Conference Program
 
NATURAL PRODUCTS

July 24-29, 2005
Tilton School
Tilton, NH

Chair:
Joseph D. Armstrong

Vice Chair:
Frederick A. Luzzio

54th GORDON RESEARCH CONFERENCE on NATURAL PRODUCTS

In its present form, the field of Natural Products Chemistry not only encompasses the more traditional disciplines of isolation, total synthesis, and methods development, but it also has expanded into medicinal chemistry, chemical biology, and molecular biology. Because of the emerging advances of neutroceuticals, some of the leading experts from this field will present a few select topics so as to synergize the pharmaceutical and neutraceutical arenas. It was with this diversity in mind that the 54th Gordon Research Conference on Natural Products was organized. As we hope you can see from the schedule, individuals who are among the leaders in their respective disciplines have agreed to present lectures at this year's conference. The topics of these lectures will literally span the rather broad scope of this discipline.

In addition to the invited lectures, the normal afternoon and evening poster sessions will be held. We encourage you to consider submitting a poster for these sessions. The poster sessions are important to the success of the meeting and are a fantastic forum to receive feedback on your latest results. In addition to all of this, a few of the posters will be chosen to give short talks at the meeting. The Vice-Chair for this year's meeting, Frederick Luzzio, will be in charge of both the poster sessions and choosing the speakers from the posters. Please take the time to forward your posters to him at FALUZZ01@GWISE.LOUISVILLE.EDU.

As has been the case since this conference moved to Tilton, we anticipate that you'll find the Tilton School an almost ideal location for this meeting. We very much look forward to seeing you in Tilton!

Joseph D. Armstrong, III (Merck & Co., Inc), Chair
Frederick A. Luzzio (Univ. of Louisville), Vice-Chair

Acknowledgements

The chairs would like to acknowledge the following companies for their generous financial support:

Abbott Laboratories
Allergan
Amgen, Inc
Arena Pharmaceuticals, Inc.
Array BioPharma, Inc.
Bayer Corporation
Boehringer Ingelheim, Inc.
Chiron Corporation
Eli Lilly & Company
Genentech, Inc.
GlaxoSmithKline
Hoffmann-LaRoche
Johnson & Johnson
M. Ross Johnson
Merck & Co., Inc.
Neurogen Corporation
Novartis, Institute for Biomedical Research, Inc.
Pfizer, Inc
Roche Palo Alto, LLC
Schering Plough Research Institute

