell Membranes Gordon Research Seminar. Please refer to the Protein Transport Across Cell Membranes GRS web page for more information.

The 2014 Conference will bring together a diverse group of investigators that share a common interest in understanding how proteins cross or insert into biological membranes. Elucidation of protein transport mechanisms remains a fundamental objective of modern cell biology as ~30% of all proteins are either transported across or integrated into cellular membranes. Achieving correct cellular compartmentalization by these mechanisms is essential for cell function, and different facets of protein translocation directly impact human health. The 2014 conference will be organized by research topic, each of which will incorporate talks employing different methodologies to solve a common conceptual problem. Research topics will include sorting and targeting of proteins among intracellular membranes, the passage of proteins through translocation channels, the mechanisms of membrane protein assembly, the structural biology of transport machines, specialized pathogenic transport pathways, biogenesis of organelles, and others. This Gordon Research Conference will foster the synthesis of new ideas by bringing together a combination of established leaders and early career scientists. In addition to invited speakers, short talks will be selected from submitted abstracts.

The 2014 conference also features a pre-conference Gordon Research Seminar (GRS), organized by postdoctoral scientists, that will be oriented towards junior investigators. The aim is to provide participants with background on common mechanisms involved in protein transport, to discuss their ongoing research projects, and to facilitate interaction and networking with their peers within this scientific community. We fully anticipate that the talks, discussions, poster sessions, and other informal interactions at this GRC and GRS will contribute to advancing our understanding of molecular mechanisms of protein trafficking, which is essential to both prokaryotic and eukaryotic cells.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmOverview and Unifying Themes of Protein Transport
7:40 pm - 7:45 pmDiscussion Leader: Ramanujan Hegde (MRC Laboratory of Molecular Biology)
"Opening Remarks"
7:45 pm - 8:10 pmWalter Neupert (Max Planck Institute for Biochemistry)
"Protein Import into Mitochondria"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmWilliam Skach (Oregon Health and Sciences University)
"Membrane Protein Insertion and Folding"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmTom Silhavy (Princeton University)
"Insights into the Function of the Bam Complex in E. coli"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmProtein Targeting to Intracellular Membranes
9:00 am - 9:05 amDiscussion Leader: Richard Zimmermann (University of Saarlandes)
"Introduction"
9:05 am - 9:25 amMaya Schuldiner (Weizmann Institute)
"The SND (Srp iNDependent) Pathway - A New Module for Targeting Proteins to the ER"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amKlemens Wild (Heidelberg University)
"Molecular Gymnastics at the Ribosomal Tunnel Exit"
9:55 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:50 amAndrey Karamysev (UT Southwestern)
"Preemptive Protein/mRNA Quality Control on the Ribosome: Defects in SRP - Nascent Chain Interactions Induce Specific mRNA Degradation"
10:50 am - 10:55 amDiscussion
10:55 am - 11:10 amJörg Tatzelt (Ruhr University Bochum)
"An Intrinsic Activity of ER Signal Peptides to Mediate Dual Targeting Interferes with Mitochondrial Integrity and Cell Viability"
11:10 am - 11:15 amDiscussion
11:15 am - 11:35 amSabine Rospert (University of Freiburg)
"Action of Ribosome-Bound Factors on Polypeptide Fate"
11:35 am - 11:45 amDiscussion
11:45 am - 12:00 pmSichen Shao (MRC Laboratory of Molecular Biology)
"Anatomy of a Triage Reaction During Protein Quality Control"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:20 pmMichael Rome (Cal Tech)
"The Get3 ATPase Drives Unidirectional Targeting of Tail-Anchored Membrane Proteins"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTranslocation Into the ER and Bacterial Periplasm
7:30 pm - 7:35 pmDiscussion Leader: Christiane Schaffizel (EMBL, Grenoble)
"Introduction"
7:35 pm - 7:55 pmRichard Zimmermann (University of Saarlandes)
"Gating Mechanisms of the Mammalian Sec61 Complex"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmNatividad Ruiz (Ohio State University)
"Transport of Peptidoglycan Precursors Across Membranes"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:50 pmKurt Vermeire (Rega Institute, KU Leuven)
"Signal Peptide-Binding Drug as a Selective Inhibitor of Co-Translational Protein Translocation"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:15 pmTassos Economou (KU Leuven)
"Mechanistic Insights into SecA-Mediated Translocation"
9:15 pm - 9:25 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMitochondrial and Chloroplast Biogenesis
9:00 am - 9:05 amDiscussion Leader: Klaus Pfanner (University of Freiburg)
"Introduction"
9:05 am - 9:25 amPeter Rehling (Goettingen University)
"Protein Transport Along the Mitochondrial Presequence Pathway"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amCarla Koehler (University of California, Los Angeles)
"Small Molecules Modulators of the TOM and TIM23 Translocons"
9:55 am - 10:05 amDiscussion
10:05 am - 10:30 amCoffee Break
10:35 am - 10:45 amNathan Alder (Univ. of Connecticut)
"Subunit Interactions and Structural Dynamics of the Mitochondrial TIM23 Protein Transport Complex"
10:45 am - 10:50 amDiscussion
10:50 am - 11:05 amAgniezka Chacinska (IIMCB, Poland)
"Unfolded Protein Response Activated by Mislocalization of Mitochondrial Proteins"
11:05 am - 11:10 amDiscussion
11:10 am - 11:30 amDanja Schunemann (Ruhr-University Bochum)
