Gordon Research Conferences
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Conference Program
 
Rare Cells in Circulation
Circulating Tumor Cells and Metastasis
August 3-8, 2014
Mount Holyoke College
South Hadley, MA

Application Deadline
Applications for this meeting must be submitted by July 6, 2014. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

This conference will focus on rare cells in circulation with a focus on human disease. Epithelial progenitor and stem cells, mesenchymal cells, fetal cells, and circulating tumor cells are normally relegated to extravascular organs but can traffic within the blood stream to initiate a number of important biological processes, such as organ repair and regeneration, angiogenesis, and metastasis. Thus, these cells represent a critically important population within the circulation and can provide a unique view into organ status, fetal health, and disease evolution. However, given their rarity within the circulation, the study of these cells poses unique challenges that will require innovative multi-disciplinary approaches.

To catalyze this embryonic field, we will bring together engineers, biologists, and clinicians to address the wide range of interest in these rare cell populations. The first conference will focus on cancer-relevant cells, primarily circulating tumor cells, including capture technology, definition of the population, correlation with disease diagnosis and progression, functional and molecular characterization, and relation to therapy.

A Note About Registration Costs: There has never been a better time to experience a Gordon Research Conference! Our high quality, cost-effective meetings are widely recognized as the world’s premier scientific conferences. The "single" room registration rate for this meeting is $880, and includes registration, meals and lodging. Likewise, a "shared" room rate of $815 is also available for those attendees who wish to share a room. Click the Registration Fees link at the top of this page for more information.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmIntroductory Comments by GRC Site Staff
7:40 pm - 7:50 pmWelcome Comments by Chair and Vice-Chairs
7:50 pm - 9:30 pmTranslating Circulating Tumor Cell (CTC) Capture Technologies for Widespread Clinical Use
Discussion Leader: Jeff Chalmers (Ohio State University)
7:50 pm - 8:20 pm Shannon Stott (Massachusetts General Hospital)
"Clinical Microfluidics: Isolation and Molecular Characterization of CTCs"
8:20 pm - 8:40 pm Discussion
8:40 pm - 9:10 pm Leon Terstappen (University of Twente)
"Towards the Biological Understanding of CTC: Capture Technologies, Definitions and Potential to Create Metastasis"
9:10 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmCan CTCs Be Used to Diagnose and Stage Cancer?
Discussion Leader: Stefanie Jeffrey (Stanford University Medical Center)
9:00 am - 9:30 am Anirban Maitra (M.D. Anderson Cancer Center)
"Genetic Progression of Metastatic Pancreatic Cancer"
9:30 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:00 am TBA
11:00 am - 11:30 am Discussion
11:30 am - 12:00 pm TBA
12:00 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTumor Microenvironment and Metastatic Potential
Discussion Leader: TBA
7:30 pm - 8:00 pm Sofia Merjaver (University of Michigan Comprehensive Cancer Center)
"Live Cell Phenotyping for Prevention and Metastatic Potential in Breast Cancer"
8:00 pm - 8:30 pm Discussion
8:30 pm - 9:00 pm Linda Vahdat (Weill-Cornell Medical College)
"Affecting the Tumor Microenvironment Through a Copper Depletion Strategy: Promoting Tumor Dormancy in Breast Cancer Patients at High Risk of Relapse"
9:00 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPrognosis with CTCs: Getting Beyond Hazard Ratio and Kaplan-Meier
Discussion Leader: David Nanus (Weill-Cornell Medical Center)
9:00 am - 9:40 am Daniel Danila (Memorial Sloan-Kettering Cancer Center)
"Circulating Tumors Cells as Biomarkers: Progress Toward Biomarker Qualification"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:00 am TBA
11:00 am - 11:30 am Discussion
11:30 am - 12:30 pm TBA (Short Presentations Selected from Posters)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMolecular and Phenotypic Features of Disseminating Cells
Discussion Leader: Howard Scher (Memorial Sloan-Kettering Cancer Center)
7:30 pm - 8:00 pm Thea Tlsty (University of California, San Francisco)
"Breast Fibroblasts Modulate Early Dissemination, Tumorigenesis, and Metastasis Through Alteration of Extracellular Matrix Characteristics"
8:00 pm - 8:30 pm Discussion
8:30 pm - 9:00 pm Tony Hollingsworth (University of Nebraska Medical Center)
"Molecular Features of Pancreatic Cancer Cells that Metastasize Early in Disease Progression"
9:00 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInteraction of Treatment with CTCs
Discussion Leader: TBA
9:00 am - 9:40 am Stuart Martin (University of Maryland Medical Center)
"Targeting Microtentacles on Circulating Breast Tumor Cells to Optimize Chemotherapy Treatments and Reduce Metastasis"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:10 am Paraskevi Giannakakou (Weill-Cornell Medical College)
"Microtubule Bundling and AR Translocation in CTCs as Biomarkers for Drug-Target Engagement in Castrate-Resistant Prostate Cancer"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pm Marjolein van Egmond (VU University Medical Center, Amsterdam)
"Macrophages Eliminate Circulating Tumor Cells After Monoclonal Antibody Therapy"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmMining Molecular Analyses of CTCs
Discussion Leader: TBA
7:30 pm - 8:00 pm Jim Hicks (Cold Spring Harbor Laboratory)
"Genome-Wide Sequence Analysis of Single Cells in Cancer Patients Evolving Resistance to Chemotherapy"
8:00 pm - 8:30 pm Discussion
8:30 pm - 9:00 pm Yibin Kang (Princeton University)
"How Cancer Cells Acquire Metastatic Traits"
9:00 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDissemination and Self-Seeding: New Insights into the Role of Circulating Cells
Discussion Leader: Andrew Rhim (University of Michigan Comprehensive Cancer Center)
9:00 am - 9:40 am Max Wicha (University of Michigan Comprehensive Cancer Center)
"Circulating Stem Cells in Breast Cancer"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:10 am Dario Marchetti (Baylor College of Medicine)
"Characterizing Breast Cancer CTCs Subsets in Mechanisms of Tumor Dormancy and Metastatic Colonization"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pm Larry Norton (Memorial Sloan-Kettering Cancer Center)
"Cancer as a Disease of Cell Mobility"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEMT: Phenotypic Changes and Its Effect on CTC Data and Its Interpretation
Discussion Leader: TBA
7:30 pm - 8:00 pm Jing Yang (University of California, San Diego)
"Epithelial-Mesenchymal Plasticity in Carcinoma Metastasis"
8:00 pm - 8:30 pm Discussion
8:30 pm - 9:30 pm TBA (Short Presentations Selected from Posters)
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Last Updated: April 8, 2014
 
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