Gordon Research Conferences
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Conference Program
 
Sensory Transduction in Microorganisms
Responding to Cells, Stress, Surfaces and Small Molecules
January 12-17, 2014
Ventura Beach Marriott
Ventura, CA
Chair:
Brian R. Crane

Vice Chair:
John Kirby

Related Meeting Information
The Sensory Transduction in Microorganisms Gordon Research Conference was held in conjunction with the Sensory Transduction in Microorganisms Gordon Research Seminar. Please refer to the Sensory Transduction in Microorganisms GRS web page for more information.

The 2014 Gordon Conference on Sensory Transduction in Microorganisms to be held in Ventura CA will explore recent advances in understanding microbial systems of signal transduction. Focus will be placed on bacterial receptors and their interactions with intracellular networks that involve phosphorelays, two-component systems, and small molecule signaling by cyclic nucleotides, reactive metabolites and autoinducers. Topics will include gene regulation by sensory input and the assembly, action and regulation of motility apparatuses, such as bacterial flagella and pili. Mechanisms underlying chemotaxis, energy monitoring, community behavior, quorum sensing and biofilm formation will be central themes, especially with respect to pathogenesis. These areas will be addressed through cutting-edge applications of molecular genetics, cell biology, biochemistry, and chemical biology as well as structural, imaging and biophysical approaches. Data from high-resolution experiments will be paired with computational efforts to probe the behavior of complex macromolecular assemblies and understand signaling circuitry. Emerging directions such as the role of the cell wall in sensing and responding to signals and the engineering of prokaryotic signaling for biotechnology will be explored. Invited speakers will include both established and early-stage investigators. In addition, poster presenters will compete for short late-breaking topic talks. For the first time, a Gordon Research Seminar for postdocs and graduate students will precede the meeting. Participants will enjoy the Conference’s open and collegial atmosphere that provides valuable opportunities to engage in scientific discussion and foster interdisciplinary collaboration.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmSystems Biology of Sensory Transduction
7:40 pm - 7:55 pmDiscussion Leader: Igor Zhulin (University of Tennessee / Oak Ridge National Laboratory)
"Introduction and More"
7:55 pm - 8:25 pmYuhai Tu (IBM T. J. Watson Research Center)
"Precision Sensing in Bacteria: From pH-Taxis to Thermo-Taxis"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:45 pmYann Dufour (Yale University)
"Characterizing the Role of Phenotypic Diversity in E. coli Chemotactic Performance"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:00 pmNicholas Bartelli (University of Missouri)
"Conformational Signaling in the Escherichia coli Aspartate Receptor"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:30 pmGeneral Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTwo Component Systems and Phosphorelays
9:00 am - 9:10 amDiscussion Leader: Sean Crosson (University of Chicago)
"Introduction"
9:10 am - 9:35 amMichael Laub (Massachusetts Institute of Technology / HHMI)
"Systematically Mapping the Sequence Space of a Signaling Protein-Protein Interface"
9:35 am - 9:40 amDiscussion
9:40 am - 10:05 amMark Buttner (John Innes Center, Norwich UK)
"Cyclic di-GMP Signalling in Streptomyces Development"
10:05 am - 10:10 amDiscussion
10:10 amCoffee Break
10:35 am - 11:00 amErin Carlson (Indiana University)
"Chemical Probes for Histidine Kinase Protein Profiling and Inhibitor Discovery"
11:00 am - 11:05 amDiscussion
11:05 am - 11:30 amKirsten Jung (Ludwig-Maximilians-Universitaet Muenchen)
"Translational Regulation of Two-Component Systems"
11:30 am - 11:35 amDiscussion
