| SUNDAY, AUGUST 4 |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 5:00 pm | Mixer |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NUCLEIC ACID SUPERSTRUCTURES AND GENE EXPRESSION |
| Discussion Leader: Ronald Berezney (SUNY, Buffalo) |
| 7:30 pm | Introduction and welcome |
| 7:45 pm - 8:20 pm | Nicole Francis (Harvard Medical School)
"Understanding mechanisms of chromatin modulation by polycomb group proteins." |
| 8:20 pm - 8:55 pm | Peter Cook (University of Oxford)
"Transcription factories as organizers of chromatin and chromosome structure." |
| 8:55 pm - 9:30 pm | Vicky Vance (University of South Carolina)
"Toward the mechanism of RNA silencing: What we can learn from viral suppressors." |
| 9:30 pm - 9:45 pm | General Discussion |
| MONDAY, AUGUST 5 |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ORGANIZATION OF CELLULAR METABOLISM |
| Discussion Leader: Judit Ovadi (Hungarian Academy of Sciences) |
| 9:00 am - 9:45 am | John Wilson (Michigan State University)
"Intramolecular and intracellular organization of the isozymes of mammalian hexokinase." |
| 9:45 am - 10:30 am | Bé Wieringa (University of Nijmegen)
"Ultrastructural and metabolic remodeling in creatine - or adenylate kinase deficient cells." |
| 10:30 am - 10:45 am | Coffee Break |
| 10:45 am - 11:30 am | Matthew Brady (The
University of Chicago)
"Spatial Compartmentalization in the Activation of Glycogen Synthase by Insulin" |
| 11:30 am - 12:15 pm | Richard Perham (University of Cambridge)
"Multifunctional catalytic machines: the contribution of supramolecular structure to catalysis" |
| 12:15 pm - 12:30 pm | General Discussion |
| 12:45 pm | Photo / Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Flashes
Brief summaries of posters by graduate students and postdoctoral fellows. |
| 6:00 pm | Dinner |
| 7:30 pm - 8:20 pm | PAUL SRERE MEMORIAL LECTURE |
| Douglas Kell (University of Wales)
"From metabolon to metabolome - and back? The 2nd Paul Srere lecture" |
| 8:20 pm - 9:30 pm | THE VIRTUAL CELL |
| Discussion Leader: Pedro Mendes (Virginia Tech) |
| 8:20 pm - 8:55 pm | László Barabási (Notre Dame University)
"Characterization of complex cellular networks: from the metabolism to protein interactions." |
| 8:55 pm - 9:30 pm | Hiroaki Kitano (Sony Biological Computing Lab)
"Toward comprehensive simulation and analysis of intra-cellular and multi-cellular systems." |
| 9:30 pm - 9:45 pm | General Discussion |
| TUESDAY, AUGUST 6 |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | THE CYTOSKELETON AND CELL FUNCTION |
| Discussion Leader: Keith Gull (University Manchester) |
| 9:00 am - 9:45 am | Robert Singer (Albert Einstein College of Medicine)
"How does RNA Move?" |
| 9:45 am - 10:30 am | Elizabeth Gavis (Princeton)
"Subcellular RNA localization and localization-dependent translational control in Drosophila." |
| 10:30 am - 10:45 am | Coffee Break |
| 10:45 am - 11:30 am | Keith Gull (University of Manchester)
"The eukaryotic flagellum: solid phase biochemistry, self assembly and much beyond." |
| 11:30 am - 12:15 pm | Kathryn Thomasson (University of North Dakota)
"Computer simulations of glycolytic enzyme/F-actin interactions." |
| 12:15 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:45 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SIGNALING |
| Discussion Leader: Dennis Bray (University of Cambridge) |
| 7:30 pm - 8:10 pm | Dennis Bray (University of Cambridge)
"Molecular events in a very small volume of cytoplasm."
