Cannabinoid function in the CNS is a new Gordon Conference whose aim is to bring together established scientists, post-docs, and graduate students interested in the roles that endogenous and exogenous cannabinoids have in neural cell function. Recent work from a number of labs suggests that endogenous cannabinoids play a major role in regulating short and long-term plasticity in several neural circuits. Simultaneously, it is becoming clear that endogenous cannabinoids are involved in CNS development and several forms of behavior, including specific forms of reward and aversion. Finally, the implications of the widespread recreational and therapeutic use of cannabinoids on the efficacy of endocannabinoid signaling are just beginning to be appreciated. It is the goal of this conference to explore these relationships in depth, identifying the most important areas of research in the cannabinoid field for the next several years.