Conference Program
 
QUANTITATIVE GENETICS AND GENOMICS

February 20-25, 2005
Ventura Beach Marriott
Ventura, CA

Chair:
Rebecca W. Doerge

Vice Chair:
Patrick C. Phillips

Quantitative genetics aims to link phenotypic variation to its underlying genetic basis in order to better understand and predict genetic composition and long term change within natural, agricultural, and human populations. Traditionally built upon statistical abstractions of genetic effects, the field is now poised to make use of recent advances in genetic technology to reveal explicit links between genes and complex phenotypes, and therefore serves as a focal point bringing together many emerging areas of genetics, genomics, statistics, and biotechnology. This synthesis is already having a large impact on the areas of evolutionary biology, plant and animal breeding, and the analysis of human disease. The strength of the Gordon Conference on "Quantitative Genetics and Genomics" has historically been the bringing together of leaders in each of these fields to explore areas of shared interest and cutting edge developments with the potential to affect all researchers within the broad field of quantitative genetics.

In planning the 2005 Gordon Conference on "Quantitative Genetics and Genomics" we looked to expanding areas of science that are founded in both classical quantitative genetics and evolution, and that are advancing quickly due to the gain in information provided by genomics and proteomics. In the process of collecting session ideas and speaker suggestions, it became abundantly clear that transcript profiling has significantly impacted how we think about quantitative variation and complex traits. Transcript profiling (e.g., microarray technology) is currently supporting the exploration of "genetic architecture" (e.g., expression QTL mapping) and in turn has created a great deal of excitement and interest across a variety of organisms. The molecular dissection of complex phenotypes is providing direct evidence about gene regulation, evolution, the genetic landscape, and the future roles of quantitative genetics. It is amazing how many people are thinking about related issues of genetic architecture. Therefore, our hope for this conference is to provide a forum for the presentation of new ideas and data so that we might all come away with a slightly stronger understanding of the genetic basis of inheritance.

We look forward to meeting you in Ventura, CA in February of 2005! Your continued participation and support of this conference is greatly appreciated. As you will see from the schedule, afternoons are free for adventure and discussion, while poster sessions will be held in the evening.

If you are a graduate student and would like to apply for the student speaker competition (registration and travel included), please apply to Rebecca Doerge (doerge@purdue.edu) by sending your CV, title, abstract, and letter of recommendation from your advisor (e-mail is fine). Deadline for travel fund application is December 1, 2004. Successful applicants will be notified shortly thereafter.

If you would like to present a poster, please be sure to indicate this on your Gordon Conference application.

Lastly, if you are interested in making a financial contribution to the Chair's fund (to support registration, travel, and social activities), please contact Rebecca Doerge (doerge@purdue.edu).

See you in Ventura!