"The SRP-Dependent Protein Transport in Chloroplasts: Molecular Mechanisms and Evolution"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amDanny Schnell (Univ. of Massachusetts)
"In Vivo Analysis of Chloroplast Hsp90 (Hsp90C) in Protein Import and Organelle Biogenesis in Chloroplasts"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmElisabeth Ankele (University of Munich)
"The Alb3/Oxa1/YidC Family Members of Arabidopsis: Membrane-Localized Insertases Essential for Plant Development"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmUnconventional Translocation Pathways
7:30 pm - 7:35 pmDiscussion Leader: Maya Schuldiner (Weizmann Institute)
"Introduction"
7:35 pm - 7:55 pmCarole Dabney-Smith (Miami University)
"Protein Transport Across Thylakoids via the Chloroplast Tat Pathway"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:20 pmJulia Fröbel (Univ. of Freiburg)
"The N-Termini of TatA/B Proteins are Pivotal Elements of Tat Translocases"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:45 pmPetr Leiman (EPFL, Lausanne)
"Central Spike Proteins of Contractile Ejection Systems"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:15 pmNicholas Noinaj (NIDDK/NIH)
"The Role of BamA in the Biogenesis of Beta-Barrel Membrane Proteins in Gram-Negative Bacteria"
9:15 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMembrane Protein Insertion into the Lipid Bilayer
9:00 am - 9:05 amDiscussion Leader: Reid Gilmore (UMass Medical Center)
"Introduction"
9:05 am - 9:25 amRoss Dalbey (Ohio State University)
"YidC/Oxa1/Alb3 Membrane Chaperones Facilitate Membrane Protein Folding and Insertion"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amVlad Denic (Harvard University)
"The Mechanism of an ER Membrane Protein Insertase"
9:55 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:50 amKaoru Kumazaki (Univ. of Tokyo)
"Crystal Structure of YidC and a Mechanism of Membrane Protein Insertion"
10:50 am - 10:55 amDiscussion
10:55 am - 11:10 amPeter Pohl (Johannel Kepler University)
"YidC Forms a Protein Translocating Channel and Alters the Size of the SecYEG Channel"
11:10 am - 11:15 amDiscussion
11:15 am - 11:35 amGunnar von Heijne (Stockholm University)
"Forces Acting on Nascent Chains During Membrane Insertion and Translocation"
11:35 am - 11:45 amDiscussion
11:45 am - 12:00 pmStephen White (UC Irvine)
"Inside the 'primed' SecY Translocon"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:20 pmJeanine de Keyzer (Univ. of Groningen)
"YidC Dependent Membrane Insertion of the Magnesium Transporter CorA"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmStructural Biology and Biophysics of Transport Factors
7:30 pm - 7:35 pmDiscussion Leader: Sabine Rospert (University of Freiburg)
"Introduction"
7:35 pm - 7:55 pmBill Clemons (California Institute of Technology)
"Structural Insights into the GET Protein Targeting Pathway"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:20 pmLukas Bischoff (LMU, Munich)
"Visualization of a Polytopic Membrane Protein Egressing from the SecY Complex"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:45 pmSebastian Hiller (Biozentrum Basel)
"Molecular Mechanism of the Holdase Skp and the Foldase TamA"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:15 pmChristiane Schaffizel (EMBL)
"Structure of the SecYEG-SecDFYajC-YidC Holotranslocon Complex"
9:15 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSpecialized Pathogenic Translocation
9:00 am - 9:05 amDiscussion Leader: Harris Bernstein (National Institutes of Health)
"Introduction"
9:05 am - 9:25 amJude Przyborski (University of Marburg)
"Into the Great Wide Open: Protein Trafficking Mechanisms in the Human Malaria Parasite P. falciparum"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amHarris Bernstein (National Institutes of Health)
"The Biogenesis of Bacterial Autotransporter Proteins"
9:55 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:50 amHan Remaut (VIB / Vrije Universiteit Brussel, Brussels)
"Structure and Mechanism of the Bacterial Amyloid Secretion Channel CsgG"
10:50 am - 10:55 amDiscussion
10:55 am - 11:10 amCatherine Baud (Center for Infection and Immunity, France)
"Tracking the Translocation Path of a Secretory Protein Across the Outer Membrane in Two-Partner Secretion"
11:10 am - 11:15 amDiscussion
11:15 am - 11:35 amJack Taunton (University of California, San Francisco)
"Sec61 Modulators for the Treatment of Multiple Myeloma"
11:35 am - 11:45 amDiscussion
11:45 am - 12:00 pmTatyana Sysoeva (Harvard)
"Dimer Recognition and Secretion by the ESX Secretion System in Bacillus subtilis"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:20 pmKonstantin Korotkov (Univ. of Kentucky)
"ESX Secretion System Takes Shape"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDislocation from Cellular Compartments
7:30 pm - 7:35 pmDiscussion Leader: Randy Hampton (University of California, San Diego)
"Introduction"
7:35 pm - 7:55 pmAri Helenius (ETH, Zurich)
"Virus Infection: Breaking and Entering"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:20 pmHeidi Vitrac (UT Health Houston)
"From Liposomes to Fliposomes: In Vitro Reconstitution of Lipid-Dependent Dual Topology of Membrane Proteins"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:40 pmMichael van de Weijer (Univ. Medical Center, Utrecht)
"A High-Complexity shRNA Library Screen Identifies Novel Components Essential for US11-Mediated HLA Class I ERAD"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmRandy Hampton (University of California, San Diego)
"Dislocation from the Endoplasmic Reticulum Membrane"
9:05 pm - 9:15 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute Of General Medical Sciences of the National Institutes of Health under Award Number R13GM109478. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Last Updated: February 28, 2014
 
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