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 9:30 pmTotal Synthesis
Discussion Leader: Jim Heck (Merck Research Laboratories)
7:30 pm - 7:40 pm Opening Remarks: Joseph D. Armstrong, III
7:40 pm - 8:20 pm Mark Rizzacasa (Melbourne Univ., Australia)
Structure Determination and Total Synthesis of Bioactive Natural Products
8:20 pm - 8:50 pmShort Talk: Alison Frontier (Univ. of Rochester)
Progress toward the Synthesis of Merrilactone A
8:50 pm - 9:30 pmSam Danishefsky (Columbia Univ.)
Recent Findings in a Venerable Science
9:30 pmChair's Reception
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 10:30 amCatalytic Methodology I
Discussion Leader: Janis Louie (Univ. of Utah)
9:00 am - 9:40 am Tim Jamison (Massachusetts Institute of Technology)
Catalytic Stereoselective Fragment Coupling Reactions in Total Synthesis
9:40 am - 10:00 amHelene Lebel (Univ. of Montreal, Canada)
Cascade Multicatalytic Strategies: Toward the Synthesis of Natural Products
10:00 am - 10:30 amBREAK
10:30 am - 12:30 pmCatalytic Methodology II
Discussion Leader: Michael Lusch (Minnesota State Univ.)
10:30 am - 11:10 amDan Yang (Univ. of Hong Kong, China)
Catalytic Asymmetric Cyclization Reactions for Natural Product Synthesis
11:10 am - 11:50 amHuw Davies (State University of New York at Buffalo)
Catalytic Enantioselective C-H Activation as a Strategic Reaction for Natural Product Synthesis
11:50 am - 12:30 pmMikiko Sodeoka (Tohuku Univ., Japan)
Catalytic Enantioselective Reactions Useful for the Synthesis of Bioactive Molecules
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pmMethodology & Total Synthesis I
Discussion Leader: Steve Wittenberger (Abbott Laboratories)
7:30 pm - 8:15 pm Jim Leighton (Columbia Univ.)
Silane Lewis Acids for the Practical Asymmetric Synthesis of Chiral Carbinols and Carbinamines
8:15 pm - 8:45 pmBrian Stoltz (California Institute of Technology)
Complex Natural Products as a Driving Force for Discovery in Organic Chemistry
8:45 pm - 9:30 pm Erick Carreira (ETH, Switzerland)
Studies in Asymmetric Synthesis
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:45 amMethodology & Total Synthesis II
Discussion Leader: Martin Lear (Univ. of Singapore)
9:00 am - 9:45 amGary Molander (Univ. of Pennsylvania)
Methods Development and Applications to Natural Product Synthesis
9:45 am - 10:15 am Corrine Aubert (Universite Pierre et Marie Curie, Paris)
Cobalt-Mediated Cyclizations as Efficient Tools for Synthesis
10:15 am - 10:45 amBREAK
10:45 am - 12:30 pmChemical Ecology/Biology
Discussion Leader: Bradley Moore (Univ. of Arizona)
10:45 am - 11:15 amJoern Piel (Max Planck Inst. for Chemical Ecology, Germany)
Exploring natural product pathways from uncultivated bacterial symbionts
11:15 am - 11:45 amNicola Pohl (Iowa State Univ.)
Microwaves and Microarrays
11:45 am - 12:30 pm Jerrold Meinwald (Cornell Univ.)
Exploring the Chemistry of Biotic Interactions
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pmDinner
7:30 pm - 9:30 pmProtein Chemical Biology
Discussion Leader: Marcey Waters (Univ of N. Carolina)
7:30 pm - 8:15 pmSuzanne Walker (Harvard Univ.)
Assembly of the Peptidoglycan Shell: When and Where Does Peptidoglycan Synthesis Take Place?
8:15 pm - 8:45 pmBen Davis (Oxford Univ.)
Sugars and Enzymes
8:45 pm - 9:30 pmHerbert Waldmann (Max Planck Institut)
Charting Biologically Relevant Chemistry Space
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:40 amMedicinal & Process Chemistry I
Discussion Leader: Vincent Sandanayaka (deCode)
9:00 am - 9:35 amMilton Brown (Univ. of Virginia, Charlottesville)
Chemical Evolution of Small Molecule Imposters of Natural Product Tubulin Inhibitors
9:35 am - 10:10 amChris Senanayake (Boehringer Ingelheim)
Practical Synthetic Methodologies for Efficient Drug Development
10:10 am - 10:40 amBREAK
10:40 am - 12:30 pmNutraceuticals & Medical Plants
Discussion Leader: Phil Crews (Univ of California - Santa Barbara)
10:40 am - 11:20 amUwe Koetter
Pharmacology and Clinical Efficacy of Medicinal Plants
11:20 am - 11:55 amQun Yi Zheng (Pure World Botanicals, Inc.)
MacaPure® - From an Andean Natural Remedy to a Standardized Nutraceutical Product
11:55 am - 12:30 pmBruce Lipshutz (Univ. of California, Santa Barbara)
The Miracle Nutrient Coenzyme Q10: We Make it & We Take It!
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 3
6:00 pmDinner
7:30 pm - 9:30 pmMedicinal & Process Chemistry II
Discussion Leader: Mike Martinelli (Amgen)
7:30 pm - 8:05 pm Musical Interlude (Jerrold Meinwald & Eiichi Nakamura)
8:05 pm - 8:45 pmAnn Weber (Merck & Co., Inc.)
Discovery of MK-0431, a Selective DPP-IV Inhibitor for the Treatment of Type 2 Diabetes
8:45 pm - 9:30 pmKarl Hansen (Merck & Co., Inc.)
Synthesis of the DPP-IV Inhibitor MK-0431
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:30 amMethodology & Total Synthesis III
Discussion Leader: Spencer Knapp (Rutgers Univ.)
9:00 am - 9:30 amShort Talk: Gregory Dudley (Florida State Univ.)
CC Bond Cleavage Strategies for Natural Product Synthesis
9:20 am - 9:40 amShort Talk: Sherry Chemley (SUNY Buffalo)
Copper(II) Promoted Intramolecular Diamination and Aminocarbonation of Unactivated Olefins for the Synthesis of Nitrogen-Containing Heterocyclic Small Molecules
9:40 am - 10:00 am Short Talk: Chulbom Lee (Princeton Univ.)
Chemical Synthesis of Kendomycin
10:00 am - 10:30 amBREAK
10:30 am - 12:30 pmMethodology & Total Synthesis IV
Discussion Leader: David Carini (BMS)
10:30 am - 11:15 amPeter Wipf (Univ. of Pittsburgh)
Chemistry & Biology of Disorazole
11:15 am - 11:45 amShort Talk: Tony Haight (Abbott)
Synthesis of quinolone antibiotic ABT-492
11:45 am - 12:30 pmEiichi Nakamura (Univ. of Tokyo, Japan)
New Metallo Enamine Chemistry
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 4
6:00 pmDinner
7:15 pm - 7:30 pmSoftball Awards & Announcements
7:30 pm - 9:30 pmMethodology & Total Synthesis V
Discussion Leader: Suzy Shuker (Georgia Tech)
7:30 pm - 8:15 pm Andy Evans (Indiana University)
Enantioselective Total Synthesis of Batzelladine A and D using Novel Reductive and Oxidative Free Radical Cyclization Reactions
8:15 pm - 8:45 pmShort Talk: Andrew Phillips (Univ. of Colorado)
Tandem Reaction Strategies for Synthesis: Cylindramide A and Aburatubolactam A
8:45 pm - 9:30 pmPaul Wender (Stanford Univ.)
Speed and Leads: Step Economy, New Reactions, New Natural and Designed Products, and New Drug Delivery Systems
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
Last Updated: August 14, 2006