Conference Program
 
Proteoglycans

July 9-14, 2006
Proctor Academy
Andover, NH

Chair:
Alan C. Rapraeger

Vice Chair:
Thomas N. Wight

Proteoglycans of the cell surface and extracellular matrix are continually emerging in new roles as this exciting field expands into all aspects of cell biology and human disease. The field is engaged in understanding the intricate structure of the proteoglycan glycosaminoglycan chains, the means by which they are synthesized and degraded within the cell, and the manner by which they regulate the signaling of growth factors and cytokines, as well as drive extracellular matrix assembly mechanisms that control organ morphogenesis and disease. Intense focus is also on interactions of the families of proteoglycan core proteins with other matrix partners in connective tissues and with neighboring receptors at the cell surface. These interactions are essential for organ form and function, establish signaling pathways that control cell behavior, and are targets for disruption by pathological mechanisms and inflammation that lead to aging and disease.

The Proteoglycan Gordon Conference boasts a dynamic, close-knit, collaborative and welcoming international community of scientists. The week of the Conference will be spent in plenary sessions with active question/answer periods, poster presentations and social activities aimed at exchanging new ideas, information and technologies, and encouraging the participation of conferees of all levels of expertise.

The program will consist of nine plenary sessions. Each session will be comprised of invited speakers (shown below) and supplemented as the conference approaches by talks selected from submitted abstracts.

The organizers would like to thank the following contributors for support of the 2006 conference:

Gordon Research Conferences
National Institutes of Health
Momenta Pharmaceuticals, Inc.
LEO-Pharma
Glycoscience Laboratories, Inc.
Mizutani Foundation for Glycoscience
Sanofi-Aventis (France)
Seikagaku Corporation
Zacharon Pharmaceuticals, Inc.
The Lupus Foundation of America, Inc.
IBEX Pharmaceuticals, Inc.
Promega Corporation
Halozyme Therapeutics, Inc.
The Carl Storm International Diversity Fellowship Program

