Conference Program
 
Prolactin & Growth Hormone Family

January 27 - February 1, 2002
Four Points Sheraton / Holiday Inn Express
Ventura, CA

Chair:
Paul A. Kelly

Vice Chair:
Shlomo Melmed

INTRODUCTION:

The 2002 Gordon Research Conference on Prolactin will be held in Ventura, California, from Jan. 27 - Feb. 1, 2002. As has been the case for the past several years, the conference will address outstanding research dealing with prolactin and growth hormone and provide a forum for the presentation and critical discussion of the molecular, structural, functional and clinical aspects of these two hormones and their receptors. There will be two highlighted presentations: The meeting begins with a Debate on Sunday evening entitled "Do prolactin and growth hormone cause cancer?" M.G. Rosenfeld will end the meeting with the Keynote Address on Thursday evening speaking on "Genetic control of pituitary development". Morning and evening sessions during the week have been scheduled covering various aspects of prolactin and growth hormone secretion, receptors, and actions. The following sessions will be presented:

  • Debate: PRL, GH and cancer
  • Mouse models, microarray analysis and proteomics
  • PRL and GH physiology
  • Pituitary development and regulation
  • Agonists, antagonists and assays
  • Effects in peripheral tissues
  • Behavior and lifestyles
  • PRL and GH signaling
  • Keynote address: Pituitary Development

There will also be eight Platform Presentations by graduate students, postdoctoral fellows, or junior faculty who will present late-breaking, up-to-the-minute results from their submitted abstracts. The remaining abstracts will be presented in two Poster sessions.