11:35 am - 11:50 amChristopher Kristich (Medical College of Wisconsin)
"Nutritional Control of Antibiotic Resistance via an Interface Between the Phosphotransferase System and a Two-Component Signaling System"
11:50 am - 11:55 amDiscussion
11:55 am - 12:10 pmAlejandro Buschiazzo (Institute Pasteur Montevideo)
"Activation of Response Regulators is Mediated by a Non-Canonical Allosteric Mechanism Linking Dimerization and Cognate Kinase Binding"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmStephani Page (University of North Carolina)
"New Small Molecule Analog for Two-Component Signal Transduction Systems"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmReceptors
7:30 pm - 7:40 pmDiscussion Leader: Lynmarie Thompson (University of Massachusetts, Amherst)
"Introduction"
7:40 pm - 8:00 pmAidong Han (Xiamen University School of Life Sciences, PRC)
"The Molecular Architecture of an Essential Sensor Histidine Kinase VicK/YycG/WalK"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmGanesh Anand (National University of Singapore)
"Signaling Across Membranes: Monitoring Conformational Dynamics of Receptors by Mass Spectrometry"
8:30 pm - 8:35 pmDiscussion
8:35 pm - 8:50 pmGerman Piñas (University of Utah)
"Signaling Roles of a Direct Interaction Between CheA Kinase and Chemoreceptors"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:05 pmKene Piasta (University of Colorado, Boulder)
"Increasing and Decreasing the Stability of Bacterial Chemosensory Arrays by Modifying Protein-Protein Interfaces"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmAlberto Marina (Institute of Biomedicine of Valencia)
"Structural Basis of Histidine Kinase Autophosphorylation"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMotility Engines
9:00 am - 9:10 amDiscussion Leader: Nyles Charon (West Virginia University School of Medicine)
"Introduction"
9:10 am - 9:35 amMorgan Beeby (Imperial College, London)
"What Structural Dissection of Bacterial Flagellar Motors In Situ Tells Us About Molecular Mechanism and Evolution"
9:35 am - 9:40 amDiscussion
9:40 am - 10:05 amSeiji Kojima (Nagoya University, Japan)
"Assembly-Coupled Activation Mechanism of the Na+-Driven Stator Complex"
10:05 am - 10:10 amDiscussion
10:10 amCoffee Break
10:35 am - 11:00 amLori Burrows (McMaster University, Canada)
"Pseudomonas Goes Fishing: Surface Detection by Type IV Pili"
11:00 am - 11:05 amDiscussion
11:05 am - 11:30 amLaura Camarena (Univ Nacional Autonoma de Méxcio)
"Beyond the Common Inventory of Flagellar Proteins in Rhodobacter sphaeroides"
11:30 am - 11:35 amDiscussion
11:35 am - 11:50 amJames Flewellen (Oxford University)
"Digital Holographic Microscopy for 3D Studies of Microorganisms"
11:50 am - 11:55 amDiscussion
11:55 am - 12:10 pmPushkar Lele (Harvard University)
"Dynamics of Mechanosensing in the Bacterial Flagellar Motor"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmKai Thormann (Justus Liebig University Giess)
"A Novel Role for a Secondary Flagellar System in Efficient Spreading"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmQuorum Sensing and Coordinated Behavior
7:30 pm - 7:45 pmDiscussion Leader: Tam Mignot (University of Marseille, France)
"Introduction"
7:45 pm - 8:05 pmIlka Bischofs (ZMBH, University of Heidelberg)
"Form-Function Relationships for Bacterial Quorum Sensing Networks"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmWai Leung Ng (Tufts University School of Medicine)
"Signal Transduction in the Major Quorum-Sensing System of Vibrio cholerae"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmMichael Federle (University of Illinois at Chicago)
"Cell-Cell Signaling with Peptide Pheromones"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmZaara Sarwar (New York University)
"Determining the Mechanism of Activation and Inhibition of the Staphylococcus aureus Quorum Sensing Regulator AgrC"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmWalls and Surfaces
9:00 am - 9:10 amDiscussion Leader: Urs Jenal (University of Basel)
