Conference Program
 
BIOELECTROCHEMISTRY

September 3-8, 2006
Centre Paul Langevin
Aussois, France

Chair:
Justin Teissie

Vice Chair:
Ann M. Rajnicek

The 2006 Bioelectrochemistry Conference will continue to examine the latest advances in our understanding of the molecular and cellular biophysics of cellular interactions with electric fields and currents. A large part of the 2006 program will be devoted specifically at the advances at the temporal and spatial nanoscale for studying cell dynamics. Our tradition of international participation will continue, with significant involvement of speakers from both the US and abroad.

Conference Theme
The particular focus, the mechanisms of cellular interactions with electric fields at a nanoscale, emphasizes the physicochemical interactions that may account for observed biological functions. This approach encourages the interpretation of experimental observations in terms of hypotheses that involve biophysical mechanisms that alter life processes. Although the scheduled presentations are a clear focus ((clear clues of the conference discussions contents)) of the discussions, all participants are encouraged to present posters that will stimulate additional discussions. To this end, some of the posters will be selected for short presentations to the entire group at the "Hot Topics" session.

Aims and Relevance
Both the presentations and the ensuing discussions are intended to emphasize new results and concepts for a nanoscale description of bioelectrochemical effects processes?. This means that considerable attention will be paid to how fields and currents can interact with ongoing biological processes both at the molecular level and at a submicrosecond time scale. Moreover, once hypotheses for field control of molecular processes are formulated, consideration is given to what biological and fundamental competition exists (e.g. endogenous electric fields, local structural and dynamic changes, thermal and shot noise, respectively). This allows pursuit of a solid foundation for considering the bioelectrochemical aspects of cellular, and then tissue processes. These tools and concepts of nanobiotechnology should provide a basis for evaluating significant human health risks and developing new bioassays as well as new biomedical applications.