Rebecca and Patrick
Chair: R.W. Doerge
Co-Chair: Patrick Phillips


SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
Chair: Rebecca Doerge (Purdue University)
Welcome, Opening Remarks, & Announcements
7:30 pm - 9:30 pmAt the Interface of Quantitative Genetics and Systems Biology
Discussion Leader: Bill Beavis (National Center for Genome Resources)
7:30 pm - 7:40 pm Introduction and concepts (Bill Beavis)
7:40 pm - 8:25 pmBruce Weir (North Carolina State Univerrsity)
"Quantitative Genetics or Quantitative Genomics?"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:20 pmEric Davidson (California Institute of Technology)
"The genomic regulatory system for embryonic development in the sea urchin"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenetic Variation and Evolutionary Change
Discussion Leader: Patrick Phillips (University of Oregon)
9:00 am - 9:10 amIntroduction and concepts (Patrick Phillips)
9:10 am - 9:40 am Frédéric Hospital (INRA)
"The impact of selection on the apparent architecture of quantitative traits'"
9:45 am - 10:15 am Tom Osborn (University of Wisconsin, Madison)
"Genetic and epigenetic changes in newly formed polyploids"
10:20 am - 10:40 am Coffee Break
10:40 am - 11:10 amJoanna Masel (University of Arizona)
"A population genetics framework to predict the evolution of evolutionary capacitance"
11:15 am GROUP PHOTO
11:45 am - 12:15 pmSergey Nuzhdin (University of California, Davis)
"Functional analysis of expression variation: yeast and flies"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Viewing
6:00 pmDinner
7:30 pm - 9:30 pmMapping Genes Affecting Complex Traits in Humans
Discussion Leader: Zhao-Bang Zeng (North Carolina State University)
7:30 pm - 7:40 pmIntroduction and concepts (Zhao-Bang Zeng)
7:40 pm - 8:25 pmHeather Cordell (Cambridge Institute for Medical Research)
"Detection and estimation of effects at interacting loci under varying ascertainment schemes in genetic association studies"
8:30 pm - 9:15 pm Lon Cardon (Wellcome Trust Centre for Human Genetics)
"Genome-wide linkage disequilibrium meets disease association"
9:15 pm - 9:30 pmDiscussion
9:30 pmPosters and refreshments
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenetic Architecture of Transcript Abundance Variation
Discussion Leader: Gary Churchill (Jackson Laboratories)
9:00 am - 9:10 amIntroduction and concepts (Gary Churchill)
9:10 am - 9:40 amLeonid Kruglyak / Rachel Brem (Fred Hutchinson Cancer Research Center)
"The landscape of genetic complexity in the yeast transcriptome"
9:45 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 am Daniel Pomp (University of Nebraska, Lincoln)
"Genomic architecture of obesity predisposition"
11:05 am - 11:35 amRob Williams (University of Tennessee)
"Genetic network analysis of brain transcriptome, structure and function"
11:40 am - 12:10 pm Peter Keightley (University of Edinburgh)
"Resolving genes that underlie quantitative variation for growth in mice"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Viewing
6:00 pmDinner
7:30 pm - 9:30 pmSo Much Diversity: Applied Genetics and Genomics in Trees
Discussion Leader: Bill Hill (University of Edinburgh)
7:30 pm - 7:40 pmIntroduction and concepts (Bill Hill)
7:40 pm - 8:10 pm Jeanne Romero-Severson (University of Notre Dame)
"Genetic maps in intractable species of forest trees"
8:15 pm - 8:45 pm Dave Neale (University of California, Davis)
"Association genetics of natural genetic diversity and complex traits in pine"
8:50 pm - 9:20 pmRon Sederoff (North Carolina State University)
"Transcript abundance variation in forest trees and the molecular basis of superior phenotypes"
9:20 pm - 9:30 pmDiscussion
9:30 pmPosters and refreshments
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStatistical Genetics and QTL Analysis
Discussion Leader: Lauren McIntyre (Purdue University)
9:00 am - 9:10 amIntroduction and concepts (Lauren McIntyre)
9:10 am - 9:55 am Örjan Carlborg (Uppsala University)
"Interactive genetics - Epistasis and the control of complex traits"
10:00 am - 10:30 amCoffee Break
10:30 am - 11:15 amDina St. Clair (University of California, Davis)
"Quantitative traits in plants: QTL architecture, interactions, and dissection"
11:20 am - 12:05 pmPeter Visscher (University of Edinburgh)
"Estimation of past effective population size from linkage disequilibrium between genetic markers"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Viewing
6:00 pmDinner
7:30 pm - 9:30 pmLivestock Proteomics and Student Presentation
Discussion Leader: Max Rothschild (Iowa State University)
7:30 pm - 8:15 pm Min Zhang (Cornell University): Student Travel Award Winner
"Mapping Multiple QTL by Bayesian Classification"
8:20 pm - 8:50 pmBUSINESS MEETING
8:50 pm - 9:20 pm Shane Burgess (Mississippi State University)
"Livestock proteomics: challenges of GOing from MuDPITs"
9:20 pm - 9:30 pm Discussion
9:30 pmPosters and refreshments
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInference of Evolutionary History
Discussion Leader: Doug Crawford (University of Miami)
9:00 am - 9:10 am Introduction and concepts (Doug Crawford)
9:10 am - 9:55 am Michael Purugganan (North Carolina State University)
"Evolutionary genetics of plant adaptation"
10:00 am - 10:30 am Coffee Break
10:30 am - 11:15 amLaura Salter (University of New Mexico)
"Prospects and pitfalls of whole-genome phylogeny based on DNA sequences"
11:20 am - 12:05 pmThomas Mitchell-Olds (Max Planck Institute for Chemical Ecology)
"Evolutionary significance of ecologically important variation in Arabidopsis relatives"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Viewing
6:00 pmDinner
7:30 pm - 9:30 pmFalse Discovery Rate (FDR) for Genetic and Genomic Data
Discussion Leader: Sandrine Dudoit (University of California, Berkeley)
7:30 pm - 7:40 pmIntroduction and concepts (Sandrine Dudoit)
7:40 pm - 8:25 pm John Storey (University of Washington)
"Statistical significance for multiple locus linkage analysis of genome-wide expression"
8:30 pm - 9:15 pm Yoav Benjamini (Tel Aviv University)
"Multiplicity issues in Statistical Genetics: QTL analysis, microarrays, and behavior genetics"
9:15 pm - 9:30 pm Discussion
9:30 pm Posters and refreshments
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Last Updated: August 14, 2006