SUNDAY
2:00 pm - 9:00 pmArrival and check-in
6:00 pmDinner
7:30 pm - 9:30 pmDEBATE: DO PRL AND GH CAUSE CANCER?
Discussion Leader: Paul A. Kelly (Faculty of Medicine Necker, Paris, France)
7:30 pm - 9:30 pmStephen M Shalet (Christie Hospital, Manchester, UK)
and
Jeff Holly (Bristol Royal Infirmary, Bristol, UK)
MONDAY
7:30 am - 8:30 amBreakfast
8:40 am - 8:55 am Group Photograph
9:00 am -12:00 pmMOUSE MODELS, MICROARRAY ANALYSIS & PROTEOMICS
Discussion Leader: Arthur Gutierrez-Hartmann (University of Colorado Medical Center, Denver, CO)
9:00 am - 9:40 amMartin Hrabé-De Angelis (GSF National Research Center of Environment, Neurherberg, Germany)
"Large scale production and characterization of mouse models for inherited diseases in man"
9:40 am - 10:20 amGunnar Norstedt (Karolinska Institute, Stockholm, Sweden)
"Microarray analysis of growth hormone regulated gene expression in the rat"
10:20 am -10:40 am Coffee Break
10:40 am-11:20 amChristopher J. Ormandy (Garvan Institute of Medical Research, Sydney, Australia)
"Identification of prolactin responsive genes by microarray analysis"
11:20 am-12:00 pmDominic M. Desiderio (University of Tennessee, Memphis, TN)
"Proteomic analysis of the human pituitary"
12:00 pm-12:30 pmPLATFORM PRESENTATIONS
Discussion Leader: Shlomo Melmed (Cedars Sinai, Los Angeles, CA)
12:00 pm-12:15 pmMatthew J. LeBaron (Uniformed Sciences University, Bethesda, MD)
"Strategy to identify interaction sites of transcription factor Stat5 within the human genome"
12:15 pm-12:30 pmAllan J. Nixon (Ruakuva Research Center, Hamilton, New Zealand)
"Expression patterns of prolactin receptor, prolactin, placental lactogen and growth hormone over a hair cycle induced in murine skin"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPRL AND GH PHYSIOLOGY
Discussion Leader: Geula Gibori, (University of Illinois, Chicago, IL)
7:30 pm - 8:10 pmDavid Kleinberg (New York University Medical Center, New York, NY)
"GH and prostate function"
8:10 pm - 8:50 pmOlle Isaksson (Sahlgrenska University Hospital, Gothenburg, Sweden)
"Physiological significance of endocrine versus locally produced growth factors/hormones in the PRL/GH regulatory system"
8:50 pm - 9:30 pmFilipe F. Casanueva (Santiago de Compostela University, Spain)
"GH and PRL interactions with the leptin axis"
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:00 pmPITUITARY DEVELOPMENT AND REGULATION
Discussion Leader: Nira Ben-Jonathan (University of Cincinnati, OH)
9:00 am - 9:40 amShane Hentges(Oregon Health Sciences University, Portland, OR)
"Pituitary lactotroph regulation in D2R-PRLR deficient mice"
9:40 am - 10:20 amPriscilla Dannies (Yale University, New Haven, CT)
"Sorting of prolactin and growth hormone into secretory granules"
10:20 am-10:40 amCoffee Break
10:40 am-11:20 amRula Abbud (Cedars Sinai Research Institute, Los Angeles, CA)
"Differential regulation or PRL, GH and POMC by Leukemia Inhibitory Factor (LIF)"
11:20 am-12:00 pm Michael O Thorner (University of Virginia School of Medicine, Charlottesville, VA)
"GH secretagogues in humans
12:00 pm-12:30 pmPLATFORM PRESENTATIONS
Discussion Leader: Shlomo Melmed (Cedars Sinai, Los Angeles, CA)
12:00 pm-12:15 pmMarcello Bronstein (University of Sao Paulo, Brazil)
"Prolactin: it isn't always what it seems"
12:15 pm-12:30 pmSophie Bernichtein (Necker Faculty of Medicine, Paris, France)
"Development and importance of new homologous bioassays for human lactogens: which assay for what purpose?"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAGONISTS, ANTAGONISTS AND ASSAYS
Discussion Leader: John Kopchick (Ohio University, Athens, OH)
7:30 pm - 8:10 pmVincent Goffin (Faculty of Medicine Necker, Paris, France)
"Development and use of prolactin antagonists"
8:10 pm - 8:50 pmPeter J. Trainer (Christie Hospital, Manchester, UK)
"GH receptor antagonists in man"
8:50 pm - 9:30 pmChristian J. Strasburger (Ludwig Maximilians University, Munich, Germany)
"GH, placental hormones and PRL assays: state of the art"
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am -12:00 pmEFFECTS OF PRL AND GH IN PERIPHERAL TISSUES
Discussion Leader: Elisabeth L. Hooghe-Peters (Free University of Brussels, Belgium)
9:00 am - 9:40 amAnnette Moldrup (Hagedorn Research Institute, Gentofte, Denmark)
"Mechanisms of GH- and PRL-induced replication of pancreatic beta-cells"
9:40 am -10:20 amMichael Freemark (Duke University School of Medicine, Durham, NC)
"Metabolism and weight gain in PRL receptor deficient mice"
10:20 am-10:40 amCoffee Break
10:40 am-11:20 amNelson Horseman (University of Cincinnati, Cincinnati, OH)
"Prolactin induction of mammary tryptophan hydroxylase expression: mechanisms and physiology"
11:20 am-11:50 amPLATFORM PRESENTATIONS
Discussion Leader: Shlomo Melmed (Cedars Sinai, Los Angeles, CA)
11:20 am-11:35 amKaren Liby (University of Cincinnati, Cincinnati, OH)
"Prolactin as a local growth/anti-apoptotic factor in MDA-MB-435 breast cancer cells"
11:35 am-11:50 amSok-Hyong Lee (Baylor College of Medicine, Houston, TX)
"Anti-inflammatory effects of estrogen and prolactin during hemorrhagic shock"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 8:00 pmBusiness Meeting
8:00 pm - 9:30 pmBEHAVIOR AND LIFESTYLES
Discussion Leader: Susan Berry (University of Minnesota, Minneapolis, MN)
8:00 pm - 8:45 pmLuz Torner (Regensburg University, Regensburg, Germany)
"Anxiolytic and anti-stress effects of brain prolactin"
8:45 pm - 9:30 pmSteven Lamberts (University Hospital Dijkzigt, Rotterdam, Netherlands)
"The role of IGF-I in frailty and lifestyles"
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am -12:00 pmPRL and GH Signaling
Discussion Leader: Linda Schuler (University of Wisconsin, Madison, WI)
9:00 am -9:40 amLi Yu-Lee (Baylor College of Medicine, Houston, TX)
"Prolactin and activation of interferon regulated factor-1 gene transcription"
9:40 am -10:20 amSuhad Ali (McGill University, Montreal, Canada)
"Phosphatases and prolactin signaling"
10:20 am-10:40 amCoffee Break
10:40 am-11:20 amCharles V. Clevenger (University of Pennsylvania, Philadelphia, PA)
"The importance of nuclear prolactin in signal transduction"
11:20 am-12:00 pmDavid R. Clemmons (University of North Carolina, Chapel Hill, NC)
"Cellular context determines GH and IGF-I receptor responsiveness"
12:00 pm-12:30 pmPLATFORM PRESENTATIONS
Discussion Leader: Shlomo Melmed (Cedars Sinai, Los Angeles, CA)
12:00 pm-12:15 pmMonica M. Richert (University of Colorado Health Sciences Center, Denver, CO)
"Deletion of downstream effectors of PRLR signaling affect mouse mammary gland development"
12:15 pm-12:30 pmCharlotte A. Ling (Goteborg University, Goteborg, Sweden)
"PRL mediated effects in adipocytes"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:00 pmKEYNOTE ADDRESS
Discussion Leader: Shlomo Melmed (Cedars Sinai Research Institute, Los Angeles, CA)
7:30 pm - 9:00 pmMichael Geoff Rosenfeld (University of California at San Diego, CA)
"Genetic control of pituitary development"
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

The generous support of the following organizations is gratefully acknowledged:

  • Eli Lilly, Inc.
  • Endocrine Research and Education
  • Foundation Ipsen
  • Genzyme Corporation
  • Gordon Research Conferences
  • National Institutes of Health
  • Novartis, Inc.
  • Novo-Nordisk Biotech, Inc.
  • Pharmacia, Inc.
  • Serono Foundation
Last Updated: May 4, 2006