CONTRIBUTORS


SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments
7:40 pm - 9:30 pm EXCHANGE ACROSS BIOLOGICAL BARRIERS I: A IN SILICO APPROACH
Discussion Leader: Peter Tieleman (University of Calgary, Calgary, Canada)
7:40 pm - 7:50 pmIntroduction
7:50 pm - 8:25 pm Tadej Kotnik (University Of Ljubljana, Slovenia)
"Theoretical evaluation of voltage inducement on internal membranes of cells exposed to electric fields"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:10 pm Marek Tarek (CNRS Nancy France)
"Insight into electroporation phenomena from atomistic Molecular Dynamics simulations"
9:10 pm - 9:20 pmDiscussion
9:20 pm- 9:30 pmConclusion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm EXCHANGE ACROSS BIOLOGICAL BARRIERS II: MEMBRANE COHESION AND STABILITY
Discussion Leader: Eberhard Neumann (University of Bielefeld, Germany)
9:00 am - 9:10 amIntroduction
9:10 am - 9:40 am Nicolas Borghi (Laboratoire PCC Institut Curie/CNRS UMR 168, Paris, France)
"Transport: role of transient pores and lipidic tubes"
9:40 am - 9:45 amDiscussion
9:45 am - 10:15 am Stephanie Tristram-Nagle (Biological Physics Group, Physics Department, Carnegie Mellon University, Pittsburgh,)
"Implications of Structure for Water Permeability through Fully Hydrated Fluid Lipid Bilayers"
10:15 am - 10:20 amDiscussion
10:20 amGroup Photo / Coffee Break
10:45 am - 11:15 am Eefjan Breukink (University of Utrecht , The Netherlands)
"Lipid-peptide interactions during pore-formation by a peptide antibiotic"
11:15 pm - 11:20 pmDiscussion
11:20 am - 11:50 pm Malgorzata Kotulska ( Wroclaw University of Technology, Poland.)
"Flicker noise from electro-nanopore in lipid bilayer"
11:50 pm - 11:55 amDiscussion
11:55 am - 12:25 pm Wanda Krassowska (Department of Biomedical Engineering, Duke University, Durham,)
"Modeling Electropores for DNA Delivery"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm ENDOGENOUS ELECTRIC FIELDS I: SENSITIVITY BY ANIMALS
Discussion Leader: Hans Gruler (University of Ulm, Germany)
7:30 pm - 7:40 pmIntroduction
7:40 pm - 8:15 pm Kevin Henbest (Physical and Theoretical Chemistry, University of Oxford, Oxford ,U.K.)
"The effect of weak static and oscillating magnetic fields on radical recombination reactions"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 9:00 pm Henrike Mouritsen (Volkswagen Nachwuchsgruppe Animal Navigation, Institute of Biology, University of Oldenburg, Germany)
"Cryptochromes and their possible role in the magnetic compass of migratory birds"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmConclusion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm EXCHANGE ACROSS BIOLOGICAL BARRIERS III: DEVELOPMENTS OF SYNTHETIC NANOPORES
Discussion Leader: Mathias Winterhalter (iu-bremen., Germany)
9:00 am - 9:10 amIntroduction
9:10 am - 9:40 am John J. Kasianowicz (National Institute of Standards and Technology, Gaithersburg)
"DNA and Protein Transport in Protein Ion Channels"
9:40 am - 9:45 amDiscussion
9:45 am - 10:15 am Daniel Branton (Molecular and Cellular Biology, Harvard University, Cambridge)
"Prospects for Improved Temporal and Spatial Resolution of Nanopores as Bioelectrochemical Sensors"
10:15 am - 10:20 amDiscussion
10:20 amCoffee Break
10:50 am - 11:25 am Aleksel Aksimentiev (Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign)
"Imaging DNA Translocation through Nanopores with Molecular Dynamics"
11:25 am - 11:30 amDiscussion
11:30 am - 12:05 pm Rafi Korenstein (Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel)
"Electroendocytosis - stimulation of endocytic pathways by pulsed low electric fields"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmConclusion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmELECTRICAL DETECTION OF DNA
Discussion Leader: Hubert H. Girault (Electrochimie Physique et Analytique, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland)
7:30 pm - 7:40 pmIntroduction
7:40 pm - 8:10 pm Ashok Mulchandani (Chemical and Environmental Engineering, and Center for Nanoscale Science and Engineering, University of California-Riverside, Riverside, and Jet Propulsion Laboratory, California Institute of Technology, Pasadena)
"Nanowire nanosensors"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:50 pm Serge Cosnier (Electrochimie Organique et de Photochimie Redox UMR 5630 CNRS, Universite Joseph Fourier, Grenoble, France)
"Biointerface design by electropolymerized films"
8:50 pm - 8:55 pmDiscussion
8:55 pm- 9:25 pm Chad A. Mirkin (Dept of Chemistry and Institute for Nanotechnology, Northwestern University, Evanston)
"Bio Barcode Amplification PCR-like Sensitivity for Proteins"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm EXCHANGE ACROSS BIOLOGICAL BARRIERS IV FROM EXOCYTOSIS TO PATCH CLAMP
Discussion Leader: J.P. Henry (Institut de Biologie Physico-Chimique,CNRS UPR 1929, Paris, France)
9:00 am - 9:10 amIntroduction
9:10 am - 9:40 am Jens Rettig (Universität des Saarlandes, Physiologisches Institut ,Homburg/Saar, Germany)
"Measuring Exocytosis with Capacitance and Amperometry"
9:40 am - 9:45 amDiscussion
9:45 am - 10:15 am Stephane Arbault (Ecole Normale Superieure, UMR CNRS-ENS-UPMC 8640 PASTEUR, Paris, France.)
"Exocytosis and Oxidative Stress: Coupling Good and Bad in Brain Functionnal Behavior"
10:15 am - 10:20 amDiscussion
10:20 amCoffee Break
10:50 am - 11:25 pm Francisco Bezanilla (Physiology, D. Geffen School of Medicine at UCLA, Los Angeles)
"Voltage sensors in ion channels"
11:25 pm - 11:30 pmDiscussion
11:30 am - 12:05 pm Ian Parker (Neurobiology and Behavior, University of California, Irvine)
"Optical patch-clamping : Imaging Ca2+ flux through single channels"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmConclusion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm ENDOGENOUS ELECTRIC FIELDS II: ROLE IN WOUND HEALING AND SPINAL CORD REGENERATION
Discussion Leader: Raphael C. Lee (Electrical Trauma Research Laboratory/Department of Surgery University of Chicago Chicago)
7:30 pm - 7:40 pmIntroduction
7:40 pm - 8:15 pm Richard Borgens / Pedro Irazoqui (School of Veterinary Medicine, School of Engineering, Purdue University)
"Treating the Damaged Human Nervous System through Biophysics"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 9:00 pm Colin McCaig (University of Aberdeen, Aberdeen, UK)
"Controlling cell behaviour electrically"
9:00 pm - 9:10 pmDiscussion
9:10 pm- 9:30 pmConclusion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm EXCHANGE ACROSS BIOLOGICAL BARRIERS V: ELECTRICALLY INDUCED TRANSPORT BY ULTRASHORT AND LOW INTENSITY PULSES
Discussion Leader: Lluis Mir (IGR CNRS, Villejuif, France)
9:00 am - 9:10 amIntroduction
9:10 am - 9:40 am Karl H. Schoenbach (Frank Reidy Research Center for Bioelectrics, Old Dominion University)
"Subcellular Effects of Nanosecond Electrical Pulses"
9:40 am - 9:45 amDiscussion
9:45 am - 10:15 am Ephrem Tekle (Biochemistry, NHLBI, NIH, Bethesda)
"Sensitivity of membrane proteins to nsPEFs"
10:15 am - 10:20 amDiscussion
10:20 amCoffee Break
10:50 am - 11:25 pm Richard Nuccitelli (Frank Reidy Research Center for Bioelectrics, Old Dominion University)
"Nanosecond Pulsed Electric Fields Stimulate Melanomas to Self-Destruct"
11:25 pm - 11:30 pmDiscussion
11:30 am - 12:05 pm Rumy Dimova (Max Planck Institute of Colloids and Interfaces, Golm, Germany)
"Electro-deformation, -poration, and -fusion of model membranes viewed with high temporal resolution"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmConclusion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm HOT TOPICS AND SELECTED POSTER PRESENTATIONS
Discussion Leader: Ann M. Rajnicek (Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK)
7:30 pm - 7:40 pmIntroduction
7:40 pm - 7:55 pm Yinghua Sun (USC, Los Angeles CA, USA)
"Transient membrane permeability induced by nanoelectropulses detected with the early apoptosis probe YO0PRO-1"
7:55 pm - 8:10 pm Helene Ceremonie (CEGELY, ECL, Ecully, France)
"Natural electrotransformation or lightning transformation of Pseudomonas sp. N3 in soil"
8:10 pm - 8:25 pm Ben Greenebaum (University of Wisconsin, Parkside WI, USA)
"Does electric field or current provide a test of mechanism involved in nerve regeneration?"
8:25 pm - 8:40 pm Eugenia Kovacs (Carol Davila Medical School, Bucharest, Romania)
"New methods proposed for evaluation of photoreceptor cells viability in retinal transplant based on cell polarity"
8:40 pm - 8:55 pm Gale Craviso (University of Nevada, Reno NV, USA)
"Elevation of intracellular calcium in bovine adrenal chromaffin cells subjected to a single nanosecond electric pulse"
8:55 pm - 9:10 pm Carlos Martino (University of Colorado, Boulder CO, USA)
"Electromagnetic stimulation of osteoblast-like cells"
9:10 pm - 9:25 pm David Woolley (University of Manchester, Manchester UK)
"Electrochemical monitoring of rat mammary carcinoma cells in response to four anticancer drugs"
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Last Updated: October 11, 2006