"Introduction"
9:10 am - 9:35 amGrant Jensen (California Institute of Technology / HHMI)
"Architecture, Assembly, and Morphogenetic Remodeling of Bacterial Cell Walls"
9:35 am - 9:40 amDiscussion
9:40 am - 10:05 amJoshua Shaevitz (Princeton University)
"Curvature-Based Feedback During Rod-Shaped Elongation in Bacteria"
10:05 am - 10:10 amDiscussion
10:10 amCoffee Break
10:35 am - 11:00 amCarrie Harwood (University of Washington)
"How Bacteria Sense Surfaces"
11:00 am - 11:05 amDiscussion
11:05 am - 11:30 amGeorge O'Toole (Dartmouth College School of Medicine)
"To Build a Biofilm"
11:30 am - 11:35 amDiscussion
11:35 am - 12:00 pmTracy Raivio (University of Alberta, Canada)
"Signaling Through the Cell Envelope"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:25 pmAkhirio Kawamoto (Osaka University)
"Common and Distinct Structural Features of Salmonella Injectisome and Flagellar Basal Body"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmAlternative Sensing Mechanisms
7:30 pm - 7:35 pmDiscussion Leader: Steven Porter (University of Exeter)
"Introduction"
7:35 pm - 8:05 pmAndy LiWang (University of California, Merced)
"If I Could Keep Time in a Bottle, I Would..."
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:45 pmJohn Helmann (Cornell University)
"Specificity and Crosstalk in Metalloregulation"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:10 pmPeter Kim (Yale University)
"An Ancient Riboswitch Class in Bacteria Regulates Purine Biosynthesis and One-Carbon Metabolism"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmChristopher Jones (Oxford University)
"Dynamics, Formation and Segregation of the Cytoplasmic Chemoreceptor Cluster in Rhodobacter sphaeroides"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell-Cell Communication
9:00 am - 9:10 amDiscussion Leader: Linda McCarter (University of Iowa)
"Introduction"
9:10 am - 9:35 amDaniel Lopez (University of Wurzburg, Germany)
"Organization and Assembly of Lipid Rafts in Bacteria"
9:35 am - 9:40 amDiscussion
9:40 am - 10:05 amElizabeth Shank (University of North Carolina, Chapel Hill)
"The Mechanisms and Molecules of Bacillus Biofilm Formation"
10:05 am - 10:10 amDiscussion
10:10 amCoffee Break
10:25 am - 10:50 amMarek Basler (University of Basel)
"Effector Translocation by the Type VI Secretion System"
10:50 am - 10:55 amDiscussion
10:55 am - 11:20 amFitnat Yildiz (University of California, Santa Cruz)
"Molecular Mechanisms of Vibrio cholerae Biofilm Formation"
11:20 am - 11:25 amDiscussion
11:25 am - 11:50 amAndy Camilli (Tufts University Medical School / HHMI)
"A Battle of Microbial Immune Systems"
11:50 am - 11:55 amDiscussion
11:55 am - 12:10 pmChristina Saak (Harvard University)
"Bacterial Self-Identity Tunes Population Migration"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmChinweike Okegbe (Columbia University)
"Redox Sensing Community Organizers in Biofilm Development"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSmall Molecule Signaling
7:30 pm - 7:40 pmDiscussion Leader: Alan Wolfe (Loyola School of Medicine)
"Introduction"
7:40 pm - 8:00 pmElizabeth Boon (Stony Brook University)
"Nitric Oxide Mediation of Bacterial Biofilm Formation"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmRasika Harshey (University of Texas, Austin)
"Cyclic-di-GMP and Cell Division Control"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmSusan Lovett (Brandeis University)
"Control of DNA Dynamics Through the Stringent Response"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmChristopher Rath (Novartis Institutes for Biomedicine)
"3D Surface Mass Spectrometry of a Man and a Woman: Visualizing Host-Microbiota Interactions"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute Of General Medical Sciences of the National Institutes of Health under Award Number R13GM109643. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Last Updated: March 25, 2014
 
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