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
5:00 pm - 6:00 pmWine and Cheese Reception
6:00 pmDinner
7:30 pm - 7:45 pmWelcome and Introductions (Alan C. Rapraeger, Conference Chair)
7:45 pm - 9:30 pmLate Breaking Developments in Proteoglycan Research
Discussion Leader: Alan C. Rapraeger (University of Wisconsin-Madison, USA)
7:45 pm - 8:02 pmMatthew P. Hoffman (National Institutes of Health, USA)
"Heparan sulfate regulation of FGF10 function during salivary gland branching morphogenesis"
8:02 pm - 8:10 pmDiscussion
8:10 pm - 8:27 pmHideto Watanabe (Aichi Medical University, Japan)
"Glycosyltransferase(s) critical for chondroitin sulfate biosynthesis in cartilage"
8:27 pm - 8:35 pmDiscussion
8:35 pm - 8:52 pmJuan Larrain (Pontificia Universidad Católica de Chile, Chile)
"Proteoglycan function during early development of Xenopus embryos"
8:52 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmDeannaLee Beauvais (University of Wisconsin-Madison, USA)
"Regulation of alphavß3 and alphavß5 integrins by syndecan-1 in angiogenesis"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSuniti Misra (Medical University of South Carolina, USA)
"Regulation of Receptor Tyrosine kinases and COX-2 by Hyaluronan and its potential role in colon cancer"
9:15 pm - 9:30 pmDiscussion
9:30 pmReception at Posters
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmBiosynthesis and Structure of Glycosaminoglycans
Discussion Leader: Barbara Mulloy (National Institute for Biological Standards and Control, UK)
9:00 am - 9:20 amLena Kjellén (Uppsala University, Sweden)
"Cellular design of heparan sulfate"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amKazuyuki Sugahara (Kobe Pharmaceutical University, Japan)
"Functions and structural motifs of chondroitin sulfate/dermatan sulfate"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amJeremy Turnbull (Univ. Liverpool, UK)
"Exploitation of heparan sulfates in directed neuronal differentiation of stem cells"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amWilliam Lamanna (Univ. Goettingen, Germany)
"mSulf1 and mSulf2 differentially modify heparan sulfate 6-O sulfation patterning"
10:25 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 amMarco Maccarana (Lund University, Sweden)
"Dermatan sulfate epimerases"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amJulie Leary (University of California-Davis, USA)
"Mapping GAG-Chemokine Interactions and Multimer Specificity"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJames Funderburgh (Univ. Pittsburgh, USA)
"Identification of enzymes involved in corneal keratan sulfate synthesis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmGuido Jenniskens (Univ. Medical Center Nijmegen, Netherlands)
"Myo-glycomics: glycosaminoglycans in healthy and diseased muscle interstitium"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Softball Match
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStructure-Activity of Glycosaminoglycans
Discussion Leader: Dina Ron (Technion, Israel)
7:30 pm - 7:50 pmJohn Gallagher (University of Manchester, UK)
"Design and Function in Heparan Sulfate"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMoosa Mohammadi (New York University, USA)
"A protein canyon in the FGF-FGFR dimer selects from an à la carte menu of heparan sulfate motifs"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmAmanda Proudfoot (Serono Pharmaceutical Research Institute, Switzerland)
"The role of chemokine-proteoglycan interactions in chemokine biology"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmElliot Chaikof (Emory Univ., USA)
"Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmMalcolm Lyon (Univ. Manchester, UK)
"The specificity of glycosaminoglycan interactions with hepatocyte growth factor / scatter factor (HGF/SF)"
9:25 pm - 9:30 pmDiscussion
9:30 pmDiscussion at Posters
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProteoglycans of the Musculoskeletal System
Discussion Leader: Renato Iozzo (Thomas Jefferson University, USA)
9:00 am - 9:20 amMarian Young (National Institutes of Health, USA)
"SLRPs in skeletal function and aging"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amLilliana Schaefer (University of Muenster, Germany)
"Decorin- and biglycan-signaling in inflammation and fibrosis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amJens W. Fischer (Univ. Dusseldorf, Germany)
"Biglycan is required for adaptive remodeling after myocardial infarction"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amStacey C. Schutte (Georgia Institute of Technology, USA)
"The effects of decorin on collagen synthesis and strength in blood vessel substitutes"
10:25 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 amEnrique Brandan (Catholic University of Chile, Chile)
"Role of SLRPs during skeletal muscle formation and disease"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amWinston Kao (University of Cincinnati, USA)
"Lumican in epithelial-mesenchymal transition and wound healing"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShukti Chakravarti (John Hopkins Univ., USA)
"Extracellular matrix proteoglycan lumican promotes CD14-TLR4-mediated innate immune response to bacterial lipopolysacharide"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmKevin McCarthy (Louisiana State Univ., USA)
"Targeted deletion of EXT1 in glomerular podocytes leads to compromise of the ultrastructure of the glomerular capillary wall in mice"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Cricket Match
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmProteoglycans in Cell Signaling Mechanisms
Discussion Leader: Anne Woods (University of Alabama-Birmingham, USA)
7:30 pm - 7:50 pmPascale Zimmermann (University of Leuven, Belgium)
"Intracellular mechanisms of syntenin/syndecan signaling"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmPeisong Ma (Univ. Virginia, USA)
