| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 5:00 pm - 6:00 pm | Welcome reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Cell Surface Proteolysis |
| Discussion Leader: Toni Antalis (American Red Cross Holland Laboratory, Rockville, MD) |
| 7:30 pm - 7:35 pm | Toni Antalis (Introduction) |
| 7:35 pm - 8:10 pm | Thomas Bugge (National Institute of Dental and Craniofacial Research, Bethesda, MD)
"Matriptase/MT-SP1 in Epidermal Development and Squamous Cell Carcinogenesis" |
| 8:10 pm - 8:50 pm | David Ginsburg (University of Michigan, Ann Arbor)
"ADAMTS13 and Thrombotic Thrombocytopenic Purpura (TTP)" |
| 8:50 pm - 9:30 pm | Qingyu Wu (Berlex Biosciences, Richmond, CA)
"Biochemical and Genetic Studies of the Cardiac Transmembrane Serine Protease Corin" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Proteases and Inhibitors in Neurobiology |
| Discussion Leader: Sidney Strickland (Rockefeller University, New York) |
| 9:00 am - 9:05 am | Sidney Strickland (Introduction) |
| 9:05 am - 9:40 am | Sidney Strickland (Rockefeller University)
"tPA in the Nervous System" |
| 9:40 am - 10:15 am | Manuel Yepes (American Red Cross Holland Laboratory, Rockville, MD)
"The Role of tPA and Neuroserpin in Cerebral Ischemia" |
| 10:15 am | Coffee Break |
| 10:45 am - 11:20 am | Stella Tsirka (SUNY, Stony Brook)
"tPA and Neuronal Cell Death" |
| 11:20 am - 11:55 am | Denis G. Vivien (Université de Caen, CAEN, France)
"Tissue type plasminogen activator (tPA), a key partner for the working brain" |
| 11:55 am - 12:30 pm | Florence Molinari (Hôpital Necker-Enfants Malades, Paris, France)
"Neurotrypsin Defect Associated with Cognitive Impairments in Humans" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Fibrinogen and
Fibrinolysis |
| Discussion Leader: Nuala Booth (University of Aberdeen, UK) |
| 7:30 pm - 7:35 pm | Nuala Booth (Introduction) |
| 7:35 pm - 8:10 pm | Nuala Booth (University of Aberdeen, UK)
"Cross-Linking and Inhibitors - What Really Stabilizes Fibrin?" |
| 8:10 pm - 8:50 pm | Jay Degen (Cincinnati Children's Hospital Medical Center, Cincinnati)
"Genetic Dissection of the Hemostatic and Inflammatory Systems" |
| 8:50 pm - 9:30 pm | John W. Weisel (University of Pennsylvania, Philadelphia)
"The Physical Process of Fibrinolysis Visualized in Real Time" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Plasminogen-Independent Extracellular Proteolysis |
| Discussion Leader: Sharon Stack (Northwestern University, Chicago) |
| 9:00 am - 9:05 am | Sharon Stack (Introduction) |
| 9:05 am - 9:40 am | Sharon Stack (Northwestern University, Chicago)
"Adhesion Regulated Proteinase Activity" |
| 9:40 am - 10:15 am | Peter Brooks (New York University, New York)
"PEXSTATIN accelerates autocatalytic processing of MMP-2 and inhibits angiogenesis and tumor growth in vivo" |
| 10:15 am | Coffee Break
|
| 10:45 am - 11:20 am | Peter Friedl (University of Wuerzburg, Wuerzburg, Germany)
"Widening the Space: 5D Imaging of Pericellular Collagenolysis in Cancer Invasion" |
| 11:20 am - 11:55 am | William G. Stetler-Stevenson (National Cancer Institute, Bethesda, MD)
"TIMP-2 Inhibition of Cell Growth" |
| 11:55 am - 12:30 pm | Barbara Furie (Harvard Medical School, Boston)
"Microparticles and a P-selectin dependent pathway of blood coagulation" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Rational Drug Design and the Plasminogen Activation System
|
| Discussion Leader: Ed Madison (Dendreon, San Diego) |
| 7:30 pm - 7:35 pm | Ed Madison (Introduction) |
| 7:35 pm - 8:10 pm | David Crandall (Wyeth Research, Collegeville, PA)
"Development of Small Molecule PAI-1 Inactivators" |
| 8:10 pm - 8:50 pm | Peter A. Andreasen (University of Aarhus, Aarhus, Denmark)
"PAI-1 and uPA as Therapeutic Targets" |
| 8:50 pm - 9:30 pm | Stephen Leppla (National Institute of Dental and Craniofacial Research, Bethesda, MD)
"Protease-activated cytotoxins with high specificity for tumor cells" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Extracellular Proteolysis and Disease |
| Discussion Leader: Keld Danø (Finsen Laboratory, Copenhagen, Denmark) |
| 9:00 am - 9:05 am | Keld Danø (Introduction) |
| 9:05 am - 9:40 am | William Fay (University of Michigan, Ann Arbor)