|
| 8:10 pm - 8:50 pm | Steve Kay (The Scripps Research Institute)
"Comparative genomics and biological clocks - from transcription to behavior." |
| 8:50 pm - 9:30 pm | Sui Huang (Harvard Medical School)
"Genomic networks: An integrative view of signal transduction in cell fate control." |
| 9:30 pm -9:45 pm | General Discussion |
| WEDNESDAY, AUGUST 7 |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ORGANIZATION OF TRANSLATION |
| Discussion Leader: Murray Deutscher (University of Miami School of Medicine) |
| 9:00 am - 9:45 am | Sunghoon Kim (Seoul National University)
"Structural organization and functional significance of multi-tRNA synthetase complex." |
| 9:45 am - 10:30 am | Murray Deutscher (University of Miami School of Medicine)
"The mammalian cell as macromolecular assembly." |
| 10:30 am - 10:45 am | Coffee Break |
| 10:45 am - 11:30 am | Ada Yonath (Weizmann Institute and MaxPlanck Research Institute)
"Antibiotics targeting ribosomes." |
| 11:30 am - 12:15 pm | Agamemnon J. Carpousis (CNRS-Toulouse)
"The E. coli degradosome: structure, function and relationship to other ribonucleolytic complexes." |
| 12:15 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:45 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NEW TECHNOLOGIES FOR THE POST-GENOMIC ERA |
| Discussion Leader: Stephen Oliver (University of Manchester) |
| 7:30 pm - 8:10 pm | Ronald T. Raines (University of Wisconsin)
"Protein assembly to mine the human genome." |
| 8:10 pm - 8:50 pm | Ioannis Xenarios (UCLA)
"Mapping cellular protein interactions: In silico protein function and interaction predictors." |
| 8:50 pm - 9:30 pm | Oliver Fiehn (Max-Planck Institute of Molecular Plant Physiology)
"Prospects and obstacles of metabolomics: lessons we learn from cucurbits." |
| 9:30 pm - 9:45 pm | Business Meeting |
| THURSDAY, AUGUST 8 |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MOLECULAR IMAGING IN INTACT LIVING SYSTEMS |
| Discussion Leader: Kevin Brindle, University of Cambridge |
| 9:00 am - 9:45 am | Sanjiv Sam Gambhir (UCLA School of Medicine)
"Multimodality molecular imaging." |
| 9:45 am - 10:30 am | Rainer Pepperkok (EMBL)
"Live cell imaging: Illuminating structure and function in the secretory pathway." |
| 10:30 am - 10:45 am | Coffee Break |
| 10:45 am - 11:30 am | Petra Schwille (Max Planck Institute for Biophysical Chemistry)
"Fluorescence correlation spectroscopy: Single molecule techniques for cell biology." |
| 11:30 am - 12:15 pm | Wolfgang Baumeister (Max Planck Institute for Biochemistry)
"Electron tomography: Towards visualizing supramolecular architecture in intact cells." |
| 12:15 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time
|
| 4:00 pm - 5:15 pm | Poster Discussion Session
Discussion of select posters. |
| 5:15 pm | Reception |
| 6:00 pm | Conference Banquet |
| 7:30 pm - 9:30 pm | IMAGING OF INTRACELLULAR PROCESSES |
| Discussion Leader: Chris Hardin, University of Missouri |
| 7:30 pm - 8:10 pm | John Presley (McGill University)
"Probing Golgi structure and function using confocal microscopy and photobleach techniques." |
| 8:20 pm - 8:50 pm | Pamela Silver (Harvard University)
"Genome-wide mapping of nuclear organization reveals connections between transcription and nuclear transport." |
| 8:50 pm - 9:30 pm | Glenn D. Prestwich (The University of Utah)
"Eavesdropping on intracellular phospholipid metabolism." |
| 9:30 pm - 9:45 pm | General Discussion |
| FRIDAY, AUGUST 9 |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 | Departure |