"Heparanase deglycanation of syndecan-1 is required for binding of epithelial-restricted prosecretory mitogen 'lacritin'"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmBradley Olwin (University of Colorado-Boulder, USA)
"Syndecan regulation of the muscle stem cell niche"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmEok-Soo Oh (Ewha Womans University, Korea)
"Syndecan-2 signaling activity in tumorigenesis"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmManoranjan M. Santra (Henry Ford Hospital, USA)
"Neuro protection by de novo decorin expression in an ischemic cell culture model system"
9:25 pm - 9:30 pmDiscussion
9:30 pmDiscussion at Posters
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProteoglycans in Development
Discussion Leader: Scott Selleck (University of Minnesota, USA)
9:00 am - 9:20 amRahul Warrior (University of California-Irvine, USA)
"Developmental regulation of heparan sulfate proteoglycan synthesis in Drosophila"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amHenry Roehl (University of Sheffield, UK)
"The role of HSPGs during zebrafish skeletal morphogenesis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amSimona Zisman-Rozen (Technion Institute of Technology, Israel)
"Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amKeisuke Kamimura (Aichi Medical University, Japan)
"Specific and flexible roles of heparan sulfate modifications in drosophila FGF signaling"
10:25 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 amNorman Rosenblum (Hospital for Sick Children, Canada)
"Modulation of signaling and morphogenesis in the kidney by HSPGs"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amSara Olson (University of California-San Diego, USA)
"A novel class of CSPGs mediate early embryogenesis in C. elegans"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmScott Saunders (Washington Univ., USA)
"Functional role of glypican-3 in hematopoiesis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmYasuhiro Katagiri (National Institutes of Health, USA)
"Quantitative differential sulfation pattern of chondroitin regulates axonal guidance"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmProteoglycans in Injury and Inflammation
Discussion Leader: Thomas Wight (Benaroya Research Institute, USA)
7:30 pm - 7:50 pmBurton Yang (Sunnybrook and Women's Health Science Center, Canada)
"The role of proteoglycan versican in mediating endothelial cell activities and angiogenesis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmPaul Noble (Yale University, USA)
"Location matters: The role of Hyaluronan in lung injury and repair"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmAnna Plaas (University of South Florida, USA)
"Proteoglycanolysis in the Arthritic Joint: Pro-and Anti-inflammatory Roles of ADAMTSs and MMPs"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:07 pmHerbert Geller (National Institutes of Health, USA)
"Chondroitin sulfate proteoglycan glycosaminoglycan chain synthesis: a potential molecular target"
9:07 pm - 9:10 pmDiscussion
9:10 pm - 9:17 pmCharles W. Frevert (Univ. Washington, USA)
"The role of MyD88 in regulating the expression of proteoglycans and hyaluronan synthases in lungs of mice exposed to lipopolysaccharide"
9:17 pm - 9:20 pmDiscussion
9:20 pm - 9:27 pmCarol de La Motte (Cleveland Clinic Foundation, USA)
"Hyaluronan-mediated platelet-endothelial cell interactions specifically generate signaling-sized fragments of hyaluronan that promote inflammation and angiogenesis"
9:27 pm - 9:30 pmDiscussion
9:30 pmDiscussion at Posters
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProteoglycans in Cancer
Discussion Leader: Ralph Sanderson (University of Alabama-Birmingham, USA)
9:00 am - 9:20 amRenato Iozzo (Thomas Jefferson Univ., USA)
"Processed forms of perlecan regulate tumor angiogenesis"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSteven Rosen (University of California-San Francisco, USA)
"Hsulf in pancreatic cancer and wnt signaling"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amMelanie Simpson (Univ. Nebraska, USA)
"Progression of prostate cancer is induced by hyaluronan synthesis and turnover"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amAndreas Friedl (Univ. Wisconsin-Madison, USA)
"Glypican-1 is required for cell cycle progression in mouse brain endothelial cells"
10:25 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 amLena Claesson-Welch (Uppsala University, Sweden)
"Heparan sulfate in transactivation of growth factor receptors"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amHiroyuki Aburatani (University of Tokyo, Japan)
"Glypican-3 as a novel diagnostic and therapeutic target for hepatocellular carcinoma"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmQin Yu (Univ. Pennsylvania, USA)
"The pro- and anti-metastatic activity exerted by full-length ADAMTS-1 and the ADAMTS-1 fragments, respectively, is regulated by heparan sulfate proteoglycan"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmJoji Iida (Univ. Minnesota, USA)
"Chondroitin sulfate enhances pro-MMP-2 (progelatinase A) activation by membrane-type 3 matrix metalloproteinase (MT3-MMP) in vitro"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Soccer Match
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 7:50 pmPoster Awards
Leader: Tom Wight, Conference Vice-Chair
7:50 pm - 9:30 pmProteoglycans in Disease Models
Discussion Leader: Shukti Chakravarti (Johns Hopkins University, USA)
7:50 pm - 8:20 pmJeffrey Esko (University of California-San Diego, USA)
"The amazing proteoglycans of model organisms"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:05 pmBryan Toole (Medical University of South Carolina, USA)
"Hyaluronan in tumorigenesis"
9:05 pm - 9:20 pmDiscussion
9:30 pmDiscussion at Posters
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
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Last Updated: October 11, 2006