"The Role of the PA-System in the Pathogenesis of Streptococcal Infection" |
| 9:40 am - 10:15 am | David Loskutoff (The Scripps Research Institute, La Jolla, CA)
"Leptin and Thrombosis" |
| 10:15 am | Coffee Break |
| 10:45 am - 11:20 am | Hartmut Weiler (Blood Research Institute, Milwaukee, WI)
"Regulation of Placental Cell Death by Fibrin Degradation Products" |
| 11:20 am - 11:55 am | Douglas Vaughan (Vanderbilt University, Nashville, TN)
"Functional Insights from Structural Mutations in PAI-1 Transgenic Mice" |
| 11:55 am - 12:30 pm | Niels Behrendt (Finsen Laboratory, Copenhagen, Denmark)
"Plasminogen System in Cancer" |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Afternoon Trip to Santa Barbara (bus transportation provided) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Late Breaking Hot Topics from Abstracts |
| Discussion Leaders: Peter A. Andreasen (University of Aarhus, Aarhus, Denmark) & Hartmut Weiler (Blood Research Institute, Milwaukee, WI) |
| 7:30 pm - 7:45 pm | Katerina Akassoglou (University of California, San Diego)
"p75 Neutrophin Receptor Inhibits Fibrinolysis" |
| 7:45 pm - 8:00 pm | Nathalie Lebeurrier (Université de Caen, Caen, France)
"Neuroserpin in Excitotoxic Neuronal Death" |
| 8:00 pm - 8:15 pm | Todd Hembrough (Entremed, Inc., Rockville, MD)
"Novel Antagonists of PAR-2: Inhibition of Tumor Growth, Angiogenesis and Inflammation" |
| 8:15 pm - 8:30 pm | Junfeng Liang (Stevens Institute of Technology, Hoboken, NJ)
"Use of Mutant tPAs to Avoid Plasminogen Activator Treatment Associated Bleeding Risks" |
| 8:30 pm - 8:45 pm | Ralf-Peter Czekay (The Scripps Research Institute, La Jolla, CA)
"PAI-1 Initiates Cell Detachment by Selectively Targeting Matrix-Engaged Integrins: Critical Role of uPAR" |
| 8:45 pm - 9:00 pm | Gerald Prager (Medical University of Vienna, Vienna, Austria)
"Regulatory Role of the Urokinase Receptor (uPAR) in Integrin beta-1 Redistribution upon Vascular Endothelial Growth Factor (VEGF)-induced Endothelial Cell Stimulation" |
| 9:00 pm - 9:15 pm | Khalid Bajou (Children's Hospital, Los Angeles, CA)
"Plasminogen Activator Inhibitor-1 Promotes Angiogenesis in Neuroblastoma by Protecting Endothelial Cells from Apoptosis" |
| 9:15 pm - 9:30 pm | Elena Deryugina (The Scripps Research Institute, La Jolla, CA)
"Collagenolysis-Dependent Angiogenesis Mediated by Plasmin-Activated MMP-13" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Protease Receptors and Cell-Signaling |
| Discussion Leader: Steve Gonias (University of Virginia, Charlottesville) |
| 9:00 am - 9:05 am | Steve Gonias (Introduction) |
| 9:05 am - 9:40 am | Steve Gonias (University of Virginia)
"Urokinase Receptor-initiated Cell Signaling" |
| 9:40 am - 10:15 am | Francesco Blasi (DIBIT, Milano, Italy)
"Urokinase Receptor Signaling: New Insights in the Mechanisms Involved in Anti-HIV Effects and in Cancer Cell Proliferation"
|
| 10:15 am | Coffee Break |
| 10:45 am - 11:20 am | Dudley Strickland (American Red Cross Holland Laboratory, Rockville, MD)
"LRP Mediated Cell Signaling" |
| 11:20 am - 11:55 am | Joachim Herz (University of Texas Southwestern Medical Center, Dallas)
"Control of Vessel Wall Stability by ApoE Receptor Signaling" |
| 11:55 am - 12:30 pm | Katherine Hajjar (Cornell University, New York)
"Annexin II and Vascular Homeostasis" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 5:00 pm | Business Meeting |
| 5:00 pm - 6:00 pm | Farewell Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Proteolysis in the Post Genomic Era |
| Discussion Leader: Bruce Furie (Harvard Medical School, Boston) |
| 7:30 pm - 7:35 pm | Bruce Furie (Introduction) |
| 7:35 pm - 8:10 pm | Bruce Furie (Harvard Medical School, Boston)
"In Vivo Biochemistry and Cell Biology: High Speed Confocal and Widefield Fluorescence Imaging of the Microcirculation of a Living Mouse" |
| 8:10 pm - 8:50 pm | Stephen G. Young (University of California, San Francisco)
"BayGenomics, a Gene-trapping Resource" |
| 8:50 pm - 9:30 pm | Christopher M. Overall (University of British Columbia)
"Degradomics: Protease substrate discovery by Isotope Coded Affinity Tag-Mass Spectrometry" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |